Staff at EMBL

Dr. Martin Beck

Group Leader
Beck Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

PhD 2006, Max Planck Institute of Biochemistry, Martinsried, Germany.
Postdoctoral research at the Institute for Molecular Systems Biology, ETH Zurich, Switzerland.
Group leader at EMBL since 2010.
ERC Investigator.

Publications

Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines. Ori, A., Banterle, N., Iskar, M., Andres-Pons, A., Escher, C., Khanh Bui, H., Sparks, L., Solis-Mezarino, V., Rinner, O., Bork, P., Lemke, E.A. & Beck, M. Mol Syst Biol. 2013 Mar 19;9:648. doi: 10.1038/msb.2013.4. PubMed

Facilitated aggregation of FG nucleoporins under molecular crowding conditions. Milles, S., Huy Bui, K., Koehler, C., Eltsov, M., Beck, M. & Lemke, E.A. EMBO Rep. 2012 Dec 14. doi: 10.1038/embor.2012.204. PubMed

Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry. Herzog, F., Kahraman, A., Boehringer, D., Mak, R., Bracher, A., Walzthoeni, T., Leitner, A., Beck, M., Hartl, F.U., Ban, N., Malmstrom, L. & Aebersold, R. Science. 2012 Sep 14;337(6100):1348-52. PubMed

False discovery rate estimation for cross-linked peptides identified by mass spectrometry. Walzthoeni, T., Claassen, M., Leitner, A., Herzog, F., Bohn, S., Forster, F., Beck, M. & Aebersold, R. Nat Methods. 2012 Jul 8. doi: 10.1038/nmeth.2103. PubMed

High-throughput subtomogram alignment and classification by Fourier space constrained fast volumetric matching. Xu, M., Beck, M. & Alber, F. J Struct Biol. 2012 Mar 7. PubMed

The quantitative proteome of a human cell line. Beck, M., Schmidt, A., Malmstroem, J., Claassen, M., Ori, A., Szymborska, A., Herzog, F., Rinner, O., Ellenberg, J. & Aebersold, R. Mol Syst Biol. 2011 Nov 8;7:549. doi: 10.1038/msb.2011.82. PubMed

Absolute quantification of microbial proteomes at different states by directed mass spectrometry. Schmidt, A., Beck, M., Malmstrom, J., Lam, H., Claassen, M., Campbell, D. & Aebersold, R. Mol Syst Biol. 2011 Jul 19;7:510. doi: 10.1038/msb.2011.37. PubMed

Template-free detection of macromolecular complexes in cryo electron tomograms. Xu, M., Beck, M. & Alber, F. Bioinformatics. 2011 Jul 1;27(13):i69-i76. PubMed

mProphet: automated data processing and statistical validation for large-scale SRM experiments. Reiter, L., Rinner, O., Picotti, P., Huttenhain, R., Beck, M., Brusniak, M.Y., Hengartner, M.O. & Aebersold, R. Nat Methods. 2011 Mar 20. PubMed

Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Bohn, S., Beck, F., Sakata, E., Walzthoeni, T., Beck, M., Aebersold, R., Forster, F., Baumeister, W. & Nickell, S. Proc Natl Acad Sci U S A. 2010 Nov 22. PubMed

Exploring the Spatial and Temporal Organization of a Cell's Proteome. Beck, M., Topf, M., Frazier, Z., Tjong, H., Xu, M., Zhang, S. & Alber, F. J Struct Biol. 2010 Nov 19. PubMed

Comprehensive proteomics. Beck, M., Claassen, M. & Aebersold, R. Curr Opin Biotechnol. 2010 Sep 29. PubMed

Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics. Leitner, A., Walzthoeni, T., Kahraman, A., Herzog, F., Rinner, O., Beck, M. & Aebersold, R. Mol Cell Proteomics. 2010 Aug;9(8):1634-49. Epub 2010 Mar 31. PubMed

Visual proteomics. Forster, F., Han, B.G. & Beck, M. Methods Enzymol. 2010;483:215-43. PubMed

Visual proteomics of the human pathogen Leptospira interrogans. Beck, M., Malmstrom, J.A., Lange, V., Schmidt, A., Deutsch, E.W. & Aebersold, R. Nat Methods. 2009 Nov;6(11):817-23. Epub 2009 Oct 18. PubMed

Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans. Malmstrom, J., Beck, M., Schmidt, A., Lange, V., Deutsch, E.W. & Aebersold, R. Nature. 2009 Aug 6;460(7256):762-5. Epub 2009 Jul 15. PubMed

Architecture and molecular mechanism of PAN, the archaeal proteasome regulatory ATPase. Medalia, N., Beer, A., Zwickl, P., Mihalache, O., Beck, M., Medalia, O. & Navon, A. J Biol Chem. 2009 Aug 21;284(34):22952-60. Epub 2009 Apr 10. PubMed

Structural and functional insights into nucleocytoplasmic transport. Beck, M. & Medalia, O. Histol Histopathol. 2008 Aug;23(8):1025-33. PubMed

Identification of cross-linked peptides from large sequence databases. Rinner, O., Seebacher, J., Walzthoeni, T., Mueller, L.N., Beck, M., Schmidt, A., Mueller, M. & Aebersold, R. Nat Methods. 2008 Apr;5(4):315-8. Epub 2008 Mar 9. PubMed

Snapshots of nuclear pore complexes in action captured by cryo-electron tomography. Beck, M., Lucic, V., Forster, F., Baumeister, W. & Medalia, O. Nature. 2007 Oct 4;449(7162):611-5. Epub 2007 Sep 12. PubMed

Organization of actin networks in intact filopodia. Medalia, O., Beck, M., Ecke, M., Weber, I., Neujahr, R., Baumeister, W. & Gerisch, G. Curr Biol. 2007 Jan 9;17(1):79-84. PubMed

Luminal particles within cellular microtubules. Garvalov, B.K., Zuber, B., Bouchet-Marquis, C., Kudryashev, M., Gruska, M., Beck, M., Leis, A., Frischknecht, F., Bradke, F., Baumeister, W., Dubochet, J. & Cyrklaff, M. J Cell Biol. 2006 Sep 11;174(6):759-65. Epub 2006 Sep 5. PubMed

Cryo-electron tomography of biological specimens. Leis, A. P., Beck, M., Gruska, M., Best, C., Hegerl, R., Baumeister, W., and Leis, J. W. IEEE Signal Processing Magazine

Nuclear pore complex structure and dynamics revealed by cryoelectron tomography. Beck, M., Forster, F., Ecke, M., Plitzko, J.M., Melchior, F., Gerisch, G., Baumeister, W. & Medalia, O. Science. 2004 Nov 19;306(5700):1387-90. Epub 2004 Oct 28. PubMed