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Steinmetz GroupResearch Highlights

Journal Highlights

 
Source article: Pelechano, V. et al. Extensive transcriptional heterogeneity revealed by isoform profiling. Nature 497:127-131 (2013). DOI | Pubmed
Nature News and Views: The ends justify the means. Pugh, B.F.Nature 497:48-9 (2013). DOI
 
 
Source article: Landry, J.M. et al. The genomic and transcriptomic landscape of a HeLa cell line. G3: Genes | Genomes | Genetics 11 Mar (2013). DOI | Pubmed
Research Highlight: The fractured genome of HeLa cells. Mittelman, D., Wilson, J.H. Genome Biology 14:111 (2013). DOI
 
 
Source article: Tan-Wong, S.M. et al. Gene loops enhance transcriptional directionality. Science 338:671-5 (2012). DOI | Pubmed
Perspective: A new direction for gene loops. Hampsey, M. Science 338:624-5 (2012). DOI | Pubmed
 
 
Source article: Xu, Z., Wei, W., et al. Antisense expression increases gene expression variability and locus interdependency. Mol. Syst. Biol. 7:468 (2011). DOI | Pubmed
Cell Select: Meddling in Your Neighbor's Expression Pattern. Szewczak, L. & Plosky, B. Cell 144:831,833 (2011). DOI
 
 
Source article: Xu, Z. et al. Bidirectional promoters generate pervasive transcription in yeast. Nature 457:1033-7 (2009). DOI | Pubmed
Nature News and Views: The long and short of RNAs. Carninci, P. Nature 457:974-975 (2009). DOI | Pubmed
 
 
Source article: Mancera, E. et al. High-resolution mapping of meiotic crossovers and noncrossovers in yeast. Nature 454:479-485 (2008). DOI | Pubmed
Nature News and Views: Thoroughly modern meiosis. Lichten, M. Nature 454:421-422 (2008). DOI | Pubmed
Previews: Probing meiotic recombination decisions. Roig, I. & Keeney, S. Dev. Cell 15:331-332 (2008). DOI | Pubmed
Research Highlight: Recombination: it takes four. Pflumm, M. Nature Methods 5:754-755 (2008). DOI
 
 
Source article: Perocchi, F. et al. Assessing systems properties of yeast mitochondria through an interaction map of the organelle. PLoS Genet. 2 (2006). DOI | Pubmed
Minireview: Expanding the mitochondrial interactome. Shutt, T.E. & Shadel, G.S. Genome Biol. 8:203 (2007). DOI | Pubmed
 
 
Source article: Gu, Z. et al. Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 102:1092–1097 (2005). DOI | Pubmed
Nature Research Highlight: Lab yeast on the fast track. Pearson, H. Nature 433:210 (2005). DOI
 
 
Source article: Prokisch, H. et al. Integrative analysis of the mitochondrial proteome in yeast. PLoS Biol. 2:795-804 (2004). DOI | Pubmed
PLoS Synopsis: Combining measures to characterize subcellular machinery. PLoS Biol. 2:e193 (2004). DOI
 
 
Source article: Gu, Z., Steinmetz, L.M., et al. Role of duplicate genes in genetic robustness against null mutations. Nature 421:63-66 (2003). DOI | Pubmed
Nature News and Views: Duplication, duplication. Meyer, A. Nature 421:31-32 (2003). DOI | Pubmed
 
 
Source article: Steinmetz, L.M. et al. Dissecting the architecture of a quantitative trait locus in yeast. Nature 416:326-330 (2002) DOI | Pubmed
Research Highlight: Turning up the heat on QTL mapping. Gunter, C. Nature Rev. Genet. 3:237 (2002). DOI
Research Update: Complexities in the genetic dissection of quantitative trait loci. Darvasi, A. & Pisanté-Shalom, A. Trends Genet. 18:489–491 (2002). DOI | Pubmed
Dispatch: Genetic architecture: dissecting the genetic basis of phenotypic variation. Christians, J.K. & Keightley, P.D. Current Biol. 12:R415–R416 (2002). DOI | Pubmed
 
 
Source article: Steinmetz, L.M. et al. Systematic screen for human disease genes in yeast. Nature Genet. 31:400–404 (2002). DOI | Pubmed
Research Highlight: Functional genomics: Fully functional. Skipper, M. Nature Rev. Genet. 3:645 (2002). DOI
Update: Searching for nuclear-mitochondrial genes. Chinnery, P.F. Trends Genet. 19:60-62 (2003). DOI | Pubmed

 

Faculty of 1000 Reviews

The Faculty of 1000 (F1000) is a "peer-nominated, global panel of over 10,000 expert scientists" who perform post-publication peer review on the top published articles in biology and medicine.
The F1000 has reviewed 16 articles from the Steinmetz laboratory.

EMBL Annual Reports

Features on Steinmetz Lab Research:

  • "Making sense of antisense" (2010-2011) PDF (topic: antisense transcription)
  • "The dark side of the cell" (2010-2011) PDF (topic: cell cycle transcription atlas)
  • "Cue factors" (2009-2010) PDF (topic: genetic variation in transcription factor binding)
  • "The usual suspects" (2009-2010) PDF (topic: mosquito alleles that determine susceptibility to malaria)
  • "When the exception becomes the rule" (2008-2009) PDF (topic: pervasive transcription and bidirectional promoters)
  • "The spice of life" (2008-2009) PDF (topic: meiotic recombination)
  • "The house guest that stayed" (2006-2007) PDF (topic: mitochondrial interaction network)
  • "Reappraising the genome" (2005-2006) PDF (topic: novel transcripts in yeast discovered via tiling arrays)

The EMBL Annual Report is published once a year in July after having been approved by the EMBL Council. It covers the past academic year and puts research at EMBL into a broad context of current molecular biology to make it comprehensible to a wide, non-specialist audience.

Media Coverage

Please see our press releases page.