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Staff at EMBL

CP-60003358

Dr. Anne-Claude Gavin

Group Leader and Senior Scientist
Gavin Group Joint appointment: Genome Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Biography

PhD 1992, University of Geneva.
Postdoctoral research at EMBL.
Director, Molecular and Cell Biology, Cellzome AG, Heidelberg.
Group leader at EMBL since 2005.
Senior scientist since 2011.
Elected EMBO Member since 2013.
Group leader in the Molecular Medicine Partnership Unit.

Publications

Total: 54 publication(s)

2014

Maeda K, Poletto M, Chiapparino A, Gavin AC. (2014)
A generic protocol for the purification and characterization of water-soluble complexes of affinity-tagged proteins and lipids
Nat Protoc 9(9):2256-2266. doi:10.1038/nprot.2014.148
Europe PMC | doi

Saliba AE, Vonkova I, Ceschia S, Findlay GM, Maeda K, Tischer C, Deghou S, van Noort V, Bork P, Pawson T, Ellenberg J, Gavin AC. (2014)
A quantitative liposome microarray to systematically characterize protein-lipid interactions
Nat. Methods 11(1):47-50. doi:10.1038/nmeth.2734
Europe PMC | doi


2013

Maeda K, Anand K, Chiapparino A, Kumar A, Poletto M, Kaksonen M, Gavin AC. (2013)
Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins
Nature 501(7466):257-261. doi:10.1038/nature12430
Europe PMC | doi

Marcotte E, Boone C, Babu MM, Gavin AC. (2013)
Network Biology editorial 2013
Mol Biosyst 9(7):1557-1558. doi:10.1039/c3mb90018e
Europe PMC | doi

Taylor NM, Glatt S, Hennrich ML, von Scheven G, Grötsch H, Fernández-Tornero C, Rybin V, Gavin AC, Kolb P, Müller CW. (2013)
Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC
J. Biol. Chem. 288(21):15110-15120. doi:10.1074/jbc.m112.427856
Europe PMC | doi

Haberkant P, Raijmakers R, Wildwater M, Sachsenheimer T, Brügger B, Maeda K, Houweling M, Gavin AC, Schultz C, van Meer G, Heck AJ, Holthuis JC. (2013)
In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids
Angew. Chem. Int. Ed. Engl. 52(14):4033-4038. doi:10.1002/anie.201210178
Europe PMC | doi

Iskar M, Zeller G, Blattmann P, Campillos M, Kuhn M, Kaminska KH, Runz H, Gavin AC, Pepperkok R, van Noort V, Bork P. (2013)
Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding
Mol. Syst. Biol. 9:662. doi:10.1038/msb.2013.20
Europe PMC | doi

Gallego O, Specht T, Brach T, Kumar A, Gavin AC, Kaksonen M. (2013)
Detection and characterization of protein interactions in vivo by a simple live-cell imaging method
PLoS ONE 8(5):e62195. doi:10.1371/journal.pone.0062195
Europe PMC | doi

Kuhn M, Al Banchaabouchi M, Campillos M, Jensen LJ, Gross C, Gavin AC, Bork P. (2013)
Systematic identification of proteins that elicit drug side effects
Mol. Syst. Biol. 9:663. doi:10.1038/msb.2013.10
Europe PMC | doi


2012

Bonn S, Zinzen RP, Perez-Gonzalez A, Riddell A, Gavin AC, Furlong EE. (2012)
Cell type-specific chromatin immunoprecipitation from multicellular complex samples using BiTS-ChIP
Nat Protoc 7(5):978-994. doi:10.1038/nprot.2012.049
Europe PMC | doi

van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC. (2012)
Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium
Mol. Syst. Biol. 8:571. doi:10.1038/msb.2012.4
Europe PMC | doi

Minguez P, Parca L, Diella F, Mende DR, Kumar R, Helmer-Citterich M, Gavin AC, van Noort V, Bork P. (2012)
Deciphering a global network of functionally associated post-translational modifications
Mol. Syst. Biol. 8:599. doi:10.1038/msb.2012.31
Europe PMC | doi

Anand K, Maeda K, Gavin AC. (2012)
Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site
PLoS ONE 7(5):e36526. doi:10.1371/journal.pone.0036526
Europe PMC | doi

Yus E, Güell M, Vivancos AP, Chen WH, Lluch-Senar M, Delgado J, Gavin AC, Bork P, Serrano L. (2012)
Transcription start site associated RNAs in bacteria
Mol. Syst. Biol. 8:585. doi:10.1038/msb.2012.16
Europe PMC | doi


2011

Seebacher J, Gavin AC. (2011)
SnapShot: Protein-protein interaction networks
Cell 144(6):1000, 1000.e1. doi:10.1016/j.cell.2011.02.025
Europe PMC | doi

Gavin AC, Maeda K, Kühner S. (2011)
Recent advances in charting protein-protein interaction: mass spectrometry-based approaches
Curr. Opin. Biotechnol. 22(1):42-49. doi:10.1016/j.copbio.2010.09.007
Europe PMC | doi

Lane LA, Fernández-Tornero C, Zhou M, Morgner N, Ptchelkine D, Steuerwald U, Politis A, Lindner D, Gvozdenovic J, Gavin AC, Müller CW, Robinson CV. (2011)
Mass spectrometry reveals stable modules in holo and apo RNA polymerases I and III
Structure 19(1):90-100. doi:10.1016/j.str.2010.11.009
Europe PMC | doi

Maier T, Schmidt A, Güell M, Kühner S, Gavin AC, Aebersold R, Serrano L. (2011)
Quantification of mRNA and protein and integration with protein turnover in a bacterium
Mol. Syst. Biol. 7:511. doi:10.1038/msb.2011.38
Europe PMC | doi


2010

Gallego O, Betts MJ, Gvozdenovic-Jeremic J, Maeda K, Matetzki C, Aguilar-Gurrieri C, Beltran-Alvarez P, Bonn S, Fernández-Tornero C, Jensen LJ, Kuhn M, Trott J, Rybin V, Müller CW, Bork P, Kaksonen M, Russell RB, Gavin AC. (2010)
A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae
Mol. Syst. Biol. 6:430. doi:10.1038/msb.2010.87
Europe PMC | doi

Sander M, Begley TJ, Desaintes C, Gavin AC, Pelroy R, Pothof J, Shiloh Y, van Gent D, Van Houten B, Yaffe M, Mullenders L. (2010)
3rd US-EU workshop: systems level understanding of DNA damage responses
Mutat. Res. 692(1-2):53-60. doi:10.1016/j.mrfmmm.2010.07.012
Europe PMC | doi

Gehlenborg N, O'Donoghue SI, Baliga NS, Goesmann A, Hibbs MA, Kitano H, Kohlbacher O, Neuweger H, Schneider R, Tenenbaum D, Gavin AC. (2010)
Visualization of omics data for systems biology
Nat. Methods 7(3 Suppl):S56-68. doi:10.1038/nmeth.1436
Europe PMC | doi

O'Donoghue SI, Gavin AC, Gehlenborg N, Goodsell DS, Hériché JK, Nielsen CB, North C, Olson AJ, Procter JB, Shattuck DW, Walter T, Wong B. (2010)
Visualizing biological data-now and in the future
Nat. Methods 7(3 Suppl):S2-4. doi:10.1038/nmeth.f.301
Europe PMC | doi


2009

Yus E, Maier T, Michalodimitrakis K, van Noort V, Yamada T, Chen WH, Wodke JA, Güell M, Martínez S, Bourgeois R, Kühner S, Raineri E, Letunic I, Kalinina OV, Rode M, Herrmann R, Gutiérrez-Gallego R, Russell RB, Gavin AC, Bork P, Serrano L. (2009)
Impact of genome reduction on bacterial metabolism and its regulation
Science 326(5957):1263-1268. doi:10.1126/science.1177263
Europe PMC | doi

Kühner S, van Noort V, Betts MJ, Leo-Macias A, Batisse C, Rode M, Yamada T, Maier T, Bader S, Beltran-Alvarez P, Castaño-Diez D, Chen WH, Devos D, Güell M, Norambuena T, Racke I, Rybin V, Schmidt A, Yus E, Aebersold R, Herrmann R, Böttcher B, Frangakis AS, Russell RB, Serrano L, Bork P, Gavin AC. (2009)
Proteome organization in a genome-reduced bacterium
Science 326(5957):1235-1240. doi:10.1126/science.1176343
Europe PMC | doi

Güell M, van Noort V, Yus E, Chen WH, Leigh-Bell J, Michalodimitrakis K, Yamada T, Arumugam M, Doerks T, Kühner S, Rode M, Suyama M, Schmidt S, Gavin AC, Bork P, Serrano L. (2009)
Transcriptome complexity in a genome-reduced bacterium
Science 326(5957):1268-1271. doi:10.1126/science.1176951
Europe PMC | doi


2008

Gavin AC, Aebersold R, Heck AJ. (2008)
Meeting report on the 7th World Congress of the Human Proteome Organization (HUPO) in Amsterdam: Proteome Biology
Mol. Cell Proteomics 7(11):2288-2291. doi:10.1074/mcp.h800011-mcp200
Europe PMC | doi

Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P. (2008)
Drug target identification using side-effect similarity
Science 321(5886):263-266. doi:10.1126/science.1158140
Europe PMC | doi

Bader S, Kühner S, Gavin AC. (2008)
Interaction networks for systems biology
Paper presented at the Conference on Targeting and Tinkering with Interaction Networks, Barcelona, SPAIN, APR 14-16, 2008.FEBS Lett. 582(8):1220-1224. doi:10.1016/j.febslet.2008.02.015
Europe PMC | doi

Charbonnier S, Gallego O, Gavin AC. (2008)
The social network of a cell: recent advances in interactome mapping
Biotechnol Annu Rev 14:1-28. doi:10.1016/s1387-2656(08)00001-x
Europe PMC | doi


2007

Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H. (2007)
The minimum information required for reporting a molecular interaction experiment (MIMIx)
Nat. Biotechnol. 25(8):894-898. doi:10.1038/nbt1324
Europe PMC | doi

Kühner S, Gavin AC. (2007)
Towards quantitative analysis of proteome dynamics
Nat. Biotechnol. 25(3):298-300. doi:10.1038/nbt0307-298
Europe PMC | doi

Gallego O, Gavin AC. (2007)
New perspectives on an old disease: proteomics in cancer research
Genome Biol. 8(4):303. doi:10.1186/gb-2007-8-4-303
Europe PMC | doi


2006

Cheusova T, Khan MA, Schubert SW, Gavin AC, Buchou T, Jacob G, Sticht H, Allende J, Boldyreff B, Brenner HR, Hashemolhosseini S. (2006)
Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction
Genes Dev. 20(13):1800-1816. doi:10.1101/gad.375206
Europe PMC | doi

Gavin AC, Aloy P, Grandi P, Krause R, Boesche M, Marzioch M, Rau C, Jensen LJ, Bastuck S, Dümpelfeld B, Edelmann A, Heurtier MA, Hoffman V, Hoefert C, Klein K, Hudak M, Michon AM, Schelder M, Schirle M, Remor M, Rudi T, Hooper S, Bauer A, Bouwmeester T, Casari G, Drewes G, Neubauer G, Rick JM, Kuster B, Bork P, Russell RB, Superti-Furga G. (2006)
Proteome survey reveals modularity of the yeast cell machinery
Nature 440(7084):631-636. doi:10.1038/nature04532
Europe PMC | doi

Gavin AC, Heck A. (2006)
Expanding the frontiers in proteomics
Drug Discov Today Technol 3(3):315-316. doi:10.1016/j.ddtec.2006.09.016
Europe PMC | doi

Gavin A-C, Hopf C. (2006)
Protein co-membership and biochemical affinity purifications
Drug Discov Today Technol 3(3):325-330. doi:10.1016/j.ddtec.2006.07.001
Europe PMC | doi


2005

Gavin AC. (2005)
Keystone symposia: proteomics and bioinformatics and systems and biology
Expert Rev Proteomics 2(3):291-293. doi:10.1586/14789450.2.3.291
Europe PMC | doi


2004

Aloy P, Böttcher B, Ceulemans H, Leutwein C, Mellwig C, Fischer S, Gavin AC, Bork P, Superti-Furga G, Serrano L, Russell RB. (2004)
Structure-based assembly of protein complexes in yeast
Science 303(5666):2026-2029. doi:10.1126/science.1092645
Europe PMC | doi

Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G. (2004)
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
Nat. Cell Biol. 6(2):97-105. doi:10.1038/ncb1086
Europe PMC | doi


2003

Gavin AC, Superti-Furga G. (2003)
Protein complexes and proteome organization from yeast to man
Curr Opin Chem Biol 7(1):21-27. doi:10.1016/s1367-5931(02)00007-8
Europe PMC | doi


2002

Grandi P, Rybin V, Bassler J, Petfalski E, Strauss D, Marzioch M, Schäfer T, Kuster B, Tschochner H, Tollervey D, Gavin AC, Hurt E. (2002)
90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors
Mol. Cell 10(1):105-115. doi:10.1016/s1097-2765(02)00579-8
Europe PMC | doi

Aloy P, Ciccarelli FD, Leutwein C, Gavin AC, Superti-Furga G, Bork P, Bottcher B, Russell RB. (2002)
A complex prediction: three-dimensional model of the yeast exosome
EMBO Rep. 3(7):628-635. doi:10.1093/embo-reports/kvf135
Europe PMC | doi

Gavin AC, Bösche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Höfert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G. (2002)
Functional organization of the yeast proteome by systematic analysis of protein complexes
Nature 415(6868):141-147. doi:10.1038/415141a
Europe PMC | doi


1999

Nebreda AR, Gavin AC. (1999)
Perspectives: signal transduction. Cell survival demands some Rsk
Science 286(5443):1309-1310. doi:10.1126/science.286.5443.1309
Europe PMC | doi

Gavin AC, Ni Ainle A, Chierici E, Jones M, Nebreda AR. (1999)
A p90(rsk) mutant constitutively interacting with MAP kinase uncouples MAP kinase from p34(cdc2)/cyclin B activation in Xenopus oocytes
Mol. Biol. Cell 10(9):2971-2986. doi:10.1091/mbc.10.9.2971
Europe PMC | doi

Gavin AC, Nebreda AR. (1999)
A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1
Curr. Biol. 9(5):281-284. doi:10.1016/s0960-9822(99)80120-1
Europe PMC | doi

Dorey K, Barilá D, Gavin AC, Nebreda AR, Superti-Furga G. (1999)
Regulation of human c-Abl tyrosine kinase activity in Xenopus oocytes and acceleration of progesterone-induced G2/M transition by oncogenic forms
Biol. Chem. 380(2):223-230. doi:10.1515/bc.1999.030
Europe PMC | doi


1998

Palmer A, Gavin AC, Nebreda AR. (1998)
A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1
EMBO J. 17(17):5037-5047. doi:10.1093/emboj/17.17.5037
Europe PMC | doi


1997

Gavin AC, Schorderet-Slatkine S. (1997)
Ribosomal S6 kinase p90rsk and mRNA cap-binding protein eIF4E phosphorylations correlate with MAP kinase activation during meiotic reinitiation of mouse oocytes
Mol. Reprod. Dev. 46(3):383-391. doi:10.1002/(sici)1098-2795(199703)46:33.3.co;2-m
Europe PMC | doi


1996

de Vant'ery C, Gavin AC, Vassalli JD, Schorderet-Slatkine S. (1996)
An accumulation of p34cdc2 at the end of mouse oocyte growth correlates with the acquisition of meiotic competence
Dev. Biol. 174(2):335-344. doi:10.1006/dbio.1996.0078
Europe PMC | doi


1994

Gavin AC, Cavadore JC, Schorderet-Slatkine S. (1994)
Histone H1 kinase activity, germinal vesicle breakdown and M phase entry in mouse oocytes
J. Cell. Sci. 107 ( Pt 1):275-283.
Europe PMC


1992

Gavin AC, Vassalli JD, Cavadore JC, Schorderet-Slatkine S. (1992)
Okadaic acid and p13suc1 modulate the reinitiation of meiosis in mouse oocytes
Mol. Reprod. Dev. 33(3):287-296. doi:10.1002/mrd.1080330309
Europe PMC | doi


1991

Gavin AC, Tsukitani Y, Schorderet-Slatkine S. (1991)
Induction of M-phase entry of prophase-blocked mouse oocytes through microinjection of okadaic acid, a specific phosphatase inhibitor
Exp. Cell Res. 192(1):75-81. doi:10.1016/0014-4827(91)90159-r
Europe PMC | doi


1988

Gavin AC, Schorderet-Slatkine S. (1988)
The interaction of lithium with forskolin-inhibited meiotic maturation of denuded mouse oocytes
Exp. Cell Res. 179(1):298-302. doi:10.1016/0014-4827(88)90369-2
Europe PMC | doi