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Staff at EMBL

Dr. Lars Steinmetz

Associate Head of Unit and Senior Scientist
Steinmetz Group Directors' Research

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Biography

PhD 1997-2001, Stanford University.
Postdoctoral research at Stanford Genome Technology Center.
Visiting group leader since 2003. Co-Director since 2013.
Group leader at EMBL since 2003. Senior Scientist since 2009. Joint Head of Genome Biology Unit 2009-2013. Associate Head of Unit since 2013.
Professor of Genetics, Stanford University since 2013.
ERC Advanced Investigator since 2012.

Publications

A Genome-Wide Map of Mitochondrial DNA Recombination in Yeast. Fritsch, E.S., Chabbert, C.D., Klaus, B. & Steinmetz, L.M. Genetics. 2014 Jul 31. pii: genetics.114.166637. Europe PMC

Genome-wide identification of transcript start and end sites by transcript isoform sequencing. Pelechano, V., Wei, W., Jakob, P. & Steinmetz, L.M. Nat Protoc. 2014 Jun;9(7):1740-59. doi: 10.1038/nprot.2014.121. Epub 2014 Jun 26. Europe PMC

Heritability and genetic basis of protein level variation in an outbred population. Parts, L., Liu, Y.C., Tekkedil, M., Steinmetz, L.M., Caudy, A.A., Fraser, A.G., Boone, C., Andrews, B.J. & Rosebrock, A.P. Genome Res. 2014 May 13. pii: gr.170506.113. Europe PMC

Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast. Castelnuovo, M., Zaugg, J.B., Guffanti, E., Maffioletti, A., Camblong, J., Xu, Z., Clauder-Munster, S., Steinmetz, L.M., Luscombe, N.M. & Stutz, F. Nucleic Acids Res. 2014 Apr;42(7):4348-62. doi: 10.1093/nar/gku100. Epub 2014 Feb4. Europe PMC

Control of Cdc28 CDK1 by a stress-induced lncRNA. Nadal-Ribelles, M., Sole, C., Xu, Z., Steinmetz, L.M., de Nadal, E. & Posas, F. Mol Cell. 2014 Feb 20;53(4):549-61. doi: 10.1016/j.molcel.2014.01.006. Epub 2014Feb 6. Europe PMC

Yeast Growth Plasticity Is Regulated by Environment Specific Multi-QTL Interactions. Bhatia, A., Yadav, A., Gagneur, J., Zhu, C., Steinmetz, L.M., Bhanot, G. & Sinha, H. G3 (Bethesda). 2014 Jan 28. pii: g3.113.009142v1. doi: 10.1534/g3.113.009142. Europe PMC

Alternative polyadenylation diversifies post-transcriptional regulation by selective RNA-protein interactions. Gupta, I., Clauder-Munster, S., Klaus, B., Jarvelin, A.I., Aiyar, R.S., Benes, V., Wilkening, S., Huber, W., Pelechano, V. & Steinmetz, L.M. Mol Syst Biol. 2014 Feb 25;10:719. doi: 10.1002/msb.135068. Print 2014. Europe PMC

An Evaluation of High-Throughput Approaches to QTL Mapping in Saccharomyces cerevisiae. Wilkening, S., Lin, G., Fritsch, E.S., Tekkedil, M.M., Anders, S., Kuehn, R., Nguyen, M., Aiyar, R.S., Proctor, M., Sakhanenko, N.A., Galas, D.J., Gagneur, J., Deutschbauer, A. & Steinmetz, L.M. Genetics. 2013 Dec 27. Europe PMC

Gene regulation by antisense transcription. Pelechano, V. & Steinmetz, L.M. Nat Rev Genet. 2013 Dec;14(12):880-93. doi: 10.1038/nrg3594. Epub 2013 Nov 12. Europe PMC

Extensive variation in chromatin states across humans. Kasowski, M., Kyriazopoulou-Panagiotopoulou, S., Grubert, F., Zaugg, J.B., Kundaje, A., Liu, Y., Boyle, A.P., Zhang, Q.C., Zakharia, F., Spacek, D.V., Li, J., Xie, D., Olarerin-George, A., Steinmetz, L.M., Hogenesch, J.B., Kellis, M., Batzoglou, S. & Snyder, M. Science. 2013 Nov 8;342(6159):750-2. doi: 10.1126/science.1242510. Epub 2013 Oct17. Europe PMC

Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype. Gagneur, J., Stegle, O., Zhu, C., Jakob, P., Tekkedil, M.M., Aiyar, R.S., Schuon, A.K., Pe'er, D. & Steinmetz, L.M. PLoS Genet. 2013 Sep;9(9):e1003803. doi: 10.1371/journal.pgen.1003803. Epub 2013Sep 19. Europe PMC

Drift and conservation of differential exon usage across tissues in primate species. Reyes, A., Anders, S., Weatheritt, R.J., Gibson, T.J., Steinmetz, L.M. & Huber, W. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15377-82. doi:10.1073/pnas.1307202110. Epub 2013 Sep 3. Europe PMC

Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality. Ntini, E., Jarvelin, A.I., Bornholdt, J., Chen, Y., Boyd, M., Jorgensen, M., Andersson, R., Hoof, I., Schein, A., Andersen, P.R., Andersen, P.K., Preker, P., Valen, E., Zhao, X., Pelechano, V., Steinmetz, L.M., Sandelin, A. & Jensen, T.H. Nat Struct Mol Biol. 2013 Aug;20(8):923-8. doi: 10.1038/nsmb.2640. Epub 2013 Jul14. Europe PMC

The genomic and transcriptomic landscape of a HeLa cell line. Landry, J.J., Pyl, P.T., Rausch, T., Zichner, T., Tekkedil, M.M., Stutz, A.M., Jauch, A., Aiyar, R.S., Pau, G., Delhomme, N., Gagneur, J., Korbel, J.O., Huber, W. & Steinmetz, L.M. G3 (Bethesda). 2013 Aug 7;3(8):1213-24. doi: 10.1534/g3.113.005777. Europe PMC

Multiple genomic changes associated with reorganization of gene regulation and adaptation in yeast. David, L., Ben-Harosh, Y., Stolovicki, E., Moore, L.S., Nguyen, M., Tamse, R., Dean, J., Mancera, E., Steinmetz, L.M. & Braun, E. Mol Biol Evol. 2013 Jul;30(7):1514-26. doi: 10.1093/molbev/mst071. Epub 2013 Apr14. Europe PMC

Extensive transcriptional heterogeneity revealed by isoform profiling. Pelechano, V., Wei, W. & Steinmetz, L.M. Nature. 2013 May 2;497(7447):127-31. doi: 10.1038/nature12121. Epub 2013 Apr 24. Europe PMC

An efficient method for genome-wide polyadenylation site mapping and RNA quantification. Wilkening, S., Pelechano, V., Jarvelin, A.I., Tekkedil, M.M., Anders, S., Benes, V. & Steinmetz, L.M. Nucleic Acids Res. 2013 Mar 1;41(5):e65. doi: 10.1093/nar/gks1249. Epub 2013 Jan7. Europe PMC

Genotyping 1000 yeast strains by next-generation sequencing. Wilkening, S., Tekkedil, M.M., Lin, G., Fritsch, E.S., Wei, W., Gagneur, J., Lazinski, D.W., Camilli, A. & Steinmetz, L.M. BMC Genomics. 2013 Feb 9;14:90. doi: 10.1186/1471-2164-14-90. Europe PMC

System-wide identification of RNA-binding proteins by interactome capture. Castello, A., Horos, R., Strein, C., Fischer, B., Eichelbaum, K., Steinmetz, L.M., Krijgsveld, J. & Hentze, M.W. Nat Protoc. 2013 Feb 14;8(3):491-500. doi: 10.1038/nprot.2013.020. Epub 2013 Feb14. Europe PMC

The Role of Ctk1 Kinase in Termination of Small Non-Coding RNAs. Lenstra, T.L., Tudek, A., Clauder, S., Xu, Z., Pachis, S.T., van Leenen, D., Kemmeren, P., Steinmetz, L.M., Libri, D. & Holstege, F.C. PLoS One. 2013 Dec 4;8(12):e80495. doi: 10.1371/journal.pone.0080495. Europe PMC

Silencing of Genes and Alleles by RNAi in Anopheles gambiae. Lamacchia, M., Clayton, J.R., Wang-Sattler, R., Steinmetz, L.M., Levashina, E.A. & Blandin, S.A. Methods Mol Biol. 2013;923:161-76. Europe PMC

Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability. Fehrmann, S., Bottin-Duplus, H., Leonidou, A., Mollereau, E., Barthelaix, A., Wei, W., Steinmetz, L.M. & Yvert, G. Mol Syst Biol. 2013 Oct 8;9:695. doi: 10.1038/msb.2013.53. Europe PMC

Gene loops enhance transcriptional directionality. Tan-Wong, S.M., Zaugg, J.B., Camblong, J., Xu, Z., Zhang, D.W., Mischo, H.E., Ansari, A.Z., Luscombe, N.M., Steinmetz, L.M. & Proudfoot, N.J. Science. 2012 Nov 2;338(6107):671-5. doi: 10.1126/science.1224350. Epub 2012 Sep27. Europe PMC

RNA Polymerase II Collision Interrupts Convergent Transcription. Hobson, D.J., Wei, W., Steinmetz, L.M. & Svejstrup, J.Q. Mol Cell. 2012 Oct 2. pii: S1097-2765(12)00770-8. doi:10.1016/j.molcel.2012.08.027. Europe PMC

easyRNASeq: a bioconductor package for processing RNA-Seq data. Delhomme, N., Padioleau, I., Furlong, E.E. & Steinmetz, L.M. Bioinformatics. 2012 Oct 1;28(19):2532-3. Epub 2012 Jul 30. Europe PMC

Set3 HDAC mediates effects of overlapping noncoding transcription on gene induction kinetics. Kim, T., Xu, Z., Clauder-Munster, S., Steinmetz, L.M. & Buratowski, S. Cell. 2012 Sep 14;150(6):1158-69. doi: 10.1016/j.cell.2012.08.016. Epub 2012 Sep6. Europe PMC

Extensive Degradation of RNA Precursors by the Exosome in Wild-Type Cells. Gudipati, R.K., Xu, Z., Lebreton, A., Seraphin, B., Steinmetz, L.M., Jacquier, A. & Libri, D. Mol Cell. 2012 Sep 19. pii: S1097-2765(12)00736-8. doi:10.1016/j.molcel.2012.08.018. Europe PMC

Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms. Abraham, A.L., Nagarajan, M., Veyrieras, J.B., Bottin, H., Steinmetz, L.M. & Yvert, G. PLoS Genet. 2012 Sep;8(9):e1002958. doi: 10.1371/journal.pgen.1002958. Epub 2012Sep 20. Europe PMC

Experimental Relocation of the Mitochondrial ATP9 Gene to the Nucleus Reveals Forces Underlying Mitochondrial Genome Evolution. Bietenhader, M.*, Martos, A.*, Tetaud, E.*, Aiyar, R.S.*, Sellem, C.H., Kucharczyk, R., Clauder-Munster, S., Giraud, M.F., Godard, F., Salin, B., Sagot, I., Gagneur, J., Dequard-Chablat, M., Contamine, V., Denmat, S.H., Sainsard-Chanet, A., Steinmetz, L.M. & di Rago, J.P. PLoS Genet. 2012 Aug;8(8):e1002876. Epub 2012 Aug 16.
*equal contributors Europe PMC

Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins. Schmid, M., Poulsen, M.B., Olszewski, P., Pelechano, V., Saguez, C., Gupta, I., Steinmetz, L.M., Moore, C. & Jensen, T.H. Mol Cell. 2012 Jul 27;47(2):267-80. doi: 10.1016/j.molcel.2012.05.005. Epub 2012Jun 7. Europe PMC

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins. Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B.M., Strein, C., Davey, N.E., Humphreys, D.T., Preiss, T., Steinmetz, L.M., Krijgsveld, J. & Hentze, M.W. Cell. 2012 Jun 8;149(6):1393-406. Epub 2012 May 31. Europe PMC

Genome-wide H4 K16 acetylation by SAS-I is deposited independently of transcription and histone exchange. Heise, F., Chung, H.R., Weber, J.M., Xu, Z., Klein-Hitpass, L., Steinmetz, L.M., Vingron, M. & Ehrenhofer-Murray, A.E. Nucleic Acids Res. 2012 Jan;40(1):65-74. doi: 10.1093/nar/gkr649. Epub 2011 Sep9. Europe PMC

Genome-wide polyadenylation site mapping. Pelechano, V., Wilkening, S., Jarvelin, A.I., Tekkedil, M.M. & Steinmetz, L.M. Methods Enzymol. 2012;513:271-96. doi: 10.1016/B978-0-12-391938-0.00012-4. Europe PMC

Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae. Marvin, M.C., Clauder-Munster, S., Walker, S.C., Sarkeshik, A., Yates JR, 3rd, Steinmetz, L.M. & Engelke, D.R. RNA. 2011 Aug;17(8):1441-50. doi: 10.1261/rna.2737511. Epub 2011 Jun 10. Europe PMC

A yeast-based assay identifies drugs active against human mitochondrial disorders. Couplan, E.*, Aiyar, R.S.*, Kucharczyk, R., Kabala, A., Ezkurdia, N., Gagneur, J., St Onge, R.P., Salin, B., Soubigou, F., Le Cann, M., Steinmetz, L.M., di Rago, J.P. & Blondel, M. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11989-94. doi:10.1073/pnas.1101478108. Epub 2011 Jun 29.
*equal contributors Europe PMC

Functional consequences of bidirectional promoters. Wei, W., Pelechano, V., Jarvelin, A.I. & Steinmetz, L.M. Trends Genet. 2011 Jul;27(7):267-76. doi: 10.1016/j.tig.2011.04.002. Epub 2011May 24. Europe PMC

Genome-wide survey of post-meiotic segregation during yeast recombination. Mancera, E., Bourgon, R., Huber, W. & Steinmetz, L.M. Genome Biol. 2011 Apr 11;12(4):R36. Europe PMC

Antisense expression increases gene expression variability and locus interdependency. Xu, Z., Wei, W., Gagneur, J., Clauder-Munster, S., Smolik, M., Huber, W. & Steinmetz, L.M. Mol Syst Biol. 2011 Feb 15;7:468. doi: 10.1038/msb.2011.1. Europe PMC

Execution of the meiotic noncoding RNA expression program and the onset of gametogenesis in yeast require the conserved exosome subunit Rrp6. Lardenois, A., Liu, Y., Walther, T., Chalmel, F., Evrard, B., Granovskaia, M., Chu, A., Davis, R.W., Steinmetz, L.M. & Primig, M. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1058-63. doi:10.1073/pnas.1016459108. Epub 2010 Dec 13. Europe PMC

Yeast Sen1 helicase protects the genome from transcription-associated instability. Mischo, H.E., Gomez-Gonzalez, B., Grzechnik, P., Rondon, A.G., Wei, W., Steinmetz, L.M., Aguilera, A. & Proudfoot, N.J. Mol Cell. 2011 Jan 7;41(1):21-32. Europe PMC

Genome-wide transcriptome analysis in yeast using high-density tiling arrays. David, L., Clauder-Munster, S. & Steinmetz, L.M. Methods Mol Biol. 2011;759:107-23. Europe PMC

The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis. Nishant, K.T., Wei, W., Mancera, E., Argueso, J.L., Schlattl, A., Delhomme, N., Ma, X., Bustamante, C.D., Korbel, J.O., Gu, Z., Steinmetz, L.M. & Alani, E. PLoS Genet. 2010 Sep 9;6(9):e1001109. doi: 10.1371/journal.pgen.1001109. Europe PMC

Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen. Guan, W., Jiang, H., Guo, X., Mancera, E., Xu, L., Li, Y., Steinmetz, L.M., Li, Y. & Gu, Z. PLoS One. 2010 Jun 25;5(6):e11309. Europe PMC

Genetic analysis of variation in transcription factor binding in yeast. Zheng, W., Zhao, H., Mancera, E., Steinmetz, L.M. & Snyder, M. Nature. 2010 Apr 22;464(7292):1187-91. doi: 10.1038/nature08934. Epub 2010 Mar17. Europe PMC

Natural single-nucleosome epi-polymorphisms in yeast. Nagarajan, M., Veyrieras, J.B., de Dieuleveult, M., Bottin, H., Fehrmann, S., Abraham, A.L., Croze, S., Steinmetz, L.M., Gidrol, X. & Yvert, G. PLoS Genet. 2010 Apr 22;6(4):e1000913. Europe PMC

High-resolution transcription atlas of the mitotic cell cycle in budding yeast. Granovskaia, M.V., Jensen, L.J., Ritchie, M.E., Toedling, J., Ning, Y., Bork, P., Huber, W. & Steinmetz, L.M. Genome Biol. 2010 Mar 1;11(3):R24. Europe PMC

Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. Blandin, S.A., Wang-Sattler, R., Lamacchia, M., Gagneur, J., Lycett, G., Ning, Y., Levashina, E.A. & Steinmetz, L.M. Science. 2009 Oct 2;326(5949):147-50. doi: 10.1126/science.1175241. Europe PMC

Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiae. Camblong, J., Beyrouthy, N., Guffanti, E., Schlaepfer, G., Steinmetz, L.M. & Stutz, F. Genes Dev. 2009 Jul 1;23(13):1534-45. Europe PMC

Genome-wide allele- and strand-specific expression profiling. Gagneur, J., Sinha, H., Perocchi, F., Bourgon, R., Huber, W. & Steinmetz, L.M. Mol Syst Biol. 2009;5:274. Epub 2009 Jun 16. Europe PMC

Array-based genotyping in S.cerevisiae using semi-supervised clustering. Bourgon, R., Mancera, E., Brozzi, A., Steinmetz, L.M. & Huber, W. Bioinformatics. 2009 Apr 15;25(8):1056-62. doi: 10.1093/bioinformatics/btp104.Epub 2009 Feb 23. Europe PMC

Bidirectional promoters generate pervasive transcription in yeast. Xu, Z., Wei, W., Gagneur, J., Perocchi, F., Clauder-Munster, S., Camblong, J., Guffanti, E., Stutz, F., Huber, W. & Steinmetz, L.M. Nature. 2009 Feb 19;457(7232):1033-7. Epub 2009 Jan 25. Europe PMC

Widespread bidirectional promoters are the major source of cryptic transcripts in yeast. Neil, H., Malabat, C., d'Aubenton-Carafa, Y., Xu, Z., Steinmetz, L.M. & Jacquier, A. Nature. 2009 Feb 19;457(7232):1038-42. Epub 2009 Jan 25. Europe PMC

Identification of mitochondrial disease genes through integrative analysis of multiple datasets. Aiyar, R.S., Gagneur, J. & Steinmetz, L.M. Methods. 2008 Dec;46(4):248-55. Epub 2008 Oct 16. Europe PMC

Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast. Sinha, H., David, L., Pascon, R.C., Clauder-Munster, S., Krishnakumar, S., Nguyen, M., Shi, G., Dean, J., Davis, R.W., Oefner, P.J., McCusker, J.H. & Steinmetz, L.M. Genetics. 2008 Nov;180(3):1661-70. Epub 2008 Sep 9. Europe PMC

High-resolution mapping of meiotic crossovers and non-crossovers in yeast. Mancera, E., Bourgon, R., Brozzi, A., Huber, W. & Steinmetz, L.M. Nature. 2008 Jul 24;454(7203):479-85. Epub 2008 Jul 9. Europe PMC

Systematic screens for human disease genes, from yeast to human and back. Perocchi, F., Mancera, E. & Steinmetz, L.M. Mol Biosyst. 2008 Jan;4(1):18-29. Epub 2007 Sep 25. Europe PMC

Antisense artifacts in transcriptome microarray experiments are resolved by actinomycin D. Perocchi, F., Xu, Z., Clauder-Munster, S. & Steinmetz, L.M. Nucleic Acids Res. 2007;35(19):e128. Epub 2007 Sep 26. Europe PMC

Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789. Wei, W., McCusker, J.H., Hyman, R.W., Jones, T., Ning, Y., Cao, Z., Gu, Z., Bruno, D., Miranda, M., Nguyen, M., Wilhelmy, J., Komp, C., Tamse, R., Wang, X., Jia, P., Luedi, P., Oefner, P.J., David, L., Dietrich, F.S., Li, Y., Davis, R.W. & Steinmetz, L.M. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12825-30. Epub 2007 Jul 25. Europe PMC

Mosaic Genome Architecture of the Anopheles gambiae Species Complex. Wang-Sattler, R., Blandin, S., Ning, Y., Blass, C., Dolo, G., Toure, Y.T., Torre, A.D., Lanzaro, G.C., Steinmetz, L.M., Kafatos, F.C. & Zheng, L. PLoS ONE. 2007 Nov 28;2(11):e1249. Europe PMC

Assessing systems properties of yeast mitochondria through an interaction map of the organelle. Perocchi, F., Jensen, L.J., Gagneur, J., Ahting, U., von Mering, C., Bork, P., Prokisch, H. & Steinmetz, L.M. PLoS Genet. 2006 Oct 20;2(10):e170. Europe PMC

Transcript mapping with high-density oligonucleotide tiling arrays. Huber, W., Toedling, J. & Steinmetz, L.M. Bioinformatics. 2006 Aug 15;22(16):1963-70. Epub 2006 Jun 20. Europe PMC

Capturing cellular machines by systematic screens of protein complexes. Gagneur, J., David, L. & Steinmetz, L.M. Trends Microbiol. 2006 Aug;14(8):336-9. Epub 2006 Jun 16. Europe PMC

Complex genetic interactions in a quantitative trait locus. Sinha, H., Nicholson, B.P., Steinmetz, L.M. & McCusker, J.H. PLoS Genet. 2006 Feb 3;2(2):e13. Europe PMC

A high-resolution map of transcription in the yeast genome. David, L., Huber, W., Granovskaia, M., Toedling, J., Palm, C.J., Bofkin, L., Jones, T., Davis, R.W. & Steinmetz, L.M. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5320-5. Epub 2006 Mar 28. Europe PMC

Re-analysis of data and its integration. Jensen, L.J. & Steinmetz, L.M. FEBS Lett 2005 Mar 21;579(8):1802-7. Europe PMC

Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae. Gu, Z., David, L., Petrov, D., Jones, T., Davis, R.W. & Steinmetz, L.M. Proc Natl Acad Sci U S A 2005 Jan 25;102(4):1092-7. Epub 2005 Jan 12. Europe PMC

Integrative analysis of the mitochondrial proteome in yeast. Prokisch, H., Scharfe, C., Camp DG, 2nd, Xiao, W., David, L., Andreoli, C., Monroe, M.E., Moore, R.J., Gritsenko, M.A., Kozany, C., Hixson, K.K., Mottaz, H.M., Zischka, H., Ueffing, M., Herman, Z.S., Davis, R.W., Meitinger, T., Oefner, P.J., Smith, R.D. & Steinmetz, L.M. PLoS Biol 2004 Jun;2(6):e160. Epub 2004 Jun 15. Europe PMC

Maximizing the potential of functional genomics. Steinmetz, L.M. & Davis, R.W. Nat Rev Genet. 2004 Mar;5(3):190-201. Europe PMC

Role of duplicate genes in genetic robustness against null mutations. Gu, Z., Steinmetz, L.M., Gu, X., Scharfe, C., Davis, R.W. & Li, W.H. Nature 2003 Jan 2;421(6918):63-6. Europe PMC

Gene function on a genomic scale. Steinmetz, L.M. & Deutschbauer, A.M. J Chromatogr B Analyt Technol Biomed Life Sci 2002 Dec 25;782(1-2):151-63. Europe PMC

Systematic screen for human disease genes in yeast. Steinmetz, L.M., Scharfe, C., Deutschbauer, A.M., Mokranjac, D., Herman, Z.S., Jones, T., Chu, A.M., Giaever, G., Prokisch, H., Oefner, P.J. & Davis, R.W. Nat Genet 2002 Aug;31(4):400-4. Europe PMC

Evolutionary rate in the protein interaction network. Fraser, H.B., Hirsh, A.E., Steinmetz, L.M., Scharfe, C. & Feldman, M.W. Science 2002 Apr 26;296(5568):750-2. Europe PMC

Dissecting the architecture of a quantitative trait locus in yeast. Steinmetz, L.M., Sinha, H., Richards, D.R., Spiegelman, J.I., Oefner, P.J., McCusker, J.H. & Davis, R.W. Nature 2002 Mar 21;416(6878):326-30. Europe PMC

Transcriptional regulation and function during the human cell cycle. Cho, R.J., Huang, M., Campbell, M.J., Dong, H., Steinmetz, L., Sapinoso, L., Hampton, G., Elledge, S.J., Davis, R.W. & Lockhart, D.J. Nat Genet. 2001 Jan;27(1):48-54. Europe PMC

Combining genome sequences and new technologies for dissecting the genetics of complex phenotypes. Steinmetz, L.M., Mindrinos, M. & Oefner, P.J. Trends Plant Sci 2000 Sep;5(9):397-401. Europe PMC

High-density arrays and insights into genome function. Steinmetz, L.M. & Davis, R.W. Biotechnol Genet Eng Rev 2000;17:109-46. Europe PMC

A genome-wide transcriptional analysis of the mitotic cell cycle. Cho, R.J., Campbell, M.J., Winzeler, E.A., Steinmetz, L., Conway, A., Wodicka, L., Wolfsberg, T.G., Gabrielian, A.E., Landsman, D., Lockhart, D.J. & Davis, R.W. Mol Cell. 1998 Jul;2(1):65-73. Europe PMC