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Staff at EMBL

CP-60002218

Dr. Maja Köhn

Group Leader
Köhn Group Joint appointment: Cell Biology and Biophysics Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Biography

PhD 2005 MPI for Molecular Physiology, Dortmund, Germany.
Postdoctoral work at Harvard University, Cambridge, USA.
Group Leader at EMBL since 2007.
ERC Investigator.

Publications

Total: 31 publication(s)

2014

Duan G, Li X, Köhn M. (2014)
The human DEPhOsphorylation database DEPOD: a 2015 update.
Nucleic Acids Res.
Europe PMC

Hoeger B, Diether M, Ballester PJ, Köhn M. (2014)
Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver
Eur J Med Chem doi:10.1016/j.ejmech.2014.08.060
Europe PMC | doi

Köhn M, Meijler MM, Kaiser M. (2014)
Building up a chemical proteomics network in europe and beyond
ACS Chem. Biol. 9(8):1647-1648. doi:10.1021/cb5005299
Europe PMC | doi

Ríos P, Nunes-Xavier CE, Tabernero L, Köhn M, Pulido R. (2014)
Dual-specificity phosphatases as molecular targets for inhibition in human disease
Antioxid. Redox Signal. 20(14):2251-2273. doi:10.1089/ars.2013.5709
Europe PMC | doi

Pavic K, Rios P, Dzeyk K, Koehler C, Lemke EA, Köhn M. (2014)
Unnatural Amino Acid Mutagenesis Reveals Dimerization As a Negative Regulatory Mechanism of VHR's Phosphatase Activity
ACS Chem. Biol. doi:10.1021/cb500240n
Europe PMC | doi

Meyer C, Hoeger B, Temmerman K, Tatarek-Nossol M, Pogenberg V, Bernhagen J, Wilmanns M, Kapurniotu A, Köhn M. (2014)
Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells
ACS Chem. Biol. 9(3):769-776. doi:10.1021/cb400903u
Europe PMC | doi


2013

Reither G, Chatterjee J, Beullens M, Bollen M, Schultz C, Köhn M. (2013)
Chemical activators of protein phosphatase-1 induce calcium release inside intact cells
Chem. Biol. 20(9):1179-1186. doi:10.1016/j.chembiol.2013.07.008
Europe PMC | doi

Chatterjee J, Köhn M. (2013)
Targeting the untargetable: recent advances in the selective chemical modulation of protein phosphatase-1 activity
Curr Opin Chem Biol 17(3):361-368. doi:10.1016/j.cbpa.2013.04.008
Europe PMC | doi

Li X, Wilmanns M, Thornton J, Köhn M. (2013)
Elucidating human phosphatase-substrate networks
Sci Signal 6(275):rs10. doi:10.1126/scisignal.2003203
Europe PMC | doi

De Munter S, Köhn M, Bollen M. (2013)
Challenges and opportunities in the development of protein phosphatase-directed therapeutics
ACS Chem. Biol. 8(1):36-45. doi:10.1021/cb300597g
Europe PMC | doi

Rios P, Li X, Köhn M. (2013)
Molecular mechanisms of the PRL phosphatases
FEBS J. 280(2):505-524. doi:10.1111/j.1742-4658.2012.08565.x
Europe PMC | doi


2012

Chatterjee J, Beullens M, Sukackaite R, Qian J, Lesage B, Hart DJ, Bollen M, Köhn M. (2012)
Development of a peptide that selectively activates protein phosphatase-1 in living cells
Angew. Chem. Int. Ed. Engl. 51(40):10054-10059. doi:10.1002/anie.201204308
Europe PMC | doi

Meyer C, Köhn M. (2012)
A molecular tete-a-tete arranged by a designed adaptor protein
Angew. Chem. Int. Ed. Engl. 51(33):8160-8162. doi:10.1002/anie.201203345
Europe PMC | doi

Pavic K, Köhn M. (2012)
Chemical biology techniques unlock the secrets of casein kinase 2 regulation by phosphorylation and glycosylation
Chembiochem 13(9):1253-1255. doi:10.1002/cbic.201200235
Europe PMC | doi

Köhn M. (2012)
Omics and chemical biology--a powerful synergism
Curr Opin Chem Biol 16(1-2):204-205. doi:10.1016/j.cbpa.2012.03.001
Europe PMC | doi

Bru M, Kotkar SP, Kar N, Köhn M. (2012)
Development of a solid phase synthesis strategy for soluble phosphoinositide analogues
Chem Sci 3(6):1893-1902. doi:10.1039/c2sc01061e
Europe PMC | doi


2011

McParland V, Varsano G, Li X, Thornton J, Baby J, Aravind A, Meyer C, Pavic K, Rios P, Köhn M. (2011)
The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides
Biochemistry 50(35):7579-7590. doi:10.1021/bi201095z
Europe PMC | doi

Meyer C, Köhn M. (2011)
Efficient scaled-up synthesis of N-alpha-Fmoc-4-Phosphono(difluoromethyl)-L-phenylalanine and its incorporation into peptides
Synthesis (Stuttg) 2011(20):3255-3260. doi:10.1055/s-0030-1260206
Europe PMC | doi


2010

Weinrich D, Köhn M, Jonkheijm P, Westerlind U, Dehmelt L, Engelkamp H, Christianen PC, Kuhlmann J, Maan JC, Nüsse D, Schröder H, Wacker R, Voges E, Breinbauer R, Kunz H, Niemeyer CM, Waldmann H. (2010)
Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization
Chembiochem 11(2):235-247. doi:10.1002/cbic.200900559
Europe PMC | doi


2009

McGinty RK, Köhn M, Chatterjee C, Chiang KP, Pratt MR, Muir TW. (2009)
Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B
ACS Chem. Biol. 4(11):958-968. doi:10.1021/cb9002255
Europe PMC | doi

Köhn M. (2009)
Immobilization strategies for small molecule, peptide and protein microarrays
J. Pept. Sci. 15(6):393-397. doi:10.1002/psc.1130
Europe PMC | doi

Köhn M, Schultz C. (2009)
Chemical biologists gather in Heidelberg
Nat. Chem. Biol. 5(2):66-69. doi:10.1038/nchembio0209-66
Europe PMC | doi


2008

Schultz C, Köhn M. (2008)
Simultaneous protein tagging in two colors
Chem. Biol. 15(2):91-92. doi:10.1016/j.chembiol.2008.02.004
Europe PMC | doi

Jonkheijm P, Weinrich D, Köhn M, Engelkamp H, Christianen PC, Kuhlmann J, Maan JC, Nüsse D, Schroeder H, Wacker R, Breinbauer R, Niemeyer CM, Waldmann H. (2008)
Photochemical surface patterning by the thiol-ene reaction
Angew. Chem. Int. Ed. Engl. 47(23):4421-4424. doi:10.1002/anie.200800101
Europe PMC | doi


2007

Köhn M, Gutierrez-Rodriguez M, Jonkheijm P, Wetzel S, Wacker R, Schroeder H, Prinz H, Niemeyer CM, Breinbauer R, Szedlacsek SE, Waldmann H. (2007)
A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase
Angew. Chem. Int. Ed. Engl. 46(40):7700-7703. doi:10.1002/anie.200701601
Europe PMC | doi


2006

Watzke A, Köhn M, Gutierrez-Rodriguez M, Wacker R, Schröder H, Breinbauer R, Kuhlmann J, Alexandrov K, Niemeyer CM, Goody RS, Waldmann H. (2006)
Site-selective protein immobilization by Staudinger ligation
Angew. Chem. Int. Ed. Engl. 45(9):1408-1412. doi:10.1002/anie.200502057
Europe PMC | doi


2005

de Araújo AD, Palomo JM, Cramer J, Köhn M, Schröder H, Wacker R, Niemeyer C, Alexandrov K, Waldmann H. (2005)
Diels-Alder ligation and surface immobilization of proteins
Angew. Chem. Int. Ed. Engl. 45(2):296-301. doi:10.1002/anie.200502266
Europe PMC | doi


2004

Köhn M, Benito JM, Ortiz Mellet C, Lindhorst TK, García Fernández JM. (2004)
Functional evaluation of carbohydrate-centred glycoclusters by enzyme-linked lectin assay: ligands for concanavalin A
Chembiochem 5(6):771-777. doi:10.1002/cbic.200300807
Europe PMC | doi

Köhn M, Breinbauer R. (2004)
The Staudinger ligation-a gift to chemical biology
Angew. Chem. Int. Ed. Engl. 43(24):3106-3116. doi:10.1002/anie.200401744
Europe PMC | doi


2003

Breinbauer R, Köhn M. (2003)
Azide-alkyne coupling: a powerful reaction for bioconjugate chemistry
Chembiochem 4(11):1147-1149. doi:10.1002/cbic.200300705
Europe PMC | doi

Köhn M, Wacker R, Peters C, Schröder H, Soulère L, Breinbauer R, Niemeyer CM, Waldmann H. (2003)
Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays
Angew. Chem. Int. Ed. Engl. 42(47):5830-5834. doi:10.1002/anie.200352877
Europe PMC | doi