EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

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  • PhD 1997-2001, Stanford University.
    Postdoctoral research at Stanford Genome Technology Center.
    Visiting group leader since 2003. Co-Director since 2013.
    Group leader at EMBL since 2003. Senior Scientist since 2009. Joint Head of Genome Biology Unit 2009-2013. Associate Head of Unit since 2013.
    Professor of Genetics, Stanford University since 2013.
    ERC Advanced Investigator since 2012.


Total: 112 publication(s)


Chen Y, Pai AA, Herudek J, Lubas M, Meola N, Järvelin AI, Andersson R, Pelechano V, Steinmetz LM, Jensen TH, Sandelin A. (2016)

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters.

Nat. Genet. 48(9):984-994. doi: 10.1038/ng.3616
Europe PMC | doi

Huber F, Bunina D, Gupta I, Khmelinskii A, Meurer M, Theer P, Steinmetz LM, Knop M. (2016)

Protein Abundance Control by Non-coding Antisense Transcription.

Cell Rep 15(12):2625-2636. doi: 10.1016/j.celrep.2016.05.043
Europe PMC | doi

Gupta S, Radhakrishnan A, Nitin R, Raharja-Liu P, Lin G, Steinmetz LM, Gagneur J, Sinha H. (2016)

Meiotic Interactors of a Mitotic Gene TAO3 Revealed by Functional Analysis of its Rare Variant.

G3 (Bethesda) doi: 10.1534/g3.116.029900
Europe PMC | doi

Gupta I, Villanyi Z, Kassem S, Hughes C, Panasenko OO, Steinmetz LM, Collart MA. (2016)

Translational Capacity of a Cell Is Determined during Transcription Elongation via the Ccr4-Not Complex.

Cell Rep 15(8):1782-1794. doi: 10.1016/j.celrep.2016.04.055
Europe PMC | doi

Adjalley SH, Chabbert CD, Klaus B, Pelechano V, Steinmetz LM. (2016)

Landscape and Dynamics of Transcription Initiation in the Malaria Parasite Plasmodium falciparum.

Cell Rep 14(10):2463-2475. doi: 10.1016/j.celrep.2016.02.025
Europe PMC | doi

Smith JD, Suresh S, Schlecht U, Wu M, Wagih O, Peltz G, Davis RW, Steinmetz LM, Parts L, St Onge RP. (2016)

Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design.

Genome Biol. 17(1) doi: 10.1186/s13059-016-0900-9
Europe PMC | doi

Pelechano V, Wei W, Steinmetz LM. (2016)

Genome-wide quantification of 5'-phosphorylated mRNA degradation intermediates for analysis of ribosome dynamics.

Nat Protoc 11(2):359-376. doi: 10.1038/nprot.2016.026
Europe PMC | doi

Brooks AN, Mueller WF, Steinmetz LM. (2016)

SYGNALing a Red Light for Glioblastoma.

Cell Sys doi: 10.1016/j.cels.2016.08.002

Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW. (2016)

Comprehensive Identification of RNA-Binding Proteins by RNA Interactome Capture.

Methods Mol. Biol. 1358:131-139. doi: 10.1007/978-1-4939-3067-8_8
Europe PMC | doi

Wilkening S, Pelechano V, Steinmetz LM. (2016)

Genome-Wide Identification of Alternative Polyadenylation Events Using 3'T-Fill.

Methods Mol. Biol. 1358:295-302. doi: 10.1007/978-1-4939-3067-8_18
Europe PMC | doi


Holmes RK, Tuck AC, Zhu C, Dunn-Davies HR, Kudla G, Clauder-Munster S, Granneman S, Steinmetz LM, Guthrie C, Tollervey D. (2015)

Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough.

PLoS Genet. 11(12) doi: 10.1371/journal.pgen.1005735
Europe PMC | doi

Rege M, Subramanian V, Zhu C, Hsieh TH, Weiner A, Friedman N, Clauder-Münster S, Steinmetz LM, Rando OJ, Boyer LA, Peterson CL. (2015)

Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis.

Cell Rep 13(8):1610-1622. doi: 10.1016/j.celrep.2015.10.030
Europe PMC | doi

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA. (2015)

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.

Cell Stem Cell 17(4):422-434. doi: 10.1016/j.stem.2015.07.007
Europe PMC | doi

Grubert F, Zaugg JB, Kasowski M, Ursu O, Spacek DV, Martin AR, Greenside P, Srivas R, Phanstiel DH, Pekowska A, Heidari N, Euskirchen G, Huber W, Pritchard JK, Bustamante CD, Steinmetz LM, Kundaje A, Snyder M. (2015)

Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions.

Cell 162(5):1051-1065. doi: 10.1016/j.cell.2015.07.048
Europe PMC | doi

Brennecke P, Reyes A, Pinto S, Rattay K, Nguyen M, Küchler R, Huber W, Kyewski B, Steinmetz LM. (2015)

Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells.

Nat. Immunol. 16(9):933-941. doi: 10.1038/ni.3246
Europe PMC | doi

Schmid M, Olszewski P, Pelechano V, Gupta I, Steinmetz LM, Jensen TH. (2015)

The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production.

Cell Rep 12(1):128-139. doi: 10.1016/j.celrep.2015.06.008
Europe PMC | doi

Pelechano V, Wei W, Steinmetz LM. (2015)

Widespread Co-translational RNA Decay Reveals Ribosome Dynamics.

Cell 161(6):1400-1412. doi: 10.1016/j.cell.2015.05.008
Europe PMC | doi

Velten L, Anders S, Pekowska A, Järvelin AI, Huber W, Pelechano V, Steinmetz LM. (2015)

Single-cell polyadenylation site mapping reveals 3' isoform choice variability.

Mol. Syst. Biol. 11(6) doi: 10.15252/msb.20156198
Europe PMC | doi

Gupta S, Radhakrishnan A, Raharja-Liu P, Lin G, Steinmetz LM, Gagneur J, Sinha H. (2015)

Temporal expression profiling identifies pathways mediating effect of causal variant on phenotype.

PLoS Genet. 11(6) doi: 10.1371/journal.pgen.1005195
Europe PMC | doi

Lasserre JP, Dautant A, Aiyar RS, Kucharczyk R, Glatigny A, Tribouillard-Tanvier D, Rytka J, Blondel M, Skoczen N, Reynier P, Pitayu L, Rotig A, Delahodde A, Steinmetz LM, Dujardin G, Procaccio V, di Rago JP. (2015)

Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies

Dis. Model. Mech. 8(6):509-526. doi: 10.1242/dmm.020438
Europe PMC | doi

Bader DM, Wilkening S, Lin G, Tekkedil MM, Dietrich K, Steinmetz LM, Gagneur J. (2015)

Negative feedback buffers effects of regulatory variants.

Mol. Syst. Biol. 11 doi: 10.15252/msb.20145844
Europe PMC | doi

Chabbert CD, Adjalley SH, Klaus B, Fritsch ES, Gupta I, Pelechano V, Steinmetz LM. (2015)

A high-throughput ChIP-Seq for large-scale chromatin studies.

Mol. Syst. Biol. 11(1):1-14. doi: 10.15252/msb.20145776
Europe PMC | doi

Lardenois A, Stuparevic I, Liu Y, Law MJ, Becker E, Smagulova F, Waern K, Guilleux MH, Horecka J, Chu A, Kervarrec C, Strich R, Snyder M, Davis RW, Steinmetz LM, Primig M. (2015)

The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development.

Nucleic Acids Res. doi: 10.1093/nar/gku1185
Europe PMC | doi


Jordán-Pla A, Gupta I, de Miguel-Jiménez L, Steinmetz LM, Chávez S, Pelechano V, Pérez-Ortín JE. (2014)

Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle.

Nucleic Acids Res. doi: 10.1093/nar/gku1349
Europe PMC | doi

Aiyar RS, Bohnert M, Duvezin-Caubet S, Voisset C, Gagneur J, Fritsch ES, Couplan E, von der Malsburg K, Funaya C, Soubigou F, Courtin F, Suresh S, Kucharczyk R, Evrard J, Antony C, St Onge RP, Blondel M, di Rago JP, van der Laan M, Steinmetz LM. (2014)

Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.

Nat Commun 5:5585. doi: 10.1038/ncomms6585
Europe PMC | doi

Frechin M, Enkler L, Tetaud E, Laporte D, Senger B, Blancard C, Hammann P, Bader G, Clauder-Münster S, Steinmetz LM, Martin RP, di Rago JP, Becker HD. (2014)

Expression of Nuclear and Mitochondrial Genes Encoding ATP Synthase Is Synchronized by Disassembly of a Multisynthetase Complex.

Mol. Cell 56(6):763-776. doi: 10.1016/j.molcel.2014.10.015
Europe PMC | doi

Colin J, Candelli T, Porrua O, Boulay J, Zhu C, Lacroute F, Steinmetz LM, Libri D. (2014)

Roadblock termination by reb1p restricts cryptic and readthrough transcription.

Mol. Cell 56(5):667-680. doi: 10.1016/j.molcel.2014.10.026
Europe PMC | doi

Krishnaprasad GN, Anand MT, Lin G, Tekkedil MM, Steinmetz LM, Nishant KT. (2014)

Variation in Crossover Frequencies Perturb Crossover Assurance Without Affecting Meiotic Chromosome Segregation in Saccharomyces cerevisiae.

Genetics doi: 10.1534/genetics.114.172320
Europe PMC | doi

Nguyen T, Fischl H, Howe FS, Woloszczuk R, Serra Barros A, Xu Z, Brown D, Murray SC, Haenni S, Halstead JM, O'Connor L, Shipkovenska G, Steinmetz LM, Mellor J. (2014)

Transcription mediated insulation and interference direct gene cluster expression switches.

Elife 3 doi: 10.7554/elife.03635
Europe PMC | doi

Hughes CS, Foehr S, Garfield DA, Furlong EE, Steinmetz LM, Krijgsveld J. (2014)

Ultrasensitive proteome analysis using paramagnetic bead technology.

Mol. Syst. Biol. 10(10) doi: 10.15252/msb.20145625
Europe PMC | doi

Moore LS, Wei W, Stolovicki E, Benbenishty T, Wilkening S, Steinmetz LM, Braun E, David L. (2014)

Induced Mutations in Yeast Cell Populations Adapting to an Unforeseen Challenge.

PLoS ONE 9(10) doi: 10.1371/journal.pone.0111133
Europe PMC | doi

Villanyi Z, Ribaud V, Kassem S, Panasenko OO, Pahi Z, Gupta I, Steinmetz L, Boros I, Collart MA. (2014)

The Not5 Subunit of the Ccr4-Not Complex Connects Transcription and Translation.

PLoS Genet. 10(10):e1004569. doi: 10.1371/journal.pgen.1004569
Europe PMC | doi

Fritsch ES, Chabbert CD, Klaus B, Steinmetz LM. (2014)

A Genome-Wide Map of Mitochondrial DNA Recombination in Yeast

Genetics 198(2):755-771. doi: 10.1534/genetics.114.166637
Europe PMC | doi

Pelechano V, Wei W, Jakob P, Steinmetz LM. (2014)

Genome-wide identification of transcript start and end sites by transcript isoform sequencing

Nat Protoc 9(7):1740-1759. doi: 10.1038/nprot.2014.121
Europe PMC | doi

Bhatia A, Yadav A, Gagneur J, Zhu C, Steinmetz LM, Bhanot G, Sinha H. (2014)

Yeast Growth Plasticity Is Regulated by Environment-Specific Multi-QTL Interactions

G3 (Bethesda) 4(5):769-777. doi: 10.1534/g3.113.009142
Europe PMC | doi

Parts L, Liu YC, Tekkedil M, Steinmetz LM, Caudy AA, Fraser AG, Boone C, Andrews BJ, Rosebrock AP. (2014)

Heritability and genetic basis of protein level variation in an outbred population.

Genome Res. 24(8):1363-1370. doi: 10.1101/gr.170506.113
Europe PMC | doi

Castelnuovo M, Zaugg JB, Guffanti E, Maffioletti A, Camblong J, Xu Z, Clauder-Münster S, Steinmetz LM, Luscombe NM, Stutz F. (2014)

Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast.

Nucleic Acids Res. 42(7):4348-4362. doi: 10.1093/nar/gku100
Europe PMC | doi

Wilkening S, Lin G, Fritsch ES, Tekkedil MM, Anders S, Kuehn R, Nguyen M, Aiyar RS, Proctor M, Sakhanenko NA, Galas DJ, Gagneur J, Deutschbauer A, Steinmetz LM. (2014)

An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae

Genetics 196(3):853-865. doi: 10.1534/genetics.113.160291
Europe PMC | doi

Gupta I, Clauder-Münster S, Klaus B, Järvelin AI, Aiyar RS, Benes V, Wilkening S, Huber W, Pelechano V, Steinmetz LM. (2014)

Alternative polyadenylation diversifies post-transcriptional regulation by selective RNA-protein interactions

Mol. Syst. Biol. 10(2):719. doi: 10.1002/msb.135068
Europe PMC | doi

Nadal-Ribelles M, Solé C, Xu Z, Steinmetz LM, de Nadal E, Posas F. (2014)

Control of Cdc28 CDK1 by a stress-induced lncRNA

Mol. Cell 53(4):549-561. doi: 10.1016/j.molcel.2014.01.006
Europe PMC | doi


Pelechano V, Steinmetz LM. (2013)

Gene regulation by antisense transcription

Nat. Rev. Genet. 14(12):880-893. doi: 10.1038/nrg3594
Europe PMC | doi

Kasowski M, Kyriazopoulou-Panagiotopoulou S, Grubert F, Zaugg JB, Kundaje A, Liu Y, Boyle AP, Zhang QC, Zakharia F, Spacek DV, Li J, Xie D, Olarerin-George A, Steinmetz LM, Hogenesch JB, Kellis M, Batzoglou S, Snyder M. (2013)

Extensive variation in chromatin states across humans

Science 342(6159):750-752. doi: 10.1126/science.1242510
Europe PMC | doi

Reyes A, Anders S, Weatheritt RJ, Gibson TJ, Steinmetz LM, Huber W. (2013)

Drift and conservation of differential exon usage across tissues in primate species

Proc. Natl. Acad. Sci. U.S.A. 110(38):15377-15382. doi: 10.1073/pnas.1307202110
Europe PMC | doi

Landry JJ, Pyl PT, Rausch T, Zichner T, Tekkedil MM, Stütz AM, Jauch A, Aiyar RS, Pau G, Delhomme N, Gagneur J, Korbel JO, Huber W, Steinmetz LM. (2013)

The genomic and transcriptomic landscape of a HeLa cell line

G3 (Bethesda) 3(8):1213-1224. doi: 10.1534/g3.113.005777
Europe PMC | doi

Ntini E, Järvelin AI, Bornholdt J, Chen Y, Boyd M, Jørgensen M, Andersson R, Hoof I, Schein A, Andersen PR, Andersen PK, Preker P, Valen E, Zhao X, Pelechano V, Steinmetz LM, Sandelin A, Jensen TH. (2013)

Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality

Nat. Struct. Mol. Biol. 20(8):923-928. doi: 10.1038/nsmb.2640
Europe PMC | doi

David L, Ben-Harosh Y, Stolovicki E, Moore LS, Nguyen M, Tamse R, Dean J, Mancera E, Steinmetz LM, Braun E. (2013)

Multiple genomic changes associated with reorganization of gene regulation and adaptation in yeast

Mol. Biol. Evol. 30(7):1514-1526. doi: 10.1093/molbev/mst071
Europe PMC | doi

Wilkening S, Pelechano V, Jarvelin AI, Tekkedil MM, Anders S, Benes V, Steinmetz LM. (2013)

An efficient method for genome-wide polyadenylation site mapping and RNA quantification (vol 41, pg e65, 2013)

Nucleic Acids Res 41(12):6370. doi: 10.1093/nar/gkt364

Pelechano V, Wei W, Steinmetz LM. (2013)

Extensive transcriptional heterogeneity revealed by isoform profiling

Nature 497(7447):127-131. doi: 10.1038/nature12121
Europe PMC | doi

Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW. (2013)

System-wide identification of RNA-binding proteins by interactome capture

Nat Protoc 8(3):491-500. doi: 10.1038/nprot.2013.020
Europe PMC | doi

Wilkening S, Pelechano V, Järvelin AI, Tekkedil MM, Anders S, Benes V, Steinmetz LM. (2013)

An efficient method for genome-wide polyadenylation site mapping and RNA quantification

Nucleic Acids Res. 41(12):6370. doi: 10.1093/nar/gks1249
Europe PMC | doi

Fehrmann S, Bottin-Duplus H, Leonidou A, Mollereau E, Barthelaix A, Wei W, Steinmetz LM, Yvert G. (2013)

Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability

Mol. Syst. Biol. 9:695. doi: 10.1038/msb.2013.53
Europe PMC | doi

Gagneur J, Stegle O, Zhu C, Jakob P, Tekkedil MM, Aiyar RS, Schuon AK, Pe'er D, Steinmetz LM. (2013)

Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype

PLoS Genet. 9(9):e1003803. doi: 10.1371/journal.pgen.1003803
Europe PMC | doi

Lamacchia M, Clayton JR, Wang-Sattler R, Steinmetz LM, Levashina EA, Blandin SA. (2013)

Silencing of genes and alleles by RNAi in Anopheles gambiae

Methods Mol. Biol. 923:161-176. doi: 10.1007/978-1-62703-026-7_11
Europe PMC | doi

Lenstra TL, Tudek A, Clauder S, Xu Z, Pachis ST, van Leenen D, Kemmeren P, Steinmetz LM, Libri D, Holstege FC. (2013)

The role of Ctk1 kinase in termination of small non-coding RNAs

PLoS ONE 8(12):e80495. doi: 10.1371/journal.pone.0080495
Europe PMC | doi

Reyes A, Blume Carolin, Pelechano V, Jakob P, Steinmetz LM, Zenz T, Huber W. (2013)

Mutated SF3B1 is associated with transcript isoform changes of the genes UQCC and RPL31 both in CLLs and uveal melanomas

doi: http://dx.doi.org/10.1101/000992

Wilkening S, Tekkedil MM, Lin G, Fritsch ES, Wei W, Gagneur J, Lazinski DW, Camilli A, Steinmetz LM. (2013)

Genotyping 1000 yeast strains by next-generation sequencing

BMC Genomics 14:90. doi: 10.1186/1471-2164-14-90
Europe PMC | doi


Gudipati RK, Xu Z, Lebreton A, Séraphin B, Steinmetz LM, Jacquier A, Libri D. (2012)

Extensive degradation of RNA precursors by the exosome in wild-type cells

Mol. Cell 48(3):409-421. doi: 10.1016/j.molcel.2012.08.018
Europe PMC | doi

Hobson DJ, Wei W, Steinmetz LM, Svejstrup JQ. (2012)

RNA polymerase II collision interrupts convergent transcription

Mol. Cell 48(3):365-374. doi: 10.1016/j.molcel.2012.08.027
Europe PMC | doi

Tan-Wong SM, Zaugg JB, Camblong J, Xu Z, Zhang DW, Mischo HE, Ansari AZ, Luscombe NM, Steinmetz LM, Proudfoot NJ. (2012)

Gene loops enhance transcriptional directionality

Science 338(6107):671-675. doi: 10.1126/science.1224350
Europe PMC | doi

Delhomme N, Padioleau I, Furlong EE, Steinmetz LM. (2012)

easyRNASeq: a bioconductor package for processing RNA-Seq data

Bioinformatics 28(19):2532-2533. doi: 10.1093/bioinformatics/bts477
Europe PMC | doi

Abraham AL, Nagarajan M, Veyrieras JB, Bottin H, Steinmetz LM, Yvert G. (2012)

Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms

PLoS Genet. 8(9):e1002958. doi: 10.1371/journal.pgen.1002958
Europe PMC | doi

Kim T, Xu Z, Clauder-Münster S, Steinmetz LM, Buratowski S. (2012)

Set3 HDAC mediates effects of overlapping noncoding transcription on gene induction kinetics

Cell 150(6):1158-1169. doi: 10.1016/j.cell.2012.08.016
Europe PMC | doi

Schmid M, Poulsen MB, Olszewski P, Pelechano V, Saguez C, Gupta I, Steinmetz LM, Moore C, Jensen TH. (2012)

Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins

Mol. Cell 47(2):267-280. doi: 10.1016/j.molcel.2012.05.005
Europe PMC | doi

Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW. (2012)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

Cell 149(6):1393-1406. doi: 10.1016/j.cell.2012.04.031
Europe PMC | doi

Bietenhader M, Martos A, Tetaud E, Aiyar RS, Sellem CH, Kucharczyk R, Clauder-Münster S, Giraud MF, Godard F, Salin B, Sagot I, Gagneur J, Déquard-Chablat M, Contamine V, Hermann-Le Denmat S, Sainsard-Chanet A, Steinmetz LM, di Rago JP. (2012)

Experimental relocation of the mitochondrial ATP9 gene to the nucleus reveals forces underlying mitochondrial genome evolution

PLoS Genet. 8(8):e1002876. doi: 10.1371/journal.pgen.1002876
Europe PMC | doi

Heise F, Chung HR, Weber JM, Xu Z, Klein-Hitpass L, Steinmetz LM, Vingron M, Ehrenhofer-Murray AE. (2012)

Genome-wide H4 K16 acetylation by SAS-I is deposited independently of transcription and histone exchange

Nucleic Acids Res. 40(1):65-74. doi: 10.1093/nar/gkr649
Europe PMC | doi

Pelechano V, Wilkening S, Järvelin AI, Tekkedil MM, Steinmetz LM. (2012)

Genome-wide polyadenylation site mapping

Meth. Enzymol. 513:271-296. doi: 10.1016/b978-0-12-391938-0.00012-4
Europe PMC | doi


Marvin MC, Clauder-Münster S, Walker SC, Sarkeshik A, Yates JR 3rd, Steinmetz LM, Engelke DR. (2011)

Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae

RNA 17(8):1441-1450. doi: 10.1261/rna.2737511
Europe PMC | doi

Couplan E, Aiyar RS, Kucharczyk R, Kabala A, Ezkurdia N, Gagneur J, St Onge RP, Salin B, Soubigou F, Le Cann M, Steinmetz LM, di Rago JP, Blondel M. (2011)

A yeast-based assay identifies drugs active against human mitochondrial disorders

Proc. Natl. Acad. Sci. U.S.A. 108(29):11989-11994. doi: 10.1073/pnas.1101478108
Europe PMC | doi

Wei W, Pelechano V, Järvelin AI, Steinmetz LM. (2011)

Functional consequences of bidirectional promoters

Trends Genet. 27(7):267-276. doi: 10.1016/j.tig.2011.04.002
Europe PMC | doi

Xu Z, Wei W, Gagneur J, Clauder-Münster S, Smolik M, Huber W, Steinmetz LM. (2011)

Antisense expression increases gene expression variability and locus interdependency

Mol. Syst. Biol. 7:468. doi: 10.1038/msb.2011.1
Europe PMC | doi

David L, Clauder-Münster S, Steinmetz LM. (2011)

Genome-wide transcriptome analysis in yeast using high-density tiling arrays

Methods Mol. Biol. 759:107-123. doi: 10.1007/978-1-61779-173-4_7
Europe PMC | doi

Lardenois A, Liu Y, Walther T, Chalmel F, Evrard B, Granovskaia M, Chu A, Davis RW, Steinmetz LM, Primig M. (2011)

Execution of the meiotic noncoding RNA expression program and the onset of gametogenesis in yeast require the conserved exosome subunit Rrp6

Proc. Natl. Acad. Sci. U.S.A. 108(3):1058-1063. doi: 10.1073/pnas.1016459108
Europe PMC | doi

Mancera E, Bourgon R, Huber W, Steinmetz LM. (2011)

Genome-wide survey of post-meiotic segregation during yeast recombination

Genome Biol. 12(4):R36. doi: 10.1186/gb-2011-12-4-r36
Europe PMC | doi

Mischo HE, Gómez-González B, Grzechnik P, Rondón AG, Wei W, Steinmetz L, Aguilera A, Proudfoot NJ. (2011)

Yeast Sen1 helicase protects the genome from transcription-associated instability

Mol. Cell 41(1):21-32. doi: 10.1016/j.molcel.2010.12.007
Europe PMC | doi


Nishant KT, Wei W, Mancera E, Argueso JL, Schlattl A, Delhomme N, Ma X, Bustamante CD, Korbel JO, Gu Z, Steinmetz LM, Alani E. (2010)

The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis

PLoS Genet. 6(9):e1001109. doi: 10.1371/journal.pgen.1001109
Europe PMC | doi

Nagarajan M, Veyrieras JB, de Dieuleveult M, Bottin H, Fehrmann S, Abraham AL, Croze S, Steinmetz LM, Gidrol X, Yvert G. (2010)

Natural single-nucleosome epi-polymorphisms in yeast

PLoS Genet. 6(4):e1000913. doi: 10.1371/journal.pgen.1000913
Europe PMC | doi

Zheng W, Zhao H, Mancera E, Steinmetz LM, Snyder M. (2010)

Genetic analysis of variation in transcription factor binding in yeast

Nature 464(7292):1187-1191. doi: 10.1038/nature08934
Europe PMC | doi

Granovskaia MV, Jensen LJ, Ritchie ME, Toedling J, Ning Y, Bork P, Huber W, Steinmetz LM. (2010)

High-resolution transcription atlas of the mitotic cell cycle in budding yeast

Genome Biol. 11(3):R24. doi: 10.1186/gb-2010-11-3-r24
Europe PMC | doi

Guan W, Jiang H, Guo X, Mancera E, Xu L, Li Y, Steinmetz L, Li Y, Gu Z. (2010)

Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen

PLoS ONE 5(6):e11309. doi: 10.1371/journal.pone.0011309
Europe PMC | doi


Blandin SA, Wang-Sattler R, Lamacchia M, Gagneur J, Lycett G, Ning Y, Levashina EA, Steinmetz LM. (2009)

Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae

Science 326(5949):147-150. doi: 10.1126/science.1175241
Europe PMC | doi

Camblong J, Beyrouthy N, Guffanti E, Schlaepfer G, Steinmetz LM, Stutz F. (2009)

Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiae

Genes Dev. 23(13):1534-1545. doi: 10.1101/gad.522509
Europe PMC | doi

Bourgon R, Mancera E, Brozzi A, Steinmetz LM, Huber W. (2009)

Array-based genotyping in S.cerevisiae using semi-supervised clustering

Bioinformatics 25(8):1056-1062. doi: 10.1093/bioinformatics/btp104
Europe PMC | doi

Neil H, Malabat C, d'Aubenton-Carafa Y, Xu Z, Steinmetz LM, Jacquier A. (2009)

Widespread bidirectional promoters are the major source of cryptic transcripts in yeast

Nature 457(7232):1038-1042. doi: 10.1038/nature07747
Europe PMC | doi

Xu Z, Wei W, Gagneur J, Perocchi F, Clauder-Münster S, Camblong J, Guffanti E, Stutz F, Huber W, Steinmetz LM. (2009)

Bidirectional promoters generate pervasive transcription in yeast

Nature 457(7232):1033-1037. doi: 10.1038/nature07728
Europe PMC | doi

Gagneur J, Sinha H, Perocchi F, Bourgon R, Huber W, Steinmetz LM. (2009)

Genome-wide allele- and strand-specific expression profiling

Mol. Syst. Biol. 5:274. doi: 10.1038/msb.2009.31
Europe PMC | doi


Aiyar RS, Gagneur J, Steinmetz LM. (2008)

Identification of mitochondrial disease genes through integrative analysis of multiple datasets

Methods 46(4):248-255. doi: 10.1016/j.ymeth.2008.10.002
Europe PMC | doi

Sinha H, David L, Pascon RC, Clauder-Münster S, Krishnakumar S, Nguyen M, Shi G, Dean J, Davis RW, Oefner PJ, McCusker JH, Steinmetz LM. (2008)

Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast

Genetics 180(3):1661-1670. doi: 10.1534/genetics.108.092932
Europe PMC | doi

Mancera E, Bourgon R, Brozzi A, Huber W, Steinmetz LM. (2008)

High-resolution mapping of meiotic crossovers and non-crossovers in yeast

Nature 454(7203):479-485. doi: 10.1038/nature07135
Europe PMC | doi

Perocchi F, Mancera E, Steinmetz LM. (2008)

Systematic screens for human disease genes, from yeast to human and back

Mol Biosyst 4(1):18-29. doi: 10.1039/b709494a
Europe PMC | doi


Wei W, McCusker JH, Hyman RW, Jones T, Ning Y, Cao Z, Gu Z, Bruno D, Miranda M, Nguyen M, Wilhelmy J, Komp C, Tamse R, Wang X, Jia P, Luedi P, Oefner PJ, David L, Dietrich FS, Li Y, Davis RW, Steinmetz LM. (2007)

Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789

Proc. Natl. Acad. Sci. U.S.A. 104(31):12825-12830. doi: 10.1073/pnas.0701291104
Europe PMC | doi

Perocchi F, Xu Z, Clauder-Münster S, Steinmetz LM. (2007)

Antisense artifacts in transcriptome microarray experiments are resolved by actinomycin D

Nucleic Acids Res. 35(19):e128. doi: 10.1093/nar/gkm683
Europe PMC | doi

Wang-Sattler R, Blandin S, Ning Y, Blass C, Dolo G, Touré YT, delle Torre A, Lanzaro GC, Steinmetz LM, Kafatos FC, Zheng L. (2007)

Mosaic genome architecture of the Anopheles gambiae species complex

PLoS ONE 2(11):e1249. doi: 10.1371/journal.pone.0001249
Europe PMC | doi


Perocchi F, Jensen LJ, Gagneur J, Ahting U, von Mering C, Bork P, Prokisch H, Steinmetz LM. (2006)

Assessing systems properties of yeast mitochondria through an interaction map of the organelle

PLoS Genet. 2(10):e170. doi: 10.1371/journal.pgen.0020170
Europe PMC | doi

Gagneur J, David L, Steinmetz LM. (2006)

Capturing cellular machines by systematic screens of protein complexes

Trends Microbiol. 14(8):336-339. doi: 10.1016/j.tim.2006.06.002
Europe PMC | doi

Huber W, Toedling J, Steinmetz LM. (2006)

Transcript mapping with high-density oligonucleotide tiling arrays

Bioinformatics 22(16):1963-1970. doi: 10.1093/bioinformatics/btl289
Europe PMC | doi

David L, Huber W, Granovskaia M, Toedling J, Palm CJ, Bofkin L, Jones T, Davis RW, Steinmetz LM. (2006)

A high-resolution map of transcription in the yeast genome

Proc. Natl. Acad. Sci. U.S.A. 103(14):5320-5325. doi: 10.1073/pnas.0601091103
Europe PMC | doi

Sinha H, Nicholson BP, Steinmetz LM, McCusker JH. (2006)

Complex genetic interactions in a quantitative trait locus

PLoS Genet. 2(2):e13. doi: 10.1371/journal.pgen.0020013
Europe PMC | doi


Jensen LJ, Steinmetz LM. (2005)

Re-analysis of data and its integration

FEBS Lett. 579(8):1802-1807. doi: 10.1016/j.febslet.2005.02.006
Europe PMC | doi

Gu Z, David L, Petrov D, Jones T, Davis RW, Steinmetz LM. (2005)

Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae

Proc. Natl. Acad. Sci. U.S.A. 102(4):1092-1097. doi: 10.1073/pnas.0409159102
Europe PMC | doi