Köhn GroupPublications
The Metastasis-Promoting Phosphatase PRL-3 Shows Activity toward Phosphoinositides.
McParland, V., Varsano, G., Li, X., Thornton, J., Baby, J., Aravind, A., Meyer, C., Pavic, K., Rios, P. & Köhn, M.
Biochemistry. 2011 Sep 6;50(35):7579-7590. Epub 2011 Aug 11. PubMed
Efficient Scaled-Up Synthesis of N-a-Fmoc 4-Phosphono(difluoromethyl)-Lphenylalanine and Its Incorporation into Peptides
Meyer, C. and Köhn, M.
Synthesis 2011 Oct 17;20:3255-3260. Epub 2011 Sep 6.
Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization.
Weinrich, D., Köhn, M., Jonkheijm, P., Westerlind, U., Dehmelt, L., Engelkamp, H., Christianen, P.C., Kuhlmann, J., Maan, J.C., Nusse, D., Schroder, H., Wacker, R., Voges, E., Breinbauer, R., Kunz, H., Niemeyer, C.M. & Waldmann, H.
Chembiochem. 2010 Jan 25;11(2):235-47. PubMed
Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.
McGinty, R.K., Köhn, M., Chatterjee, C., Chiang, K.P., Pratt, M.R. & Muir, T.W.
ACS Chem Biol. 2009 Nov 20;4(11):958-68. PubMed
Immobilization strategies for small molecule, peptide and protein microarrays.
Köhn, M.
J Pept Sci. 2009 Mar 23;15(6):393-397. PubMed
Chemical biologists gather in Heidelberg.
Köhn, M. & Schultz, C.
Nat Chem Biol. 2009 Feb;5(2):66-9. PubMed
Simultaneous protein tagging in two colors.
Schultz, C. & Köhn, M.
Chem Biol. 2008 Feb;15(2):91-2. PubMed
Photochemical surface patterning by the thiol-ene reaction.
Jonkheijm, P., Weinrich, D., Köhn, M., Engelkamp, H., Christianen, P.C., Kuhlmann, J., Maan, J.C., Nusse, D., Schroeder, H., Wacker, R., Breinbauer, R., Niemeyer, C.M. & Waldmann, H.
Angew Chem Int Ed Engl. 2008;47(23):4421-4. PubMed
A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase.
Köhn, M., Gutierrez-Rodriguez, M., Jonkheijm, P., Wetzel, S., Wacker, R., Schroeder, H., Prinz, H., Niemeyer, C.M., Breinbauer, R., Szedlacsek, S.E. & Waldmann, H.
Angew Chem Int Ed Engl. 2007;46(40):7700-3. PubMed
Site-selective protein immobilization by Staudinger ligation.
Watzke, A., Köhn, M., Gutierrez-Rodriguez, M., Wacker, R., Schroder, H., Breinbauer, R., Kuhlmann, J., Alexandrov, K., Niemeyer, C.M., Goody, R.S. & Waldmann, H.
Angew Chem Int Ed Engl. 2006 Feb 20;45(9):1408-12. PubMed
Diels-Alder ligation and surface immobilization of proteins.
de Araujo, A.D., Palomo, J.M., Cramer, J., Köhn, M., Schroder, H., Wacker, R., Niemeyer, C., Alexandrov, K. & Waldmann, H.
Angew Chem Int Ed Engl. 2005 Dec 23;45(2):296-301. PubMed
Functional evaluation of carbohydrate-centred glycoclusters by enzyme-linked lectin assay: ligands for concanavalin A.
Köhn, M., Benito, J.M., Ortiz Mellet, C., Lindhorst, T.K. & Garcia Fernandez, J.M.
Chembiochem. 2004 Jun 7;5(6):771-7. PubMed
The Staudinger ligation-a gift to chemical biology.
Köhn, M. & Breinbauer, R.
Angew Chem Int Ed Engl. 2004 Jun 14;43(24):3106-16. PubMed
Small Molecule Arrays.
Breinbauer, R., Köhn, M. & Peters, C.
in C. Schmuck, H. Wennemers (Eds.), 2004, Highlights in Bioorganic Chemistry, Wiley-VCH, Weinheim
Azide-alkyne coupling: a powerful reaction for bioconjugate chemistry.
Breinbauer, R. & Köhn, M.
Chembiochem. 2003 Nov 7;4(11):1147-9. PubMed
Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays.
Köhn, M., Wacker, R., Peters, C., Schroder, H., Soulere, L., Breinbauer, R., Niemeyer, C.M. & Waldmann, H.
Angew Chem Int Ed Engl. 2003;42(47):5830-4. PubMed
10 years of the human genome
EMBL scientists mark a decade since the first draft human genome sequence. Click on the image to play.
Duration: 6 mins.