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Steinmetz GroupPublications

Total: 89 publication(s)


Aiyar RS, Bohnert M, Duvezin-Caubet S, Voisset C, Gagneur J, Fritsch ES, Couplan E, von der Malsburg K, Funaya C, Soubigou F, Courtin F, Suresh S, Kucharczyk R, Evrard J, Antony C, St Onge RP, Blondel M, di Rago JP, van der Laan M, Steinmetz LM. (2014)
Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.
Nat Commun 5:5585. doi:10.1038/ncomm6585
Europe PMC | doi

Colin J, Candelli T, Porrua O, Boulay J, Zhu C, Lacroute F, Steinmetz LM, Libri D. (2014)
Roadblock termination by reb1p restricts cryptic and readthrough transcription.
Mol. Cell 56(5):667-680. doi:10.1016/j.molcel.2014.10.026
Europe PMC | doi

Lardenois A, Stuparevic I, Liu Y, Law MJ, Becker E, Smagulova F, Waern K, Guilleux MH, Horecka J, Chu A, Kervarrec C, Strich R, Snyder M, Davis RW, Steinmetz LM, Primig M. (2014)
The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development.
Nucleic Acids Res. doi:10.1093/nar/gku1185
Europe PMC | doi

Krishnaprasad GN, Anand MT, Lin G, Tekkedil MM, Steinmetz LM, Nishant KT. (2014)
Variation in Crossover Frequencies Perturb Crossover Assurance Without Affecting Meiotic Chromosome Segregation in Saccharomyces cerevisiae.
Genetics doi:10.1534/genetics.114.172320
Europe PMC | doi

Frechin M, Enkler L, Tetaud E, Laporte D, Senger B, Blancard C, Hammann P, Bader G, Clauder-Münster S, Steinmetz LM, Martin RP, di Rago JP, Becker HD. (2014)
Expression of Nuclear and Mitochondrial Genes Encoding ATP Synthase Is Synchronized by Disassembly of a Multisynthetase Complex.
Mol. Cell doi:10.1016/j.molcel.2014.10.015
Europe PMC | doi

Nguyen T, Fischl H, Howe FS, Woloszczuk R, Serra Barros A, Xu Z, Brown D, Murray SC, Haenni S, Halstead JM, O'Connor L, Shipkovenska G, Steinmeetz LM, Mellor J. (2014)
Transcription mediated insulation and interference direct gene cluster expression switches.
Elife 3 doi:10.7554/elife.03635
Europe PMC | doi

Hughes CS, Foehr S, Garfield DA, Furlong EE, Steinmetz LM, Krijgsveld J. (2014)
Ultrasensitive proteome analysis using paramagnetic bead technology.
Mol. Syst. Biol. 10(10) doi:10.15252/msb.20145625
Europe PMC | doi

Moore LS, Wei W, Stolovicki E, Benbenishty T, Wilkening S, Steinmetz LM, Braun E, David L. (2014)
Induced Mutations in Yeast Cell Populations Adapting to an Unforeseen Challenge.
PLoS ONE 9(10) doi:10.1371/journal.pone.0111133
Europe PMC | doi

Villanyi Z, Ribaud V, Kassem S, Panasenko OO, Pahi Z, Gupta I, Steinmetz L, Boros I, Collart MA. (2014)
The Not5 Subunit of the Ccr4-Not Complex Connects Transcription and Translation.
PLoS Genet. 10(10) doi:10.1371/journal.pgen.1004569
Europe PMC | doi

Fritsch ES, Chabbert CD, Klaus B, Steinmetz LM. (2014)
A Genome-Wide Map of Mitochondrial DNA Recombination in Yeast
Genetics 198(2):755-771. doi:10.1534/genetics.114.166637
Europe PMC | doi

Pelechano V, Wei W, Jakob P, Steinmetz LM. (2014)
Genome-wide identification of transcript start and end sites by transcript isoform sequencing
Nat Protoc 9(7):1740-1759. doi:10.1038/nprot.2014.121
Europe PMC | doi

Parts L, Liu YC, Tekkedil M, Steinmetz LM, Caudy AA, Fraser AG, Boone C, Andrews BJ, Rosebrock AP. (2014)
Heritability and genetic basis of protein level variation in an outbred population.
Genome Res. 24(8):1363-1370. doi:10.1101/gr.170506.113
Europe PMC | doi

Bhatia A, Yadav A, Gagneur J, Zhu C, Steinmetz LM, Bhanot G, Sinha H. (2014)
Yeast Growth Plasticity Is Regulated by Environment-Specific Multi-QTL Interactions
G3 (Bethesda) 4(5):769-777. doi:10.1534/g3.113.009142
Europe PMC | doi

Castelnuovo M, Zaugg JB, Guffanti E, Maffioletti A, Camblong J, Xu Z, Clauder-Münster S, Steinmetz LM, Luscombe NM, Stutz F. (2014)
Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast
Nucleic Acids Res. 42(7):4348-4362. doi:10.1093/nar/gku100
Europe PMC | doi

Wilkening S, Lin G, Fritsch ES, Tekkedil MM, Anders S, Kuehn R, Nguyen M, Aiyar RS, Proctor M, Sakhanenko NA, Galas DJ, Gagneur J, Deutschbauer A, Steinmetz LM. (2014)
An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae
Genetics 196(3):853-865. doi:10.1534/genetics.113.160291
Europe PMC | doi

Nadal-Ribelles M, Solé C, Xu Z, Steinmetz LM, de Nadal E, Posas F. (2014)
Control of Cdc28 CDK1 by a stress-induced lncRNA
Mol. Cell 53(4):549-561. doi:10.1016/j.molcel.2014.01.006
Europe PMC | doi

Gupta I, Clauder-Münster S, Klaus B, Järvelin AI, Aiyar RS, Benes V, Wilkening S, Huber W, Pelechano V, Steinmetz LM. (2014)
Alternative polyadenylation diversifies post-transcriptional regulation by selective RNA-protein interactions
Mol. Syst. Biol. 10(2):719. doi:10.1002/msb.135068
Europe PMC | doi


Pelechano V, Steinmetz LM. (2013)
Gene regulation by antisense transcription
Nat. Rev. Genet. 14(12):880-893. doi:10.1038/nrg3594
Europe PMC | doi

Kasowski M, Kyriazopoulou-Panagiotopoulou S, Grubert F, Zaugg JB, Kundaje A, Liu Y, Boyle AP, Zhang QC, Zakharia F, Spacek DV, Li J, Xie D, Olarerin-George A, Steinmetz LM, Hogenesch JB, Kellis M, Batzoglou S, Snyder M. (2013)
Extensive variation in chromatin states across humans
Science 342(6159):750-752. doi:10.1126/science.1242510
Europe PMC | doi

Reyes A, Anders S, Weatheritt RJ, Gibson TJ, Steinmetz LM, Huber W. (2013)
Drift and conservation of differential exon usage across tissues in primate species
Proc. Natl. Acad. Sci. U.S.A. 110(38):15377-15382. doi:10.1073/pnas.1307202110
Europe PMC | doi

Ntini E, Järvelin AI, Bornholdt J, Chen Y, Boyd M, Jørgensen M, Andersson R, Hoof I, Schein A, Andersen PR, Andersen PK, Preker P, Valen E, Zhao X, Pelechano V, Steinmetz LM, Sandelin A, Jensen TH. (2013)
Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality
Nat. Struct. Mol. Biol. 20(8):923-928. doi:10.1038/nsmb.2640
Europe PMC | doi

Landry JJ, Pyl PT, Rausch T, Zichner T, Tekkedil MM, Stütz AM, Jauch A, Aiyar RS, Pau G, Delhomme N, Gagneur J, Korbel JO, Huber W, Steinmetz LM. (2013)
The genomic and transcriptomic landscape of a HeLa cell line
G3 (Bethesda) 3(8):1213-1224. doi:10.1534/g3.113.005777
Europe PMC | doi

Wilkening S, Pelechano V, Jarvelin AI, Tekkedil MM, Anders S, Benes V, Steinmetz LM. (2013)
An efficient method for genome-wide polyadenylation site mapping and RNA quantification (vol 41, pg e65, 2013)
Nucleic Acids Res 41(12):6370. doi:10.1093/nar/gkt364

David L, Ben-Harosh Y, Stolovicki E, Moore LS, Nguyen M, Tamse R, Dean J, Mancera E, Steinmetz LM, Braun E. (2013)
Multiple genomic changes associated with reorganization of gene regulation and adaptation in yeast
Mol. Biol. Evol. 30(7):1514-1526. doi:10.1093/molbev/mst071
Europe PMC | doi

Pelechano V, Wei W, Steinmetz LM. (2013)
Extensive transcriptional heterogeneity revealed by isoform profiling
Nature 497(7447):127-131. doi:10.1038/nature12121
Europe PMC | doi

Wilkening S, Pelechano V, Järvelin AI, Tekkedil MM, Anders S, Benes V, Steinmetz LM. (2013)
An efficient method for genome-wide polyadenylation site mapping and RNA quantification
Nucleic Acids Res. 41(12):6370. doi:10.1093/nar/gks1249
Europe PMC | doi

Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW. (2013)
System-wide identification of RNA-binding proteins by interactome capture
Nat Protoc 8(3):491-500. doi:10.1038/nprot.2013.020
Europe PMC | doi

Gagneur J, Stegle O, Zhu C, Jakob P, Tekkedil MM, Aiyar RS, Schuon AK, Pe'er D, Steinmetz LM. (2013)
Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype
PLoS Genet. 9(9):e1003803. doi:10.1371/journal.pgen.1003803
Europe PMC | doi

Wilkening S, Tekkedil MM, Lin G, Fritsch ES, Wei W, Gagneur J, Lazinski DW, Camilli A, Steinmetz LM. (2013)
Genotyping 1000 yeast strains by next-generation sequencing
BMC Genomics 14:90. doi:10.1186/1471-2164-14-90
Europe PMC | doi

Reyes A, Blume Carolin, Pelechano V, Jakob P, Steinmetz LM, Zenz T, Huber W. (2013)
Mutated SF3B1 is associated with transcript isoform changes of the genes UQCC and RPL31 both in CLLs and uveal melanomas

Fehrmann S, Bottin-Duplus H, Leonidou A, Mollereau E, Barthelaix A, Wei W, Steinmetz LM, Yvert G. (2013)
Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability
Mol. Syst. Biol. 9:695. doi:10.1038/msb.2013.53
Europe PMC | doi

Lamacchia M, Clayton JR, Wang-Sattler R, Steinmetz LM, Levashina EA, Blandin SA. (2013)
Silencing of genes and alleles by RNAi in Anopheles gambiae
Methods Mol. Biol. 923:161-176. doi:10.1007/978-1-62703-026-7_11
Europe PMC | doi

Lenstra TL, Tudek A, Clauder S, Xu Z, Pachis ST, van Leenen D, Kemmeren P, Steinmetz LM, Libri D, Holstege FC. (2013)
The role of Ctk1 kinase in termination of small non-coding RNAs
PLoS ONE 8(12):e80495. doi:10.1371/journal.pone.0080495
Europe PMC | doi


Gudipati RK, Xu Z, Lebreton A, Séraphin B, Steinmetz LM, Jacquier A, Libri D. (2012)
Extensive degradation of RNA precursors by the exosome in wild-type cells
Mol. Cell 48(3):409-421. doi:10.1016/j.molcel.2012.08.018
Europe PMC | doi

Tan-Wong SM, Zaugg JB, Camblong J, Xu Z, Zhang DW, Mischo HE, Ansari AZ, Luscombe NM, Steinmetz LM, Proudfoot NJ. (2012)
Gene loops enhance transcriptional directionality
Science 338(6107):671-675. doi:10.1126/science.1224350
Europe PMC | doi

Hobson DJ, Wei W, Steinmetz LM, Svejstrup JQ. (2012)
RNA polymerase II collision interrupts convergent transcription
Mol. Cell 48(3):365-374. doi:10.1016/j.molcel.2012.08.027
Europe PMC | doi

Delhomme N, Padioleau I, Furlong EE, Steinmetz LM. (2012)
easyRNASeq: a bioconductor package for processing RNA-Seq data
Bioinformatics 28(19):2532-2533. doi:10.1093/bioinformatics/bts477
Europe PMC | doi

Abraham AL, Nagarajan M, Veyrieras JB, Bottin H, Steinmetz LM, Yvert G. (2012)
Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms
PLoS Genet. 8(9):e1002958. doi:10.1371/journal.pgen.1002958
Europe PMC | doi

Kim T, Xu Z, Clauder-Münster S, Steinmetz LM, Buratowski S. (2012)
Set3 HDAC mediates effects of overlapping noncoding transcription on gene induction kinetics
Cell 150(6):1158-1169. doi:10.1016/j.cell.2012.08.016
Europe PMC | doi

Schmid M, Poulsen MB, Olszewski P, Pelechano V, Saguez C, Gupta I, Steinmetz LM, Moore C, Jensen TH. (2012)
Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins
Mol. Cell 47(2):267-280. doi:10.1016/j.molcel.2012.05.005
Europe PMC | doi

Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW. (2012)
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
Cell 149(6):1393-1406. doi:10.1016/j.cell.2012.04.031
Europe PMC | doi

Bietenhader M, Martos A, Tetaud E, Aiyar RS, Sellem CH, Kucharczyk R, Clauder-Münster S, Giraud MF, Godard F, Salin B, Sagot I, Gagneur J, Déquard-Chablat M, Contamine V, Hermann-Le Denmat S, Sainsard-Chanet A, Steinmetz LM, di Rago JP. (2012)
Experimental relocation of the mitochondrial ATP9 gene to the nucleus reveals forces underlying mitochondrial genome evolution
PLoS Genet. 8(8):e1002876. doi:10.1371/journal.pgen.1002876
Europe PMC | doi

Heise F, Chung HR, Weber JM, Xu Z, Klein-Hitpass L, Steinmetz LM, Vingron M, Ehrenhofer-Murray AE. (2012)
Genome-wide H4 K16 acetylation by SAS-I is deposited independently of transcription and histone exchange
Nucleic Acids Res. 40(1):65-74. doi:10.1093/nar/gkr649
Europe PMC | doi

Pelechano V, Wilkening S, Järvelin AI, Tekkedil MM, Steinmetz LM. (2012)
Genome-wide polyadenylation site mapping
Meth. Enzymol. 513:271-296. doi:10.1016/b978-0-12-391938-0.00012-4
Europe PMC | doi


Marvin MC, Clauder-Münster S, Walker SC, Sarkeshik A, Yates JR 3rd, Steinmetz LM, Engelke DR. (2011)
Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae
RNA 17(8):1441-1450. doi:10.1261/rna.2737511
Europe PMC | doi

Couplan E, Aiyar RS, Kucharczyk R, Kabala A, Ezkurdia N, Gagneur J, St Onge RP, Salin B, Soubigou F, Le Cann M, Steinmetz LM, di Rago JP, Blondel M. (2011)
A yeast-based assay identifies drugs active against human mitochondrial disorders
Proc. Natl. Acad. Sci. U.S.A. 108(29):11989-11994. doi:10.1073/pnas.1101478108
Europe PMC | doi

Wei W, Pelechano V, Järvelin AI, Steinmetz LM. (2011)
Functional consequences of bidirectional promoters
Trends Genet. 27(7):267-276. doi:10.1016/j.tig.2011.04.002
Europe PMC | doi

Xu Z, Wei W, Gagneur J, Clauder-Münster S, Smolik M, Huber W, Steinmetz LM. (2011)
Antisense expression increases gene expression variability and locus interdependency
Mol. Syst. Biol. 7:468. doi:10.1038/msb.2011.1
Europe PMC | doi

Lardenois A, Liu Y, Walther T, Chalmel F, Evrard B, Granovskaia M, Chu A, Davis RW, Steinmetz LM, Primig M. (2011)
Execution of the meiotic noncoding RNA expression program and the onset of gametogenesis in yeast require the conserved exosome subunit Rrp6
Proc. Natl. Acad. Sci. U.S.A. 108(3):1058-1063. doi:10.1073/pnas.1016459108
Europe PMC | doi

Mancera E, Bourgon R, Huber W, Steinmetz LM. (2011)
Genome-wide survey of post-meiotic segregation during yeast recombination
Genome Biol. 12(4):R36. doi:10.1186/gb-2011-12-4-r36
Europe PMC | doi

David L, Clauder-Münster S, Steinmetz LM. (2011)
Genome-wide transcriptome analysis in yeast using high-density tiling arrays
Methods Mol. Biol. 759:107-123. doi:10.1007/978-1-61779-173-4_7
Europe PMC | doi

Mischo HE, Gómez-González B, Grzechnik P, Rondón AG, Wei W, Steinmetz L, Aguilera A, Proudfoot NJ. (2011)
Yeast Sen1 helicase protects the genome from transcription-associated instability
Mol. Cell 41(1):21-32. doi:10.1016/j.molcel.2010.12.007
Europe PMC | doi


Nishant KT, Wei W, Mancera E, Argueso JL, Schlattl A, Delhomme N, Ma X, Bustamante CD, Korbel JO, Gu Z, Steinmetz LM, Alani E. (2010)
The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis
PLoS Genet. 6(9):e1001109. doi:10.1371/journal.pgen.1001109
Europe PMC | doi

Zheng W, Zhao H, Mancera E, Steinmetz LM, Snyder M. (2010)
Genetic analysis of variation in transcription factor binding in yeast
Nature 464(7292):1187-1191. doi:10.1038/nature08934
Europe PMC | doi

Nagarajan M, Veyrieras JB, de Dieuleveult M, Bottin H, Fehrmann S, Abraham AL, Croze S, Steinmetz LM, Gidrol X, Yvert G. (2010)
Natural single-nucleosome epi-polymorphisms in yeast
PLoS Genet. 6(4):e1000913. doi:10.1371/journal.pgen.1000913
Europe PMC | doi

Guan W, Jiang H, Guo X, Mancera E, Xu L, Li Y, Steinmetz L, Li Y, Gu Z. (2010)
Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen
PLoS ONE 5(6):e11309. doi:10.1371/journal.pone.0011309
Europe PMC | doi

Granovskaia MV, Jensen LJ, Ritchie ME, Toedling J, Ning Y, Bork P, Huber W, Steinmetz LM. (2010)
High-resolution transcription atlas of the mitotic cell cycle in budding yeast
Genome Biol. 11(3):R24. doi:10.1186/gb-2010-11-3-r24
Europe PMC | doi


Blandin SA, Wang-Sattler R, Lamacchia M, Gagneur J, Lycett G, Ning Y, Levashina EA, Steinmetz LM. (2009)
Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae
Science 326(5949):147-150. doi:10.1126/science.1175241
Europe PMC | doi

Camblong J, Beyrouthy N, Guffanti E, Schlaepfer G, Steinmetz LM, Stutz F. (2009)
Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiae
Genes Dev. 23(13):1534-1545. doi:10.1101/gad.522509
Europe PMC | doi

Bourgon R, Mancera E, Brozzi A, Steinmetz LM, Huber W. (2009)
Array-based genotyping in S.cerevisiae using semi-supervised clustering
Bioinformatics 25(8):1056-1062. doi:10.1093/bioinformatics/btp104
Europe PMC | doi

Xu Z, Wei W, Gagneur J, Perocchi F, Clauder-Münster S, Camblong J, Guffanti E, Stutz F, Huber W, Steinmetz LM. (2009)
Bidirectional promoters generate pervasive transcription in yeast
Nature 457(7232):1033-1037. doi:10.1038/nature07728
Europe PMC | doi

Neil H, Malabat C, d'Aubenton-Carafa Y, Xu Z, Steinmetz LM, Jacquier A. (2009)
Widespread bidirectional promoters are the major source of cryptic transcripts in yeast
Nature 457(7232):1038-1042. doi:10.1038/nature07747
Europe PMC | doi

Gagneur J, Sinha H, Perocchi F, Bourgon R, Huber W, Steinmetz LM. (2009)
Genome-wide allele- and strand-specific expression profiling
Mol. Syst. Biol. 5:274. doi:10.1038/msb.2009.31
Europe PMC | doi


Aiyar RS, Gagneur J, Steinmetz LM. (2008)
Identification of mitochondrial disease genes through integrative analysis of multiple datasets
Methods 46(4):248-255. doi:10.1016/j.ymeth.2008.10.002
Europe PMC | doi

Sinha H, David L, Pascon RC, Clauder-Münster S, Krishnakumar S, Nguyen M, Shi G, Dean J, Davis RW, Oefner PJ, McCusker JH, Steinmetz LM. (2008)
Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast
Genetics 180(3):1661-1670. doi:10.1534/genetics.108.092932
Europe PMC | doi

Mancera E, Bourgon R, Brozzi A, Huber W, Steinmetz LM. (2008)
High-resolution mapping of meiotic crossovers and non-crossovers in yeast
Nature 454(7203):479-485. doi:10.1038/nature07135
Europe PMC | doi

Perocchi F, Mancera E, Steinmetz LM. (2008)
Systematic screens for human disease genes, from yeast to human and back
Mol Biosyst 4(1):18-29. doi:10.1039/b709494a
Europe PMC | doi


Wei W, McCusker JH, Hyman RW, Jones T, Ning Y, Cao Z, Gu Z, Bruno D, Miranda M, Nguyen M, Wilhelmy J, Komp C, Tamse R, Wang X, Jia P, Luedi P, Oefner PJ, David L, Dietrich FS, Li Y, Davis RW, Steinmetz LM. (2007)
Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789
Proc. Natl. Acad. Sci. U.S.A. 104(31):12825-12830. doi:10.1073/pnas.0701291104
Europe PMC | doi

Perocchi F, Xu Z, Clauder-Münster S, Steinmetz LM. (2007)
Antisense artifacts in transcriptome microarray experiments are resolved by actinomycin D
Nucleic Acids Res. 35(19):e128. doi:10.1093/nar/gkm683
Europe PMC | doi

Wang-Sattler R, Blandin S, Ning Y, Blass C, Dolo G, Touré YT, delle Torre A, Lanzaro GC, Steinmetz LM, Kafatos FC, Zheng L. (2007)
Mosaic genome architecture of the Anopheles gambiae species complex
PLoS ONE 2(11):e1249. doi:10.1371/journal.pone.0001249
Europe PMC | doi


Perocchi F, Jensen LJ, Gagneur J, Ahting U, von Mering C, Bork P, Prokisch H, Steinmetz LM. (2006)
Assessing systems properties of yeast mitochondria through an interaction map of the organelle
PLoS Genet. 2(10):e170. doi:10.1371/journal.pgen.0020170
Europe PMC | doi

Gagneur J, David L, Steinmetz LM. (2006)
Capturing cellular machines by systematic screens of protein complexes
Trends Microbiol. 14(8):336-339. doi:10.1016/j.tim.2006.06.002
Europe PMC | doi

Huber W, Toedling J, Steinmetz LM. (2006)
Transcript mapping with high-density oligonucleotide tiling arrays
Bioinformatics 22(16):1963-1970. doi:10.1093/bioinformatics/btl289
Europe PMC | doi

David L, Huber W, Granovskaia M, Toedling J, Palm CJ, Bofkin L, Jones T, Davis RW, Steinmetz LM. (2006)
A high-resolution map of transcription in the yeast genome
Proc. Natl. Acad. Sci. U.S.A. 103(14):5320-5325. doi:10.1073/pnas.0601091103
Europe PMC | doi

Sinha H, Nicholson BP, Steinmetz LM, McCusker JH. (2006)
Complex genetic interactions in a quantitative trait locus
PLoS Genet. 2(2):e13. doi:10.1371/journal.pgen.0020013
Europe PMC | doi


Jensen LJ, Steinmetz LM. (2005)
Re-analysis of data and its integration
FEBS Lett. 579(8):1802-1807. doi:10.1016/j.febslet.2005.02.006
Europe PMC | doi

Gu Z, David L, Petrov D, Jones T, Davis RW, Steinmetz LM. (2005)
Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. U.S.A. 102(4):1092-1097. doi:10.1073/pnas.0409159102
Europe PMC | doi


Prokisch H, Scharfe C, Camp DG 2nd, Xiao W, David L, Andreoli C, Monroe ME, Moore RJ, Gritsenko MA, Kozany C, Hixson KK, Mottaz HM, Zischka H, Ueffing M, Herman ZS, Davis RW, Meitinger T, Oefner PJ, Smith RD, Steinmetz LM. (2004)
Integrative analysis of the mitochondrial proteome in yeast
PLoS Biol. 2(6):e160. doi:10.1371/journal.pbio.0020160
Europe PMC | doi

Steinmetz LM, Davis RW. (2004)
Maximizing the potential of functional genomics
Nat. Rev. Genet. 5(3):190-201. doi:10.1038/nrg1293
Europe PMC | doi


Gu Z, Steinmetz LM, Gu X, Scharfe C, Davis RW, Li WH. (2003)
Role of duplicate genes in genetic robustness against null mutations
Nature 421(6918):63-66. doi:10.1038/nature01198
Europe PMC | doi


Steinmetz LM, Deutschbauer AM. (2002)
Gene function on a genomic scale
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 782(1-2):151-163. doi:10.1016/s1570-0232(02)00549-4
Europe PMC | doi

Steinmetz LM, Scharfe C, Deutschbauer AM, Mokranjac D, Herman ZS, Jones T, Chu AM, Giaever G, Prokisch H, Oefner PJ, Davis RW. (2002)
Systematic screen for human disease genes in yeast
Nat. Genet. 31(4):400-404.
Europe PMC

Fraser HB, Hirsh AE, Steinmetz LM, Scharfe C, Feldman MW. (2002)
Evolutionary rate in the protein interaction network
Science 296(5568):750-752. doi:10.1126/science.1068696
Europe PMC | doi

Steinmetz LM, Sinha H, Richards DR, Spiegelman JI, Oefner PJ, McCusker JH, Davis RW. (2002)
Dissecting the architecture of a quantitative trait locus in yeast
Nature 416(6878):326-330. doi:10.1038/416326a
Europe PMC | doi


Cho RJ, Huang M, Campbell MJ, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ. (2001)
Transcriptional regulation and function during the human cell cycle
Nat. Genet. 27(1):48-54. doi:10.1038/83751
Europe PMC | doi


Steinmetz LM, Mindrinos M, Oefner PJ. (2000)
Combining genome sequences and new technologies for dissecting the genetics of complex phenotypes
Trends Plant Sci. 5(9):397-401. doi:10.1016/s1360-1385(00)01724-6
Europe PMC | doi

Davis RW. (2000)
High-Density Arrays and Insights into Genome function

Steinmetz LM, Davis RW. (2000)
High-density arrays and insights into genome function
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A genome-wide transcriptional analysis of the mitotic cell cycle
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