Staff at EMBL
Dr. Grischa Toedt
Postdoctoral Fellow
Gibson Team
EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
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Publications
A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins. Jiang, K., Toedt, G., Montenegro Gouveia, S., Davey, N.E., Hua, S., van der Vaart, B., Grigoriev, I., Larsen, J., Pedersen, L.B., Bezstarosti, K., Lince-Faria, M., Demmers, J., Steinmetz, M.O., Gibson, T.J. & Akhmanova, A. Curr Biol. 2012 Oct 9;22(19):1800-7. doi: 10.1016/j.cub.2012.07.047. Epub 2012Aug 9. PubMed
Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro. Dittmann, L.M., Danner, A., Gronych, J., Wolter, M., Stuhler, K., Grzendowski, M., Becker, N., Bageritz, J., Goidts, V., Toedt, G., Felsberg, J., Sabel, M.C., Barbus, S., Reifenberger, G., Lichter, P. & Tews, B. Oncogene. 2012 Jul 19;31(29):3409-18. doi: 10.1038/onc.2011.513. Epub 2011 Dec12. PubMed
Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration. Haag, D., Zipper, P., Westrich, V., Karra, D., Pfleger, K., Toedt, G., Blond, F., Delhomme, N., Hahn, M., Reifenberger, J., Reifenberger, G. & Lichter, P. PLoS Genet. 2012 Mar;8(3):e1002572. Epub 2012 Mar 15. PubMed
Attributes of short linear motifs. Davey, N.E., Van Roey, K., Weatheritt, R.J., Toedt, G., Uyar, B., Altenberg, B., Budd, A., Diella, F., Dinkel, H. & Gibson, T.J. Mol Biosyst. 2012 Jan;8(1):268-81. doi: 10.1039/c1mb05231d. Epub 2011 Sep 12. PubMed
ELM--the database of eukaryotic linear motifs. Dinkel, H., Michael, S., Weatheritt, R.J., Davey, N.E., Van Roey, K., Altenberg, B., Toedt, G., Uyar, B., Seiler, M., Budd, A., Jodicke, L., Dammert, M.A., Schroeter, C., Hammer, M., Schmidt, T., Jehl, P., McGuigan, C., Dymecka, M., Chica, C., Luck, K., Via, A., Chatr-Aryamontri, A., Haslam, N., Grebnev, G., Edwards, R.J., Steinmetz, M.O., Meiselbach, H., Diella, F. & Gibson, T.J. Nucleic Acids Res. 2012 Jan 1;40(D1):D242-D251. Epub 2011 Nov 21. PubMed
FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma. Remke, M., Hielscher, T., Korshunov, A., Northcott, P.A., Bender, S., Kool, M., Westermann, F., Benner, A., Cin, H., Ryzhova, M., Sturm, D., Witt, H., Haag, D., Toedt, G., Wittmann, A., Schottler, A., von Bueren, A.O., von Deimling, A., Rutkowski, S., Scheurlen, W., Kulozik, A.E., Taylor, M.D., Lichter, P. & Pfister, S.M. J Clin Oncol. 2011 Oct 10;29(29):3852-61. Epub 2011 Sep 12. PubMed
Molecular signatures classify astrocytic gliomas by IDH1 mutation status. Toedt, G., Barbus, S., Wolter, M., Felsberg, J., Tews, B., Blond, F., Sabel, M.C., Hofmann, S., Becker, N., Hartmann, C., Ohgaki, H., von Deimling, A., Wiestler, O.D., Hahn, M., Lichter, P., Reifenberger, G. & Radlwimmer, B. Int J Cancer. 2011 Mar 1;128(5):1095-103. doi: 10.1002/ijc.25448. PubMed
Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL2. Schulz, A., Toedt, G., Zenz, T., Stilgenbauer, S., Lichter, P. & Seiffert, M. Haematologica. 2011 Mar;96(3):408-16. Epub 2010 Dec 6. PubMed
Elastic SCAD as a novel penalization method for SVM classification tasks in high-dimensional data. Becker, N., Toedt, G., Lichter, P. & Benner, A. BMC Bioinformatics. 2011 May 9;12:138. PubMed
Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain. Stange, D.E., Engel, F., Longerich, T., Koo, B.K., Koch, M., Delhomme, N., Aigner, M., Toedt, G., Schirmacher, P., Lichter, P., Weitz, J. & Radlwimmer, B. Gut. 2010 Sep;59(9):1236-44. Epub 2010 May 17. PubMed
Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma. Freier, K., Knoepfle, K., Flechtenmacher, C., Pungs, S., Devens, F., Toedt, G., Hofele, C., Joos, S., Lichter, P. & Radlwimmer, B. Genes Chromosomes Cancer. 2010 Jan;49(1):9-16. PubMed
High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response. Remke, M., Pfister, S., Kox, C., Toedt, G., Becker, N., Benner, A., Werft, W., Breit, S., Liu, S., Engel, F., Wittmann, A., Zimmermann, M., Stanulla, M., Schrappe, M., Ludwig, W.D., Bartram, C.R., Radlwimmer, B., Muckenthaler, M.U., Lichter, P. & Kulozik, A.E. Blood. 2009 Jul 30;114(5):1053-62. Epub 2009 Apr 30. PubMed
penalizedSVM: a R-package for feature selection SVM classification. Becker, N., Werft, W., Toedt, G., Lichter, P. & Benner, A. Bioinformatics. 2009 Jul 1;25(13):1711-2. Epub 2009 Apr 27. PubMed
Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. Pfister, S., Remke, M., Benner, A., Mendrzyk, F., Toedt, G., Felsberg, J., Wittmann, A., Devens, F., Gerber, N.U., Joos, S., Kulozik, A., Reifenberger, G., Rutkowski, S., Wiestler, O.D., Radlwimmer, B., Scheurlen, W., Lichter, P. & Korshunov, A. J Clin Oncol. 2009 Apr 1;27(10):1627-36. Epub 2009 Mar 2. PubMed
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. Pfister, S., Janzarik, W.G., Remke, M., Ernst, A., Werft, W., Becker, N., Toedt, G., Wittmann, A., Kratz, C., Olbrich, H., Ahmadi, R., Thieme, B., Joos, S., Radlwimmer, B., Kulozik, A., Pietsch, T., Herold-Mende, C., Gnekow, A., Reifenberger, G., Korshunov, A., Scheurlen, W., Omran, H. & Lichter, P. J Clin Invest. 2008 May;118(5):1739-49. PubMed
Etiology-dependent molecular mechanisms in human hepatocarcinogenesis. Schlaeger, C., Longerich, T., Schiller, C., Bewerunge, P., Mehrabi, A., Toedt, G., Kleeff, J., Ehemann, V., Eils, R., Lichter, P., Schirmacher, P. & Radlwimmer, B. Hepatology. 2008 Feb;47(2):511-20. PubMed
Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas. Pfister, S., Remke, M., Toedt, G., Werft, W., Benner, A., Mendrzyk, F., Wittmann, A., Devens, F., von Hoff, K., Rutkowski, S., Kulozik, A., Radlwimmer, B., Scheurlen, W., Lichter, P. & Korshunov, A. Genes Chromosomes Cancer. 2007 Sep;46(9):839-51. PubMed
Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q. Tews, B., Roerig, P., Hartmann, C., Hahn, M., Felsberg, J., Blaschke, B., Sabel, M., Kunitz, A., Toedt, G., Neben, K., Benner, A., von Deimling, A., Reifenberger, G. & Lichter, P. Oncogene. 2007 Jul 26;26(34):5010-6. Epub 2007 Feb 19. PubMed
Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations. Martinez, R., Roggendorf, W., Baretton, G., Klein, R., Toedt, G., Lichter, P., Schackert, G. & Joos, S. Cancer Genet Cytogenet. 2007 May;175(1):26-34. PubMed
DNA microarray analysis identifies candidate regions and genes in unexplained mental retardation. Engels, H., Brockschmidt, A., Hoischen, A., Landwehr, C., Bosse, K., Walldorf, C., Toedt, G., Radlwimmer, B., Propping, P., Lichter, P. & Weber, R.G. Neurology. 2007 Mar 6;68(10):743-50. PubMed
Identification of novel oligodendroglioma-associated candidate tumor suppressor genes in 1p36 and 19q13 using microarray-based expression profiling. Tews, B., Felsberg, J., Hartmann, C., Kunitz, A., Hahn, M., Toedt, G., Neben, K., Hummerich, L., von Deimling, A., Reifenberger, G. & Lichter, P. Int J Cancer. 2006 Aug 15;119(4):792-800. PubMed
Gene expression signature predicting pathologic complete response with gemcitabine, epirubicin, and docetaxel in primary breast cancer. Thuerigen, O., Schneeweiss, A., Toedt, G., Warnat, P., Hahn, M., Kramer, H., Brors, B., Rudlowski, C., Benner, A., Schuetz, F., Tews, B., Eils, R., Sinn, H.P., Sohn, C. & Lichter, P. J Clin Oncol. 2006 Apr 20;24(12):1839-45. PubMed
Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma. Mendrzyk, F., Korshunov, A., Benner, A., Toedt, G., Pfister, S., Radlwimmer, B. & Lichter, P. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2070-9. PubMed
Isochromosome breakpoints on 17p in medulloblastoma are flanked by different classes of DNA sequence repeats. Mendrzyk, F., Korshunov, A., Toedt, G., Schwarz, F., Korn, B., Joos, S., Hochhaus, A., Schoch, C., Lichter, P. & Radlwimmer, B. Genes Chromosomes Cancer. 2006 Apr;45(4):401-10. PubMed
Recurrent coamplification of cytoskeleton-associated genes EMS1 and SHANK2 with CCND1 in oral squamous cell carcinoma. Freier, K., Sticht, C., Hofele, C., Flechtenmacher, C., Stange, D., Puccio, L., Toedt, G., Radlwimmer, B., Lichter, P. & Joos, S. Genes Chromosomes Cancer. 2006 Feb;45(2):118-25. PubMed
High-resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer. Stange, D.E., Radlwimmer, B., Schubert, F., Traub, F., Pich, A., Toedt, G., Mendrzyk, F., Lehmann, U., Eils, R., Kreipe, H. & Lichter, P. Clin Cancer Res. 2006 Jan 15;12(2):345-52. PubMed
Patient-based cross-platform comparison of oligonucleotide microarray expression profiles. Schlingemann, J., Habtemichael, N., Ittrich, C., Toedt, G., Kramer, H., Hambek, M., Knecht, R., Lichter, P., Stauber, R. & Hahn, M. Lab Invest. 2005 Aug;85(8):1024-39. PubMed
Detection of chromosomal imbalances in retinoblastoma by matrix-based comparative genomic hybridization. Zielinski, B., Gratias, S., Toedt, G., Mendrzyk, F., Stange, D.E., Radlwimmer, B., Lohmann, D.R. & Lichter, P. Genes Chromosomes Cancer. 2005 Jul;43(3):294-301. PubMed
Effective transcriptome amplification for expression profiling on sense-oriented oligonucleotide microarrays. Schlingemann, J., Thuerigen, O., Ittrich, C., Toedt, G., Kramer, H., Hahn, M. & Lichter, P. Nucleic Acids Res. 2005 Feb 17;33(3):e29. PubMed
FACT--a framework for the functional interpretation of high-throughput experiments. Kokocinski, F., Delhomme, N., Wrobel, G., Hummerich, L., Toedt, G. & Lichter, P. BMC Bioinformatics. 2005 Jun 28;6:161. PubMed
Site-specific protein modification to identify the MutL interface of MutH. Toedt, G.H., Krishnan, R. & Friedhoff, P. Nucleic Acids Res. 2003 Feb 1;31(3):819-25. PubMed