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Staff at EMBL

Dr. Nassos Typas

Group Leader
Typas Group Joint appointment: Structural and Computational Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany



PhD 2006, Institute of Microbiology and Plant Physiology, Freie Universität Berlin, Germany.
Postgraduate research, University of California, San Francisco.
Group leader at EMBL since 2011.
Joint appointment with the Structural and Computational Biology Unit.


Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B. Egan, A.J., Jean, N.L., Koumoutsi, A., Bougault, C.M., Biboy, J., Sassine, J., Solovyova, A.S., Breukink, E., Typas, A., Vollmer, W. & Simorre, J.P. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8197-202. doi:10.1073/pnas.1400376111. Epub 2014 May 12. Europe PMC

Dynamic protein complexes for cell growth. Banzhaf, M. & Typas, A. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4355-6. doi:10.1073/pnas.1402016111. Epub 2014 Mar 17. Europe PMC

A genome-wide screen for bacterial envelope biogenesis mutants identifies a novel factor involved in cell wall precursor metabolism. Paradis-Bleau, C., Kritikos, G., Orlova, K., Typas, A. & Bernhardt, T.G. PLoS Genet. 2014 Jan;10(1):e1004056. doi: 10.1371/journal.pgen.1004056. Epub 2014Jan 2. Europe PMC

Country-specific antibiotic use practices impact the human gut resistome. Forslund, K., Sunagawa, S., Kultima, J.R., Mende, D.R., Arumugam, M., Typas, A. & Bork, P. Genome Res. 2013 Jul;23(7):1163-9. doi: 10.1101/gr.155465.113. Epub 2013 Apr 8. Europe PMC

High-throughput approaches to understanding gene function and mapping network architecture in bacteria. Brochado, A.R. & Typas, A. Curr Opin Microbiol. 2013 Apr;16(2):199-206. doi: 10.1016/j.mib.2013.01.008. Epub2013 Feb 9. Europe PMC

Fe-S cluster biosynthesis controls uptake of aminoglycosides in a ROS-less death pathway. Ezraty, B., Vergnes, A., Banzhaf, M., Duverger, Y., Huguenot, A., Brochado, A.R., Su, S.Y., Espinosa, L., Loiseau, L., Py, B., Typas, A. & Barras, F. Science. 2013 Jun 28;340(6140):1583-7. doi: 10.1126/science.1238328. Europe PMC

From the regulation of peptidoglycan synthesis to bacterial growth and morphology. Typas, A., Banzhaf, M., Gross, C.A. & Vollmer, W. Nat Rev Microbiol. 2012 Feb;10(2):123-36. doi: 10.1038/nrmicro2677. Europe PMC

Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo. Oh, E., Becker, A.H., Sandikci, A., Huber, D., Chaba, R., Gloge, F., Nichols, R.J., Typas, A., Gross, C.A., Kramer, G., Weissman, J.S. & Bukau, B. Cell. 2011 Dec 9;147(6):1295-308. Europe PMC

Escherichia coli sigma senses sequence and conformation of the promoter spacer region. Singh, S.S., Typas, A., Hengge, R. & Grainger, D.C. Nucleic Acids Res. 2011 Jul;39(12):5109-18. Epub 2011 Mar 11. Europe PMC

Phenotypic landscape of a bacterial cell. Nichols, R.J., Sen, S., Choo, Y.J., Beltrao, P., Zietek, M., Chaba, R., Lee, S., Kazmierczak, K.M., Lee, K.J., Wong, A., Shales, M., Lovett, S., Winkler, M.E., Krogan, N.J., Typas, A. & Gross, C.A. Cell. 2011 Jan 7;144(1):143-56. Epub 2010 Dec 23. Europe PMC

Regulation of peptidoglycan synthesis by outer-membrane proteins. Typas, A., Banzhaf, M., van den Berg van Saparoea, B., Verheul, J., Biboy, J., Nichols, R.J., Zietek, M., Beilharz, K., Kannenberg, K., von Rechenberg, M., Breukink, E., den Blaauwen, T., Gross, C.A. & Vollmer, W. Cell. 2010 Dec 23;143(7):1097-109. Europe PMC

High-throughput, quantitative analyses of genetic interactions in E. coli. Typas, A., Nichols, R.J., Siegele, D.A., Shales, M., Collins, S.R., Lim, B., Braberg, H., Yamamoto, N., Takeuchi, R., Wanner, B.L., Mori, H., Weissman, J.S., Krogan, N.J. & Gross, C.A. Nat Methods. 2008 Sep;5(9):781-7. Europe PMC

Stationary phase reorganisation of the Escherichia coli transcription machinery by Crl protein, a fine-tuner of sigmas activity and levels. Typas, A., Barembruch, C., Possling, A. & Hengge, R. EMBO J. 2007 Mar 21;26(6):1569-78. Epub 2007 Mar 1. Europe PMC

The molecular basis of selective promoter activation by the sigmaS subunit of RNA polymerase. Typas, A., Becker, G. & Hengge, R. Mol Microbiol. 2007 Mar;63(5):1296-306. Europe PMC

The -35 sequence location and the Fis-sigma factor interface determine sigmas selectivity of the proP (P2) promoter in Escherichia coli. Typas, A., Stella, S., Johnson, R.C. & Hengge, R. Mol Microbiol. 2007 Feb;63(3):780-96. Europe PMC

The sigmaS subunit of RNA polymerase as a signal integrator and network master regulator in the general stress response in Escherichia coli. Klauck, E., Typas, A. & Hengge, R. Sci Prog. 2007;90(Pt 2-3):103-27. Europe PMC

Role of the spacer between the -35 and -10 regions in sigmas promoter selectivity in Escherichia coli. Typas, A. & Hengge, R. Mol Microbiol. 2006 Feb;59(3):1037-51. Europe PMC

Differential ability of sigma(s) and sigma70 of Escherichia coli to utilize promoters containing half or full UP-element sites. Typas, A. & Hengge, R. Mol Microbiol. 2005 Jan;55(1):250-60. Europe PMC