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Staff at EMBL

Dr. Bernd Simon

NMR Facility Manager
Carlomagno Group

EMBL Heidelberg, Meyerhofstra├če 1, 69117 Heidelberg, Germany

E-mail: send a mail


NMR approaches for structural analysis of multidomain proteins and complexes in solution. Gobl, C., Madl, T., Simon, B. & Sattler, M. Prog Nucl Magn Reson Spectrosc. 2014 Jul;80C:26-63. doi:10.1016/j.pnmrs.2014.05.003. Epub 2014 May 23. Europe PMC

(1)H, (1)(3)C, and (1)(5)N chemical shift assignments of the phosphotyrosine binding domain 2 (PTB2) of human FE65. Dietl, A., Wild, K. & Simon, B. Biomol NMR Assign. 2014 Apr;8(1):93-5. doi: 10.1007/s12104-013-9460-z. Epub 2013Jan 12. Europe PMC

The structure of the box C/D enzyme reveals regulation of RNA methylation. Lapinaite, A., Simon, B., Skjaerven, L., Rakwalska-Bange, M., Gabel, F. & Carlomagno, T. Nature. 2013 Oct 24;502(7472):519-23. doi: 10.1038/nature12581. Epub 2013 Oct 13. Europe PMC

Efficient detection of hydrogen bonds in dynamic regions of RNA by sensitivity-optimized NMR pulse sequences. Dallmann, A., Simon, B., Duszczyk, M.M., Kooshapur, H., Pardi, A., Bermel, W. & Sattler, M. Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10487-90. doi: 10.1002/anie.201304391.Epub 2013 Aug 14. Europe PMC

A Suite of Solid-State NMR Experiments for RNA Intranucleotide Resonance Assignment in a 21 kDa Protein-RNA Complex. Marchanka, A., Simon, B. & Carlomagno, T. Angew Chem Int Ed Engl. 2013 Jul 26. doi: 10.1002/anie.201304779. Europe PMC

Structural principles of RNA catalysis in a 2'-5' lariat-forming ribozyme. Carlomagno, T., Amata, I., Codutti, L., Falb, M., Fohrer, J., Masiewicz, P. & Simon, B. J Am Chem Soc. 2013 Mar 20;135(11):4403-11. doi: 10.1021/ja311868t. Epub 2013 Mar8. Europe PMC

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Ballare, C., Lange, M., Lapinaite, A., Martin, G.M., Morey, L., Pascual, G., Liefke, R., Simon, B., Shi, Y., Gozani, O., Carlomagno, T., Benitah, S.A. & Di Croce, L. Nat Struct Mol Biol. 2012 Dec;19(12):1257-65. doi: 10.1038/nsmb.2434. Epub 2012Oct 28. Europe PMC

Structure and VP16 binding of the Mediator Med25 activator interaction domain. Vojnic, E., Mourao, A., Seizl, M., Simon, B., Wenzeck, L., Lariviere, L., Baumli, S., Baumgart, K., Meisterernst, M., Sattler, M. & Cramer, P. Nat Struct Mol Biol. 2011 Apr;18(4):404-9. Epub 2011 Mar 6. Europe PMC

Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein. Simon, B., Kirkpatrick, J.P., Eckhardt, S., Reuter, M., Rocha, E.A., Andrade-Navarro, M.A., Sehr, P., Pillai, R.S. & Carlomagno, T. Structure. 2011 Feb 9;19(2):172-80. Epub 2011 Jan 20. Europe PMC

Structure of the K-turn U4 RNA: a combined NMR and SANS study. Falb, M., Amata, I., Gabel, F., Simon, B. & Carlomagno, T. Nucleic Acids Res. 2010 Oct;38(18):6274-85. doi: 10.1093/nar/gkq380. Epub 2010May 13. Europe PMC

Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling. Stauch, B., Simon, B., Basile, T., Schneider, G., Malek, N.P., Kalesse, M. & Carlomagno, T. Angew Chem Int Ed Engl. 2010 May 25;49(23):3934-8. Europe PMC

The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin. Marino, M., Zou, P., Svergun, D., Garcia, P., Edlich, C., Simon, B., Wilmanns, M., Muhle-Goll, C. & Mayans, O. Structure. 2006 Sep;14(9):1437-47. Europe PMC

Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD). Kang, C.B., Ye, H., Vivekanandan, S., Simon, B., Sattler, M. & Yoon, H.S. J Biomol NMR. 2006;36 Suppl 1:37. Epub 2006 May 23. Europe PMC

A target function for quaternary structural refinement from small angle scattering and NMR orientational restraints. Gabel, F., Simon, B. & Sattler, M. Eur Biophys J. 2006 Apr;35(4):313-27. Epub 2006 Jan 14. Europe PMC

New NMR assignment 1H, 13C, and 15N assignment of the second PH domain of human pleckstrin (234-350). Edlich, C., Simon, B., Sattler, M. & Muhle-Goll, C. J Biomol NMR. 2006;36 Suppl 1:21. Europe PMC

The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. Lingel, A., Simon, B., Izaurralde, E. & Sattler, M. EMBO Rep 2005 Dec;6(12):1149-55. Europe PMC

NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease. Bottomley, M.J., Stier, G., Pennacchini, D., Legube, G., Simon, B., Akhtar, A., Sattler, M. & Musco, G. J Biol Chem 2005 Mar 25;280(12):11505-12. Epub 2005 Jan 13. Europe PMC

NMR assignment of the Drosophila Argonaute2 PAZ domain. Lingel, A., Simon, B., Izaurralde, E. & Sattler, M. J Biomol NMR 2004 Jul;29(3):421-2. Europe PMC

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Lingel, A., Simon, B., Izaurralde, E. & Sattler, M. Nat Struct Mol Biol 2004 Jun;11(6):576-7. Epub 2004 May 23. Europe PMC

Fast identification of folded human protein domains expressed in E. coli suitable for structural analysis. Scheich, C., Leitner, D., Sievert, V., Leidert, M., Schlegel, B., Simon, B., Letunic, I., Bussow, K. & Diehl, A. BMC Struct Biol 2004 Mar 8;4(1):4. Europe PMC

Speeding up biomolecular NMR spectroscopy. Simon, B. & Sattler, M. Angew Chem Int Ed Engl 2004 Feb 6;43(7):782-6. Europe PMC

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Lingel, A., Simon, B., Izaurralde, E. & Sattler, M. Nature 2003 Nov 27;426(6965):465-9. Epub 2003 Nov 16. Europe PMC

Establishing the yeast Saccharomyces cerevisiae as a system for expression of human proteins on a proteome-scale. Holz, C., Prinz, B., Bolotina, N., Sievert, V., Bussow, K., Simon, B., Stahl, U. & Lang, C. J Struct Funct Genomics 2003;4(2-3):97-108. Europe PMC

De novo structure determination from residual dipolar couplings by NMR spectroscopy. Simon, B. & Sattler, M. Angew Chem Int Ed Engl 2002 Feb 1;41(3):437-40. Europe PMC

NMR of large proteins Sattler, M., and Simon, B. The ELSO Gazette 11, Oct 2002

A TROSY relayed HCCH-COSY experiment for correlating adenine H2/H8 resonances in uniformly 13C-labeled RNA molecules. Simon, B., Zanier, K. & Sattler, M. J Biomol NMR 2001 Jun;20(2):173-6. Europe PMC

Heteronuclear relaxation study of the PH domain of beta-spectrin: restriction of loop motions upon binding inositol trisphosphate. Gryk, M.R., Abseher, R., Simon, B., Nilges, M. & Oschkinat, H. J Mol Biol 1998 Jul 31 280(5) 879-896 Europe PMC