Staff at EMBL
Dr. Maja Köhn
Group Leader
Köhn Group
Joint appointment: Cell Biology and Biophysics Unit
EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
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Biography
PhD 2005 MPI for Molecular Physiology, Dortmund, Germany
Postdoctoral work at Harvard University, Cambridge, USA
Group Leader at EMBL since 2007
Publications
Molecular mechanisms of the PRL phosphatases. Rios, P., Li, X. & Kohn, M. FEBS J. 2013 Jan;280(2):505-24. doi: 10.1111/j.1742-4658.2012.08565.x. Epub 2012Apr 10. PubMed
Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics. De Munter, S., Köhn, M. & Bollen, M. ACS Chem Biol. 2012 Dec 20. PubMed
Development of a peptide that selectively activates protein phosphatase-1 in living cells. Chatterjee, J., Beullens, M., Sukackaite, R., Qian, J., Lesage, B., Hart, D.J., Bollen, M. & Köhn, M. Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10054-9. doi: 10.1002/anie.201204308.Epub 2012 Sep 7. PubMed
A Molecular Tete-a-Tete Arranged by a Designed Adaptor Protein. Meyer, C. & Köhn, M. Angew Chem Int Ed Engl. 2012 Aug 13;51(33):8160-2. doi: 10.1002/anie.201203345.Epub 2012 Jul 13. PubMed
Chemical biology techniques unlock the secrets of casein kinase 2 regulation by phosphorylation and glycosylation. Pavic, K. & Köhn, M. Chembiochem. 2012 Jun 18;13(9):1253-5. doi: 10.1002/cbic.201200235. Epub 2012 May3. PubMed
Omics and chemical biology-a powerful synergism. Köhn, M. Curr Opin Chem Biol. 2012 Apr;16(1-2):204-5. Epub 2012 Mar 23. PubMed
Development of a solid phase synthesis strategy for soluble phosphoinositide analogues. Bru, M., Kotkar, S.P., Kar, N. & Köhn, M. Chem. Sci., 2012, 3, 1893-1902, doi: 10.1039/C2SC01061E.
The Metastasis-Promoting Phosphatase PRL-3 Shows Activity toward Phosphoinositides. McParland, V., Varsano, G., Li, X., Thornton, J., Baby, J., Aravind, A., Meyer, C., Pavic, K., Rios, P. & Köhn, M. Biochemistry. 2011 Sep 6;50(35):7579-7590. Epub 2011 Aug 11. PubMed
Efficient Scaled-Up Synthesis of N-a-Fmoc 4-Phosphono(difluoromethyl)-Lphenylalanine and Its Incorporation into Peptides Meyer, C. and Köhn, M. Synthesis 2011 Oct 17;20:3255-3260. Epub 2011 Sep 6.
Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization. Weinrich, D., Köhn, M., Jonkheijm, P., Westerlind, U., Dehmelt, L., Engelkamp, H., Christianen, P.C., Kuhlmann, J., Maan, J.C., Nusse, D., Schroder, H., Wacker, R., Voges, E., Breinbauer, R., Kunz, H., Niemeyer, C.M. & Waldmann, H. Chembiochem. 2010 Jan 25;11(2):235-47. PubMed
Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B. McGinty, R.K., Köhn, M., Chatterjee, C., Chiang, K.P., Pratt, M.R. & Muir, T.W. ACS Chem Biol. 2009 Nov 20;4(11):958-68. PubMed
Immobilization strategies for small molecule, peptide and protein microarrays. Köhn, M. J Pept Sci. 2009 Mar 23;15(6):393-397. PubMed
Chemical biologists gather in Heidelberg. Köhn, M. & Schultz, C. Nat Chem Biol. 2009 Feb;5(2):66-9. PubMed
Simultaneous protein tagging in two colors. Schultz, C. & Köhn, M. Chem Biol. 2008 Feb;15(2):91-2. PubMed
Photochemical surface patterning by the thiol-ene reaction. Jonkheijm, P., Weinrich, D., Köhn, M., Engelkamp, H., Christianen, P.C., Kuhlmann, J., Maan, J.C., Nusse, D., Schroeder, H., Wacker, R., Breinbauer, R., Niemeyer, C.M. & Waldmann, H. Angew Chem Int Ed Engl. 2008;47(23):4421-4. PubMed
A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase. Köhn, M., Gutierrez-Rodriguez, M., Jonkheijm, P., Wetzel, S., Wacker, R., Schroeder, H., Prinz, H., Niemeyer, C.M., Breinbauer, R., Szedlacsek, S.E. & Waldmann, H. Angew Chem Int Ed Engl. 2007;46(40):7700-3. PubMed
Site-selective protein immobilization by Staudinger ligation. Watzke, A., Köhn, M., Gutierrez-Rodriguez, M., Wacker, R., Schroder, H., Breinbauer, R., Kuhlmann, J., Alexandrov, K., Niemeyer, C.M., Goody, R.S. & Waldmann, H. Angew Chem Int Ed Engl. 2006 Feb 20;45(9):1408-12. PubMed
Diels-Alder ligation and surface immobilization of proteins. de Araujo, A.D., Palomo, J.M., Cramer, J., Köhn, M., Schroder, H., Wacker, R., Niemeyer, C., Alexandrov, K. & Waldmann, H. Angew Chem Int Ed Engl. 2005 Dec 23;45(2):296-301. PubMed
Functional evaluation of carbohydrate-centred glycoclusters by enzyme-linked lectin assay: ligands for concanavalin A. Köhn, M., Benito, J.M., Ortiz Mellet, C., Lindhorst, T.K. & Garcia Fernandez, J.M. Chembiochem. 2004 Jun 7;5(6):771-7. PubMed
The Staudinger ligation-a gift to chemical biology. Köhn, M. & Breinbauer, R. Angew Chem Int Ed Engl. 2004 Jun 14;43(24):3106-16. PubMed
Small Molecule Arrays. Breinbauer, R., Köhn, M. & Peters, C. in C. Schmuck, H. Wennemers (Eds.), 2004, Highlights in Bioorganic Chemistry, Wiley-VCH, Weinheim
Azide-alkyne coupling: a powerful reaction for bioconjugate chemistry. Breinbauer, R. & Köhn, M. Chembiochem. 2003 Nov 7;4(11):1147-9. PubMed
Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays. Köhn, M., Wacker, R., Peters, C., Schroder, H., Soulere, L., Breinbauer, R., Niemeyer, C.M. & Waldmann, H. Angew Chem Int Ed Engl. 2003;42(47):5830-4. PubMed
