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Staff at EMBL

Christoph Merten

Group Leader
Merten Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 2004, University of Frankfurt.
Postdoctoral research at the MRC Laboratory of Molecular Biology, Cambridge.
Junior group leader at the Institut de Science et d'Ingénierie Supramoléculaire, Strasbourg.
Group leader at EMBL since 2010.


Fragmentation of DNA in a sub-microliter microfluidic sonication device. Tseng, Q., Lomonosov, A.M., Furlong, E.E. & Merten, C.A. Lab Chip. 2012 Nov 21;12(22):4677-82. doi: 10.1039/c2lc40595d. Europe PMC

Functional single-cell hybridoma screening using droplet-based microfluidics. El Debs, B., Utharala, R., Balyasnikova, I.V., Griffiths, A.D. & Merten, C.A. Proc Natl Acad Sci U S A. 2012 Jul 2. Research Highlight in Nature Methods
9(9): 866. 2012. Epub 2012 Jul 2. Europe PMC

Micro segmented-flow in biochemical and cell-based assays. Clausell-Tormos, J. & Merten, C.A. Front Biosci (Elite Ed). 2012 Jan 1;4:1768-79. Europe PMC

A competitive co-cultivation assay for cancer drug specificity evaluation. El Debs, B.W., Tschulena, U., Griffiths, A.D. & Merten, C.A. J Biomol Screen. 2011 Sep;16(8):818-24. Epub 2011 Jul 25. Europe PMC

Microfluidic devices for diagnostic applications. Eicher, D. & Merten, C.A. Expert Rev Mol Diagn. 2011 Jun;11(5):505-19. doi: 10.1586/ERM.11.25. Europe PMC

Retroviral display in gene therapy, protein engineering, and vaccine development. Urban, J.H. & Merten, C.A. ACS Chem Biol. 2011 Jan 21;6(1):61-74. Epub 2010 Dec 20. Europe PMC

Miniaturization and Parallelization of Biological and Chemical Assays in Microfluidic Devices. Vyawahare, S., Griffiths, A.D. & Merten, C.A. Chem Biol. 2010 Oct 29;17(10):1052-65. Europe PMC

Screening Europe 2010: an update about the latest technologies and applications in high-throughput screening. Merten, C.A. Expert Rev Mol Diagn. 2010 Jul;10(5):559-63. Europe PMC

An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries. Clausell-Tormos, J., Griffiths, A.D. & Merten, C.A. Lab Chip. 2010 May 21;10(10):1302-7. Epub 2010 Mar 3. Europe PMC

Coupling the inhibition of viral transduction with a positive fluorescence signal. Clausell-Tormos, J., Griffiths, A.D. & Merten, C.A. Comb Chem High Throughput Screen. 2010 May;13(4):352-7. Europe PMC

Nanoliter plates--versatile tools for the screening of split-and-mix libraries on-bead and off-bead. Upert, G., Merten, C.A. & Wennemers, H. Chem Commun (Camb). 2010 Apr 7;46(13):2209-11. Epub 2010 Feb 23. Europe PMC

High-throughput screening of enzymes by retroviral display using droplet-based microfluidics. Granieri, L., Baret, J.C., Griffiths, A.D. & Merten, C.A. Chem Biol. 2010 Mar 26;17(3):229-35. Europe PMC

A competition-based assay for the screening of species-specific antibiotics. Granieri, L., Miller, O.J., Griffiths, A.D. & Merten, C.A. J Antimicrob Chemother. 2009 Jul;64(1):62-8. Epub 2009 Apr 28. Europe PMC

Droplets and emulsions: very high-throughput screening in biology Baret, J.C., Taly, V., Ryckelynck, M., Merten, C.A. & Griffiths, A.D. Med Sci (Paris). 2009 Jun-Jul;25(6-7):627-32. Europe PMC

Imaging of mRNA in live cells using nucleic acid-templated reduction of azidorhodamine probes. Pianowski, Z., Gorska, K., Oswald, L., Merten, C.A. & Winssinger, N. J Am Chem Soc. 2009 May 13;131(18):6492-7. Europe PMC

Drop-based microfluidic devices for encapsulation of single cells. Koster, S., Angile, F.E., Duan, H., Agresti, J.J., Wintner, A., Schmitz, C., Rowat, A.C., Merten, C.A., Pisignano, D., Griffiths, A.D. & Weitz, D.A. Lab Chip. 2008 Jul;8(7):1110-5. Epub 2008 May 23. Europe PMC

Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organisms. Clausell-Tormos, J., Lieber, D., Baret, J.C., El-Harrak, A., Miller, O.J., Frenz, L., Blouwolff, J., Humphry, K.J., Koster, S., Duan, H., Holtze, C., Weitz, D.A., Griffiths, A.D. & Merten, C.A. Chem Biol. 2008 May;15(5):427-37. Research Highlight in Nature Methods 5(7): 580-581. 2008. Europe PMC

Fusoselect: cell-cell fusion activity engineered by directed evolution of a retroviral glycoprotein. Merten, C.A., Stitz, J., Braun, G., Medvedovska, J., Cichutek, K. & Buchholz, C.J. Nucleic Acids Res. 2006 Mar 15;34(5):e41. Print 2006. Europe PMC

Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP. Nikles, D., Bach, P., Boller, K., Merten, C.A., Montrasio, F., Heppner, F.L., Aguzzi, A., Cichutek, K., Kalinke, U. & Buchholz, C.J. J Virol. 2005 Apr;79(7):4033-42. Europe PMC

Directed evolution of retrovirus envelope protein cytoplasmic tails guided by functional incorporation into lentivirus particles. Merten, C.A., Stitz, J., Braun, G., Poeschla, E.M., Cichutek, K. & Buchholz, C.J. J Virol. 2005 Jan;79(2):834-40. Europe PMC

Displaying epidermal growth factor on spleen necrosis virus-derived targeting vectors. Merten, C.A., Engelstaedter, M., Buchholz, C.J. & Cichutek, K. Virology. 2003 Jan 5;305(1):106-14. Europe PMC