Top image

Staff at EMBL

CP-60009090

Adrian Stütz

Research Technician
Korbel Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Publications

Total: 38 publication(s)

2014

Moncunill V, Gonzalez S, Beà S, Andrieux LO, Salaverria I, Royo C, Martinez L, Puiggròs M, Segura-Wang M, Stütz AM, Navarro A, Royo R, Gelpí JL, Gut IG, López-Otín C, Orozco M, Korbel JO, Campo E, Puente XS, Torrents D. (2014)
Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads.
Nat. Biotechnol.
Europe PMC

Northcott PA, Lee C, Zichner T, Stütz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, Bader GD, VandenBerg S, Esparza LA, Ryzhova M, Wang W, Wittmann A, Stark S, Sieber L, Seker-Cin H, Linke L, Kratochwil F, Jäger N, Buchhalter I, Imbusch CD, Zipprich G, Raeder B, Schmidt S, Diessl N, Wolf S, Wiemann S, Brors B, Lawerenz C, Eils J, Warnatz HJ, Risch T, Yaspo ML, Weber UD, Bartholomae CC, von Kalle C, Turányi E, Hauser P, Sanden E, Darabi A, Siesjö P, Sterba J, Zitterbart K, Sumerauer D, van Sluis P, Versteeg R, Volckmann R, Koster J, Schuhmann MU, Ebinger M, Grimes HL, Robinson GW, Gajjar A, Mynarek M, von Hoff K, Rutkowski S, Pietsch T, Scheurlen W, Felsberg J, Reifenberger G, Kulozik AE, von Deimling A, Witt O, Eils R, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Korbel JO, Wechsler-Reya RJ, Pfister SM. (2014)
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
Nature doi:10.1038/nature13379
Europe PMC | doi

Bandapalli OR, Schuessele S, Kunz JB, Rausch T, Stütz AM, Tal N, Geron I, Gershman N, Izraeli S, Eilers J, Vaezipour N, Kirschner-Schwabe R, Hof J, von Stackelberg A, Schrappe M, Stanulla M, Zimmermann M, Koehler R, Avigad S, Handgretinger R, Frismantas V, Bourquin JP, Bornhauser B, Korbel JO, Muckenthaler MU, Kulozik AE. (2014)
The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse
Haematologica doi:10.3324/haematol.2014.104992
Europe PMC | doi

Bens S, Zichner T, Stütz AM, Caliebe A, Wagener R, Hoff K, Korbel JO, von Bismarck P, Siebert R. (2014)
SPAG7 is a candidate gene for the periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome
Genes Immun. 15(3):190-194. doi:10.1038/gene.2013.73
Europe PMC | doi

Mack SC, Witt H, Piro RM, Gu L, Zuyderduyn S, Stütz AM, Wang X, Gallo M, Garzia L, Zayne K, Zhang X, Ramaswamy V, Jäger N, Jones DT, Sill M, Pugh TJ, Ryzhova M, Wani KM, Shih DJ, Head R, Remke M, Bailey SD, Zichner T, Faria CC, Barszczyk M, Stark S, Seker-Cin H, Hutter S, Johann P, Bender S, Hovestadt V, Tzaridis T, Dubuc AM, Northcott PA, Peacock J, Bertrand KC, Agnihotri S, Cavalli FM, Clarke I, Nethery-Brokx K, Creasy CL, Verma SK, Koster J, Wu X, Yao Y, Milde T, Sin-Chan P, Zuccaro J, Lau L, Pereira S, Castelo-Branco P, Hirst M, Marra MA, Roberts SS, Fults D, Massimi L, Cho YJ, Van Meter T, Grajkowska W, Lach B, Kulozik AE, von Deimling A, Witt O, Scherer SW, Fan X, Muraszko KM, Kool M, Pomeroy SL, Gupta N, Phillips J, Huang A, Tabori U, Hawkins C, Malkin D, Kongkham PN, Weiss WA, Jabado N, Rutka JT, Bouffet E, Korbel JO, Lupien M, Aldape KD, Bader GD, Eils R, Lichter P, Dirks PB, Pfister SM, Korshunov A, Taylor MD. (2014)
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Nature 506(7489):445-450. doi:10.1038/nature13108
Europe PMC | doi


2013

Gokcumen O, Tischler V, Tica J, Zhu Q, Iskow RC, Lee E, Fritz MH, Langdon A, Stütz AM, Pavlidis P, Benes V, Mills RE, Park PJ, Lee C, Korbel JO. (2013)
Primate genome architecture influences structural variation mechanisms and functional consequences
Proc. Natl. Acad. Sci. U.S.A. 110(39):15764-15769. doi:10.1073/pnas.1305904110
Europe PMC | doi

Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM, International Cancer Genome Consortium PedBrain Tumor Project. (2013)
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
Nat. Genet. 45(8):927-932. doi:10.1038/ng.2682
Europe PMC | doi

Landry JJ, Pyl PT, Rausch T, Zichner T, Tekkedil MM, Stütz AM, Jauch A, Aiyar RS, Pau G, Delhomme N, Gagneur J, Korbel JO, Huber W, Steinmetz LM. (2013)
The genomic and transcriptomic landscape of a HeLa cell line
G3 (Bethesda) 3(8):1213-1224. doi:10.1534/g3.113.005777
Europe PMC | doi

Greil J, Rausch T, Giese T, Bandapalli OR, Daniel V, Bekeredjian-Ding I, Stütz AM, Drees C, Roth S, Ruland J, Korbel JO, Kulozik AE. (2013)
Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency
J. Allergy Clin. Immunol. 131(5):1376-83.e3. doi:10.1016/j.jaci.2013.02.012
Europe PMC | doi

Zichner T, Garfield DA, Rausch T, Stütz AM, Cannavó E, Braun M, Furlong EE, Korbel JO. (2013)
Impact of genomic structural variation in Drosophila melanogaster based on population-scale sequencing
Genome Res. 23(3):568-579. doi:10.1101/gr.142646.112
Europe PMC | doi

Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, Minner S, Wuttig D, Warnatz HJ, Stehr H, Rausch T, Jäger N, Gu L, Bogatyrova O, Stütz AM, Claus R, Eils J, Eils R, Gerhäuser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Fälth M, Gade S, Schmidt M, Amschler N, Haß T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sültmann H, Sauter G, Plass C, Brors B, Yaspo ML, Korbel JO, Schlomm T. (2013)
Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer
Cancer Cell 23(2):159-170. doi:10.1016/j.ccr.2013.01.002
Europe PMC | doi

Grosch M, Grüner B, Spranger S, Stütz AM, Rausch T, Korbel JO, Seelow D, Nürnberg P, Sticht H, Lausch E, Zabel B, Winterpacht A, Tagariello A. (2013)
Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype
Matrix Biol. 32(7-8):387-392. doi:10.1016/j.matbio.2013.05.001
Europe PMC | doi


2012

1000 Genomes Project Consortium, Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean GA. (2012)
An integrated map of genetic variation from 1,092 human genomes
Nature 491(7422):56-65. doi:10.1038/nature11632
Europe PMC | doi

Rausch T, Zichner T, Schlattl A, Stütz AM, Benes V, Korbel JO. (2012)
DELLY: structural variant discovery by integrated paired-end and split-read analysis
Paper presented at the 11th European Conference on Computational Biology (ECCB) / Conference of the Intelligent Systems in Molecular Biology (ISMB), Basel, SWITZERLAND, SEP 09-12, 2012.Bioinformatics 28(18):i333-i339. doi:10.1093/bioinformatics/bts378
Europe PMC | doi

Jones DT, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, Cho YJ, Pugh TJ, Hovestadt V, Stütz AM, Rausch T, Warnatz HJ, Ryzhova M, Bender S, Sturm D, Pleier S, Cin H, Pfaff E, Sieber L, Wittmann A, Remke M, Witt H, Hutter S, Tzaridis T, Weischenfeldt J, Raeder B, Avci M, Amstislavskiy V, Zapatka M, Weber UD, Wang Q, Lasitschka B, Bartholomae CC, Schmidt M, von Kalle C, Ast V, Lawerenz C, Eils J, Kabbe R, Benes V, van Sluis P, Koster J, Volckmann R, Shih D, Betts MJ, Russell RB, Coco S, Tonini GP, Schüller U, Hans V, Graf N, Kim YJ, Monoranu C, Roggendorf W, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, von Deimling A, Witt O, Maass E, Rössler J, Ebinger M, Schuhmann MU, Frühwald MC, Hasselblatt M, Jabado N, Rutkowski S, von Bueren AO, Williamson D, Clifford SC, McCabe MG, Collins VP, Wolf S, Wiemann S, Lehrach H, Brors B, Scheurlen W, Felsberg J, Reifenberger G, Northcott PA, Taylor MD, Meyerson M, Pomeroy SL, Yaspo ML, Korbel JO, Korshunov A, Eils R, Pfister SM, Lichter P. (2012)
Dissecting the genomic complexity underlying medulloblastoma
Nature 488(7409):100-105. doi:10.1038/nature11284
Europe PMC | doi

Rice TK, Sarzynski MA, Sung YJ, Argyropoulos G, Stütz AM, Teran-Garcia M, Rao DC, Bouchard C, Rankinen T. (2012)
Fine mapping of a QTL on chromosome 13 for submaximal exercise capacity training response: the HERITAGE Family Study
Eur. J. Appl. Physiol. 112(8):2969-2978. doi:10.1007/s00421-011-2274-8
Europe PMC | doi

Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AG, Thiessen NT, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fèvre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognár L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD. (2012)
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Nature 488(7409):49-56. doi:10.1038/nature11327
Europe PMC | doi

Sipos B, Massingham T, Stütz AM, Goldman N. (2012)
An improved protocol for sequencing of repetitive genomic regions and structural variations using mutagenesis and next generation sequencing
PLoS ONE 7(8):e43359. doi:10.1371/journal.pone.0043359
Europe PMC | doi

Rausch T, Jones DT, Zapatka M, Stütz AM, Zichner T, Weischenfeldt J, Jäger N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Blake J, Benes V, Kulozik AE, Witt O, Martin D, Zhang C, Porat R, Merino DM, Wasserman J, Jabado N, Fontebasso A, Bullinger L, Rücker FG, Döhner K, Döhner H, Koster J, Molenaar JJ, Versteeg R, Kool M, Tabori U, Malkin D, Korshunov A, Taylor MD, Lichter P, Pfister SM, Korbel JO. (2012)
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
Cell 148(1-2):59-71. doi:10.1016/j.cell.2011.12.013
Europe PMC | doi


2011

Stewart C, Kural D, Strömberg MP, Walker JA, Konkel MK, Stütz AM, Urban AE, Grubert F, Lam HY, Lee WP, Busby M, Indap AR, Garrison E, Huff C, Xing J, Snyder MP, Jorde LB, Batzer MA, Korbel JO, Marth GT, 1000 Genomes Project. (2011)
A comprehensive map of mobile element insertion polymorphisms in humans
PLoS Genet. 7(8):e1002236. doi:10.1371/journal.pgen.1002236
Europe PMC | doi

Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon SC, Ye K, Cheetham RK, Chinwalla A, Conrad DF, Fu Y, Grubert F, Hajirasouliha I, Hormozdiari F, Iakoucheva LM, Iqbal Z, Kang S, Kidd JM, Konkel MK, Korn J, Khurana E, Kural D, Lam HY, Leng J, Li R, Li Y, Lin CY, Luo R, Mu XJ, Nemesh J, Peckham HE, Rausch T, Scally A, Shi X, Stromberg MP, Stütz AM, Urban AE, Walker JA, Wu J, Zhang Y, Zhang ZD, Batzer MA, Ding L, Marth GT, McVean G, Sebat J, Snyder M, Wang J, Ye K, Eichler EE, Gerstein MB, Hurles ME, Lee C, McCarroll SA, Korbel JO, 1000 Genomes Project. (2011)
Mapping copy number variation by population-scale genome sequencing
Nature 470(7332):59-65. doi:10.1038/nature09708
Europe PMC | doi

Ilnytska O, Stütz AM, Park-York M, York DA, Ribnicky DM, Zuberi A, Cefalu WT, Argyropoulos G. (2011)
Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite
Diabetes 60(1):97-106. doi:10.2337/db10-0172
Europe PMC | doi


2010

1000 Genomes Project Consortium, Abecasis GR, Altshuler D, Auton A, Brooks LD, Durbin RM, Gibbs RA, Hurles ME, McVean GA. (2010)
A map of human genome variation from population-scale sequencing
Nature 467(7319):1061-1073. doi:10.1038/nature09534
Europe PMC | doi

Mahon PB, Stütz AM, Seifuddin F, Huo Y, Goes FS, Jancic D, Judy JT, Depaulo JR Jr, Gershon ES, McMahon FJ, Zandi PP, Potash JB, Willour VL. (2010)
Case-control association study of TGOLN2 in attempted suicide
Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B(5):1016-1023. doi:10.1002/ajmg.b.31068
Europe PMC | doi

Lam HY, Mu XJ, Stütz AM, Tanzer A, Cayting PD, Snyder M, Kim PM, Korbel JO, Gerstein MB. (2010)
Nucleotide-resolution analysis of structural variants using BreakSeq and a breakpoint library
Nat. Biotechnol. 28(1):47-55. doi:10.1038/nbt.1600
Europe PMC | doi

Stutz AM, Korbel JO. (2010)
Potential and challenges of personalized genomics and the 1000 Genome Project
Med. Genet. 22(2):242-247. doi:10.1007/s11825-010-0220-5
Europe PMC | doi

Waszak SM, Hasin Y, Zichner T, Olender T, Keydar I, Khen M, Stütz AM, Schlattl A, Lancet D, Korbel JO. (2010)
Systematic inference of copy-number genotypes from personal genome sequencing data reveals extensive olfactory receptor gene content diversity
PLoS Comput. Biol. 6(11):e1000988. doi:10.1371/journal.pcbi.1000988
Europe PMC | doi


2009

Stütz AM, Teran-Garcia M, Rao DC, Rice T, Bouchard C, Rankinen T. (2009)
Functional identification of the promoter of SLC4A5, a gene associated with cardiovascular and metabolic phenotypes in the HERITAGE Family Study
Eur. J. Hum. Genet. 17(11):1481-1489. doi:10.1038/ejhg.2009.64
Europe PMC | doi

Argyropoulos G, Stütz AM, Ilnytska O, Rice T, Teran-Garcia M, Rao DC, Bouchard C, Rankinen T. (2009)
KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise
Physiol. Genomics 36(2):79-88. doi:10.1152/physiolgenomics.00003.2008
Europe PMC | doi


2007

Stütz AM, Staszkiewicz J, Ptitsyn A, Argyropoulos G. (2007)
Circadian expression of genes regulating food intake
Obesity (Silver Spring) 15(3):607-615. doi:10.1038/oby.2007.564
Europe PMC | doi


2005

Pan W, Kastin AJ, Yu Y, Cain CM, Fairburn T, Stütz AM, Morrison C, Argyropoulos G. (2005)
Selective tissue uptake of agouti-related protein(82-131) and its modulation by fasting
Endocrinology 146(12):5533-5539. doi:10.1210/en.2005-0578
Europe PMC | doi

Stütz AM, Morrison CD, Argyropoulos G. (2005)
The agouti-related protein and its role in energy homeostasis
Peptides 26(10):1771-1781. doi:10.1016/j.peptides.2004.12.024
Europe PMC | doi

Stütz A, Graf P, Beinhauer B, Hammerschmid F, Neumann C, Woisetschläger M, Jung T. (2005)
CD45 isoform expression is associated with different susceptibilities of human naive and effector CD4+ T cells to respond to IL-4
Eur. J. Immunol. 35(2):575-583. doi:10.1002/eji.200425056
Europe PMC | doi


2003

Stütz AM, Pickart LA, Trifilieff A, Baumruker T, Prieschl-Strassmayr E, Woisetschläger M. (2003)
The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism
J. Immunol. 170(4):1789-1796.
Europe PMC


2002

Woisetschlager M, Stutz AM, Ettmayer P. (2002)
Prevention of Immunoglobulin E Production as a Therapeutic Target
Drug News Perspect. 15(2):78-84.
Europe PMC


2001

Stütz AM, Hoeck J, Natt F, Cuenoud B, Woisetschläger M. (2001)
Inhibition of interleukin-4- and CD40-induced IgE germline gene promoter activity by 2'-aminoethoxy-modified triplex-forming oligonucleotides
J. Biol. Chem. 276(15):11759-11765. doi:10.1074/jbc.m010260200
Europe PMC | doi


1999

Stütz AM, Woisetschläger M. (1999)
Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription
J. Immunol. 163(8):4383-4391.
Europe PMC


1997

Messner B, Stütz AM, Albrecht B, Peiritsch S, Woisetschläger M. (1997)
Cooperation of binding sites for STAT6 and NF kappa B/rel in the IL-4-induced up-regulation of the human IgE germline promoter
J. Immunol. 159(7):3330-3337.
Europe PMC