Staff at EMBL

Dr. Nassos Typas

Group Leader
Typas Group Joint appointment: Structural and Computational Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

PhD 2006, Institute of Microbiology and Plant Physiology, Freie Universität Berlin, Germany.
Postgraduate research, University of California, San Francisco.
Group leader at EMBL since 2011.
Joint appointment with the Structural and Computational Biology Unit.

Publications

Country-specific antibiotic use practices impact the human gut resistome. Forslund, K., Sunagawa, S., Roat Kultima, J., Mende, D., Arumugam, M., Typas, A. & Bork, P. Genome Res. 2013 Apr 8. PubMed

From the regulation of peptidoglycan synthesis to bacterial growth and morphology. Typas, A., Banzhaf, M., Gross, C.A. & Vollmer, W. Nat Rev Microbiol. 2012 Feb;10(2):123-36. doi: 10.1038/nrmicro2677. PubMed

Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo. Oh, E., Becker, A.H., Sandikci, A., Huber, D., Chaba, R., Gloge, F., Nichols, R.J., Typas, A., Gross, C.A., Kramer, G., Weissman, J.S. & Bukau, B. Cell. 2011 Dec 9;147(6):1295-308. PubMed

Escherichia coli sigma senses sequence and conformation of the promoter spacer region. Singh, S.S., Typas, A., Hengge, R. & Grainger, D.C. Nucleic Acids Res. 2011 Jul;39(12):5109-18. Epub 2011 Mar 11. PubMed

Phenotypic landscape of a bacterial cell. Nichols, R.J., Sen, S., Choo, Y.J., Beltrao, P., Zietek, M., Chaba, R., Lee, S., Kazmierczak, K.M., Lee, K.J., Wong, A., Shales, M., Lovett, S., Winkler, M.E., Krogan, N.J., Typas, A. & Gross, C.A. Cell. 2011 Jan 7;144(1):143-56. Epub 2010 Dec 23. PubMed

Regulation of peptidoglycan synthesis by outer-membrane proteins. Typas, A., Banzhaf, M., van den Berg van Saparoea, B., Verheul, J., Biboy, J., Nichols, R.J., Zietek, M., Beilharz, K., Kannenberg, K., von Rechenberg, M., Breukink, E., den Blaauwen, T., Gross, C.A. & Vollmer, W. Cell. 2010 Dec 23;143(7):1097-109. PubMed

High-throughput, quantitative analyses of genetic interactions in E. coli. Typas, A., Nichols, R.J., Siegele, D.A., Shales, M., Collins, S.R., Lim, B., Braberg, H., Yamamoto, N., Takeuchi, R., Wanner, B.L., Mori, H., Weissman, J.S., Krogan, N.J. & Gross, C.A. Nat Methods. 2008 Sep;5(9):781-7. PubMed

Stationary phase reorganisation of the Escherichia coli transcription machinery by Crl protein, a fine-tuner of sigmas activity and levels. Typas, A., Barembruch, C., Possling, A. & Hengge, R. EMBO J. 2007 Mar 21;26(6):1569-78. Epub 2007 Mar 1. PubMed

The molecular basis of selective promoter activation by the sigmaS subunit of RNA polymerase. Typas, A., Becker, G. & Hengge, R. Mol Microbiol. 2007 Mar;63(5):1296-306. PubMed

The -35 sequence location and the Fis-sigma factor interface determine sigmas selectivity of the proP (P2) promoter in Escherichia coli. Typas, A., Stella, S., Johnson, R.C. & Hengge, R. Mol Microbiol. 2007 Feb;63(3):780-96. PubMed

The sigmaS subunit of RNA polymerase as a signal integrator and network master regulator in the general stress response in Escherichia coli. Klauck, E., Typas, A. & Hengge, R. Sci Prog. 2007;90(Pt 2-3):103-27. PubMed

Role of the spacer between the -35 and -10 regions in sigmas promoter selectivity in Escherichia coli. Typas, A. & Hengge, R. Mol Microbiol. 2006 Feb;59(3):1037-51. PubMed

Differential ability of sigma(s) and sigma70 of Escherichia coli to utilize promoters containing half or full UP-element sites. Typas, A. & Hengge, R. Mol Microbiol. 2005 Jan;55(1):250-60. PubMed