Staff at EMBL

Dr. Maja Köhn

Group Leader
Köhn Group Joint appointment: Cell Biology and Biophysics Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

PhD 2005 MPI for Molecular Physiology, Dortmund, Germany
Postdoctoral work at Harvard University, Cambridge, USA
Group Leader at EMBL since 2007

Publications

Molecular mechanisms of the PRL phosphatases. Rios, P., Li, X. & Kohn, M. FEBS J. 2013 Jan;280(2):505-24. doi: 10.1111/j.1742-4658.2012.08565.x. Epub 2012Apr 10. Europe PMC

Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics. De Munter, S., Köhn, M. & Bollen, M. ACS Chem Biol. 2012 Dec 20. Europe PMC

Development of a peptide that selectively activates protein phosphatase-1 in living cells. Chatterjee, J., Beullens, M., Sukackaite, R., Qian, J., Lesage, B., Hart, D.J., Bollen, M. & Köhn, M. Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10054-9. doi: 10.1002/anie.201204308.Epub 2012 Sep 7. Europe PMC

A Molecular Tete-a-Tete Arranged by a Designed Adaptor Protein. Meyer, C. & Köhn, M. Angew Chem Int Ed Engl. 2012 Aug 13;51(33):8160-2. doi: 10.1002/anie.201203345.Epub 2012 Jul 13. Europe PMC

Chemical biology techniques unlock the secrets of casein kinase 2 regulation by phosphorylation and glycosylation. Pavic, K. & Köhn, M. Chembiochem. 2012 Jun 18;13(9):1253-5. doi: 10.1002/cbic.201200235. Epub 2012 May3. Europe PMC

Omics and chemical biology-a powerful synergism. Köhn, M. Curr Opin Chem Biol. 2012 Apr;16(1-2):204-5. Epub 2012 Mar 23. Europe PMC

Development of a solid phase synthesis strategy for soluble phosphoinositide analogues. Bru, M., Kotkar, S.P., Kar, N. & Köhn, M. Chem. Sci., 2012, 3, 1893-1902, doi: 10.1039/C2SC01061E.

The Metastasis-Promoting Phosphatase PRL-3 Shows Activity toward Phosphoinositides. McParland, V., Varsano, G., Li, X., Thornton, J., Baby, J., Aravind, A., Meyer, C., Pavic, K., Rios, P. & Köhn, M. Biochemistry. 2011 Sep 6;50(35):7579-7590. Epub 2011 Aug 11. Europe PMC

Efficient Scaled-Up Synthesis of N-a-Fmoc 4-Phosphono(difluoromethyl)-Lphenylalanine and Its Incorporation into Peptides Meyer, C. and Köhn, M. Synthesis 2011 Oct 17;20:3255-3260. Epub 2011 Sep 6.

Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization. Weinrich, D., Köhn, M., Jonkheijm, P., Westerlind, U., Dehmelt, L., Engelkamp, H., Christianen, P.C., Kuhlmann, J., Maan, J.C., Nusse, D., Schroder, H., Wacker, R., Voges, E., Breinbauer, R., Kunz, H., Niemeyer, C.M. & Waldmann, H. Chembiochem. 2010 Jan 25;11(2):235-47. Europe PMC

Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B. McGinty, R.K., Köhn, M., Chatterjee, C., Chiang, K.P., Pratt, M.R. & Muir, T.W. ACS Chem Biol. 2009 Nov 20;4(11):958-68. Europe PMC

Immobilization strategies for small molecule, peptide and protein microarrays. Köhn, M. J Pept Sci. 2009 Mar 23;15(6):393-397. Europe PMC

Chemical biologists gather in Heidelberg. Köhn, M. & Schultz, C. Nat Chem Biol. 2009 Feb;5(2):66-9. Europe PMC

Simultaneous protein tagging in two colors. Schultz, C. & Köhn, M. Chem Biol. 2008 Feb;15(2):91-2. Europe PMC

Photochemical surface patterning by the thiol-ene reaction. Jonkheijm, P., Weinrich, D., Köhn, M., Engelkamp, H., Christianen, P.C., Kuhlmann, J., Maan, J.C., Nusse, D., Schroeder, H., Wacker, R., Breinbauer, R., Niemeyer, C.M. & Waldmann, H. Angew Chem Int Ed Engl. 2008;47(23):4421-4. Europe PMC

A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase. Köhn, M., Gutierrez-Rodriguez, M., Jonkheijm, P., Wetzel, S., Wacker, R., Schroeder, H., Prinz, H., Niemeyer, C.M., Breinbauer, R., Szedlacsek, S.E. & Waldmann, H. Angew Chem Int Ed Engl. 2007;46(40):7700-3. Europe PMC

Site-selective protein immobilization by Staudinger ligation. Watzke, A., Köhn, M., Gutierrez-Rodriguez, M., Wacker, R., Schroder, H., Breinbauer, R., Kuhlmann, J., Alexandrov, K., Niemeyer, C.M., Goody, R.S. & Waldmann, H. Angew Chem Int Ed Engl. 2006 Feb 20;45(9):1408-12. Europe PMC

Diels-Alder ligation and surface immobilization of proteins. de Araujo, A.D., Palomo, J.M., Cramer, J., Köhn, M., Schroder, H., Wacker, R., Niemeyer, C., Alexandrov, K. & Waldmann, H. Angew Chem Int Ed Engl. 2005 Dec 23;45(2):296-301. Europe PMC

Functional evaluation of carbohydrate-centred glycoclusters by enzyme-linked lectin assay: ligands for concanavalin A. Köhn, M., Benito, J.M., Ortiz Mellet, C., Lindhorst, T.K. & Garcia Fernandez, J.M. Chembiochem. 2004 Jun 7;5(6):771-7. Europe PMC

The Staudinger ligation-a gift to chemical biology. Köhn, M. & Breinbauer, R. Angew Chem Int Ed Engl. 2004 Jun 14;43(24):3106-16. Europe PMC

Small Molecule Arrays. Breinbauer, R., Köhn, M. & Peters, C. in C. Schmuck, H. Wennemers (Eds.), 2004, “Highlights in Bioorganic Chemistry”, Wiley-VCH, Weinheim

Azide-alkyne coupling: a powerful reaction for bioconjugate chemistry. Breinbauer, R. & Köhn, M. Chembiochem. 2003 Nov 7;4(11):1147-9. Europe PMC

Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays. Köhn, M., Wacker, R., Peters, C., Schroder, H., Soulere, L., Breinbauer, R., Niemeyer, C.M. & Waldmann, H. Angew Chem Int Ed Engl. 2003;42(47):5830-4. Europe PMC