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Staff at EMBL

CP-60003265

Dr. Christoph Müller

Joint Head of Unit and Senior Scientist
Structural and Computational Biology Müller Group Joint appointment: Genome Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Biography

PhD 1991, University of Freiburg.
Postdoctoral work at Harvard University, Cambridge, USA.
Group leader at EMBL Grenoble since 1995.
Joint Head of Unit at EMBL Heidelberg since 2007.
Joint appointment with the Genome Biology Unit.
ERC Advanced Investigator.

Publications

Total: 75 publication(s)

2014

Kalb R, Latwiel S, Baymaz HI, Jansen PW, Müller CW, Vermeulen M, Müller J. (2014)
Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression
Nat. Struct. Mol. Biol. 21(6):569-571. doi:10.1038/nsmb.2833
Europe PMC | doi


2013

Alfieri C, Gambetta MC, Matos R, Glatt S, Sehr P, Fraterman S, Wilm M, Müller J, Müller CW. (2013)
Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements
Genes Dev. 27(21):2367-2379. doi:10.1101/gad.226621.113
Europe PMC | doi

Fernández-Tornero C, Moreno-Morcillo M, Rashid UJ, Taylor NM, Ruiz FM, Gruene T, Legrand P, Steuerwald U, Müller CW. (2013)
Crystal structure of the 14-subunit RNA polymerase I
Nature 502(7473):644-649. doi:10.1038/nature12636
Europe PMC | doi

Taylor NM, Baudin F, von Scheven G, Müller CW. (2013)
RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74
Nucleic Acids Res. 41(19):9183-9196. doi:10.1093/nar/gkt664
Europe PMC | doi

Dian C, Bernaudat F, Langer K, Oliva MF, Fornerod M, Schoehn G, Müller CW, Petosa C. (2013)
Structure of a truncation mutant of the nuclear export factor CRM1 provides insights into the auto-inhibitory role of its C-terminal helix
Structure 21(8):1338-1349. doi:10.1016/j.str.2013.06.003
Europe PMC | doi

Taylor NM, Glatt S, Hennrich ML, von Scheven G, Grötsch H, Fernández-Tornero C, Rybin V, Gavin AC, Kolb P, Müller CW. (2013)
Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC
J. Biol. Chem. 288(21):15110-15120. doi:10.1074/jbc.m112.427856
Europe PMC | doi

Glatt S, Müller CW. (2013)
Structural insights into Elongator function
Curr. Opin. Struct. Biol. 23(2):235-242. doi:10.1016/j.sbi.2013.02.009
Europe PMC | doi

Baudin F, Müller CW. (2013)
Bacterial expression, purification, and crystallization of tyrosine phosphorylated STAT proteins
Methods Mol. Biol. 967:301-317. doi:10.1007/978-1-62703-242-1_21
Europe PMC | doi


2012

Glatt S, Létoquart J, Faux C, Taylor NM, Séraphin B, Müller CW. (2012)
The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase
Nat. Struct. Mol. Biol. 19(3):314-320. doi:10.1038/nsmb.2234
Europe PMC | doi

Glatt S, Séraphin B, Müller CW. (2012)
Elongator: transcriptional or translational regulator?
Transcription 3(6):273-276. doi:10.4161/trns.21525
Europe PMC | doi


2011

Nowak AJ, Alfieri C, Stirnimann CU, Rybin V, Baudin F, Ly-Hartig N, Lindner D, Müller CW. (2011)
Chromatin-modifying complex component Nurf55/p55 associates with histones H3 and H4 and polycomb repressive complex 2 subunit Su(z)12 through partially overlapping binding sites
J. Biol. Chem. 286(26):23388-23396. doi:10.1074/jbc.m110.207407
Europe PMC | doi

Glatt S, Alfieri C, Müller CW. (2011)
Recognizing and remodeling the nucleosome
Curr. Opin. Struct. Biol. 21(3):335-341. doi:10.1016/j.sbi.2011.02.003
Europe PMC | doi

Fernández-Tornero C, Böttcher B, Rashid UJ, Müller CW. (2011)
Analyzing RNA polymerase III by electron cryomicroscopy
RNA Biol 8(5):760-765. doi:10.4161/rna.8.5.16021
Europe PMC | doi

Boulo S, Akarsu H, Lotteau V, Müller CW, Ruigrok RW, Baudin F. (2011)
Human importin alpha and RNA do not compete for binding to influenza A virus nucleoprotein
Virology 409(1):84-90. doi:10.1016/j.virol.2010.10.001
Europe PMC | doi

Langer K, Dian C, Rybin V, Müller CW, Petosa C. (2011)
Insights into the function of the CRM1 cofactor RanBP3 from the structure of its Ran-binding domain
PLoS ONE 6(2):e17011. doi:10.1371/journal.pone.0017011
Europe PMC | doi

Lane LA, Fernández-Tornero C, Zhou M, Morgner N, Ptchelkine D, Steuerwald U, Politis A, Lindner D, Gvozdenovic J, Gavin AC, Müller CW, Robinson CV. (2011)
Mass spectrometry reveals stable modules in holo and apo RNA polymerases I and III
Structure 19(1):90-100. doi:10.1016/j.str.2010.11.009
Europe PMC | doi


2010

Gallego O, Betts MJ, Gvozdenovic-Jeremic J, Maeda K, Matetzki C, Aguilar-Gurrieri C, Beltran-Alvarez P, Bonn S, Fernández-Tornero C, Jensen LJ, Kuhn M, Trott J, Rybin V, Müller CW, Bork P, Kaksonen M, Russell RB, Gavin AC. (2010)
A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae
Mol. Syst. Biol. 6:430. doi:10.1038/msb.2010.87
Europe PMC | doi

Fernández-Tornero C, Böttcher B, Rashid UJ, Steuerwald U, Flörchinger B, Devos DP, Lindner D, Müller CW. (2010)
Conformational flexibility of RNA polymerase III during transcriptional elongation
EMBO J. 29(22):3762-3772. doi:10.1038/emboj.2010.266
Europe PMC | doi

Gajda A, Towpik J, Steuerwald U, Müller CW, Lefebvre O, Boguta M. (2010)
Full repression of RNA polymerase III transcription requires interaction between two domains of its negative regulator Maf1
J. Biol. Chem. 285(46):35719-35727. doi:10.1074/jbc.m110.125286
Europe PMC | doi

Mattaj IW, Müller CW. (2010)
Solving the NES problem
Nat. Struct. Mol. Biol. 17(11):1288-1289. doi:10.1038/nsmb1110-1288
Europe PMC | doi

Stirnimann CU, Petsalaki E, Russell RB, Müller CW. (2010)
WD40 proteins propel cellular networks
Trends Biochem. Sci. 35(10):565-574. doi:10.1016/j.tibs.2010.04.003
Europe PMC | doi

Stirnimann CU, Ptchelkine D, Grimm C, Müller CW. (2010)
Structural basis of TBX5-DNA recognition: the T-box domain in its DNA-bound and -unbound form
J. Mol. Biol. 400(1):71-81. doi:10.1016/j.jmb.2010.04.052
Europe PMC | doi

Rousseaux S, Petosa C, Müller CW, Khochbin S. (2010)
[A novel key element in post-meiotic male genome reprogramming]
Med Sci (Paris) 26(2):130-132. doi:10.1051/medsci/2010262130
Europe PMC | doi


2009

Morinière J, Rousseaux S, Steuerwald U, Soler-López M, Curtet S, Vitte AL, Govin J, Gaucher J, Sadoul K, Hart DJ, Krijgsveld J, Khochbin S, Müller CW, Petosa C. (2009)
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain
Nature 461(7264):664-668. doi:10.1038/nature08397
Europe PMC | doi

Grimm C, Matos R, Ly-Hartig N, Steuerwald U, Lindner D, Rybin V, Müller J, Müller CW. (2009)
Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt
EMBO J. 28(13):1965-1977. doi:10.1038/emboj.2009.147
Europe PMC | doi


2008

Hamès C, Ptchelkine D, Grimm C, Thevenon E, Moyroud E, Gérard F, Martiel JL, Benlloch R, Parcy F, Müller CW. (2008)
Structural basis for LEAFY floral switch function and similarity with helix-turn-helix proteins
EMBO J. 27(19):2628-2637. doi:10.1038/emboj.2008.184
Europe PMC | doi

Clapier CR, Chakravarthy S, Petosa C, Fernández-Tornero C, Luger K, Müller CW. (2008)
Structure of the Drosophila nucleosome core particle highlights evolutionary constraints on the H2A-H2B histone dimer
Proteins 71(1):1-7. doi:10.1002/prot.21720
Europe PMC | doi


2007

Grimm C, de Ayala Alonso AG, Rybin V, Steuerwald U, Ly-Hartig N, Fischle W, Müller J, Müller CW. (2007)
Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg
EMBO Rep. 8(11):1031-1037. doi:10.1038/sj.embor.7401085
Europe PMC | doi

Fernández-Tornero C, Böttcher B, Riva M, Carles C, Steuerwald U, Ruigrok RW, Sentenac A, Müller CW, Schoehn G. (2007)
Insights into transcription initiation and termination from the electron microscopy structure of yeast RNA polymerase III
Mol. Cell 25(6):813-823. doi:10.1016/j.molcel.2007.02.016
Europe PMC | doi

Berger JM, Muller CW. (2007)
Protein-nucleic acid interactions: some assembly required - Editorial overview
CURR OPIN STRUC BIOL 17(1):77-79. doi:10.1016/j.sbi.2007.01.010
doi


2006

Mylona A, Fernández-Tornero C, Legrand P, Haupt M, Sentenac A, Acker J, Müller CW. (2006)
Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly
Mol. Cell 24(2):221-232. doi:10.1016/j.molcel.2006.08.013
Europe PMC | doi

Boyault C, Gilquin B, Zhang Y, Rybin V, Garman E, Meyer-Klaucke W, Matthias P, Müller CW, Khochbin S. (2006)
HDAC6-p97/VCP controlled polyubiquitin chain turnover
EMBO J. 25(14):3357-3366. doi:10.1038/sj.emboj.7601210
Europe PMC | doi

Conti E, Müller CW, Stewart M. (2006)
Karyopherin flexibility in nucleocytoplasmic transport
Curr. Opin. Struct. Biol. 16(2):237-244. doi:10.1016/j.sbi.2006.03.010
Europe PMC | doi

Morand P, Budayova-Spano M, Perrissin M, Müller CW, Petosa C. (2006)
Expression, purification, crystallization and preliminary X-ray analysis of a C-terminal fragment of the Epstein-Barr virus ZEBRA protein
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62(Pt 3):210-214.
Europe PMC

Mylona A, Acker J, Fernández-Tornero C, Sentenac A, Müller CW. (2006)
Expression, proteolytic analysis, reconstitution, and crystallization of the tau60/tau91 subcomplex of yeast TFIIIC
Protein Expr. Purif. 45(2):255-261. doi:10.1016/j.pep.2005.06.013
Europe PMC | doi

Petosa C, Morand P, Baudin F, Moulin M, Artero JB, Müller CW. (2006)
Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein
Mol. Cell 21(4):565-572. doi:10.1016/j.molcel.2006.01.006
Europe PMC | doi

Morand, P & Müller, C.W. (2006)
Protein/DNA Interaction
In: Ganten, D. & Ruckpaul, K.(Eds.), Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer. pp 1538-1542.


2005

Hartlepp KF, Fernández-Tornero C, Eberharter A, Grüne T, Müller CW, Becker PB. (2005)
The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions
Mol. Cell. Biol. 25(22):9886-9896. doi:10.1128/mcb.25.22.9886-9896.2005
Europe PMC | doi

Garcia-Robles I, Akarsu H, Müller CW, Ruigrok RW, Baudin F. (2005)
Interaction of influenza virus proteins with nucleosomes
Virology 332(1):329-336. doi:10.1016/j.virol.2004.09.036
Europe PMC | doi


2004

Petosa C, Schoehn G, Askjaer P, Bauer U, Moulin M, Steuerwald U, Soler-López M, Baudin F, Mattaj IW, Müller CW. (2004)
Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex
Mol. Cell 16(5):761-775. doi:10.1016/j.molcel.2004.11.018
Europe PMC | doi

Angelov D, Lenouvel F, Hans F, Müller CW, Bouvet P, Bednar J, Moudrianakis EN, Cadet J, Dimitrov S. (2004)
The histone octamer is invisible when NF-kappaB binds to the nucleosome
J. Biol. Chem. 279(41):42374-42382. doi:10.1074/jbc.m407235200
Europe PMC | doi

Soler-Lopez M, Petosa C, Fukuzawa M, Ravelli R, Williams JG, Müller CW. (2004)
Structure of an activated Dictyostelium STAT in its DNA-unbound form
Mol. Cell 13(6):791-804. doi:10.1016/s1097-2765(04)00130-3
Europe PMC | doi


2003

Akarsu H, Burmeister WP, Petosa C, Petit I, Müller CW, Ruigrok RW, Baudin F. (2003)
Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2)
EMBO J. 22(18):4646-4655. doi:10.1093/emboj/cdg449
Europe PMC | doi

Grüne T, Brzeski J, Eberharter A, Clapier CR, Corona DF, Becker PB, Müller CW. (2003)
Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI
Mol. Cell 12(2):449-460. doi:10.1016/s1097-2765(03)00273-9
Europe PMC | doi

Angelov D, Charra M, Müller CW, Cadet J, Dimitrov S. (2003)
Solution study of the NF-kappaB p50-DNA complex by UV laser protein-DNA cross-linking
Photochem. Photobiol. 77(6):592-596. doi:10.1562/0031-8655(2003)0772.0.co;2
Europe PMC | doi

Cohen SX, Moulin M, Hashemolhosseini S, Kilian K, Wegner M, Müller CW. (2003)
Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition
EMBO J. 22(8):1835-1845. doi:10.1093/emboj/cdg182
Europe PMC | doi

Müller CW, Soler-Lopez M, Gewinner C, Groner B. (2003)
X-ray crystal structure of STAT proteins and structure-activity relationships
Springer Netherlands.doi:10.1007/978-94-017-3000-6_21
Europe PMC | doi


2002

Cohen SX, Moulin M, Schilling O, Meyer-Klaucke W, Schreiber J, Wegner M, Müller CW. (2002)
The GCM domain is a Zn-coordinating DNA-binding domain
FEBS Lett. 528(1-3):95-100. doi:10.1016/s0014-5793(02)03257-x
Europe PMC | doi

Coll M, Seidman JG, Müller CW. (2002)
Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome
Structure 10(3):343-356. doi:10.1016/s0969-2126(02)00722-0
Europe PMC | doi


2001

Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U, Müller CW. (2001)
Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family
EMBO J. 20(22):6180-6190. doi:10.1093/emboj/20.22.6180
Europe PMC | doi

Andrade MA, Petosa C, O'Donoghue SI, Müller CW, Bork P. (2001)
Comparison of ARM and HEAT protein repeats
J. Mol. Biol. 309(1):1-18. doi:10.1006/jmbi.2001.4624
Europe PMC | doi

Müller CW. (2001)
Transcription factors: global and detailed views
Curr. Opin. Struct. Biol. 11(1):26-32. doi:10.1016/s0959-440x(00)00163-9
Europe PMC | doi

Müller CW. (2001)
DNA recognition by NF kappa B and STAT transcription factors
Ernst Schering Res. Found. Workshop (34):143-166.
Europe PMC


2000

Cingolani G, Lashuel HA, Gerace L, Müller CW. (2000)
Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association
FEBS Lett. 484(3):291-298. doi:10.1016/s0014-5793(00)02154-2
Europe PMC | doi


1999

Cramer P, Varrot A, Barillas-Mury C, Kafatos FC, Müller CW. (1999)
Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA
Structure 7(7):841-852. doi:10.1016/s0969-2126(99)80107-5
Europe PMC | doi

Cingolani G, Petosa C, Weis K, Müller CW. (1999)
Structure of importin-beta bound to the IBB domain of importin-alpha
Nature 399(6733):221-229. doi:10.1038/20367
Europe PMC | doi

Basson CT, Huang T, Lin RC, Bachinsky DR, Weremowicz S, Vaglio A, Bruzzone R, Quadrelli R, Lerone M, Romeo G, Silengo M, Pereira A, Krieger J, Mesquita SF, Kamisago M, Morton CC, Pierpont ME, Müller CW, Seidman JG, Seidman CE. (1999)
Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations
Proc. Natl. Acad. Sci. U.S.A. 96(6):2919-2924. doi:10.1073/pnas.96.6.2919
Europe PMC | doi

Cramer P, Müller CW. (1999)
A firm hand on NFkappaB: structures of the IkappaBalpha-NFkappaB complex
Structure 7(1):R1-6. doi:10.1016/s0969-2126(99)80002-1
Europe PMC | doi


1998

Becker S, Corthals GL, Aebersold R, Groner B, Müller CW. (1998)
Expression of a tyrosine phosphorylated, DNA binding Stat3beta dimer in bacteria
FEBS Lett. 441(1):141-147. doi:10.1016/s0014-5793(98)01543-9
Europe PMC | doi

Becker S, Groner B, Müller CW. (1998)
Three-dimensional structure of the Stat3beta homodimer bound to DNA
Nature 394(6689):145-151. doi:10.1038/28101
Europe PMC | doi


1997

Cramer P, Larson CJ, Verdine GL, Müller CW. (1997)
Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution
EMBO J. 16(23):7078-7090. doi:10.1093/emboj/16.23.7078
Europe PMC | doi

Müller CW, Herrmann BG. (1997)
Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
Nature 389(6653):884-888. doi:10.1038/39929
Europe PMC | doi

Cramer P, Müller CW. (1997)
Engineering of diffraction-quality crystals of the NF-kappaB P52 homodimer:DNA complex.
FEBS Lett. 405(3):373-377. doi:10.1016/s0014-5793(97)00217-2
Europe PMC | doi

Ferrer E, Wiersma M, Kazimierczak B, Müller CW, Eritja R. (1997)
Preparation and properties of oligodeoxynucleotides containing 5-iodouracil and 5-bromo- and 5-iodocytosine
Bioconjug. Chem. 8(5):757-761. doi:10.1021/bc970042l
Europe PMC | doi


1996

Müller CW, Rey FA, Harrison SC. (1996)
Comparison of two different DNA-binding modes of the NF-kappa B p50 homodimer.
Nat. Struct. Biol. 3(3):224-227. doi:10.1038/nsb0396-224
Europe PMC | doi

Müller CW, Schlauderer GJ, Reinstein J, Schulz GE. (1996)
Adenylate kinase motions during catalysis: an energetic counterweight balancing substrate binding.
Structure 4(2):147-156. doi:10.1016/s0969-2126(96)00018-4
Europe PMC | doi


1995

Müller CW, Harrison SC. (1995)
The structure of the NF-kappa B p50:DNA-complex: a starting point for analyzing the Rel family.
FEBS Lett. 369(1):113-117. doi:10.1016/0014-5793(95)00541-g
Europe PMC | doi

Müller CW, Rey FA, Sodeoka M, Verdine GL, Harrison SC. (1995)
Structure of the NF-kappa B p50 homodimer bound to DNA
Nature 373(6512):311-317. doi:10.1038/373311a0
Europe PMC | doi


1993

Barberis A, Müller CW, Harrison SC, Ptashne M. (1993)
Delineation of two functional regions of transcription factor TFIIB.
Proc. Natl. Acad. Sci. U.S.A. 90(12):5628-5632. doi:10.1073/pnas.90.12.5628
Europe PMC | doi

Müller CW, Schulz GE. (1993)
Crystal structures of two mutants of adenylate kinase from Escherichia coli that modify the Gly-loop.
Proteins 15(1):42-49. doi:10.1002/prot.340150106
Europe PMC | doi


1992

Schulz GE, Dreyer M, Klein C, Kreusch A, Mittl P, Müller CW, Müller-Dieckmann J, Müller YA, Proba K, Schlauderer G, Spürgin P, Sthele T, Weisss MS. (1992)
Highly ordered crystals of channel-forming membrane proteins, of nucleoside-monophosphate kinases, of FAD-containing oxidoreductases and of sugar-processing enzymes and their mutants
J CRYST GROWTH 122(1-4):385-392. doi:10.1016/0022-0248(92)90273-L
doi

Müller CW, Schulz GE. (1992)
Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 A resolution. A model for a catalytic transition state.
J. Mol. Biol. 224(1):159-177. doi:10.1016/0022-2836(92)90582-5
Europe PMC | doi


1990

Schulz GE, Müller CW, Diederichs K. (1990)
Induced-fit movements in adenylate kinases.
J. Mol. Biol. 213(4):627-630. doi:10.1016/s0022-2836(05)80250-5
Europe PMC | doi


1989

Erdmann, V.A., Lippman, C., Betzel, C., Dauter, Z., Wilson, K., Hilgenfeld, R., Hoven, J., Liesum, A., Saenger W, Müller-Fahrnow A, Hinrichs W, Duevel M,Schulz GE, Müller CW, Wittmann HG, Yonath A, Weber G, Stegen K, Plaas-Link A. (1989)
Crystallization of proteins under microgravity
FEBS LETT 259(1):194-198. doi:10.1016/0014-5793(89)81526-1
doi


1988

Müller CW, Schulz GE. (1988)
Structure of the complex of adenylate kinase from Escherichia coli with the inhibitor P1,P5-di(adenosine-5'-)pentaphosphate.
J. Mol. Biol. 202(4):909-912. doi:10.1016/0022-2836(88)90567-0
Europe PMC | doi