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Staff at EMBL

Dr. Martin Beck

Group Leader
Beck Group

EMBL Heidelberg, Meyerhofstra├če 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 2006, Max Planck Institute of Biochemistry, Martinsried, Germany.
Postdoctoral research at the Institute for Molecular Systems Biology, ETH Zurich, Switzerland.
Group leader at EMBL since 2010.
ERC Investigator.


Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits. Piazza, I., Rutkowska, A., Ori, A., Walczak, M., Metz, J., Pelechano, V., Beck, M. & Haering, C.H. Nat Struct Mol Biol. 2014 Jun;21(6):560-8. doi: 10.1038/nsmb.2831. Epub 2014 May18. Europe PMC

Prosurvival function of the cellular apoptosis susceptibility/importin-alpha1 transport cycle is repressed by p53 in liver cancer. Winkler, J., Ori, A., Holzer, K., Sticht, C., Dauch, D., Eiteneuer, E.M., Pinna, F., Geffers, R., Ehemann, V., Andres-Pons, A., Breuhahn, K., Longerich, T., Lorenzo Bermejo, J., Gretz, N., Zender, L., Schirmacher, P., Beck, M. & Singer, S. Hepatology. 2014 May 6. doi: 10.1002/hep.27207. Europe PMC

Toward understanding the structure of the vertebrate nuclear pore complex. Beck, M. & Glavy, J.S. Nucleus. 2014 Apr 3;5(2). Europe PMC

The Use of Targeted Proteomics to Determine the Stoichiometry of Large Macromolecular Assemblies. Ori, A., Andres-Pons, A. & Beck, M. Methods Cell Biol. 2014;122C:117-146. doi: 10.1016/B978-0-12-417160-2.00006-0. Europe PMC

Integrated structural analysis of the human nuclear pore complex scaffold. Bui, K.H., von Appen, A., DiGuilio, A.L., Ori, A., Sparks, L., Mackmull, M.T., Bock, T., Hagen, W., Andres-Pons, A., Glavy, J.S. & Beck, M. Cell. 2013 Dec 5;155(6):1233-43. doi: 10.1016/j.cell.2013.10.055. Europe PMC

Protein interfaces of the conserved Nup84 complex from Chaetomium thermophilum shown by crosslinking mass spectrometry and electron microscopy. Thierbach, K., von Appen, A., Thoms, M., Beck, M., Flemming, D. & Hurt, E. Structure. 2013 Sep 3;21(9):1672-82. doi: 10.1016/j.str.2013.07.004. Epub 2013Aug 15. Europe PMC

Fourier ring correlation as a resolution criterion for super-resolution microscopy. Banterle, N., Bui, K.H., Lemke, E.A. & Beck, M. J Struct Biol. 2013 Sep;183(3):363-7. doi: 10.1016/j.jsb.2013.05.004. Epub 2013May 16. Europe PMC

Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines. Ori, A., Banterle, N., Iskar, M., Andres-Pons, A., Escher, C., Khanh Bui, H., Sparks, L., Solis-Mezarino, V., Rinner, O., Bork, P., Lemke, E.A. & Beck, M. Mol Syst Biol. 2013 Mar 19;9:648. doi: 10.1038/msb.2013.4. Europe PMC

Facilitated aggregation of FG nucleoporins under molecular crowding conditions. Milles, S., Huy Bui, K., Koehler, C., Eltsov, M., Beck, M. & Lemke, E.A. EMBO Rep. 2013 Feb;14(2):178-83. doi: 10.1038/embor.2012.204. Epub 2012 Dec 14. Europe PMC

False discovery rate estimation for cross-linked peptides identified by mass spectrometry. Walzthoeni, T., Claassen, M., Leitner, A., Herzog, F., Bohn, S., Forster, F., Beck, M. & Aebersold, R. Nat Methods. 2012 Sep;9(9):901-3. doi: 10.1038/nmeth.2103. Epub 2012 Jul 8. Europe PMC

Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry. Herzog, F., Kahraman, A., Boehringer, D., Mak, R., Bracher, A., Walzthoeni, T., Leitner, A., Beck, M., Hartl, F.U., Ban, N., Malmstrom, L. & Aebersold, R. Science. 2012 Sep 14;337(6100):1348-52. Europe PMC

High-throughput subtomogram alignment and classification by Fourier space constrained fast volumetric matching. Xu, M., Beck, M. & Alber, F. J Struct Biol. 2012 May;178(2):152-64. doi: 10.1016/j.jsb.2012.02.014. Epub 2012Mar 7. Europe PMC

The quantitative proteome of a human cell line. Beck, M., Schmidt, A., Malmstroem, J., Claassen, M., Ori, A., Szymborska, A., Herzog, F., Rinner, O., Ellenberg, J. & Aebersold, R. Mol Syst Biol. 2011 Nov 8;7:549. doi: 10.1038/msb.2011.82. Europe PMC

Absolute quantification of microbial proteomes at different states by directed mass spectrometry. Schmidt, A., Beck, M., Malmstrom, J., Lam, H., Claassen, M., Campbell, D. & Aebersold, R. Mol Syst Biol. 2011 Jul 19;7:510. doi: 10.1038/msb.2011.37. Europe PMC

Template-free detection of macromolecular complexes in cryo electron tomograms. Xu, M., Beck, M. & Alber, F. Bioinformatics. 2011 Jul 1;27(13):i69-76. doi: 10.1093/bioinformatics/btr207. Europe PMC

mProphet: automated data processing and statistical validation for large-scale SRM experiments. Reiter, L., Rinner, O., Picotti, P., Huttenhain, R., Beck, M., Brusniak, M.Y., Hengartner, M.O. & Aebersold, R. Nat Methods. 2011 May;8(5):430-5. doi: 10.1038/nmeth.1584. Epub 2011 Mar 20. Europe PMC

Exploring the spatial and temporal organization of a cell's proteome. Beck, M., Topf, M., Frazier, Z., Tjong, H., Xu, M., Zhang, S. & Alber, F. J Struct Biol. 2011 Mar;173(3):483-96. doi: 10.1016/j.jsb.2010.11.011. Epub 2010Nov 19. Europe PMC

Comprehensive proteomics. Beck, M., Claassen, M. & Aebersold, R. Curr Opin Biotechnol. 2011 Feb;22(1):3-8. doi: 10.1016/j.copbio.2010.09.002. Epub2010 Oct 1. Europe PMC

Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Bohn, S., Beck, F., Sakata, E., Walzthoeni, T., Beck, M., Aebersold, R., Forster, F., Baumeister, W. & Nickell, S. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20992-7. doi:10.1073/pnas.1015530107. Epub 2010 Nov 22. Europe PMC

Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics. Leitner, A., Walzthoeni, T., Kahraman, A., Herzog, F., Rinner, O., Beck, M. & Aebersold, R. Mol Cell Proteomics. 2010 Aug;9(8):1634-49. Epub 2010 Mar 31. Europe PMC

Visual proteomics. Forster, F., Han, B.G. & Beck, M. Methods Enzymol. 2010;483:215-43. Europe PMC

Visual proteomics of the human pathogen Leptospira interrogans. Beck, M., Malmstrom, J.A., Lange, V., Schmidt, A., Deutsch, E.W. & Aebersold, R. Nat Methods. 2009 Nov;6(11):817-23. Epub 2009 Oct 18. Europe PMC

Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans. Malmstrom, J., Beck, M., Schmidt, A., Lange, V., Deutsch, E.W. & Aebersold, R. Nature. 2009 Aug 6;460(7256):762-5. Epub 2009 Jul 15. Europe PMC

Architecture and molecular mechanism of PAN, the archaeal proteasome regulatory ATPase. Medalia, N., Beer, A., Zwickl, P., Mihalache, O., Beck, M., Medalia, O. & Navon, A. J Biol Chem. 2009 Aug 21;284(34):22952-60. Epub 2009 Apr 10. Europe PMC

Structural and functional insights into nucleocytoplasmic transport. Beck, M. & Medalia, O. Histol Histopathol. 2008 Aug;23(8):1025-33. Europe PMC

Identification of cross-linked peptides from large sequence databases. Rinner, O., Seebacher, J., Walzthoeni, T., Mueller, L.N., Beck, M., Schmidt, A., Mueller, M. & Aebersold, R. Nat Methods. 2008 Apr;5(4):315-8. Epub 2008 Mar 9. Europe PMC

Snapshots of nuclear pore complexes in action captured by cryo-electron tomography. Beck, M., Lucic, V., Forster, F., Baumeister, W. & Medalia, O. Nature. 2007 Oct 4;449(7162):611-5. Epub 2007 Sep 12. Europe PMC

Organization of actin networks in intact filopodia. Medalia, O., Beck, M., Ecke, M., Weber, I., Neujahr, R., Baumeister, W. & Gerisch, G. Curr Biol. 2007 Jan 9;17(1):79-84. Europe PMC

Luminal particles within cellular microtubules. Garvalov, B.K., Zuber, B., Bouchet-Marquis, C., Kudryashev, M., Gruska, M., Beck, M., Leis, A., Frischknecht, F., Bradke, F., Baumeister, W., Dubochet, J. & Cyrklaff, M. J Cell Biol. 2006 Sep 11;174(6):759-65. Epub 2006 Sep 5. Europe PMC

Cryo-electron tomography of biological specimens. Leis, A. P., Beck, M., Gruska, M., Best, C., Hegerl, R., Baumeister, W., and Leis, J. W. IEEE Signal Processing Magazine

Nuclear pore complex structure and dynamics revealed by cryoelectron tomography. Beck, M., Forster, F., Ecke, M., Plitzko, J.M., Melchior, F., Gerisch, G., Baumeister, W. & Medalia, O. Science. 2004 Nov 19;306(5700):1387-90. Epub 2004 Oct 28. Europe PMC