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Staff at EMBL

Dr. Anne-Claude Gavin

Group Leader and Senior Scientist
Gavin Group Joint appointment: Genome Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 1992, University of Geneva.
Postdoctoral research at EMBL.
Director, Molecular and Cell Biology, Cellzome AG, Heidelberg.
Group leader at EMBL since 2005.
Senior scientist since 2011.
Elected EMBO Member since 2013.
Group leader in the Molecular Medicine Partnership Unit.


A generic protocol for the purification and characterization of water-soluble complexes of affinity-tagged proteins and lipids. Maeda, K., Poletto, M., Chiapparino, A. & Gavin, A.C. Nat Protoc. 2014 Sep;9(9):2256-2266. doi: 10.1038/nprot.2014.148. Epub 2014 Aug28. Europe PMC

A quantitative liposome microarray to systematically characterize protein-lipid interactions. Saliba, A.E., Vonkova, I., Ceschia, S., Findlay, G.M., Maeda, K., Tischer, C., Deghou, S., van Noort, V., Bork, P., Pawson, T., Ellenberg, J. & Gavin, A.C. Nat Methods. 2014 Jan;11(1):47-50. doi: 10.1038/nmeth.2734. Epub 2013 Nov 24. Europe PMC

Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Maeda, K., Anand, K., Chiapparino, A., Kumar, A., Poletto, M., Kaksonen, M. & Gavin, A.C. Nature. 2013 Sep 12;501(7466):257-61. doi: 10.1038/nature12430. Epub 2013 Aug 11. Europe PMC

Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC. Taylor, N.M., Glatt, S., Hennrich, M.L., von Scheven, G., Grotsch, H., Fernandez-Tornero, C., Rybin, V., Gavin, A.C., Kolb, P. & Muller, C.W. J Biol Chem. 2013 May 24;288(21):15110-20. doi: 10.1074/jbc.M112.427856. Epub2013 Apr 8. Europe PMC

Detection and characterization of protein interactions in vivo by a simple live-cell imaging method. Gallego, O., Specht, T., Brach, T., Kumar, A., Gavin, A.C. & Kaksonen, M. PLoS One. 2013 May 1;8(5):e62195. doi: 10.1371/journal.pone.0062195. Print 2013. Europe PMC

Systematic identification of proteins that elicit drug side effects. Kuhn, M., Al Banchaabouchi, M., Campillos, M., Jensen, L.J., Gross, C., Gavin, A.C. & Bork, P. Mol Syst Biol. 2013;9:663. doi: 10.1038/msb.2013.10. Europe PMC

Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding. Iskar, M., Zeller, G., Blattmann, P., Campillos, M., Kuhn, M., Kaminska, K.H., Runz, H., Gavin, A.C., Pepperkok, R., van Noort, V. & Bork, P. Mol Syst Biol. 2013;9:662. doi: 10.1038/msb.2013.20. Europe PMC

In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids. Haberkant, P., Raijmakers, R., Wildwater, M., Sachsenheimer, T., Brugger, B., Maeda, K., Houweling, M., Gavin, A.C., Schultz, C., van Meer, G., Heck, A.J. & Holthuis, J.C. Angew Chem Int Ed Engl. 2013 Apr 2;52(14):4033-8. doi: 10.1002/anie.201210178.Epub 2013 Feb 28. Europe PMC

Network Biology editorial 2013. Marcotte, E., Boone, C., Babu, M.M. & Gavin, A.C. Mol Biosyst. 2013 Jul 4;9(7):1557-8. doi: 10.1039/c3mb90018e. Epub 2013 May 28. Europe PMC

Cell type-specific chromatin immunoprecipitation from multicellular complex samples using BiTS-ChIP. Bonn, S., Zinzen, R.P., Perez-Gonzalez, A., Riddell, A., Gavin, A.C. & Furlong, E.E. Nat Protoc. 2012 Apr 26;7(5):978-94. doi: 10.1038/nprot.2012.049. Europe PMC

Transcription start site associated RNAs in bacteria. Yus, E., Guell, M., Vivancos, A.P., Chen, W.H., Lluch-Senar, M., Delgado, J., Gavin, A.C., Bork, P. & Serrano, L. Mol Syst Biol. 2012 May 22;8:585. doi: 10.1038/msb.2012.16. Europe PMC

Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium. van Noort, V., Seebacher, J., Bader, S., Mohammed, S., Vonkova, I., Betts, M.J., Kuhner, S., Kumar, R., Maier, T., O'Flaherty, M., Rybin, V., Schmeisky, A., Yus, E., Stulke, J., Serrano, L., Russell, R.B., Heck, A.J., Bork, P. & Gavin, A.C. Mol Syst Biol. 2012 Feb 28;8:571. doi: 10.1038/msb.2012.4. Europe PMC

Deciphering a global network of functionally associated post-translational modifications. Minguez, P., Parca, L., Diella, F., Mende, D.R., Kumar, R., Helmer-Citterich, M., Gavin, A.C., van Noort, V. & Bork, P. Mol Syst Biol. 2012 Jul 17;8:599. doi: 10.1038/msb.2012.31. Europe PMC

Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. Anand, K., Maeda, K. & Gavin, A.C. PLoS One. 2012;7(5):e36526. Epub 2012 May 4. Europe PMC

Quantification of mRNA and protein and integration with protein turnover in a bacterium. Maier, T., Schmidt, A., Guell, M., Kuhner, S., Gavin, A.C., Aebersold, R. & Serrano, L. Mol Syst Biol. 2011 Jul 19;7:511. doi: 10.1038/msb.2011.38. Europe PMC

SnapShot: Protein-Protein Interaction Networks. Seebacher, J. & Gavin, A.C. Cell. 2011 Mar 18;144(6):1000-1000.e1. Europe PMC

Recent advances in charting protein-protein interaction: mass spectrometry-based approaches. Gavin, A.C., Maeda, K. & Kuhner, S. Curr Opin Biotechnol. 2011 Feb;22(1):42-9. doi: 10.1016/j.copbio.2010.09.007.Epub 2010 Oct 9. Europe PMC

Mass Spectrometry Reveals Stable Modules in holo and apo RNA Polymerases I and III. Lane, L.A., Fernandez-Tornero, C., Zhou, M., Morgner, N., Ptchelkine, D., Steuerwald, U., Politis, A., Lindner, D., Gvozdenovic, J., Gavin, A.C., Muller, C.W. & Robinson, C.V. Structure. 2011 Jan 12;19(1):90-100. Europe PMC

A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Gallego, O., Betts, M.J., Gvozdenovic-Jeremic, J., Maeda, K., Matetzki, C., Aguilar-Gurrieri, C., Beltran-Alvarez, P., Bonn, S., Fernandez-Tornero, C., Jensen, L.J., Kuhn, M., Trott, J., Rybin, V., Muller, C.W., Bork, P., Kaksonen, M., Russell, R.B. & Gavin, A.C. Mol Syst Biol. 2010 Nov 30;6:430. doi: 10.1038/msb.2010.87. Europe PMC

3rd US-EU workshop: systems level understanding of DNA damage responses. Sander, M., Begley, T.J., Desaintes, C., Gavin, A.C., Pelroy, R., Pothof, J., Shiloh, Y., van Gent, D., Van Houten, B., Yaffe, M. & Mullenders, L. Mutat Res. 2010 Oct 13;692(1-2):53-60. Epub 2010 Aug 19. Europe PMC

Visualizing biological data - now and in the future. O'Donoghue, S.I., Gavin, A.C., Gehlenborg, N., Goodsell, D.S., Heriche, J.K., Nielsen, C.B., North, C., Olson, A.J., Procter, J.B., Shattuck, D.W., Walter, T. & Wong, B. Nat Methods. 2010 Mar;7(3 Suppl):S2-4. Europe PMC

Visualization of omics data for systems biology. Gehlenborg, N., O'Donoghue, S.I., Baliga, N.S., Goesmann, A., Hibbs, M.A., Kitano, H., Kohlbacher, O., Neuweger, H., Schneider, R., Tenenbaum, D. & Gavin, A.C. Nat Methods. 2010 Mar;7(3 Suppl):S56-68. Europe PMC

Impact of genome reduction on bacterial metabolism and its regulation. Yus, E., Maier, T., Michalodimitrakis, K., van Noort, V., Yamada, T., Chen, W.H., Wodke, J.A., Guell, M., Martinez, S., Bourgeois, R., Kuhner, S., Raineri, E., Letunic, I., Kalinina, O.V., Rode, M., Herrmann, R., Gutierrez-Gallego, R., Russell, R.B., Gavin, A.C., Bork, P. & Serrano, L. Science. 2009 Nov 27;326(5957):1263-8. Europe PMC

Transcriptome complexity in a genome-reduced bacterium. Guell, M., van Noort, V., Yus, E., Chen, W.H., Leigh-Bell, J., Michalodimitrakis, K., Yamada, T., Arumugam, M., Doerks, T., Kuhner, S., Rode, M., Suyama, M., Schmidt, S., Gavin, A.C., Bork, P. & Serrano, L. Science. 2009 Nov 27;326(5957):1268-71. Europe PMC

Proteome organization in a genome-reduced bacterium. Kuhner, S., van Noort, V., Betts, M.J., Leo-Macias, A., Batisse, C., Rode, M., Yamada, T., Maier, T., Bader, S., Beltran-Alvarez, P., Castano-Diez, D., Chen, W.H., Devos, D., Guell, M., Norambuena, T., Racke, I., Rybin, V., Schmidt, A., Yus, E., Aebersold, R., Herrmann, R., Bottcher, B., Frangakis, A.S., Russell, R.B., Serrano, L., Bork, P. & Gavin, A.C. Science. 2009 Nov 27;326(5957):1235-40. doi: 10.1126/science.1176343.
Full text Europe PMC

Meeting report on the 7th World Congress of the Human Proteome Organization (HUPO) in Amsterdam: Proteome Biology. Gavin, A.C., Aebersold, R. & Heck, A.J. Mol Cell Proteomics. 2008 Nov;7(11):2288-91. Europe PMC

Drug target identification using side-effect similarity. Campillos, M., Kuhn, M., Gavin, A.C., Jensen, L.J. & Bork, P. Science. 2008 Jul 11;321(5886):263-6. Europe PMC

Interaction networks for systems biology. Bader, S., Kuhner, S. & Gavin, A.C. FEBS Lett. 2008 Apr 9;582(8):1220-4. Epub 2008 Feb 20. Europe PMC

The social network of a cell: Recent advances in interactome mapping. Charbonnier, S., Gallego, O. & Gavin, A.C. Biotechnol Annu Rev. 2008;14:1-28. Europe PMC

The minimum information required for reporting a molecular interaction experiment (MIMIx). Orchard, S., Salwinski, L., Kerrien, S., Montecchi-Palazzi, L., Oesterheld, M., Stumpflen, V., Ceol, A., Chatr-Aryamontri, A., Armstrong, J., Woollard, P., Salama, J.J., Moore, S., Wojcik, J., Bader, G.D., Vidal, M., Cusick, M.E., Gerstein, M., Gavin, A.C., Superti-Furga, G., Greenblatt, J., Bader, J., Uetz, P., Tyers, M., Legrain, P., Fields, S., Mulder, N., Gilson, M., Niepmann, M., Burgoon, L., Rivas Jde, L., Prieto, C., Perreau, V.M., Hogue, C., Mewes, H.W., Apweiler, R., Xenarios, I., Eisenberg, D., Cesareni, G. & Hermjakob, H. Nat Biotechnol. 2007 Aug;25(8):894-8. Europe PMC

New perspectives on an old disease: proteomics in cancer research. Gallego, O. & Gavin, A.C. Genome Biol. 2007 Apr 30;8(4):303. Europe PMC

Towards quantitative analysis of proteome dynamics. Kuhner, S. & Gavin, A.C. Nat Biotechnol. 2007 Mar;25(3):298-300. Europe PMC

Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Cheusova, T., Khan, M.A., Schubert, S.W., Gavin, A.C., Buchou, T., Jacob, G., Sticht, H., Allende, J., Boldyreff, B., Brenner, H.R. & Hashemolhosseini, S. Genes Dev. 2006 Jul 1;20(13):1800-16. Europe PMC

Proteome survey reveals modularity of the yeast cell machinery. Gavin, A.C., Aloy, P., Grandi, P., Krause, R., Boesche, M., Marzioch, M., Rau, C., Jensen, L.J., Bastuck, S., Dumpelfeld, B., Edelmann, A., Heurtier, M.A., Hoffman, V., Hoefert, C., Klein, K., Hudak, M., Michon, A.M., Schelder, M., Schirle, M., Remor, M., Rudi, T., Hooper, S., Bauer, A., Bouwmeester, T., Casari, G., Drewes, G., Neubauer, G., Rick, J.M., Kuster, B., Bork, P., Russell, R.B. & Superti-Furga, G. Nature. 2006 Mar 30;440(7084):631-6. Epub 2006 Jan 22. Europe PMC

Protein co-membership and biochemical affinity purifications. Gavin, A.C. & Hopf, C. Drug Discovery Today: Technology 2006

Expanding the frontiers of proteomics. Gavin, A.C. & Heck, A. Drug Discovery Today: Technology 2006

Keystone symposia: proteomics and bioinformatics and systems and biology. Gavin, A.C. Expert Rev Proteomics. 2005 Jun;2(3):291-3. Europe PMC

Structure-based assembly of protein complexes in yeast. Aloy, P., Böttcher, B., Ceulemans, H., Leutwein, C., Mellwig, C., Fischer, S., Gavin, A.C., Bork, P., Superti-Furga, G., Serrano, L. & Russell, R.B. Science 2004 Mar 26;303(5666):2026-9. Europe PMC

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Bouwmeester, T., Bauch, A., Ruffner, H., Angrand, P.O., Bergamini, G., Croughton, K., Cruciat, C., Eberhard, D., Gagneur, J., Ghidelli, S., Hopf, C., Huhse, B., Mangano, R., Michon, A.M., Schirle, M., Schlegl, J., Schwab, M., Stein, M.A., Bauer, A., Casari, G., Drewes, G., Gavin, A.C., Jackson, D.B., Joberty, G., Neubauer, G., Rick, J., Kuster, B. & Superti-Furga, G. Nat Cell Biol 2004 Feb;6(2):97-105. Epub 2004 Jan 25. Europe PMC

Protein complexes and proteome organization from yeast to man. Gavin, A.C. & Superti-Furga, G. Curr Opin Chem Biol 2003 Feb;7(1):21-7. Europe PMC

90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Grandi, P., Rybin, V., Bassler, J., Petfalski, E., Strauss, D., Marzioch, M., Schafer, T., Kuster, B., Tschochner, H., Tollervey, D., Gavin, A.C. & Hurt, E. Mol Cell 2002 Jul;10(1):105-15. Europe PMC

A complex prediction: three-dimensional model of the yeast exosome. Aloy, P., Ciccarelli, F.D., Leutwein, C., Gavin, A.C., Superti-Furga, G., Bork, P., Böttcher, B. & Russell, R.B. EMBO Rep 2002 Jul;3(7):628-35. Europe PMC

Functional organization of the yeast proteome by systematic analysis of protein complexes. Gavin, A.C., Bosche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J.M., Michon, A.M., Cruciat, C.M., Remor, M., Hofert, C., Schelder, M., Brajenovic, M., Ruffner, H., Merino, A., Klein, K., Hudak, M., Dickson, D., Rudi, T., Gnau, V., Bauch, A., Bastuck, S., Huhse, B., Leutwein, C., Heurtier, M.A., Copley, R.R., Edelmann, A., Querfurth, E., Rybin, V., Drewes, G., Raida, M., Bouwmeester, T., Bork, P., Seraphin, B., Kuster, B., Neubauer, G. & Superti-Furga, G. Nature 2002 Jan 10;415(6868):141-7. Europe PMC

Perspectives: signal transduction. Cell survival demands some Rsk. Nebreda, A.R. & Gavin, A.C. Science. 1999 Nov 12;286(5443):1309-10. Europe PMC

A p90(rsk) mutant constitutively interacting with MAP kinase uncouples MAP kinase from p34(cdc2)/cyclin B activation in Xenopus oocytes. Gavin, A.C., Ni Ainle, A., Chierici, E., Jones, M. & Nebreda, A.R. Mol Biol Cell 1999 Sep;10(9):2971-86. Europe PMC

A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1. Gavin, A.C. & Nebreda, A.R. Curr Biol 1999 Mar 11;9(5):281-4. Europe PMC

Regulation of human c-Abl tyrosine kinase activity in Xenopus oocytes and acceleration of progesterone-induced G2/M transition by oncogenic forms. Dorey, K., Barila, D., Gavin, A.C., Nebreda, A.R. & Superti-Furga, G. Biol Chem. 1999 Feb;380(2):223-30. Europe PMC

A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1. Palmer, A., Gavin, A.C. & Nebreda, A.R. EMBO J 1998 Sep 1;17(17):5037-47. Europe PMC

Ribosomal S6 kinase p90rsk and mRNA cap-binding protein eIF4E phosphorylations correlate with MAP kinase activation during meiotic reinitiation of mouse oocytes. Gavin, A.C. & Schorderet-Slatkine, S. Mol Reprod Dev 1997 Mar;46(3):383-91. Europe PMC

An accumulation of p34cdc2 at the end of mouse oocyte growth correlates with the acquisition of meiotic competence. de Vant'ery, C., Gavin, A.C., Vassalli, J.D. & Schorderet-Slatkine, S. Dev Biol 1996 Mar 15;174(2):335-44. Europe PMC

Histone H1 kinase activity, germinal vesicle breakdown and M phase entry in mouse oocytes. Gavin, A.C., Cavadore, J.C. & Schorderet-Slatkine, S. J Cell Sci 1994 Jan;107 ( Pt 1):275-83. Europe PMC

Okadaic acid and p13suc1 modulate the reinitiation of meiosis in mouse oocytes. Gavin, A.C., Vassalli, J.D., Cavadore, J.C. & Schorderet-Slatkine, S. Mol Reprod Dev 1992 Nov;33(3):287-96. Europe PMC

Induction of M-phase entry of prophase-blocked mouse oocytes through microinjection of okadaic acid, a specific phosphatase inhibitor. Gavin, A.C., Tsukitani, Y. & Schorderet-Slatkine, S. Exp Cell Res 1991 Jan;192(1):75-81. Europe PMC

The interaction of lithium with forskolin-inhibited meiotic maturation of denuded mouse oocytes. Gavin, A.C. & Schorderet-Slatkine, S. Exp Cell Res 1988 Nov;179(1):298-302. Europe PMC