EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Tel: +49 6221 387-8626

E-mail: orsolya.barabas@embl.de


  • PhD 2005, Eötvös Loránd University, Budapest, Hungary.
    Postdoctoral research at the National Institutes of Health, Bethesda, USA.
    Group leader at EMBL since 2009.


Total: 26 publication(s)


Bock T, Chen WH, Ori A, Malik N, Silva-Martin N, Huerta-Cepas J, Powell ST, Kastritis PL, Smyshlyaev G, Vonkova I, Kirkpatrick J, Doerks T, Nesme L, Baßler J, Kos M, Hurt E, Carlomagno T, Gavin AC, Barabas O, Müller CW, van Noort V, Beck M, Bork P. (2014)

An integrated approach for genome annotation of the eukaryotic thermophile Chaetomium thermophilum.

Nucleic Acids Res. 42(22):13525-13533. doi:10.1093/nar/gku1147
Europe PMC | doi

Schulz EC, Barabas O. (2014)

Structure of an Escherichia coli Hfq:RNA complex at 0.97 A resolution.

Acta Crystallogr F Struct Biol Commun 70(Pt 11):1492-1497. doi:10.1107/s2053230x14020044
Europe PMC | doi


Barabás O, Németh V, Bodor A, Perczel A, Rosta E, Kele Z, Zagyva I, Szabadka Z, Grolmusz VI, Wilmanns M, Vértessy BG. (2013)

Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling

Nucleic Acids Res. 41(22):10542-10555. doi:10.1093/nar/gkt756
Europe PMC | doi

Smyshlyaev G, Voigt F, Blinov A, Barabas O, Novikova O. (2013)

Acquisition of an Archaea-like ribonuclease H domain by plant L1 retrotransposons supports modular evolution

Proc. Natl. Acad. Sci. U.S.A. 110(50):20140-20145. doi:10.1073/pnas.1310958110
Europe PMC | doi


Voigt F, Reuter M, Kasaruho A, Schulz EC, Pillai RS, Barabas O. (2012)

Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc

RNA 18(12):2128-2134. doi:10.1261/rna.034967.112
Europe PMC | doi

Barabas O. (2012)

Mechanism of Single-Stranded DNA Transposition: A Structural Perspective.

In: Wiley Online Library, eLS. John Wiley & Sons Ltd:, Chichester. doi:10.1002/9780470015902.a0023178


Hickman AB, James JA, Barabas O, Pasternak C, Ton-Hoang B, Chandler M, Sommer S, Dyda F. (2010)

DNA recognition and the precleavage state during single-stranded DNA transposition in D. radiodurans

EMBO J. 29(22):3840-3852. doi:10.1038/emboj.2010.241
Europe PMC | doi


Guynet C, Achard A, Hoang BT, Barabas O, Hickman AB, Dyda F, Chandler M. (2009)

Resetting the site: redirecting integration of an insertion sequence in a predictable way

Mol. Cell 34(5):612-619. doi:10.1016/j.molcel.2009.05.017
Europe PMC | doi

Takács E, Barabás O, Petoukhov MV, Svergun DI, Vértessy BG. (2009)

Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers

FEBS Lett. 583(5):865-871. doi:10.1016/j.febslet.2009.02.011
Europe PMC | doi

Kersulyte D, Lee W, Subramaniam D, Anant S, Herrera P, Cabrera L, Balqui J, Barabas O, Kalia A, Gilman RH, Berg DE. (2009)

Helicobacter Pylori's plasticity zones are novel transposable elements

PLoS ONE 4(9):e6859. doi:10.1371/journal.pone.0006859
Europe PMC | doi


Varga B, Barabás O, Takács E, Nagy N, Nagy P, Vértessy BG. (2008)

Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor

Biochem. Biophys. Res. Commun. 373(1):8-13. doi:10.1016/j.bbrc.2008.05.130
Europe PMC | doi

Kovári J, Barabás O, Varga B, Békési A, Tölgyesi F, Fidy J, Nagy J, Vértessy BG. (2008)

Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site

Proteins 71(1):308-319. doi:10.1002/prot.21757
Europe PMC | doi

Kardos J, Harmat V, Palló A, Barabás O, Szilágyi K, Gráf L, Náray-Szabó G, Goto Y, Závodszky P, Gál P. (2008)

Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r

Mol. Immunol. 45(6):1752-1760. doi:10.1016/j.molimm.2007.09.031
Europe PMC | doi

Guynet C, Hickman AB, Barabas O, Dyda F, Chandler M, Ton-Hoang B. (2008)

In vitro reconstitution of a single-stranded transposition mechanism of IS608

Mol. Cell 29(3):302-312. doi:10.1016/j.molcel.2007.12.008
Europe PMC | doi

Barabas O, Ronning DR, Guynet C, Hickman AB, Ton-Hoang B, Chandler M, Dyda F. (2008)

Mechanism of IS200/IS605 family DNA transposases: activation and transposon-directed target site selection

Cell 132(2):208-220. doi:10.1016/j.cell.2007.12.029
Europe PMC | doi


Varga B, Barabás O, Kovári J, Tóth J, Hunyadi-Gulyás E, Klement E, Medzihradszky KF, Tölgyesi F, Fidy J, Vértessy BG. (2007)

Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase

FEBS Lett. 581(24):4783-4788. doi:10.1016/j.febslet.2007.09.005
Europe PMC | doi

Németh-Pongrácz V, Barabás O, Fuxreiter M, Simon I, Pichová I, Rumlová M, Zábranská H, Svergun D, Petoukhov M, Harmat V, Klement E, Hunyadi-Gulyás E, Medzihradszky KF, Kónya E, Vértessy BG. (2007)

Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins

Nucleic Acids Res. 35(2):495-505. doi:10.1093/nar/gkl1074
Europe PMC | doi


Barabás O, Németh V, Vértessy BG. (2006)

Crystallization and preliminary X-ray studies of dUTPase from Mason-Pfizer monkey retrovirus

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62(Pt 4):399-401. doi:10.1107/s1744309106008931
Europe PMC | doi


Barabás O, Pongrácz V, Kovári J, Wilmanns M, Vértessy BG. (2004)

Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase

J. Biol. Chem. 279(41):42907-42915. doi:10.1074/jbc.m406135200
Europe PMC | doi

Kovári J, Barabás O, Takács E, Békési A, Dubrovay Z, Pongrácz V, Zagyva I, Imre T, Szabó P, Vértessy BG. (2004)

Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme

J. Biol. Chem. 279(17):17932-17944. doi:10.1074/jbc.m313643200
Europe PMC | doi


Barabás O, Rumlová M, Erdei A, Pongrácz V, Pichová I, Vértessy BG. (2003)

dUTPase and nucleocapsid polypeptides of the Mason-Pfizer monkey virus form a fusion protein in the virion with homotrimeric organization and low catalytic efficiency

J. Biol. Chem. 278(40):38803-38812. doi:10.1074/jbc.m306967200
Europe PMC | doi


Beke G, Gergely A, Szász G, Szentesi A, Nyitray J, Barabás O, Harmath V, Mátyus P. (2002)

Synthesis and stereochemistry of dispiro substituted pyridazines: application of ellipticity-absorbance ratio spectra for proving enantiomeric relationship by HPLC-CD/UV detection

Chirality 14(5):365-371. doi:10.1002/chir.10096
Europe PMC | doi


Abran A, Csampai A, Kotschy A, Barabas O, Sohar P. (2001)

Study on ferrocenes, part 9 1 substrate selective transformations of some ferrocenylhydrazones

J Mol Struct 569(1-3):185-194.
Europe PMC

Elias O, Karolyhazy L, Stajer G, Fulop F, Czako K, Harmath V, Barabas O, Keseru K, Matyus P. (2001)

Theoretical and experimental studies on ring closure reactions of 4(5)-chloro-5(4)-hydroxyalkylamino-6-nitro-3 (2H)-pyridazinones

Theochem 545:75-96.
Europe PMC

Simo M, Csampai A, Harmat V, Barabas O, Magyarfalvy G. (2001)

Novel ring transformations of condensed 1,2,4 triazolo- 4,3-b pyridazine-6(5H)-one-3(2H)-thiones effected by dialkyl-acetylenedicarboxylates

Tetrahedron 57(33):7191-7198.
Europe PMC


Barabas O, Menyhard DK, Bocskei Z, Simon K, Kiss-Ajzert I, Takacs K, Hermecz I. (2000)

Structural basis of solid solution formation during chiral resolution

Tetrahedron Asymmetry 11(20):4061-4070.
Europe PMC