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Staff at EMBL

Adrian Stütz

Research Technician
Korbel Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Publications

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Mack, S.C., Witt, H., Piro, R.M., Gu, L., Zuyderduyn, S., Stutz, A.M., Wang, X., Gallo, M., Garzia, L., Zayne, K., Zhang, X., Ramaswamy, V., Jager, N., Jones, D.T., Sill, M., Pugh, T.J., Ryzhova, M., Wani, K.M., Shih, D.J., Head, R., Remke, M., Bailey, S.D., Zichner, T., Faria, C.C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A.M., Northcott, P.A., Peacock, J., Bertrand, K.C., Agnihotri, S., Cavalli, F.M., Clarke, I., Nethery-Brokx, K., Creasy, C.L., Verma, S.K., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M.A., Roberts, S.S., Fults, D., Massimi, L., Cho, Y.J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A.E., von Deimling, A., Witt, O., Scherer, S.W., Fan, X., Muraszko, K.M., Kool, M., Pomeroy, S.L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P.N., Weiss, W.A., Jabado, N., Rutka, J.T., Bouffet, E., Korbel, J.O., Lupien, M., Aldape, K.D., Bader, G.D., Eils, R., Lichter, P., Dirks, P.B., Pfister, S.M., Korshunov, A. & Taylor, M.D. Nature. 2014 Feb 27;506(7489):445-50. doi: 10.1038/nature13108. Epub 2014 Feb 19. Europe PMC

SPAG7 is a candidate gene for the periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome. Bens, S., Zichner, T., Stutz, A.M., Caliebe, A., Wagener, R., Hoff, K., Korbel, J.O., von Bismarck, P. & Siebert, R. Genes Immun. 2014 Jan 23. doi: 10.1038/gene.2013.73. Europe PMC

Primate genome architecture influences structural variation mechanisms and functional consequences. Gokcumen, O., Tischler, V., Tica, J., Zhu, Q., Iskow, R.C., Lee, E., Fritz, M.H., Langdon, A., Stutz, A.M., Pavlidis, P., Benes, V., Mills, R.E., Park, P.J., Lee, C. & Korbel, J.O. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15764-9. doi:10.1073/pnas.1305904110. Epub 2013 Sep 6. Europe PMC

The genomic and transcriptomic landscape of a HeLa cell line. Landry, J.J., Pyl, P.T., Rausch, T., Zichner, T., Tekkedil, M.M., Stutz, A.M., Jauch, A., Aiyar, R.S., Pau, G., Delhomme, N., Gagneur, J., Korbel, J.O., Huber, W. & Steinmetz, L.M. G3 (Bethesda). 2013 Aug 7;3(8):1213-24. doi: 10.1534/g3.113.005777. Europe PMC

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Jones, D.T., Hutter, B., Jager, N., Korshunov, A., Kool, M., Warnatz, H.J., Zichner, T., Lambert, S.R., Ryzhova, M., Quang, D.A., Fontebasso, A.M., Stutz, A.M., Hutter, S., Zuckermann, M., Sturm, D., Gronych, J., Lasitschka, B., Schmidt, S., Seker-Cin, H., Witt, H., Sultan, M., Ralser, M., Northcott, P.A., Hovestadt, V., Bender, S., Pfaff, E., Stark, S., Faury, D., Schwartzentruber, J., Majewski, J., Weber, U.D., Zapatka, M., Raeder, B., Schlesner, M., Worth, C.L., Bartholomae, C.C., von Kalle, C., Imbusch, C.D., Radomski, S., Lawerenz, C., van Sluis, P., Koster, J., Volckmann, R., Versteeg, R., Lehrach, H., Monoranu, C., Winkler, B., Unterberg, A., Herold-Mende, C., Milde, T., Kulozik, A.E., Ebinger, M., Schuhmann, M.U., Cho, Y.J., Pomeroy, S.L., von Deimling, A., Witt, O., Taylor, M.D., Wolf, S., Karajannis, M.A., Eberhart, C.G., Scheurlen, W., Hasselblatt, M., Ligon, K.L., Kieran, M.W., Korbel, J.O., Yaspo, M.L., Brors, B., Felsberg, J., Reifenberger, G., Collins, V.P., Jabado, N., Eils, R., Lichter, P. & Pfister, S.M. Nat Genet. 2013 Aug;45(8):927-32. doi: 10.1038/ng.2682. Epub 2013 Jun 30. Europe PMC

Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. Grosch, M., Gruner, B., Spranger, S., Stutz, A.M., Rausch, T., Korbel, J.O., Seelow, D., Nurnberg, P., Sticht, H., Lausch, E., Zabel, B., Winterpacht, A. & Tagariello, A. Matrix Biol. 2013 May 9. pii: S0945-053X(13)00070-X. doi:10.1016/j.matbio.2013.05.001. Europe PMC

Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency. Greil, J., Rausch, T., Giese, T., Bandapalli, O.R., Daniel, V., Bekeredjian-Ding, I., Stutz, A.M., Drees, C., Roth, S., Ruland, J., Korbel, J.O. & Kulozik, A.E. J Allergy Clin Immunol. 2013 May;131(5):1376-83.e3. doi:10.1016/j.jaci.2013.02.012. Epub 2013 Apr 3. Europe PMC

Impact of genomic structural variation in Drosophila melanogaster based on population-scale sequencing. Zichner, T., Garfield, D.A., Rausch, T., Stutz, A.M., Cannavo, E., Braun, M., Furlong, E.E. & Korbel, J.O. Genome Res. 2013 Mar;23(3):568-79. doi: 10.1101/gr.142646.112. Epub 2012 Dec 6. Europe PMC

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Weischenfeldt, J., Simon, R., Feuerbach, L., Schlangen, K., Weichenhan, D., Minner, S., Wuttig, D., Warnatz, H.J., Stehr, H., Rausch, T., Jager, N., Gu, L., Bogatyrova, O., Stutz, A.M., Claus, R., Eils, J., Eils, R., Gerhauser, C., Huang, P.H., Hutter, B., Kabbe, R., Lawerenz, C., Radomski, S., Bartholomae, C.C., Falth, M., Gade, S., Schmidt, M., Amschler, N., Hass, T., Galal, R., Gjoni, J., Kuner, R., Baer, C., Masser, S., von Kalle, C., Zichner, T., Benes, V., Raeder, B., Mader, M., Amstislavskiy, V., Avci, M., Lehrach, H., Parkhomchuk, D., Sultan, M., Burkhardt, L., Graefen, M., Huland, H., Kluth, M., Krohn, A., Sirma, H., Stumm, L., Steurer, S., Grupp, K., Sultmann, H., Sauter, G., Plass, C., Brors, B., Yaspo, M.L., Korbel, J.O. & Schlomm, T. Cancer Cell. 2013 Feb 11;23(2):159-70. doi: 10.1016/j.ccr.2013.01.002. Europe PMC

An integrated map of genetic variation from 1,092 human genomes. 1000 Genomes Project Consortium Nature. 2012 Nov 1;491(7422):56-65. doi: 10.1038/nature11632. Europe PMC

DELLY: structural variant discovery by integrated paired-end and split-read analysis. Rausch, T., Zichner, T., Schlattl, A., Stutz, A.M., Benes, V. & Korbel, J.O. Bioinformatics. 2012 Sep 15;28(18):i333-i339. Europe PMC

Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Northcott, P.A., Shih, D.J., Peacock, J., Garzia, L., Morrissy, A.S., Zichner, T., Stutz, A.M., Korshunov, A., Reimand, J., Schumacher, S.E., Beroukhim, R., Ellison, D.W., Marshall, C.R., Lionel, A.C., Mack, S., Dubuc, A., Yao, Y., Ramaswamy, V., Luu, B., Rolider, A., Cavalli, F.M., Wang, X., Remke, M., Wu, X., Chiu, R.Y., Chu, A., Chuah, E., Corbett, R.D., Hoad, G.R., Jackman, S.D., Li, Y., Lo, A., Mungall, K.L., Nip, K.M., Qian, J.Q., Raymond, A.G., Thiessen, N.T., Varhol, R.J., Birol, I., Moore, R.A., Mungall, A.J., Holt, R., Kawauchi, D., Roussel, M.F., Kool, M., Jones, D.T., Witt, H., Fernandez-L, A., Kenney, A.M., Wechsler-Reya, R.J., Dirks, P., Aviv, T., Grajkowska, W.A., Perek-Polnik, M., Haberler, C.C., Delattre, O., Reynaud, S.S., Doz, F.F., Pernet-Fattet, S.S., Cho, B.K., Kim, S.K., Wang, K.C., Scheurlen, W., Eberhart, C.G., Fevre-Montange, M., Jouvet, A., Pollack, I.F., Fan, X., Muraszko, K.M., Gillespie, G.Y., Di Rocco, C., Massimi, L., Michiels, E.M., Kloosterhof, N.K., French, P.J., Kros, J.M., Olson, J.M., Ellenbogen, R.G., Zitterbart, K., Kren, L., Thompson, R.C., Cooper, M.K., Lach, B., McLendon, R.E., Bigner, D.D., Fontebasso, A., Albrecht, S., Jabado, N., Lindsey, J.C., Bailey, S., Gupta, N., Weiss, W.A., Bognar, L., Klekner, A., Van Meter, T.E., Kumabe, T., Tominaga, T., Elbabaa, S.K., Leonard, J.R., Rubin, J.B., Liau, L.M., Van Meir, E.G., Fouladi, M., Nakamura, H., Cinalli, G., Garami, M., Hauser, P., Saad, A.G., Iolascon, A., Jung, S., Carlotti, C.G., Vibhakar, R., Ra, Y.S., Robinson, S., Zollo, M., Faria, C.C., Chan, J.A., Levy, M.L., Sorensen, P.H., Meyerson, M., Pomeroy, S.L., Cho, Y.J., Bader, G.D., Tabori, U., Hawkins, C.E., Bouffet, E., Scherer, S.W., Rutka, J.T., Malkin, D., Clifford, S.C., Jones, S.J., Korbel, J.O., Pfister, S.M., Marra, M.A. & Taylor, M.D. Nature. 2012 Aug 2;488(7409):49-56. Europe PMC

Dissecting the genomic complexity underlying medulloblastoma. Jones, D.T., Jager, N., Kool, M., Zichner, T., Hutter, B., Sultan, M., Cho, Y.J., Pugh, T.J., Hovestadt, V., Stutz, A.M., Rausch, T., Warnatz, H.J., Ryzhova, M., Bender, S., Sturm, D., Pleier, S., Cin, H., Pfaff, E., Sieber, L., Wittmann, A., Remke, M., Witt, H., Hutter, S., Tzaridis, T., Weischenfeldt, J., Raeder, B., Avci, M., Amstislavskiy, V., Zapatka, M., Weber, U.D., Wang, Q., Lasitschka, B., Bartholomae, C.C., Schmidt, M., von Kalle, C., Ast, V., Lawerenz, C., Eils, J., Kabbe, R., Benes, V., van Sluis, P., Koster, J., Volckmann, R., Shih, D., Betts, M.J., Russell, R.B., Coco, S., Tonini, G.P., Schuller, U., Hans, V., Graf, N., Kim, Y.J., Monoranu, C., Roggendorf, W., Unterberg, A., Herold-Mende, C., Milde, T., Kulozik, A.E., von Deimling, A., Witt, O., Maass, E., Rossler, J., Ebinger, M., Schuhmann, M.U., Fruhwald, M.C., Hasselblatt, M., Jabado, N., Rutkowski, S., von Bueren, A.O., Williamson, D., Clifford, S.C., McCabe, M.G., Collins, V.P., Wolf, S., Wiemann, S., Lehrach, H., Brors, B., Scheurlen, W., Felsberg, J., Reifenberger, G., Northcott, P.A., Taylor, M.D., Meyerson, M., Pomeroy, S.L., Yaspo, M.L., Korbel, J.O., Korshunov, A., Eils, R., Pfister, S.M. & Lichter, P. Nature. 2012 Aug 2;488(7409):100-5. doi: 10.1038/nature11284. Europe PMC

Fine mapping of a QTL on chromosome 13 for submaximal exercise capacity training response: the HERITAGE Family Study. Rice, T.K., Sarzynski, M.A., Sung, Y.J., Argyropoulos, G., Stutz, A.M., Teran-Garcia, M., Rao, D.C., Bouchard, C. & Rankinen, T. Eur J Appl Physiol. 2012 Aug;112(8):2969-78. doi: 10.1007/s00421-011-2274-8. Epub2011 Dec 15. Europe PMC

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations. Rausch, T., Jones, D.T., Zapatka, M., Stutz, A.M., Zichner, T., Weischenfeldt, J., Jager, N., Remke, M., Shih, D., Northcott, P.A., Pfaff, E., Tica, J., Wang, Q., Massimi, L., Witt, H., Bender, S., Pleier, S., Cin, H., Hawkins, C., Beck, C., von Deimling, A., Hans, V., Brors, B., Eils, R., Scheurlen, W., Blake, J., Benes, V., Kulozik, A.E., Witt, O., Martin, D., Zhang, C., Porat, R., Merino, D.M., Wasserman, J., Jabado, N., Fontebasso, A., Bullinger, L., Rucker, F.G., Dohner, K., Dohner, H., Koster, J., Molenaar, J.J., Versteeg, R., Kool, M., Tabori, U., Malkin, D., Korshunov, A., Taylor, M.D., Lichter, P., Pfister, S.M. & Korbel, J.O. Cell. 2012 Jan 20;148(1-2):59-71. Europe PMC

An improved protocol for sequencing of repetitive genomic regions and structural variations using mutagenesis and next generation sequencing. Sipos, B., Massingham, T., Stutz, A.M. & Goldman, N. PLoS One. 2012;7(8):e43359. doi: 10.1371/journal.pone.0043359. Epub 2012 Aug 17. Europe PMC

A comprehensive map of mobile element insertion polymorphisms in humans. Stewart, C., Kural, D., Stromberg, M.P., Walker, J.A., Konkel, M.K., Stutz, A.M., Urban, A.E., Grubert, F., Lam, H.Y., Lee, W.P., Busby, M., Indap, A.R., Garrison, E., Huff, C., Xing, J., Snyder, M.P., Jorde, L.B., Batzer, M.A., Korbel, J.O., Marth, G.T.; 1000 Genomes Project. PLoS Genet. 2011 Aug;7(8):e1002236. Epub 2011 Aug 18. Europe PMC

Mapping copy number variation by population-scale genome sequencing. Mills, R.E., Walter, K., Stewart, C., Handsaker, R.E., Chen, K., Alkan, C., Abyzov, A., Yoon, S.C., Ye, K., Cheetham, R.K., Chinwalla, A., Conrad, D.F., Fu, Y., Grubert, F., Hajirasouliha, I., Hormozdiari, F., Iakoucheva, L.M., Iqbal, Z., Kang, S., Kidd, J.M., Konkel, M.K., Korn, J., Khurana, E., Kural, D., Lam, H.Y., Leng, J., Li, R., Li, Y., Lin, C.Y., Luo, R., Mu, X.J., Nemesh, J., Peckham, H.E., Rausch, T., Scally, A., Shi, X., Stromberg, M.P., Stutz, A.M., Urban, A.E., Walker, J.A., Wu, J., Zhang, Y., Zhang, Z.D., Batzer, M.A., Ding, L., Marth, G.T., McVean, G., Sebat, J., Snyder, M., Wang, J., Ye, K., Eichler, E.E., Gerstein, M.B., Hurles, M.E., Lee, C., McCarroll, S.A., Korbel, J.O.; 1000 Genomes Project. Nature. 2011 Feb 3;470(7332):59-65. Europe PMC

Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite. Ilnytska, O., Stutz, A.M., Park-York, M., York, D.A., Ribnicky, D.M., Zuberi, A., Cefalu, W.T. & Argyropoulos, G. Diabetes. 2011 Jan;60(1):97-106. doi: 10.2337/db10-0172. Epub 2010 Oct 27. Europe PMC

Systematic inference of copy-number genotypes from personal genome sequencing data reveals extensive olfactory receptor gene content diversity. Waszak, S.M., Hasin, Y., Zichner, T., Olender, T., Keydar, I., Khen, M., Stutz, A.M., Schlattl, A., Lancet, D. & Korbel, J.O. PLoS Comput Biol. 2010 Nov 11;6(11):e1000988. doi: 10.1371/journal.pcbi.1000988. Europe PMC

A map of human genome variation from population-scale sequencing. 1000 Genomes Project Consortium. Nature. 2010 Oct 28;467(7319):1061-73 Europe PMC

Case-control association study of TGOLN2 in attempted suicide. Mahon, P.B., Stutz, A.M., Seifuddin, F., Huo, Y., Goes, F.S., Jancic, D., Judy, J.T., Depaulo JR, J.r, Gershon, E.S., McMahon, F.J., Zandi, P.P., Potash, J.B. & Willour, V.L. Am J Med Genet B Neuropsychiatr Genet. 2010 Jul;153B(5):1016-23. Europe PMC

Potential and challenges of personalized genomics and the 1000 Genome Project. Stütz, A.M. & Korbel, J.O. Medizinische Genetik 2010 22(2) 242-247

Nucleotide-resolution analysis of structural variants using BreakSeq and a breakpoint library. Lam, H.Y., Mu, X.J., Stutz, A.M., Tanzer, A., Cayting, P.D., Snyder, M., Kim, P.M., Korbel, J.O. & Gerstein, M.B. Nat Biotechnol. 2010 Jan;28(1):47-55. Epub 2009 Dec 27. Europe PMC

Functional identification of the promoter of SLC4A5, a gene associated with cardiovascular and metabolic phenotypes in the HERITAGE Family Study. Stutz, A.M., Teran-Garcia, M., Rao, D.C., Rice, T., Bouchard, C. & Rankinen, T. Eur J Hum Genet. 2009 Nov;17(11):1481-9. doi: 10.1038/ejhg.2009.64. Epub 2009 Apr22. Europe PMC

KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. Argyropoulos, G., Stutz, A.M., Ilnytska, O., Rice, T., Teran-Garcia, M., Rao, D.C., Bouchard, C. & Rankinen, T. Physiol Genomics. 2009 Jan 8;36(2):79-88. Epub 2008 Nov 4. Europe PMC

Circadian expression of genes regulating food intake. Stutz, A.M., Staszkiewicz, J., Ptitsyn, A. & Argyropoulos, G. Obesity (Silver Spring). 2007 Mar;15(3):607-15. Europe PMC

Selective tissue uptake of agouti-related protein(82-131) and its modulation by fasting. Pan, W., Kastin, A.J., Yu, Y., Cain, C.M., Fairburn, T., Stutz, A.M., Morrison, C. & Argyropoulos, G. Endocrinology. 2005 Dec;146(12):5533-9. Epub 2005 Sep 1. Europe PMC

The agouti-related protein and its role in energy homeostasis. Stutz, A.M., Morrison, C.D. & Argyropoulos, G. Peptides. 2005 Oct;26(10):1771-81. Europe PMC

CD45 isoform expression is associated with different susceptibilities of human naive and effector CD4+ T cells to respond to IL-4. Stutz, A., Graf, P., Beinhauer, B., Hammerschmid, F., Neumann, C., Woisetschlager, M. & Jung, T. Eur J Immunol. 2005 Feb;35(2):575-83. Europe PMC

The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism. Stutz, A.M., Pickart, L.A., Trifilieff, A., Baumruker, T., Prieschl-Strassmayr, E. & Woisetschlager, M. J Immunol. 2003 Feb 15;170(4):1789-96. Europe PMC

Prevention of Immunoglobulin E Production as a Therapeutic Target. Woisetschlager, M., Stutz, A.M. & Ettmayer, P. Drug News Perspect. 2002 Mar;15(2):78-84. Europe PMC

Inhibition of interleukin-4- and CD40-induced IgE germline gene promoter activity by 2'-aminoethoxy-modified triplex-forming oligonucleotides. Stutz, A.M., Hoeck, J., Natt, F., Cuenoud, B. & Woisetschlager, M. J Biol Chem. 2001 Apr 13;276(15):11759-65. Epub 2001 Jan 19. Europe PMC

Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. Stutz, A.M. & Woisetschlager, M. J Immunol. 1999 Oct 15;163(8):4383-91. Europe PMC

Cooperation of binding sites for STAT6 and NF kappa B/rel in the IL-4-induced up-regulation of the human IgE germline promoter. Messner, B., Stutz, A.M., Albrecht, B., Peiritsch, S. & Woisetschlager, M. J Immunol. 1997 Oct 1;159(7):3330-7. Europe PMC