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Staff at EMBL

Dr. Grischa Toedt

Postdoctoral Fellow
Gibson Team

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


Total: 32 publication(s)


Texier Y, Toedt G, Gorza M, Mans DA, van Reeuwijk J, Horn N, Willer J, Katsanis N, Roepman R, Gibson TJ, Ueffing M, Boldt K. (2014)
Elution profile analysis of SDS-induced subcomplexes by quantitative mass spectrometry.
Mol. Cell Proteomics 13(5):1382-1391. doi:10.1074/mcp.o113.033233
Europe PMC | doi


Jiang K, Toedt G, Montenegro Gouveia S, Davey NE, Hua S, van der Vaart B, Grigoriev I, Larsen J, Pedersen LB, Bezstarosti K, Lince-Faria M, Demmers J, Steinmetz MO, Gibson TJ, Akhmanova A. (2012)
A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins
Curr. Biol. 22(19):1800-1807. doi:10.1016/j.cub.2012.07.047
Europe PMC | doi

Dittmann LM, Danner A, Gronych J, Wolter M, Stühler K, Grzendowski M, Becker N, Bageritz J, Goidts V, Toedt G, Felsberg J, Sabel MC, Barbus S, Reifenberger G, Lichter P, Tews B. (2012)
Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro
Oncogene 31(29):3409-3418. doi:10.1038/onc.2011.513
Europe PMC | doi

Davey NE, Van Roey K, Weatheritt RJ, Toedt G, Uyar B, Altenberg B, Budd A, Diella F, Dinkel H, Gibson TJ. (2012)
Attributes of short linear motifs
Mol Biosyst 8(1):268-281. doi:10.1039/c1mb05231d
Europe PMC | doi

Dinkel H, Michael S, Weatheritt RJ, Davey NE, Van Roey K, Altenberg B, Toedt G, Uyar B, Seiler M, Budd A, Jödicke L, Dammert MA, Schroeter C, Hammer M, Schmidt T, Jehl P, McGuigan C, Dymecka M, Chica C, Luck K, Via A, Chatr-Aryamontri A, Haslam N, Grebnev G, Edwards RJ, Steinmetz MO, Meiselbach H, Diella F, Gibson TJ. (2012)
ELM--the database of eukaryotic linear motifs
Nucleic Acids Res. 40(Database issue):D242-51. doi:10.1093/nar/gkr1064
Europe PMC | doi

Haag D, Zipper P, Westrich V, Karra D, Pfleger K, Toedt G, Blond F, Delhomme N, Hahn M, Reifenberger J, Reifenberger G, Lichter P. (2012)
Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration
PLoS Genet. 8(3):e1002572. doi:10.1371/journal.pgen.1002572
Europe PMC | doi


Remke M, Hielscher T, Korshunov A, Northcott PA, Bender S, Kool M, Westermann F, Benner A, Cin H, Ryzhova M, Sturm D, Witt H, Haag D, Toedt G, Wittmann A, Schöttler A, von Bueren AO, von Deimling A, Rutkowski S, Scheurlen W, Kulozik AE, Taylor MD, Lichter P, Pfister SM. (2011)
FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma
J. Clin. Oncol. 29(29):3852-3861. doi:10.1200/jco.2011.36.2798
Europe PMC | doi

Schulz A, Toedt G, Zenz T, Stilgenbauer S, Lichter P, Seiffert M. (2011)
Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL2
Haematologica 96(3):408-416. doi:10.3324/haematol.2010.031377
Europe PMC | doi

Toedt G, Barbus S, Wolter M, Felsberg J, Tews B, Blond F, Sabel MC, Hofmann S, Becker N, Hartmann C, Ohgaki H, von Deimling A, Wiestler OD, Hahn M, Lichter P, Reifenberger G, Radlwimmer B. (2011)
Molecular signatures classify astrocytic gliomas by IDH1 mutation status
Int. J. Cancer 128(5):1095-1103. doi:10.1002/ijc.25448
Europe PMC | doi

Becker N, Toedt G, Lichter P, Benner A. (2011)
Elastic SCAD as a novel penalization method for SVM classification tasks in high-dimensional data
BMC Bioinformatics 12:138. doi:10.1186/1471-2105-12-138
Europe PMC | doi


Stange DE, Engel F, Longerich T, Koo BK, Koch M, Delhomme N, Aigner M, Toedt G, Schirmacher P, Lichter P, Weitz J, Radlwimmer B. (2010)
Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain
Gut 59(9):1236-1244. doi:10.1136/gut.2009.195701
Europe PMC | doi

Freier K, Knoepfle K, Flechtenmacher C, Pungs S, Devens F, Toedt G, Hofele C, Joos S, Lichter P, Radlwimmer B. (2010)
Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma
Genes Chromosomes Cancer 49(1):9-16. doi:10.1002/gcc.20714
Europe PMC | doi


Remke M, Pfister S, Kox C, Toedt G, Becker N, Benner A, Werft W, Breit S, Liu S, Engel F, Wittmann A, Zimmermann M, Stanulla M, Schrappe M, Ludwig WD, Bartram CR, Radlwimmer B, Muckenthaler MU, Lichter P, Kulozik AE. (2009)
High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response
Blood 114(5):1053-1062. doi:10.1182/blood-2008-10-186536
Europe PMC | doi

Becker N, Werft W, Toedt G, Lichter P, Benner A. (2009)
penalizedSVM: a R-package for feature selection SVM classification
Bioinformatics 25(13):1711-1712. doi:10.1093/bioinformatics/btp286
Europe PMC | doi

Pfister S, Remke M, Benner A, Mendrzyk F, Toedt G, Felsberg J, Wittmann A, Devens F, Gerber NU, Joos S, Kulozik A, Reifenberger G, Rutkowski S, Wiestler OD, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A. (2009)
Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci
J. Clin. Oncol. 27(10):1627-1636. doi:10.1200/jco.2008.17.9432
Europe PMC | doi


Pfister S, Janzarik WG, Remke M, Ernst A, Werft W, Becker N, Toedt G, Wittmann A, Kratz C, Olbrich H, Ahmadi R, Thieme B, Joos S, Radlwimmer B, Kulozik A, Pietsch T, Herold-Mende C, Gnekow A, Reifenberger G, Korshunov A, Scheurlen W, Omran H, Lichter P. (2008)
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
J. Clin. Invest. 118(5):1739-1749. doi:10.1172/jci33656
Europe PMC | doi

Schlaeger C, Longerich T, Schiller C, Bewerunge P, Mehrabi A, Toedt G, Kleeff J, Ehemann V, Eils R, Lichter P, Schirmacher P, Radlwimmer B. (2008)
Etiology-dependent molecular mechanisms in human hepatocarcinogenesis
Hepatology 47(2):511-520. doi:10.1002/hep.22033
Europe PMC | doi


Pfister S, Remke M, Toedt G, Werft W, Benner A, Mendrzyk F, Wittmann A, Devens F, von Hoff K, Rutkowski S, Kulozik A, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A. (2007)
Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas
Genes Chromosomes Cancer 46(9):839-851. doi:10.1002/gcc.20471
Europe PMC | doi

Tews B, Roerig P, Hartmann C, Hahn M, Felsberg J, Blaschke B, Sabel M, Kunitz A, Toedt G, Neben K, Benner A, von Deimling A, Reifenberger G, Lichter P. (2007)
Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q
Oncogene 26(34):5010-5016. doi:10.1038/sj.onc.1210297
Europe PMC | doi

Martinez R, Roggendorf W, Baretton G, Klein R, Toedt G, Lichter P, Schackert G, Joos S. (2007)
Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations
Cancer Genet. Cytogenet. 175(1):26-34. doi:10.1016/j.cancergencyto.2007.01.006
Europe PMC | doi

Engels H, Brockschmidt A, Hoischen A, Landwehr C, Bosse K, Walldorf C, Toedt G, Radlwimmer B, Propping P, Lichter P, Weber RG. (2007)
DNA microarray analysis identifies candidate regions and genes in unexplained mental retardation
Neurology 68(10):743-750. doi:10.1212/01.wnl.0000256367.70365.e0
Europe PMC | doi


Tews B, Felsberg J, Hartmann C, Kunitz A, Hahn M, Toedt G, Neben K, Hummerich L, von Deimling A, Reifenberger G, Lichter P. (2006)
Identification of novel oligodendroglioma-associated candidate tumor suppressor genes in 1p36 and 19q13 using microarray-based expression profiling
Int. J. Cancer 119(4):792-800. doi:10.1002/ijc.21901
Europe PMC | doi

Thuerigen O, Schneeweiss A, Toedt G, Warnat P, Hahn M, Kramer H, Brors B, Rudlowski C, Benner A, Schuetz F, Tews B, Eils R, Sinn HP, Sohn C, Lichter P. (2006)
Gene expression signature predicting pathologic complete response with gemcitabine, epirubicin, and docetaxel in primary breast cancer
Paper presented at the 41st Annual Meeting of the American-Society-of-Clinical-Oncology, Orlando, FL, MAY 13-17, 2005.J. Clin. Oncol. 24(12):1839-1845. doi:10.1200/jco.2005.04.7019
Europe PMC | doi

Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B, Lichter P. (2006)
Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma
Clin. Cancer Res. 12(7 Pt 1):2070-2079. doi:10.1158/1078-0432.ccr-05-2363
Europe PMC | doi

Mendrzyk F, Korshunov A, Toedt G, Schwarz F, Korn B, Joos S, Hochhaus A, Schoch C, Lichter P, Radlwimmer B. (2006)
Isochromosome breakpoints on 17p in medulloblastoma are flanked by different classes of DNA sequence repeats
Genes Chromosomes Cancer 45(4):401-410. doi:10.1002/gcc.20304
Europe PMC | doi

Freier K, Sticht C, Hofele C, Flechtenmacher C, Stange D, Puccio L, Toedt G, Radlwimmer B, Lichter P, Joos S. (2006)
Recurrent coamplification of cytoskeleton-associated genes EMS1 and SHANK2 with CCND1 in oral squamous cell carcinoma
Genes Chromosomes Cancer 45(2):118-125. doi:10.1002/gcc.20270
Europe PMC | doi

Stange DE, Radlwimmer B, Schubert F, Traub F, Pich A, Toedt G, Mendrzyk F, Lehmann U, Eils R, Kreipe H, Lichter P. (2006)
High-resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer
Clin. Cancer Res. 12(2):345-352. doi:10.1158/1078-0432.ccr-05-1633
Europe PMC | doi


Schlingemann J, Habtemichael N, Ittrich C, Toedt G, Kramer H, Hambek M, Knecht R, Lichter P, Stauber R, Hahn M. (2005)
Patient-based cross-platform comparison of oligonucleotide microarray expression profiles
Lab. Invest. 85(8):1024-1039. doi:10.1038/labinvest.3700293
Europe PMC | doi

Zielinski B, Gratias S, Toedt G, Mendrzyk F, Stange DE, Radlwimmer B, Lohmann DR, Lichter P. (2005)
Detection of chromosomal imbalances in retinoblastoma by matrix-based comparative genomic hybridization
Genes Chromosomes Cancer 43(3):294-301. doi:10.1002/gcc.20186
Europe PMC | doi

Schlingemann J, Thuerigen O, Ittrich C, Toedt G, Kramer H, Hahn M, Lichter P. (2005)
Effective transcriptome amplification for expression profiling on sense-oriented oligonucleotide microarrays
Nucleic Acids Res. 33(3):e29. doi:10.1093/nar/gni029
Europe PMC | doi

Kokocinski F, Delhomme N, Wrobel G, Hummerich L, Toedt G, Lichter P. (2005)
FACT--a framework for the functional interpretation of high-throughput experiments
BMC Bioinformatics 6:161. doi:10.1186/1471-2105-6-161
Europe PMC | doi


Toedt GH, Krishnan R, Friedhoff P. (2003)
Site-specific protein modification to identify the MutL interface of MutH
Nucleic Acids Res. 31(3):819-825. doi:10.1093/nar/gkg191
Europe PMC | doi