EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

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Biography

  • PhD 1992, University of Geneva.
    Postdoctoral research at EMBL.
    Director, Molecular and Cell Biology, Cellzome AG, Heidelberg.
    Group leader at EMBL since 2005.
    Senior scientist since 2011.
    Elected EMBO Member since 2013.
    Group leader in the Molecular Medicine Partnership Unit.

Publications

Total: 64 publication(s)

2015

Paul VD, Mühlenhoff U, Stümpfig M, Seebacher J, Kugler KG, Renicke C, Taxis C, Gavin AC, Pierik AJ. (2015)

The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion.

Elife 4 doi:10.7554/elife.08231
Europe PMC | doi

Vonkova I, Saliba AE, Deghou S, Anand K, Ceschia S, Doerks T, Galih A, Kugler KG, Maeda K, Rybin V, van Noort V, Ellenberg J, Bork P, Gavin AC. (2015)

Lipid Cooperativity as a General Membrane-Recruitment Principle for PH Domains.

Cell Rep
Europe PMC

Köberlin MS, Snijder B, Heinz LX, Baumann CL, Fauster A, Vladimer GI, Gavin AC, Superti-Furga G. (2015)

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses.

Cell doi:10.1016/j.cell.2015.05.051
Europe PMC | doi

Hennrich ML, Gavin AC. (2015)

Quantitative mass spectrometry of posttranslational modifications: Keys to confidence.

Sci Signal 8(371):re5. doi:10.1126/scisignal.aaa6466
Europe PMC | doi

Betts MJ, Lu Q, Jiang Y, Drusko A, Wichmann O, Utz M, Valtierra-Gutiérrez IA, Schlesner M, Jaeger N, Jones DT, Pfister S, Lichter P, Eils R, Siebert R, Bork P, Apic G, Gavin AC, Russell RB. (2015)

Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions.

Nucleic Acids Res. 43(2):e10. doi:10.1093/nar/gku1094
Europe PMC | doi

Lluch-Senar M, Delgado J, Chen WH, Lloréns-Rico V, O'Reilly FJ, Wodke JA, Unal EB, Yus E, Martínez S, Nichols RJ, Ferrar T, Vivancos A, Schmeisky A, Stülke J, van Noort V, Gavin AC, Bork P, Serrano L. (2015)

Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium.

Mol. Syst. Biol. 11(1) doi:10.15252/msb.20145558
Europe PMC | doi

Glatt S, Zabel R, Vonkova I, Kumar A, Netz DJ, Pierik AJ, Rybin V, Lill R, Gavin A, Balbach J, Breunig KD, Müller CW. (2015)

Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2.

Structure 23(1):149-160. doi:10.1016/j.str.2014.11.008
Europe PMC | doi


2014

Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff HJ, Gavin AC, Meehan RR, Picotti P, Pujana MA, Rajewsky N, Smith KG, Sterk PJ, Villoslada P, Benson M. (2014)

Modules, networks and systems medicine for understanding disease and aiding diagnosis.

Genome Med 6(10) doi:10.1186/s13073-014-0082-6
Europe PMC | doi

Bock T, Chen WH, Ori A, Malik N, Silva-Martin N, Huerta-Cepas J, Powell ST, Kastritis PL, Smyshlyaev G, Vonkova I, Kirkpatrick J, Doerks T, Nesme L, Baßler J, Kos M, Hurt E, Carlomagno T, Gavin AC, Barabas O, Müller CW, van Noort V, Beck M, Bork P. (2014)

An integrated approach for genome annotation of the eukaryotic thermophile Chaetomium thermophilum.

Nucleic Acids Res. 42(22):13525-13533. doi:10.1093/nar/gku1147
Europe PMC | doi

Maeda K, Poletto M, Chiapparino A, Gavin AC. (2014)

A generic protocol for the purification and characterization of water-soluble complexes of affinity-tagged proteins and lipids

Nat Protoc 9(9):2256-2266. doi:10.1038/nprot.2014.148
Europe PMC | doi

Thimiri Govinda Raj DB, Garzoni F, Gavin AC, Gibson T, Berger I. (2014)

FEBS-EMBO Concurrent Session (lecture): CS III-6-3 SynBac: designer minimal baculovirus genome for drug discovery.

Paper presented at the FEBS EMBO 2014 Conference, Paris, France, 30 August-4 September 2014. FEBS J. 281(S1):9-55. doi:10.1111/febs.12917
doi

Saliba AE, Vonkova I, Ceschia S, Findlay GM, Maeda K, Tischer C, Deghou S, van Noort V, Bork P, Pawson T, Ellenberg J, Gavin AC. (2014)

A quantitative liposome microarray to systematically characterize protein-lipid interactions

Nat. Methods 11(1):47-50. doi:10.1038/nmeth.2734
Europe PMC | doi


2013

Maeda K, Anand K, Chiapparino A, Kumar A, Poletto M, Kaksonen M, Gavin AC. (2013)

Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins

Nature 501(7466):257-261. doi:10.1038/nature12430
Europe PMC | doi

Marcotte E, Boone C, Babu MM, Gavin AC. (2013)

Network Biology editorial 2013

Mol Biosyst 9(7):1557-1558. doi:10.1039/c3mb90018e
Europe PMC | doi

Taylor NM, Glatt S, Hennrich ML, von Scheven G, Grötsch H, Fernández-Tornero C, Rybin V, Gavin AC, Kolb P, Müller CW. (2013)

Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC

J. Biol. Chem. 288(21):15110-15120. doi:10.1074/jbc.m112.427856
Europe PMC | doi

Haberkant P, Raijmakers R, Wildwater M, Sachsenheimer T, Brügger B, Maeda K, Houweling M, Gavin AC, Schultz C, van Meer G, Heck AJ, Holthuis JC. (2013)

In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids

Angew. Chem. Int. Ed. Engl. 52(14):4033-4038. doi:10.1002/anie.201210178
Europe PMC | doi

Gallego O, Specht T, Brach T, Kumar A, Gavin AC, Kaksonen M. (2013)

Detection and characterization of protein interactions in vivo by a simple live-cell imaging method

PLoS ONE 8(5):e62195. doi:10.1371/journal.pone.0062195
Europe PMC | doi

Iskar M, Zeller G, Blattmann P, Campillos M, Kuhn M, Kaminska KH, Runz H, Gavin AC, Pepperkok R, van Noort V, Bork P. (2013)

Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding

Mol. Syst. Biol. 9:662. doi:10.1038/msb.2013.20
Europe PMC | doi

Kuhn M, Al Banchaabouchi M, Campillos M, Jensen LJ, Gross C, Gavin AC, Bork P. (2013)

Systematic identification of proteins that elicit drug side effects

Mol. Syst. Biol. 9:663. doi:10.1038/msb.2013.10
Europe PMC | doi


2012

Bonn S, Zinzen RP, Perez-Gonzalez A, Riddell A, Gavin AC, Furlong EE. (2012)

Cell type-specific chromatin immunoprecipitation from multicellular complex samples using BiTS-ChIP

Nat Protoc 7(5):978-994. doi:10.1038/nprot.2012.049
Europe PMC | doi

Anand K, Maeda K, Gavin AC. (2012)

Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site

PLoS ONE 7(5):e36526. doi:10.1371/journal.pone.0036526
Europe PMC | doi

Minguez P, Parca L, Diella F, Mende DR, Kumar R, Helmer-Citterich M, Gavin AC, van Noort V, Bork P. (2012)

Deciphering a global network of functionally associated post-translational modifications

Mol. Syst. Biol. 8:599. doi:10.1038/msb.2012.31
Europe PMC | doi

van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC. (2012)

Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium

Mol. Syst. Biol. 8:571. doi:10.1038/msb.2012.4
Europe PMC | doi

Yus E, Güell M, Vivancos AP, Chen WH, Lluch-Senar M, Delgado J, Gavin AC, Bork P, Serrano L. (2012)

Transcription start site associated RNAs in bacteria

Mol. Syst. Biol. 8:585. doi:10.1038/msb.2012.16
Europe PMC | doi


2011

Seebacher J, Gavin AC. (2011)

SnapShot: Protein-protein interaction networks

Cell 144(6):1000, 1000.e1. doi:10.1016/j.cell.2011.02.025
Europe PMC | doi

Gavin AC, Maeda K, Kühner S. (2011)

Recent advances in charting protein-protein interaction: mass spectrometry-based approaches

Curr. Opin. Biotechnol. 22(1):42-49. doi:10.1016/j.copbio.2010.09.007
Europe PMC | doi

Lane LA, Fernández-Tornero C, Zhou M, Morgner N, Ptchelkine D, Steuerwald U, Politis A, Lindner D, Gvozdenovic J, Gavin AC, Müller CW, Robinson CV. (2011)

Mass spectrometry reveals stable modules in holo and apo RNA polymerases I and III

Structure 19(1):90-100. doi:10.1016/j.str.2010.11.009
Europe PMC | doi

Maier T, Schmidt A, Güell M, Kühner S, Gavin AC, Aebersold R, Serrano L. (2011)

Quantification of mRNA and protein and integration with protein turnover in a bacterium

Mol. Syst. Biol. 7:511. doi:10.1038/msb.2011.38
Europe PMC | doi


2010

Gallego O, Betts MJ, Gvozdenovic-Jeremic J, Maeda K, Matetzki C, Aguilar-Gurrieri C, Beltran-Alvarez P, Bonn S, Fernández-Tornero C, Jensen LJ, Kuhn M, Trott J, Rybin V, Müller CW, Bork P, Kaksonen M, Russell RB, Gavin AC. (2010)

A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae

Mol. Syst. Biol. 6:430. doi:10.1038/msb.2010.87
Europe PMC | doi

Sander M, Begley TJ, Desaintes C, Gavin AC, Pelroy R, Pothof J, Shiloh Y, van Gent D, Van Houten B, Yaffe M, Mullenders L. (2010)

3rd US-EU workshop: systems level understanding of DNA damage responses

Mutat. Res. 692(1-2):53-60. doi:10.1016/j.mrfmmm.2010.07.012
Europe PMC | doi

Gehlenborg N, O'Donoghue SI, Baliga NS, Goesmann A, Hibbs MA, Kitano H, Kohlbacher O, Neuweger H, Schneider R, Tenenbaum D, Gavin AC. (2010)

Visualization of omics data for systems biology

Nat. Methods 7(3 Suppl):S56-68. doi:10.1038/nmeth.1436
Europe PMC | doi

O'Donoghue SI, Gavin AC, Gehlenborg N, Goodsell DS, Hériché JK, Nielsen CB, North C, Olson AJ, Procter JB, Shattuck DW, Walter T, Wong B. (2010)

Visualizing biological data-now and in the future

Nat. Methods 7(3 Suppl):S2-4. doi:10.1038/nmeth.f.301
Europe PMC | doi


2009

Güell M, van Noort V, Yus E, Chen WH, Leigh-Bell J, Michalodimitrakis K, Yamada T, Arumugam M, Doerks T, Kühner S, Rode M, Suyama M, Schmidt S, Gavin AC, Bork P, Serrano L. (2009)

Transcriptome complexity in a genome-reduced bacterium

Science 326(5957):1268-1271. doi:10.1126/science.1176951
Europe PMC | doi

Kühner S, van Noort V, Betts MJ, Leo-Macias A, Batisse C, Rode M, Yamada T, Maier T, Bader S, Beltran-Alvarez P, Castaño-Diez D, Chen WH, Devos D, Güell M, Norambuena T, Racke I, Rybin V, Schmidt A, Yus E, Aebersold R, Herrmann R, Böttcher B, Frangakis AS, Russell RB, Serrano L, Bork P, Gavin AC. (2009)

Proteome organization in a genome-reduced bacterium

Science 326(5957):1235-1240. doi:10.1126/science.1176343
Europe PMC | doi

Yus E, Maier T, Michalodimitrakis K, van Noort V, Yamada T, Chen WH, Wodke JA, Güell M, Martínez S, Bourgeois R, Kühner S, Raineri E, Letunic I, Kalinina OV, Rode M, Herrmann R, Gutiérrez-Gallego R, Russell RB, Gavin AC, Bork P, Serrano L. (2009)

Impact of genome reduction on bacterial metabolism and its regulation

Science 326(5957):1263-1268. doi:10.1126/science.1177263
Europe PMC | doi


2008

Gavin AC, Aebersold R, Heck AJ. (2008)

Meeting report on the 7th World Congress of the Human Proteome Organization (HUPO) in Amsterdam: Proteome Biology

Mol. Cell Proteomics 7(11):2288-2291. doi:10.1074/mcp.h800011-mcp200
Europe PMC | doi

Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P. (2008)

Drug target identification using side-effect similarity

Science 321(5886):263-266. doi:10.1126/science.1158140
Europe PMC | doi

Bader S, Kühner S, Gavin AC. (2008)

Interaction networks for systems biology

Paper presented at the Conference on Targeting and Tinkering with Interaction Networks, Barcelona, SPAIN, APR 14-16, 2008. FEBS Lett. 582(8):1220-1224. doi:10.1016/j.febslet.2008.02.015
Europe PMC | doi

Charbonnier S, Gallego O, Gavin AC. (2008)

The social network of a cell: recent advances in interactome mapping

Biotechnol Annu Rev 14:1-28. doi:10.1016/s1387-2656(08)00001-x
Europe PMC | doi


2007

Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H. (2007)

The minimum information required for reporting a molecular interaction experiment (MIMIx)

Nat. Biotechnol. 25(8):894-898. doi:10.1038/nbt1324
Europe PMC | doi

Kühner S, Gavin AC. (2007)

Towards quantitative analysis of proteome dynamics

Nat. Biotechnol. 25(3):298-300. doi:10.1038/nbt0307-298
Europe PMC | doi

Gallego O, Gavin AC. (2007)

New perspectives on an old disease: proteomics in cancer research

Genome Biol. 8(4):303. doi:10.1186/gb-2007-8-4-303
Europe PMC | doi


2006

Cheusova T, Khan MA, Schubert SW, Gavin AC, Buchou T, Jacob G, Sticht H, Allende J, Boldyreff B, Brenner HR, Hashemolhosseini S. (2006)

Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction

Genes Dev. 20(13):1800-1816. doi:10.1101/gad.375206
Europe PMC | doi

Gavin AC, Aloy P, Grandi P, Krause R, Boesche M, Marzioch M, Rau C, Jensen LJ, Bastuck S, Dümpelfeld B, Edelmann A, Heurtier MA, Hoffman V, Hoefert C, Klein K, Hudak M, Michon AM, Schelder M, Schirle M, Remor M, Rudi T, Hooper S, Bauer A, Bouwmeester T, Casari G, Drewes G, Neubauer G, Rick JM, Kuster B, Bork P, Russell RB, Superti-Furga G. (2006)

Proteome survey reveals modularity of the yeast cell machinery

Nature 440(7084):631-636. doi:10.1038/nature04532
Europe PMC | doi

Gavin AC, Heck A. (2006)

Expanding the frontiers in proteomics

Drug Discov Today Technol 3(3):315-316. doi:10.1016/j.ddtec.2006.09.016
Europe PMC | doi

Gavin A-C, Hopf C. (2006)

Protein co-membership and biochemical affinity purifications

Drug Discov Today Technol 3(3):325-330. doi:10.1016/j.ddtec.2006.07.001
Europe PMC | doi


2005

Gavin AC. (2005)

Keystone symposia: proteomics and bioinformatics and systems and biology

Expert Rev Proteomics 2(3):291-293. doi:10.1586/14789450.2.3.291
Europe PMC | doi


2004

Aloy P, Böttcher B, Ceulemans H, Leutwein C, Mellwig C, Fischer S, Gavin AC, Bork P, Superti-Furga G, Serrano L, Russell RB. (2004)

Structure-based assembly of protein complexes in yeast

Science 303(5666):2026-2029. doi:10.1126/science.1092645
Europe PMC | doi

Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G. (2004)

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

Nat. Cell Biol. 6(2):97-105. doi:10.1038/ncb1086
Europe PMC | doi


2003

Gavin AC, Superti-Furga G. (2003)

Protein complexes and proteome organization from yeast to man

Curr Opin Chem Biol 7(1):21-27. doi:10.1016/s1367-5931(02)00007-8
Europe PMC | doi


2002

Aloy P, Ciccarelli FD, Leutwein C, Gavin AC, Superti-Furga G, Bork P, Bottcher B, Russell RB. (2002)

A complex prediction: three-dimensional model of the yeast exosome

EMBO Rep. 3(7):628-635. doi:10.1093/embo-reports/kvf135
Europe PMC | doi

Grandi P, Rybin V, Bassler J, Petfalski E, Strauss D, Marzioch M, Schäfer T, Kuster B, Tschochner H, Tollervey D, Gavin AC, Hurt E. (2002)

90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors

Mol. Cell 10(1):105-115. doi:10.1016/s1097-2765(02)00579-8
Europe PMC | doi

Gavin AC, Bösche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Höfert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G. (2002)

Functional organization of the yeast proteome by systematic analysis of protein complexes

Nature 415(6868):141-147. doi:10.1038/415141a
Europe PMC | doi


1999

Nebreda AR, Gavin AC. (1999)

Perspectives: signal transduction. Cell survival demands some Rsk

Science 286(5443):1309-1310. doi:10.1126/science.286.5443.1309
Europe PMC | doi

Gavin AC, Ni Ainle A, Chierici E, Jones M, Nebreda AR. (1999)

A p90(rsk) mutant constitutively interacting with MAP kinase uncouples MAP kinase from p34(cdc2)/cyclin B activation in Xenopus oocytes

Mol. Biol. Cell 10(9):2971-2986. doi:10.1091/mbc.10.9.2971
Europe PMC | doi

Gavin AC, Nebreda AR. (1999)

A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1

Curr. Biol. 9(5):281-284. doi:10.1016/s0960-9822(99)80120-1
Europe PMC | doi

Dorey K, Barilá D, Gavin AC, Nebreda AR, Superti-Furga G. (1999)

Regulation of human c-Abl tyrosine kinase activity in Xenopus oocytes and acceleration of progesterone-induced G2/M transition by oncogenic forms

Biol. Chem. 380(2):223-230. doi:10.1515/bc.1999.030
Europe PMC | doi


1998

Palmer A, Gavin AC, Nebreda AR. (1998)

A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1

EMBO J. 17(17):5037-5047. doi:10.1093/emboj/17.17.5037
Europe PMC | doi


1997

Gavin AC, Schorderet-Slatkine S. (1997)

Ribosomal S6 kinase p90rsk and mRNA cap-binding protein eIF4E phosphorylations correlate with MAP kinase activation during meiotic reinitiation of mouse oocytes

Mol. Reprod. Dev. 46(3):383-391. doi:10.1002/(sici)1098-2795(199703)46:33.3.co;2-m
Europe PMC | doi


1996

de Vant'ery C, Gavin AC, Vassalli JD, Schorderet-Slatkine S. (1996)

An accumulation of p34cdc2 at the end of mouse oocyte growth correlates with the acquisition of meiotic competence

Dev. Biol. 174(2):335-344. doi:10.1006/dbio.1996.0078
Europe PMC | doi


1994

Gavin AC, Cavadore JC, Schorderet-Slatkine S. (1994)

Histone H1 kinase activity, germinal vesicle breakdown and M phase entry in mouse oocytes

J. Cell. Sci. 107 ( Pt 1):275-283.
Europe PMC


1992

Gavin AC, Vassalli JD, Cavadore JC, Schorderet-Slatkine S. (1992)

Okadaic acid and p13suc1 modulate the reinitiation of meiosis in mouse oocytes

Mol. Reprod. Dev. 33(3):287-296. doi:10.1002/mrd.1080330309
Europe PMC | doi


1991

Gavin AC, Tsukitani Y, Schorderet-Slatkine S. (1991)

Induction of M-phase entry of prophase-blocked mouse oocytes through microinjection of okadaic acid, a specific phosphatase inhibitor

Exp. Cell Res. 192(1):75-81. doi:10.1016/0014-4827(91)90159-r
Europe PMC | doi


1988

Gavin AC, Schorderet-Slatkine S. (1988)

The interaction of lithium with forskolin-inhibited meiotic maturation of denuded mouse oocytes

Exp. Cell Res. 179(1):298-302. doi:10.1016/0014-4827(88)90369-2
Europe PMC | doi