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Staff at EMBL

Vicente Jose Pelechano

Staff Scientist
Steinmetz Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Publications

Alternative polyadenylation diversifies post-transcriptional regulation by selective RNA-protein interactions. Gupta, I., Clauder-Munster, S., Klaus, B., Jarvelin, A.I., Aiyar, R.S., Benes, V., Wilkening, S., Huber, W., Pelechano, V. & Steinmetz, L.M. Mol Syst Biol. 2014 Feb 25;10(2):719. doi: 10.1002/msb.135068. Print 2014. Europe PMC

Gene regulation by antisense transcription. Pelechano, V. & Steinmetz, L.M. Nat Rev Genet. 2013 Dec;14(12):880-93. doi: 10.1038/nrg3594. Epub 2013 Nov 12. Europe PMC

Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality. Ntini, E., Jarvelin, A.I., Bornholdt, J., Chen, Y., Boyd, M., Jorgensen, M., Andersson, R., Hoof, I., Schein, A., Andersen, P.R., Andersen, P.K., Preker, P., Valen, E., Zhao, X., Pelechano, V., Steinmetz, L.M., Sandelin, A. & Jensen, T.H. Nat Struct Mol Biol. 2013 Aug;20(8):923-8. doi: 10.1038/nsmb.2640. Epub 2013 Jul14. Europe PMC

Extensive transcriptional heterogeneity revealed by isoform profiling. Pelechano, V., Wei, W. & Steinmetz, L.M. Nature. 2013 May 2;497(7447):127-31. doi: 10.1038/nature12121. Epub 2013 Apr 24. Europe PMC

An efficient method for genome-wide polyadenylation site mapping and RNA quantification. Wilkening, S., Pelechano, V., Jarvelin, A.I., Tekkedil, M.M., Anders, S., Benes, V. & Steinmetz, L.M. Nucleic Acids Res. 2013 Mar 1;41(5):e65. doi: 10.1093/nar/gks1249. Epub 2013 Jan7. Europe PMC

Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins. Schmid, M., Poulsen, M.B., Olszewski, P., Pelechano, V., Saguez, C., Gupta, I., Steinmetz, L.M., Moore, C. & Jensen, T.H. Mol Cell. 2012 Jul 27;47(2):267-80. doi: 10.1016/j.molcel.2012.05.005. Epub 2012Jun 7. Europe PMC

Genome-wide polyadenylation site mapping. Pelechano, V., Wilkening, S., Jarvelin, A.I., Tekkedil, M.M. & Steinmetz, L.M. Methods Enzymol. 2012;513:271-96. doi: 10.1016/B978-0-12-391938-0.00012-4. Europe PMC

The Conserved Foot Domain of RNA Pol II Associates with Proteins Involved in Transcriptional Initiation and/or Early Elongation. Garcia-Lopez, M.C., Pelechano, V., Miron-Garcia, M.C., Garrido-Godino, A.I., Garcia, A., Calvo, O., Werner, M., Perez-Ortin, J.E. & Navarro, F. Genetics. 2011 Dec;189(4):1235-48. Epub 2011 Sep 27. Europe PMC

Functional consequences of bidirectional promoters. Wei, W., Pelechano, V., Jarvelin, A.I. & Steinmetz, L.M. Trends Genet. 2011 Jul;27(7):267-76. doi: 10.1016/j.tig.2011.04.002. Epub 2011May 24. Europe PMC

Genomic-wide methods to evaluate transcription rates in yeast. Garcia-Martinez, J., Pelechano, V. & Perez-Ortin, J.E. Methods Mol Biol. 2011;734:25-44. doi: 10.1007/978-1-61779-086-7_2. Europe PMC

The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors. Rodriguez-Gil, A., Garcia-Martinez, J., Pelechano, V., Munoz-Centeno Mde, L., Geli, V., Perez-Ortin, J.E. & Chavez, S. Nucleic Acids Res. 2010 Aug;38(14):4651-64. Epub 2010 Apr 12. Europe PMC

There is a steady-state transcriptome in exponentially growing yeast cells. Pelechano, V. & Perez-Ortin, J.E. Yeast. 2010 Jul;27(7):413-22. Europe PMC

A complete set of nascent transcription rates for yeast genes. Pelechano, V., Chavez, S. & Perez-Ortin, J.E. PLoS One. 2010 Nov 16;5(11) Europe PMC

Regulon-specific control of transcription elongation across the yeast genome. Pelechano, V., Jimeno-Gonzalez, S., Rodriguez-Gil, A., Garcia-Martinez, J., Perez-Ortin, J.E. & Chavez, S. PLoS Genet. 2009 Aug;5(8):e1000614. Epub 2009 Aug 21. Europe PMC

The transcriptional inhibitor thiolutin blocks mRNA degradation in yeast. Pelechano, V. & Perez-Ortin, J.E. Yeast. 2008 Feb;25(2):85-92. Europe PMC

A genomic study of the inter-ORF distances in Saccharomyces cerevisiae. Pelechano, V., Garcia-Martinez, J. & Perez-Ortin, J.E. Yeast. 2006 Jul 15;23(9):689-99. Europe PMC