EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

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Total: 28 publication(s)


Schmid M, Olszewski P, Pelechano V, Gupta I, Steinmetz LM, Jensen TH. (2015)

The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production.

Cell Rep 12(1):128-139. doi:10.1016/j.celrep.2015.06.008
Europe PMC | doi

Pelechano V, Wei W, Steinmetz LM. (2015)

Widespread Co-translational RNA Decay Reveals Ribosome Dynamics.

Cell 161(6):1400-1412. doi:10.1016/j.cell.2015.05.008
Europe PMC | doi

Velten L, Anders S, Pekowska A, Järvelin AI, Huber W, Pelechano V, Steinmetz LM. (2015)

Single-cell polyadenylation site mapping reveals 3' isoform choice variability.

Mol. Syst. Biol. 11(6) doi:10.15252/msb.20156198
Europe PMC | doi


Jordán-Pla A, Gupta I, de Miguel-Jiménez L, Steinmetz LM, Chávez S, Pelechano V, Pérez-Ortín JE. (2014)

Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle.

Nucleic Acids Res. doi:10.1093/nar/gku1349
Europe PMC | doi

Chabbert CD, Adjalley SH, Klaus B, Fritsch ES, Gupta I, Pelechano V, Steinmetz LM. (2014)

A high-throughput ChIP-Seq for large-scale chromatin studies.

Mol. Syst. Biol. 11(1):1-14. doi:10.15252/msb.20145776
Europe PMC | doi

Pelechano V, Wei W, Jakob P, Steinmetz LM. (2014)

Genome-wide identification of transcript start and end sites by transcript isoform sequencing

Nat Protoc 9(7):1740-1759. doi:10.1038/nprot.2014.121
Europe PMC | doi

Piazza I, Rutkowska A, Ori A, Walczak M, Metz J, Pelechano V, Beck M, Haering CH. (2014)

Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits

Nat. Struct. Mol. Biol. 21(6):560-568. doi:10.1038/nsmb.2831
Europe PMC | doi

Magraner-Pardo L, Pelechano V, Coloma MD, Tordera V. (2014)

Dynamic remodeling of histone modifications in response to osmotic stress in Saccharomyces cerevisiae.

BMC Genomics 15:247. doi:10.1186/1471-2164-15-247
Europe PMC | doi

Gupta I, Clauder-Münster S, Klaus B, Järvelin AI, Aiyar RS, Benes V, Wilkening S, Huber W, Pelechano V, Steinmetz LM. (2014)

Alternative polyadenylation diversifies post-transcriptional regulation by selective RNA-protein interactions

Mol. Syst. Biol. 10(2):719. doi:10.1002/msb.135068
Europe PMC | doi


Pelechano V, Steinmetz LM. (2013)

Gene regulation by antisense transcription

Nat. Rev. Genet. 14(12):880-893. doi:10.1038/nrg3594
Europe PMC | doi

Ntini E, Järvelin AI, Bornholdt J, Chen Y, Boyd M, Jørgensen M, Andersson R, Hoof I, Schein A, Andersen PR, Andersen PK, Preker P, Valen E, Zhao X, Pelechano V, Steinmetz LM, Sandelin A, Jensen TH. (2013)

Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality

Nat. Struct. Mol. Biol. 20(8):923-928. doi:10.1038/nsmb.2640
Europe PMC | doi

Wilkening S, Pelechano V, Jarvelin AI, Tekkedil MM, Anders S, Benes V, Steinmetz LM. (2013)

An efficient method for genome-wide polyadenylation site mapping and RNA quantification (vol 41, pg e65, 2013)

Nucleic Acids Res 41(12):6370. doi:10.1093/nar/gkt364

Pelechano V, Wei W, Steinmetz LM. (2013)

Extensive transcriptional heterogeneity revealed by isoform profiling

Nature 497(7447):127-131. doi:10.1038/nature12121
Europe PMC | doi

Wilkening S, Pelechano V, Järvelin AI, Tekkedil MM, Anders S, Benes V, Steinmetz LM. (2013)

An efficient method for genome-wide polyadenylation site mapping and RNA quantification

Nucleic Acids Res. 41(12):6370. doi:10.1093/nar/gks1249
Europe PMC | doi

Reyes A, Blume Carolin, Pelechano V, Jakob P, Steinmetz LM, Zenz T, Huber W. (2013)

Mutated SF3B1 is associated with transcript isoform changes of the genes UQCC and RPL31 both in CLLs and uveal melanomas



Schmid M, Poulsen MB, Olszewski P, Pelechano V, Saguez C, Gupta I, Steinmetz LM, Moore C, Jensen TH. (2012)

Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins

Mol. Cell 47(2):267-280. doi:10.1016/j.molcel.2012.05.005
Europe PMC | doi

García-Martínez J, Ayala G, Pelechano V, Chávez S, Herrero E, Pérez-Ortín JE. (2012)

The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast

Transcription 3(1):39-44. doi:10.4161/trns.3.1.19416
Europe PMC | doi

Pelechano V, Wilkening S, Järvelin AI, Tekkedil MM, Steinmetz LM. (2012)

Genome-wide polyadenylation site mapping

Meth. Enzymol. 513:271-296. doi:10.1016/b978-0-12-391938-0.00012-4
Europe PMC | doi


García-López MC, Pelechano V, Mirón-García MC, Garrido-Godino AI, García A, Calvo O, Werner M, Pérez-Ortín JE, Navarro F. (2011)

The conserved foot domain of RNA pol II associates with proteins involved in transcriptional initiation and/or early elongation

Genetics 189(4):1235-1248. doi:10.1534/genetics.111.133215
Europe PMC | doi

Wei W, Pelechano V, Järvelin AI, Steinmetz LM. (2011)

Functional consequences of bidirectional promoters

Trends Genet. 27(7):267-276. doi:10.1016/j.tig.2011.04.002
Europe PMC | doi

García-Martínez J, Pelechano V, Pérez-Ortín JE. (2011)

Genomic-wide methods to evaluate transcription rates in yeast

Methods Mol. Biol. 734:25-44. doi:10.1007/978-1-61779-086-7_2
Europe PMC | doi

Pérez-Ortín JE, Jordán-Pla A, Pelechano V. (2011)

A genomic view of mRNA turnover in yeast

C. R. Biol. 334(8-9):647-654. doi:10.1016/j.crvi.2011.05.013
Europe PMC | doi


Rodríguez-Gil A, García-Martínez J, Pelechano V, Muñoz-Centeno Mde L, Geli V, Pérez-Ortín JE, Chávez S. (2010)

The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors

Nucleic Acids Res. 38(14):4651-4664. doi:10.1093/nar/gkq215
Europe PMC | doi

Pelechano V, Pérez-Ortín JE. (2010)

There is a steady-state transcriptome in exponentially growing yeast cells

Yeast 27(7):413-422. doi:10.1002/yea.1768
Europe PMC | doi

Pelechano V, Chávez S, Pérez-Ortín JE. (2010)

A complete set of nascent transcription rates for yeast genes

PLoS ONE 5(11):e15442. doi:10.1371/journal.pone.0015442
Europe PMC | doi


Pelechano V, Jimeno-González S, Rodríguez-Gil A, García-Martínez J, Pérez-Ortín JE, Chávez S. (2009)

Regulon-specific control of transcription elongation across the yeast genome

PLoS Genet. 5(8):e1000614. doi:10.1371/journal.pgen.1000614
Europe PMC | doi


Pelechano V, Pérez-Ortín JE. (2008)

The transcriptional inhibitor thiolutin blocks mRNA degradation in yeast

Yeast 25(2):85-92. doi:10.1002/yea.1548
Europe PMC | doi


Pelechano V, García-Martínez J, Pérez-Ortín JE. (2006)

A genomic study of the inter-ORF distances in Saccharomyces cerevisiae

Yeast 23(9):689-699. doi:10.1002/yea.1390
Europe PMC | doi