Staff at EMBL

Dr. Wolfgang Huber

Group Leader and Senior Scientist
Huber Group Joint appointment: EMBL-EBI Hinxton

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

PhD 1998, Statistical Physics, University of Freiburg.
Postdoctoral research at IBM Research, San Jose, California, 1998-1999, and at DKFZ, Heidelberg, 2000-2004.
Group leader at EMBL-EBI 2004-2009 and at EMBL Heidelberg since 2009.
Senior scientist since 2011.

Publications

The Genomic and Transcriptomic Landscape of a HeLa Cell Line. Landry, J.J., Pyl, P.T., Rausch, T., Zichner, T., Tekkedil, M.M., Stutz, A.M., Jauch, A., Aiyar, R.S., Pau, G., Delhomme, N., Gagneur, J., Korbel, J.O., Huber, W. & Steinmetz, L.M. G3 (Bethesda). 2013 Mar 26. pii: g3.113.005777v6. doi: 10.1534/g3.113.005777. PubMed

Detecting differential usage of exons from RNA-seq data. Anders, S., Reyes, A. & Huber, W. Genome Res. 2012 Oct;22(10):2008-17. doi: 10.1101/gr.133744.111. Epub 2012 Jun21. PubMed

Tandem fluorescent protein timers for in vivo analysis of protein dynamics. Khmelinskii, A., Keller, P.J., Bartosik, A., Meurer, M., Barry, J.D., Mardin, B.R., Kaufmann, A., Trautmann, S., Wachsmuth, M., Pereira, G., Huber, W., Schiebel, E. & Knop, M. Nat Biotechnol. 2012 Jun 24;30(7):708-14. doi: 10.1038/nbt.2281. PubMed

Highly Coordinated Proteome Dynamics during Reprogramming of Somatic Cells to Pluripotency. Hansson J., Rafiee M.R., Reiland S., Polo J.M., Gehring J., Okawa S., Huber W., Hochedlinger K., Krijgsveld J. Cell Rep. 2012 Dec 27;2(6):1579-92. doi: 10.1016/j.celrep.2012.10.014. PubMed

cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression. Benito, E., Valor, L.M., Jimenez-Minchan, M., Huber, W. & Barco, A. J Neurosci. 2011 Dec 14;31(50):18237-50. doi: 10.1523/JNEUROSCI.4554-11.2011. PubMed

Relating CNVs to transcriptome data at fine resolution: Assessment of the effect of variant size, type, and overlap with functional regions. Schlattl, A., Anders, S., Waszak, S.M., Huber, W. & Korbel, J.O. Genome Res. 2011 Dec;21(12):2004-13. Epub 2011 Aug 23. PubMed

Enterotypes of the human gut microbiome. Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D.R., Fernandes, G.R., Tap, J., Bruls, T., Batto, J.M., Bertalan, M., Borruel, N., Casellas, F., Fernandez, L., Gautier, L., Hansen, T., Hattori, M., Hayashi, T., Kleerebezem, M., Kurokawa, K., Leclerc, M., Levenez, F., Manichanh, C., Nielsen, H.B., Nielsen, T., Pons, N., Poulain, J., Qin, J., Sicheritz-Ponten, T., Tims, S., Torrents, D., Ugarte, E., Zoetendal, E.G., Wang, J., Guarner, F., Pedersen, O., de Vos, W.M., Brunak, S., Dore, J., Antolin, M., Artiguenave, F., Blottiere, H.M., Almeida, M., Brechot, C., Cara, C., Chervaux, C., Cultrone, A., Delorme, C., Denariaz, G., Dervyn, R., Foerstner, K.U., Friss, C., van de Guchte, M., Guedon, E., Haimet, F., Huber, W., van Hylckama-Vlieg, J., Jamet, A., Juste, C., Kaci, G., Knol, J., Lakhdari, O., Layec, S., Le Roux, K., Maguin, E., Merieux, A., Melo Minardi, R., M'rini, C., Muller, J., Oozeer, R., Parkhill, J., Renault, P., Rescigno, M., Sanchez, N., Sunagawa, S., Torrejon, A., Turner, K., Vandemeulebrouck, G., Varela, E., Winogradsky, Y., Zeller, G., Weissenbach, J., Ehrlich, S.D. & Bork, P. Nature. 2011 May 12;473(7346):174-80. Epub 2011 Apr 20. PubMed

Genome-wide survey of post-meiotic segregation during yeast recombination. Mancera, E., Bourgon, R., Huber, W. & Steinmetz, L.M. Genome Biol. 2011 Apr 11;12(4):R36. PubMed

Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Horn, T., Sandmann, T., Fischer, B., Axelsson, E., Huber, W. & Boutros, M. Nat Methods. 2011 Apr;8(4):341-6. Epub 2011 Mar 6. PubMed

Antisense expression increases gene expression variability and locus interdependency. Xu, Z., Wei, W., Gagneur, J., Clauder-Munster, S., Smolik, M., Huber, W. & Steinmetz, L.M. Mol Syst Biol. 2011 Feb 15;7:468. PubMed

Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications. Huhn, S., Ingelfinger, D., Bermejo, J.L., Bevier, M., Pardini, B., Naccarati, A., Steinke, V., Rahner, N., Holinski-Feder, E., Morak, M., Schackert, H.K., Gorgens, H., Pox, C.P., Goecke, T., Kloor, M., Loeffler, M., Buttner, R., Vodickova, L., Novotny, J., Demir, K., Cruciat, C.M., Renneberg, R., Huber, W., Niehrs, C., Boutros, M., Propping, P., Vodieka, P., Hemminki, K. & Forsti, A. Int J Mol Epidemiol Genet. 2011 Jan 1;2(1):36-50. Epub 2010 Nov 25. PubMed

Contributions of the EMERALD project to assessing and improving microarray data quality. Beisvag, V., Kauffmann, A., Malone, J., Foy, C., Salit, M., Schimmel, H., Bongcam-Rudloff, E., Landegren, U., Parkinson, H., Huber, W., Brazma, A., Sandvik, A.K. & Kuiper, M. Biotechniques. 2011 Jan;50(1):27-31. PubMed

Assessing affymetrix GeneChip microarray quality. McCall, M.N., Murakami, P.N., Lukk, M., Huber, W. & Irizarry, R.A. BMC Bioinformatics. 2011 May 7;12:137. PubMed

Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. Axelsson, E., Sandmann, T., Horn, T., Boutros, M., Huber, W. & Fischer, B. BMC Bioinformatics. 2011 Aug 17;12:342. PubMed

Organelle proteomics experimental designs and analysis. Gatto, L., Vizcaino, J.A., Hermjakob, H., Huber, W. & Lilley, K.S. Proteomics. 2010 Nov;10(22):3957-69. doi: 10.1002/pmic.201000244. Epub2010 Nov 2. PubMed

Differential expression analysis for sequence count data. Anders, S. & Huber, W. Genome Biol. 2010 Oct 27;11(10):R106. PubMed

Organelle proteomics experimental designs and analysis. Gatto, L., Vizcaino, J.A., Hermjakob, H., Huber, W. & Lilley, K.S. Proteomics. 2010 Sep 30. PubMed

Addressing accuracy and precision issues in iTRAQ quantitation. Karp, N.A., Huber, W., Sadowski, P.G., Charles, P.D., Hester, S.V. & Lilley, K.S. Mol Cell Proteomics. 2010 Sep;9(9):1885-97. Epub 2010 Apr 10. PubMed

Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Fuchs, F., Pau, G., Kranz, D., Sklyar, O., Budjan, C., Steinbrink, S., Horn, T., Pedal, A., Huber, W. & Boutros, M. Mol Syst Biol. 2010 Jun 8;6:370. PubMed

Independent filtering increases detection power for high-throughput experiments. Bourgon, R., Gentleman, R. & Huber, W. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9546-51. Epub 2010 May 11. PubMed

Variation in transcription factor binding among humans. Kasowski, M., Grubert, F., Heffelfinger, C., Hariharan, M., Asabere, A., Waszak, S.M., Habegger, L., Rozowsky, J., Shi, M., Urban, A.E., Hong, M.Y., Karczewski, K.J., Huber, W., Weissman, S.M., Gerstein, M.B., Korbel, J.O. & Snyder, M. Science. 2010 Apr 9;328(5975):232-5. Epub 2010 Mar 18. PubMed

EBImage - an R package for image processing with applications to cellular phenotypes. Pau, G., Fuchs, F., Sklyar, O., Boutros, M. & Huber, W. Bioinformatics. 2010 Apr 1;26(7):979-81. PubMed

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Neumann, B., Walter, T., Heriche, J.K., Bulkescher, J., Erfle, H., Conrad, C., Rogers, P., Poser, I., Held, M., Liebel, U., Cetin, C., Sieckmann, F., Pau, G., Kabbe, R., Wünsche, A., Satagopam, V., Schmitz, M.H., Chapuis, C., Gerlich, D.W., Schneider, R., Eils, R., Huber, W., Peters, J.M., Hyman, A.A., Durbin, R., Pepperkok, R. & Ellenberg, J. Nature. 2010 Apr 1;464(7289):721-7. PubMed

High-resolution transcription atlas of the mitotic cell cycle in budding yeast. Granovskaia, M.V., Jensen, L.J., Ritchie, M.E., Toedling, J., Ning, Y., Bork, P., Huber, W. & Steinmetz, L.M. Genome Biol. 2010 Mar 1;11(3):R24. PubMed

Microarray data quality control improves the detection of differentially expressed genes. Kauffmann, A. & Huber, W. Genomics. 2010 Mar;95(3):138-42. Epub 2010 Jan 14. PubMed

A large-scale RNAi screen identifies Deaf1 as a regulator of innate immune responses in Drosophila. Kuttenkeuler, D., Pelte, N., Ragab, A., Gesellchen, V., Schneider, L., Blass, C., Axelsson, E., Huber, W. & Boutros, M. J Innate Immun. 2010 Feb;2(2):181-94. Epub 2009 Oct 13. PubMed

Genome-wide analysis of mRNA decay patterns during early Drosophila development. Thomsen, S., Anders, S., Janga, S.C., Huber, W. & Alonso, C.R. Genome Biol. 2010;11(9):R93. Epub 2010 Sep 21. PubMed

Comparison of normalization methods for Illumina BeadChip(R) HumanHT-12 v3 Ramona Schmid, Patrick Baum, Carina Ittrich, Katrin Fundel-Clemens, Huber, W. Benedikt Brors, Roland Eils, Andreas Weith, Detlev Mennerich, and Karsten Quast. BMC Genomics, 11:349, 2010

A global map of human gene expression Margus Lukk, Misha Kapushesky, Janne Nikkila, Helen Parkinson, Angela Goncalves, Huber, W., Esko Ukkonen, and Brazma, A. Nature Biotechnology, 28:322-324, 2010

Importing ArrayExpress datasets into R/Bioconductor. Kauffmann, A., Rayner, T.F., Parkinson, H., Kapushesky, M., Lukk, M., Brazma, A. & Huber, W. Bioinformatics. 2009 Aug 15;25(16):2092-4. Epub 2009 Jun 8. PubMed

Genome-wide allele- and strand-specific expression profiling. Gagneur, J., Sinha, H., Perocchi, F., Bourgon, R., Huber, W. & Steinmetz, L.M. Mol Syst Biol. 2009;5:274. Epub 2009 Jun 16. PubMed

Array-based genotyping in S. cerevisiae using semi-supervised clustering. Bourgon, R., Mancera, E., Brozzi, A., Steinmetz, L.M. & Huber, W. Bioinformatics. 2009 Feb 23. PubMed

Bidirectional promoters generate pervasive transcription in yeast. Xu, Z., Wei, W., Gagneur, J., Perocchi, F., Clauder-Munster, S., Camblong, J., Guffanti, E., Stutz, F., Huber, W. & Steinmetz, L.M. Nature. 2009 Feb 19;457(7232):1033-7. Epub 2009 Jan 25. PubMed

arrayQualityMetrics - a bioconductor package for quality assessment of microarray data. Kauffmann, A., Gentleman, R. & Huber, W. Bioinformatics. 2009 Feb 1;25(3):415-6. Epub 2008 Dec 23. PubMed

Quality assessment and data analysis for microRNA expression arrays. Sarkar, D., Parkin, R., Wyman, S., Bendoraite, A., Sather, C., Delrow, J., Godwin, A.K., Drescher, C., Huber, W., Gentleman, R. & Tewari, M. Nucleic Acids Res. 2009 Feb;37(2):e17. Epub 2008 Dec 22. PubMed

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt. Durinck, S., Spellman, P.T., Birney, E. & Huber, W. Nat Protoc. 2009;4(8):1184-91. Epub 2009 Jul 23. PubMed

Analyzing ChIP-chip data using bioconductor. Toedling, J. & Huber, W. PLoS Comput Biol. 2008 Nov;4(11):e1000227. Epub 2008 Nov 28. PubMed

High-resolution mapping of meiotic crossovers and non-crossovers in yeast. Mancera, E., Bourgon, R., Brozzi, A., Huber, W. & Steinmetz, L.M. Nature. 2008 Jul 24;454(7203):479-85. Epub 2008 Jul 9. PubMed

Estimating node degree in bait-prey graphs. Scholtens, D., Chiang, T., Huber, W. & Gentleman, R. Bioinformatics. 2008 Jan 15;24(2):218-24. Epub 2007 Nov 19. PubMed

Model-based variance-stabilizing transformation for Illumina microarray data. Lin, S.M., Du, P., Huber, W. & Kibbe, W.A. Nucleic Acids Res. 2008 Feb;36(2):e11. Epub 2008 Jan 4. PubMed

Bioconductor Case Studies Florian Hahne, Wolfgang Huber, Robert Gentleman, and Seth Falcon Use R. Springer, 2008

Combinatorial effects of four histone modifications in transcription and differentiation. Fischer, J.J., Toedling, J., Krueger, T., Schueler, M., Huber, W. & Sperling, S. Genomics. 2008 Jan;91(1):41-51. Epub 2007 Nov 8. PubMed

Rintact: enabling computational analysis of molecular interaction data from the IntAct repository. Chiang, T., Li, N., Orchard, S., Kerrien, S., Hermjakob, H., Gentleman, R. & Huber, W. Bioinformatics. 2008 Apr 15;24(8):1100-1. Epub 2007 Nov 7. PubMed

High-throughput flow cytometry-based assay to identify apoptosis-inducing proteins. Sauermann, M., Hahne, F., Schmidt, C., Majety, M., Rosenfelder, H., Bechtel, S., Huber, W., Poustka, A., Arlt, D. & Wiemann, S. J Biomol Screen. 2007 Jun;12(4):510-20. Epub 2007 May 3. PubMed

CoCo: a web application to display, store and curate ChIP-on-chip data integrated with diverse types of gene expression data. Girardot, C., Sklyar, O., Grosz, S., Huber, W. & Furlong, E.E. Bioinformatics. 2007 Mar 15;23(6):771-3. Epub 2007 Jan 17. PubMed

Ringo - an R/Bioconductor package for analyzing ChIP-chip readouts. Toedling, J., Sklyar, O. & Huber, W. BMC Bioinformatics. 2007 Jun 26;8:221. PubMed

Comparative analysis of structured RNAs in S. cerevisiae indicates a multitude of different functions. Steigele, S., Huber, W., Stocsits, C., Stadler, P.F. & Nieselt, K. BMC Biol. 2007 Jun 18;5:25. PubMed

Genomic organization of transcriptomes in mammals: Coregulation and cofunctionality. Purmann, A., Toedling, J., Schueler, M., Carninci, P., Lehrach, H., Hayashizaki, Y., Huber, W. & Sperling, S. Genomics. 2007 May;89(5):580-7. Epub 2007 Mar 21. PubMed

Graphs in molecular biology. Huber, W., Carey, V.J., Long, L., Falcon, S. & Gentleman, R. BMC Bioinformatics. 2007 Sep 27;8 Suppl 6:S8. PubMed

Making the most of high-throughput protein-interaction data. Gentleman, R. & Huber, W. Genome Biol. 2007;8(10):112. PubMed

Coverage and error models of protein-protein interaction data by directed graph analysis. Chiang, T., Scholtens, D., Sarkar, D., Gentleman, R. & Huber, W. Genome Biol. 2007;8(9):R186. PubMed

In situ analysis of cross-hybridisation on microarrays and the inference of expression correlation. Casneuf, T., Van de Peer, Y. & Huber, W. BMC Bioinformatics. 2007 Nov 26;8:461. PubMed

Transcript mapping with high-density oligonucleotide tiling arrays. Huber, W., Toedling, J. & Steinmetz, L.M. Bioinformatics. 2006 Aug 15;22(16):1963-70. Epub 2006 Jun 20. PubMed

Top-down standards will not serve systems biology. Quackenbush, J., Stoeckert, C., Ball, C., Brazma, A., Gentleman, R., Huber, W., Irizarry, R., Salit, M., Sherlock, G., Spellman, P. & Winegarden, N. Nature. 2006 Mar 2;440(7080):24. PubMed

Several articles R News special issue on Bioinformatics, 2006 Link

Visualizing genomic data. Technical Report 10 Robert Gentleman, Florian Hahne and Wolfgang Huber Bioconductor Project Working Papers, 2006 Link

The LIFEdb database in 2006. Mehrle, A., Rosenfelder, H., Schupp, I., del Val, C., Arlt, D., Hahne, F., Bechtel, S., Simpson, J., Hofmann, O., Hide, W., Glatting, K.H., Huber, W., Pepperkok, R., Poustka, A. & Wiemann, S. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D415-8. PubMed

Reproducible statistical analysis in microarray profiling studies. Mansmann, U., Ruschhaupt, M. & Huber, W. Methods Inf Med. 2006;45(2):139-45. PubMed

Statistical methods and software for the analysis of highthroughput reverse genetic assays using flow cytometry readouts. Hahne, F; Arlt, D; Sauermann, M; Majety, M; Poustka, A; Wiemann, S; Huber, W. Genome Biology 2006 7(8)

A high-resolution map of transcription in the yeast genome. David, L., Huber, W., Granovskaia, M., Toedling, J., Palm, C.J., Bofkin, L., Jones, T., Davis, R.W. & Steinmetz, L.M. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5320-5. Epub 2006 Mar 28. PubMed

Analysis of cell-based RNAi screens. Boutros, M., Bras, L. & Huber, W. Genome Biol. 2006 Jul 25;7(7):R66. PubMed

arrayMagic: two-colour cDNA microarray quality control and preprocessing. Buness, A., Huber, W., Steiner, K., Sultmann, H. & Poustka, A. Bioinformatics. 2005 Feb 15;21(4):554-6. Epub 2004 Sep 28. PubMed

Low-level analysis of microarray experiments Wolfgang Huber, Anja von Heydebreck, and Martin Vingron Bioinformatics - from Genomes to Therapies, Wiley-VCH, 2005

Bioinformatics - from Genomes to Therapies, chapter Low-level analysis of microarray experiments. Wolfgang Huber, Anja von Heydebreck, and Martin Vingron Wiley-VCH, 2005

Gene expression in kidney cancer is associated with cytogenetic abnormalities, metastasis formation, and patient survival. Sultmann, H., von Heydebreck, A., Huber, W., Kuner, R., Buness, A., Vogt, M., Gunawan, B., Vingron, M., Fuzesi, L. & Poustka, A. Clin Cancer Res 2005 Jan 15;11(2 Pt 1):646-55. PubMed

Bioinformatics and Computational Biology Solutions Using R and Bioconductor Robert Gentleman, Vincent J. Carey, Wolfgang Huber, Rafael Irizarry, and Sandrine Dudoit (eds) Springer, 2005 Link

On the synthesis of microarray experiments Robert Gentleman, Markus Ruschhaupt, and Wolfgang Huber Journal de la Société Française de Statistique, 146(1-2), 2005

Systematic comparison of surface coatings for protein microarrays. Guilleaume, B., Buness, A., Schmidt, C., Klimek, F., Moldenhauer, G., Huber, W., Arlt, D., Korf, U., Wiemann, S. & Poustka, A. Proteomics. 2005 Dec;5(18):4705-12. PubMed

BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis. Durinck, S., Moreau, Y., Kasprzyk, A., Davis, S., De Moor, B., Brazma, A. & Huber, W. Bioinformatics 2005 Aug 15;21(16):3439-40. PubMed

Novel cancer relevant cell cycle modulators identified in automated cell-based assays Dorit Arlt, Huber, W., Mamatha Sauermann, Meher Majety, Florian Hahne, Pepperkok, R., Annemarie Poustka, and Stefan Wiemann European Journal of Cell Biology, 84(Suppl. 55):30, 2005

Functional profiling: from microarrays via cell-based assays to novel tumor relevant modulators of the cell cycle. Arlt, D., Huber, W., Liebel, U., Schmidt, C., Majety, M., Sauermann, M., Rosenfelder, H., Bechtel, S., Mehrle, A., Bannasch, D., Schupp, I., Seiler, M., Simpson, J.C., Hahne, F., Moosmayer, P., Ruschhaupt, M., Guilleaume, B., Wellenreuther, R., Pepperkok, R., Sultmann, H., Poustka, A. & Wiemann, S. Cancer Res 2005 Sep 1;65(17):7733-42. PubMed

From ORFeome to biology: a functional genomics pipeline. Wiemann, S., Arlt, D., Huber, W., Wellenreuther, R., Schleeger, S., Mehrle, A., Bechtel, S., Sauermann, M., Korf, U., Pepperkok, R., Sultmann, H. & Poustka, A. Genome Res. 2004 Oct;14(10B):2136-44. PubMed

Systematic analysis of T7 RNA polymerase based in vitro linear RNA amplification for use in microarray experiments. Schneider, J., Buness, A., Huber, W., Volz, J., Kioschis, P., Hafner, M., Poustka, A. & Sultmann, H. BMC Genomics. 2004 Apr 30;5(1):29. PubMed

Error models for microarray intensities Wolfgang Huber, Anja von Heydebreck, and Martin Vingron Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. John Wiley & Sons, 2004

A compendium to ensure computational reproducibility in high-dimensional classification tasks. Ruschhaupt, M., Huber, W., Poustka, A. & Mansmann, U. Stat Appl Genet Mol Biol. 2004;3:Article37. Epub 2004 Dec 19. PubMed

matchprobes: a Bioconductor package for the sequence-matching of microarray probe elements. Huber, W. & Gentleman, R. Bioinformatics 2004 Jul 10;20(10):1651-2. Epub 2004 Feb 26. PubMed

Bioconductor: open software development for computational biology and bioinformatics. Gentleman, R.C., Carey, V.J., Bates, D.M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., Hornik, K., Hothorn, T., Huber, W., Iacus, S., Irizarry, R., Leisch, F., Li, C., Maechler, M., Rossini, A.J., Sawitzki, G., Smith, C., Smyth, G., Tierney, L., Yang, J.Y. & Zhang, J. Genome Biol. 2004;5(10):R80. Epub 2004 Sep 15. PubMed

Differential Expression with the Bioconductor Project Anja von Heydebreck, Wolfgang Huber, and Robert Gentleman Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, John Wiley & Sons, 2004

Cytogenetic and morphologic typing of 58 papillary renal cell carcinomas: evidence for a cytogenetic evolution of type 2 from type 1 tumors. Gunawan, B., von Heydebreck, A., Fritsch, T., Huber, W., Ringert, R.H., Jakse, G. & Fuzesi, L. Cancer Res. 2003 Oct 1;63(19):6200-5. PubMed

Prognostic factors influencing surgical management and outcome of gastrointestinal stromal tumours. Langer, C., Gunawan, B., Schuler, P., Huber, W., Fuzesi, L. & Becker, H. Br J Surg. 2003 Mar;90(3):332-9. PubMed

Parameter estimation for the calibration and variance stabilization of microarray data. Huber, W., et al. Statistical Applications in Genetics and Molecular Biology 2003 2 3 PubMed

Analysis of microarray gene expression data. Huber W., von Heydebreck, A. & Vingron, M. Handbook of Statistical Genetics 2003, John Wiley & Sons.

Mathematical tree models for cytogenetic development in solid tumors. Heydebreck, A.V., Gunawan, B., Huber, W., Vingron, M. & Fuzesi, L. Verh Dtsch Ges Pathol. 2003;87:188-92. PubMed

Multi-domain protein families and domain pairs: comparison with known structures and a random model of domain recombination. Apic, G., Huber, W. & Teichmann, S.A. J Struct Funct Genomics. 2003;4(2-3):67-78. PubMed

Transcription profiling of renal cell carcinoma Wolfgang Huber, Judith M. Boer, Anja von Heydebreck, Bastian Gunawan, Martin Vingron, László Füzesí, Annemarie Poustka, and Holger Sültmann Verhandlungen der Deutschen Gesellschaft für Pathologie, 86:153-164, 2002

Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Huber, W., von Heydebreck, A., Sultmann, H., Poustka, A. & Vingron, M. Bioinformatics. 2002;18 Suppl 1:S96-104. PubMed

Prognostic impacts of cytogenetic findings in clear cell renal cell carcinoma: gain of 5q31-qter predicts a distinct clinical phenotype with favorable prognosis. Gunawan, B., Huber, W., Holtrup, M., von Heydebreck, A., Efferth, T., Poustka, A., Ringert, R.H., Jakse, G. & Fuzesi, L. Cancer Res. 2001 Nov 1;61(21):7731-8. PubMed

FLASHFLOOD: a 3D field-based similarity search and alignment method for flexible molecules. Pitman, M.C., Huber, W.K., Horn, H., Kramer, A., Rice, J.E. & Swope, W.C. J Comput Aided Mol Des. 2001 Jul;15(7):587-612. PubMed

Identifying splits with clear separation: a new class discovery method for gene expression data. von Heydebreck, A., Huber, W., Poustka, A. & Vingron, M. Bioinformatics. 2001;17 Suppl 1:S107-14. PubMed

Gene expression profiling of kidney cancer using a tumor-specific cdna microarray Holger Sültmann, Wolfgang Huber, Laszlo Fuzesi, Bastian Gunawan, Anja von Heydebreck, Martin Vingron, and Annemarie Poustka Clinical Cancer Research, 7(11, Suppl. S):155, 2001

Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array. Boer J.M. et al. Genome Res. 2001 11 1861-1870 PubMed

Quasistationary distributions of dissipative nonlinear quantum oscillators in strong periodic driving fields Breuer, H.P., Huber, W. & Petruccione, F. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000May;61(5A):4883-9. PubMed

Dynamics of strongly driven open quantum systems. Wolfgang Huber. PhD thesis, University of Freiburg 1998

Vestibular-neck interaction and transformation of sensory coordinates. Mergner, T., Huber, W. & Becker, W. J Vestib Res. 1997 Jul-Aug;7(4):347-67. PubMed

Stochastic wave function method versus density matrix: a numerical comparison Heinz Peter Breuer, Wolfgang Huber, and Francesco Petruccione Computer Physics Communications, 104:46-58, 1997

Fast Monte Carlo algorithm for nonequilibrium systems. Breuer, H.P., Huber, W. & Petruccione, F. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1996Apr;53(4):4232-4235. PubMed

Spatially resolved measurement and modeling of blood brain barrier permeability Wolfgang Huber, Klaus Kopitzki, Jens Timmer, and Peter Warnke Biomedizinische Technik, 41 suppl. 1:160, 199

The macroscopic limit in a stochastic reaction-diffusion process Heinz Peter Breuer, Wolfgang Huber, and Francesco Petruccione Europhysics Letters, 30:69-74, 1995

The three-loop model: a neural network for the generation of saccadic reaction times. Fischer, B., Gezeck, S. & Huber, W. Biol Cybern. 1995;72(3):185-96. PubMed

Fluctuation effects on wave propagation in a reaction-diffusion process. Heinz Peter Breuer, Wolfgang Huber, and Francesco Petruccione Physica D, 73:259-273, 1994