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Staff at EMBL

James Reddington

Postdoctoral Fellow (EIPOD)
Furlong Group Birney Projects

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Publications

Total: 12 publication(s)

2014

Reddington JP, Sproul D, Meehan RR. (2014)
DNA methylation reprogramming in cancer: does it act by re-configuring the binding landscape of Polycomb repressive complexes?
Bioessays 36(2):134-140. doi:10.1002/bies.201300130
Europe PMC | doi


2013

Nestor CE, Reddington JP, Benson M, Meehan RR. (2013)
Investigating 5-hydroxymethylcytosine (5hmC): the state of the art.
Methods Mol. Biol. 1094:243-258. doi:10.1007/978-1-62703-706-8_19
Europe PMC | doi

Reichmann J, Reddington JP, Best D, Read D, Ollinger R, Meehan RR, Adams IR. (2013)
The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice.
Hum. Mol. Genet. 22(9):1791-1806. doi:10.1093/hmg/ddt029
Europe PMC | doi

Reddington JP, Pennings S, Meehan RR. (2013)
Non-canonical functions of the DNA methylome in gene regulation.
Biochem. J. 451(1):13-23. doi:10.1042/bj20121585
Europe PMC | doi


2012

Reddington JP, Perricone SM, Nestor CE, Reichmann J, Youngson NA, Suzuki M, Reinhardt D, Dunican DS, Prendergast JG, Mjoseng H, Ramsahoye BH, Whitelaw E, Greally JM, Adams IR, Bickmore WA, Meehan RR. (2012)
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes.
Genome Biol. 14(3) doi:10.1186/gb-2013-14-3-r25
Europe PMC | doi

Hackett JA, Reddington JP, Nestor CE, Dunican DS, Branco MR, Reichmann J, Reik W, Surani MA, Adams IR, Meehan RR. (2012)
Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline.
Development 139(19):3623-3632. doi:10.1242/dev.081661
Europe PMC | doi

Nestor CE, Ottaviano R, Reddington J, Sproul D, Reinhardt D, Dunican D, Katz E, Dixon JM, Harrison DJ, Meehan RR. (2012)
Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.
Genome Res. 22(3):467-477. doi:10.1101/gr.126417.111
Europe PMC | doi

Brook M, McCracken L, Reddington JP, Lu ZL, Morrice NA, Gray NK. (2012)
The multifunctional poly(A)-binding protein (PABP) 1 is subject to extensive dynamic post-translational modification, which molecular modelling suggests plays an important role in co-ordinating its activities.
Biochem. J. 441(3):803-812. doi:10.1042/bj20111474
Europe PMC | doi


2011

Reddington JP, Meehan RR. (2011)
Putting muscle in DNA methylation.
Cell Res. 21(11):1531-1533. doi:10.1038/cr.2011.91
Europe PMC | doi


2010

Meng HX, Hackett JA, Nestor C, Dunican DS, Madej M, Reddington JP, Pennings S, Harrison DJ, Meehan RR. (2010)
Apoptosis and DNA methylation.
Cancers (Basel) 3(2):1798-1820. doi:10.3390/cancers3021798
Europe PMC | doi


2009

Ruzov A, Hackett JA, Prokhortchouk A, Reddington JP, Madej MJ, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR. (2009)
The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways.
Development 136(5):723-727. doi:10.1242/dev.025577
Europe PMC | doi

Ruzov A, Savitskaya E, Hackett JA, Reddington JP, Prokhortchouk A, Madej MJ, Chekanov N, Li M, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR. (2009)
The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development.
Development 136(5):729-738. doi:10.1242/dev.025569
Europe PMC | doi