Staff at EMBL
Dr. Bernd Simon
NMR Facility Manager
Carlomagno Group
EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
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Publications
Structural principles of RNA catalysis in a 2'-5' lariat-forming ribozyme. Carlomagno, T., Amata, I., Codutti, L., Falb, M., Fohrer, J., Masiewicz, P. & Simon, B. J Am Chem Soc. 2013 Mar 20;135(11):4403-11. doi: 10.1021/ja311868t. Epub 2013 Mar8. PubMed
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Ballare, C., Lange, M., Lapinaite, A., Martin, G.M., Morey, L., Pascual, G., Liefke, R., Simon, B., Shi, Y., Gozani, O., Carlomagno, T., Benitah, S.A. & Di Croce, L. Nat Struct Mol Biol. 2012 Dec;19(12):1257-65. doi: 10.1038/nsmb.2434. Epub 2012Oct 28. PubMed
Structure and VP16 binding of the Mediator Med25 activator interaction domain. Vojnic, E., Mourao, A., Seizl, M., Simon, B., Wenzeck, L., Lariviere, L., Baumli, S., Baumgart, K., Meisterernst, M., Sattler, M. & Cramer, P. Nat Struct Mol Biol. 2011 Apr;18(4):404-9. Epub 2011 Mar 6. PubMed
Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein. Simon, B., Kirkpatrick, J.P., Eckhardt, S., Reuter, M., Rocha, E.A., Andrade-Navarro, M.A., Sehr, P., Pillai, R.S. & Carlomagno, T. Structure. 2011 Feb 9;19(2):172-80. Epub 2011 Jan 20. PubMed
Structure of the K-turn U4 RNA: a combined NMR and SANS study. Falb, M., Amata, I., Gabel, F., Simon, B. & Carlomagno, T. Nucleic Acids Res. 2010 Oct;38(18):6274-85. doi: 10.1093/nar/gkq380. Epub 2010May 13. PubMed
Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling. Stauch, B., Simon, B., Basile, T., Schneider, G., Malek, N.P., Kalesse, M. & Carlomagno, T. Angew Chem Int Ed Engl. 2010 May 25;49(23):3934-8. PubMed
The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin. Marino, M., Zou, P., Svergun, D., Garcia, P., Edlich, C., Simon, B., Wilmanns, M., Muhle-Goll, C. & Mayans, O. Structure. 2006 Sep;14(9):1437-47. PubMed
A target function for quaternary structural refinement from small angle scattering and NMR orientational restraints. Gabel, F., Simon, B. & Sattler, M. Eur Biophys J. 2006 Apr;35(4):313-27. Epub 2006 Jan 14. PubMed
Backbone H-1, C-13, and N-15 resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD) Kang, CB., Ye, H., Vivekanandan, S., Simon, B., Sattler, M., Yoon, H.S. Journal of Biomolecular NMR 2006 36(suppl. 1)
New NMR assignment H-1, C-13, and N-15 assignment of the second PH domain of human pleckstrin (234-350) Edlich, C., Simon, B., Sattler, M., Muhle-Goll, C. Journal of Biomolecular NMR 2006 suppl 1(36)
The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. Lingel, A., Simon, B., Izaurralde, E. & Sattler, M. EMBO Rep 2005 Dec;6(12):1149-55. PubMed
NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease. Bottomley, M.J., Stier, G., Pennacchini, D., Legube, G., Simon, B., Akhtar, A., Sattler, M. & Musco, G. J Biol Chem 2005 Mar 25;280(12):11505-12. Epub 2005 Jan 13. PubMed
NMR assignment of the Drosophila Argonaute2 PAZ domain. Lingel, A., Simon, B., Izaurralde, E. & Sattler, M. J Biomol NMR 2004 Jul;29(3):421-2. PubMed
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Lingel, A., Simon, B., Izaurralde, E. & Sattler, M. Nat Struct Mol Biol 2004 Jun;11(6):576-7. Epub 2004 May 23. PubMed
Fast identification of folded human protein domains expressed in E. coli suitable for structural analysis. Scheich, C., Leitner, D., Sievert, V., Leidert, M., Schlegel, B., Simon, B., Letunic, I., Bussow, K. & Diehl, A. BMC Struct Biol 2004 Mar 8;4(1):4. PubMed
Speeding up biomolecular NMR spectroscopy. Simon, B. & Sattler, M. Angew Chem Int Ed Engl 2004 Feb 6;43(7):782-6. PubMed
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Lingel, A., Simon, B., Izaurralde, E. & Sattler, M. Nature 2003 Nov 27;426(6965):465-9. Epub 2003 Nov 16. PubMed
Establishing the yeast Saccharomyces cerevisiae as a system for expression of human proteins on a proteome-scale. Holz, C., Prinz, B., Bolotina, N., Sievert, V., Bussow, K., Simon, B., Stahl, U. & Lang, C. J Struct Funct Genomics 2003;4(2-3):97-108. PubMed
De novo structure determination from residual dipolar couplings by NMR spectroscopy. Simon, B. & Sattler, M. Angew Chem Int Ed Engl 2002 Feb 1;41(3):437-40. PubMed
NMR of large proteins Sattler, M., and Simon, B. The ELSO Gazette 11, Oct 2002
A TROSY relayed HCCH-COSY experiment for correlating adenine H2/H8 resonances in uniformly 13C-labeled RNA molecules. Simon, B., Zanier, K. & Sattler, M. J Biomol NMR 2001 Jun;20(2):173-6. PubMed
Heteronuclear relaxation study of the PH domain of beta-spectrin: restriction of loop motions upon binding inositol trisphosphate. Gryk, M.R., Abseher, R., Simon, B., Nilges, M. & Oschkinat, H. J Mol Biol 1998 Jul 31 280(5) 879-896 PubMed