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Staff at EMBL


Dr. Martin Beck

Group Leader
Beck Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 2006, Max Planck Institute of Biochemistry, Martinsried, Germany.
Postdoctoral research at the Institute for Molecular Systems Biology, ETH Zurich, Switzerland.
Group leader at EMBL since 2010.
ERC Investigator.


Total: 32 publication(s)


Bock T, Chen WH, Ori A, Malik N, Silva-Martin N, Huerta-Cepas J, Powell ST, Kastritis PL, Smyshlyaev G, Vonkova I, Kirkpatrick J, Doerks T, Nesme L, Baßler J, Kos M, Hurt E, Carlomagno T, Gavin AC, Barabas O, Müller CW, van Noort V, Beck M, Bork P. (2014)
An integrated approach for genome annotation of the eukaryotic thermophile Chaetomium thermophilum.
Nucleic Acids Res. doi:10.1093/nar/gku1147
Europe PMC | doi

Ostenfeld MS, Jeppesen DK, Laurberg JR, Boysen AT, Bramsen JB, Primdal-Bengtson B, Hendrix A, Lamy P, Dagnaes-Hansen F, Rasmussen MH, Bui KH, Fristrup N, Christensen EI, Nordentoft I, Morth JP, Jensen JB, Pedersen JS, Beck M, Theodorescu D, Borre M, Howard KA, Dyrskjøt L, Orntoft TF. (2014)
Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties
Cancer Res. 74(20):5758-5771. doi:10.1158/0008-5472.can-13-3512
Europe PMC | doi

Piazza I, Rutkowska A, Ori A, Walczak M, Metz J, Pelechano V, Beck M, Haering CH. (2014)
Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits
Nat. Struct. Mol. Biol. 21(6):560-568. doi:10.1038/nsmb.2831
Europe PMC | doi

Ori A, Andrés-Pons A, Beck M. (2014)
The use of targeted proteomics to determine the stoichiometry of large macromolecular assemblies.
Methods Cell Biol. 122:117-146. doi:10.1016/b978-0-12-417160-2.00006-0
Europe PMC | doi

Winkler J, Ori A, Holzer K, Sticht C, Dauch D, Eiteneuer EM, Pinna F, Geffers R, Ehemann V, Andres-Pons A, Breuhahn K, Longerich T, Lorenzo Bermejo J, Gretz N, Zender L, Schirmacher P, Beck M, Singer S. (2014)
Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.
Hepatology 60(3):884-895. doi:10.1002/hep.27207
Europe PMC | doi

Beck M, Glavy JS. (2014)
Toward understanding the structure of the vertebrate nuclear pore complex
Nucleus 5(2):119-123. doi:10.4161/nucl.28739
Europe PMC | doi


Bui KH, von Appen A, DiGuilio AL, Ori A, Sparks L, Mackmull MT, Bock T, Hagen W, Andrés-Pons A, Glavy JS, Beck M. (2013)
Integrated structural analysis of the human nuclear pore complex scaffold
Cell 155(6):1233-1243. doi:10.1016/j.cell.2013.10.055
Europe PMC | doi

Banterle N, Bui KH, Lemke EA, Beck M. (2013)
Fourier ring correlation as a resolution criterion for super-resolution microscopy
J. Struct. Biol. 183(3):363-367. doi:10.1016/j.jsb.2013.05.004
Europe PMC | doi

Thierbach K, von Appen A, Thoms M, Beck M, Flemming D, Hurt E. (2013)
Protein interfaces of the conserved Nup84 complex from Chaetomium thermophilum shown by crosslinking mass spectrometry and electron microscopy
Structure 21(9):1672-1682. doi:10.1016/j.str.2013.07.004
Europe PMC | doi

Milles S, Huy Bui K, Koehler C, Eltsov M, Beck M, Lemke EA. (2013)
Facilitated aggregation of FG nucleoporins under molecular crowding conditions
EMBO Rep. 14(2):178-183. doi:10.1038/embor.2012.204
Europe PMC | doi

Ori A, Banterle N, Iskar M, Andrés-Pons A, Escher C, Khanh Bui H, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M. (2013)
Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines
Mol. Syst. Biol. 9:648. doi:10.1038/msb.2013.4
Europe PMC | doi


Walzthoeni T, Claassen M, Leitner A, Herzog F, Bohn S, Förster F, Beck M, Aebersold R. (2012)
False discovery rate estimation for cross-linked peptides identified by mass spectrometry
Nat. Methods 9(9):901-903. doi:10.1038/nmeth.2103
Europe PMC | doi

Herzog F, Kahraman A, Boehringer D, Mak R, Bracher A, Walzthoeni T, Leitner A, Beck M, Hartl FU, Ban N, Malmström L, Aebersold R. (2012)
Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry
Science 337(6100):1348-1352. doi:10.1126/science.1221483
Europe PMC | doi

Xu M, Beck M, Alber F. (2012)
High-throughput subtomogram alignment and classification by Fourier space constrained fast volumetric matching
J. Struct. Biol. 178(2):152-164. doi:10.1016/j.jsb.2012.02.014
Europe PMC | doi


Xu M, Beck M, Alber F. (2011)
Template-free detection of macromolecular complexes in cryo electron tomograms
Paper presented at the 19th Annual International Conference on Intelligent Systems for Molecular Biology/10th European Conference on Computational Biology, Vienna, AUSTRIA, JUL 17-19, 2011.Bioinformatics 27(13):i69-76. doi:10.1093/bioinformatics/btr207
Europe PMC | doi

Reiter L, Rinner O, Picotti P, Hüttenhain R, Beck M, Brusniak MY, Hengartner MO, Aebersold R. (2011)
mProphet: automated data processing and statistical validation for large-scale SRM experiments
Nat. Methods 8(5):430-435. doi:10.1038/nmeth.1584
Europe PMC | doi

Beck M, Topf M, Frazier Z, Tjong H, Xu M, Zhang S, Alber F. (2011)
Exploring the spatial and temporal organization of a cell's proteome
J. Struct. Biol. 173(3):483-496. doi:10.1016/j.jsb.2010.11.011
Europe PMC | doi

Beck M, Claassen M, Aebersold R. (2011)
Comprehensive proteomics
Curr. Opin. Biotechnol. 22(1):3-8. doi:10.1016/j.copbio.2010.09.002
Europe PMC | doi

Schmidt A, Beck M, Malmström J, Lam H, Claassen M, Campbell D, Aebersold R. (2011)
Absolute quantification of microbial proteomes at different states by directed mass spectrometry
Mol. Syst. Biol. 7:510. doi:10.1038/msb.2011.37
Europe PMC | doi

Beck M, Schmidt A, Malmstroem J, Claassen M, Ori A, Szymborska A, Herzog F, Rinner O, Ellenberg J, Aebersold R. (2011)
The quantitative proteome of a human cell line
Mol. Syst. Biol. 7:549. doi:10.1038/msb.2011.82
Europe PMC | doi


Bohn S, Beck F, Sakata E, Walzthoeni T, Beck M, Aebersold R, Förster F, Baumeister W, Nickell S. (2010)
Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution
Proc. Natl. Acad. Sci. U.S.A. 107(49):20992-20997. doi:10.1073/pnas.1015530107
Europe PMC | doi

Leitner A, Walzthoeni T, Kahraman A, Herzog F, Rinner O, Beck M, Aebersold R. (2010)
Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics
Mol. Cell Proteomics 9(8):1634-1649. doi:10.1074/mcp.r000001-mcp201
Europe PMC | doi

Förster F, Han BG, Beck M. (2010)
Visual proteomics
Meth. Enzymol. 483:215-243. doi:10.1016/s0076-6879(10)83011-3
Europe PMC | doi


Beck M, Malmström JA, Lange V, Schmidt A, Deutsch EW, Aebersold R. (2009)
Visual proteomics of the human pathogen Leptospira interrogans
Nat. Methods 6(11):817-823. doi:10.1038/nmeth.1390
Europe PMC | doi

Medalia N, Beer A, Zwickl P, Mihalache O, Beck M, Medalia O, Navon A. (2009)
Architecture and molecular mechanism of PAN, the archaeal proteasome regulatory ATPase
J. Biol. Chem. 284(34):22952-22960. doi:10.1074/jbc.m809643200
Europe PMC | doi

Malmström J, Beck M, Schmidt A, Lange V, Deutsch EW, Aebersold R. (2009)
Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans
Nature 460(7256):762-765. doi:10.1038/nature08184
Europe PMC | doi


Beck M, Medalia O. (2008)
Structural and functional insights into nucleocytoplasmic transport
Histol. Histopathol. 23(8):1025-1033.
Europe PMC

Rinner O, Seebacher J, Walzthoeni T, Mueller LN, Beck M, Schmidt A, Mueller M, Aebersold R. (2008)
Identification of cross-linked peptides from large sequence databases
Nat. Methods 5(4):315-318. doi:10.1038/nmeth.1192
Europe PMC | doi


Beck M, Lucić V, Förster F, Baumeister W, Medalia O. (2007)
Snapshots of nuclear pore complexes in action captured by cryo-electron tomography
Nature 449(7162):611-615. doi:10.1038/nature06170
Europe PMC | doi

Medalia O, Beck M, Ecke M, Weber I, Neujahr R, Baumeister W, Gerisch G. (2007)
Organization of actin networks in intact filopodia
Curr. Biol. 17(1):79-84. doi:10.1016/j.cub.2006.11.022
Europe PMC | doi


Garvalov BK, Zuber B, Bouchet-Marquis C, Kudryashev M, Gruska M, Beck M, Leis A, Frischknecht F, Bradke F, Baumeister W, Dubochet J, Cyrklaff M. (2006)
Luminal particles within cellular microtubules
J. Cell Biol. 174(6):759-765. doi:10.1083/jcb.200606074
Europe PMC | doi


Beck M, Förster F, Ecke M, Plitzko JM, Melchior F, Gerisch G, Baumeister W, Medalia O. (2004)
Nuclear pore complex structure and dynamics revealed by cryoelectron tomography
Science 306(5700):1387-1390. doi:10.1126/science.1104808
Europe PMC | doi