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Staff at EMBL

Dr. Christoph Müller

Joint Head of Unit and Senior Scientist
Structural and Computational Biology Müller Group Joint appointment: Genome Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 1991, University of Freiburg.
Postdoctoral work at Harvard University, Cambridge, USA.
Group leader at EMBL Grenoble since 1995.
Joint Head of Unit at EMBL Heidelberg since 2007.
Joint appointment with the Genome Biology Unit.
ERC Advanced Investigator.


Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression. Kalb, R., Latwiel, S., Baymaz, H.I., Jansen, P.W., Muller, C.W., Vermeulen, M. & Muller, J. Nat Struct Mol Biol. 2014 Jun;21(6):569-71. doi: 10.1038/nsmb.2833. Epub 2014 May18. Europe PMC

Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements. Alfieri, C., Gambetta, M.C., Matos, R., Glatt, S., Sehr, P., Fraterman, S., Wilm, M., Muller, J. & Muller, C.W. Genes Dev. 2013 Nov 1;27(21):2367-79. doi: 10.1101/gad.226621.113. Europe PMC

Crystal structure of the 14-subunit RNA polymerase I. Fernandez-Tornero, C., Moreno-Morcillo, M., Rashid, U.J., Taylor, N.M., Ruiz, F.M., Gruene, T., Legrand, P., Steuerwald, U. & Muller, C.W. Nature. 2013 Oct 31;502(7473):644-9. doi: 10.1038/nature12636. Epub 2013 Oct 23. Europe PMC

RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74. Taylor, N.M., Baudin, F., von Scheven, G. & Muller, C.W. Nucleic Acids Res. 2013 Oct;41(19):9183-96. doi: 10.1093/nar/gkt664. Epub 2013Aug 5. Europe PMC

Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC. Taylor, N.M., Glatt, S., Hennrich, M.L., von Scheven, G., Grotsch, H., Fernandez-Tornero, C., Rybin, V., Gavin, A.C., Kolb, P. & Muller, C.W. J Biol Chem. 2013 May 24;288(21):15110-20. doi: 10.1074/jbc.M112.427856. Epub2013 Apr 8. Europe PMC

Structural insights into Elongator function. Glatt, S. & Muller, C.W. Curr Opin Struct Biol. 2013 Apr;23(2):235-42. doi: 10.1016/ 2013 Mar 16. Europe PMC

Structure of a Truncation Mutant of the Nuclear Export Factor CRM1 Provides Insights into the Auto-Inhibitory Role of Its C-Terminal Helix. Dian, C., Bernaudat, F., Langer, K., Oliva, M.F., Fornerod, M., Schoehn, G., Muller, C.W. & Petosa, C. Structure. 2013 Aug 6;21(8):1338-49. doi: 10.1016/j.str.2013.06.003. Epub 2013Jul 11. Europe PMC

Bacterial expression, purification, and crystallization of tyrosine phosphorylated STAT proteins. Baudin, F. & Muller, C.W. Methods Mol Biol. 2013;967:301-17. doi: 10.1007/978-1-62703-242-1_21. Europe PMC

Elongator: transcriptional or translational regulator? Glatt, S., Seraphin, B. & Muller, C.W. Transcription. 2012 Nov-Dec;3(6):273-6. doi: 10.4161/trns.21525. Epub 2012 Aug14. Europe PMC

Proteins linked to diseases. Mueller, C. TrAC Trends in Analytical Chemistry 2012 34(1) VII-VII

The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase. Glatt, S., Letoquart, J., Faux, C., Taylor, N.M., Seraphin, B. & Muller, C.W. Nat Struct Mol Biol. 2012 Feb 19;19(3):314-20. doi: 10.1038/nsmb.2234. Europe PMC

Analyzing RNA polymerase III by electron cryomicroscopy. Fernandez-Tornero, C., Bottcher, B., Rashid, U.J. & Muller, C.W. RNA Biol. 2011 Sep-Oct;8(5):760-5. doi: 10.4161/rna.8.5.16021. Epub 2011 Sep 1. Europe PMC

Chromatin-modifying Complex Component Nurf55/p55 Associates with Histones H3 and H4 and Polycomb Repressive Complex 2 Subunit Su(z)12 through Partially Overlapping Binding Sites. Nowak, A.J., Alfieri, C., Stirnimann, C.U., Rybin, V., Baudin, F., Ly-Hartig, N., Lindner, D. & Muller, C.W. J Biol Chem. 2011 Jul 1;286(26):23388-96. Epub 2011 May 5. Europe PMC

Recognizing and remodeling the nucleosome. Glatt, S., Alfieri, C. & Muller, C.W. Curr Opin Struct Biol. 2011 Jun;21(3):335-41. Epub 2011 Mar 4. Europe PMC

Insights into the function of the CRM1 cofactor RanBP3 from the structure of its Ran-binding domain. Langer, K., Dian, C., Rybin, V., Muller, C.W. & Petosa, C. PLoS One. 2011 Feb 25;6(2):e17011. Europe PMC

Mass Spectrometry Reveals Stable Modules in holo and apo RNA Polymerases I and III. Lane, L.A., Fernandez-Tornero, C., Zhou, M., Morgner, N., Ptchelkine, D., Steuerwald, U., Politis, A., Lindner, D., Gvozdenovic, J., Gavin, A.C., Muller, C.W. & Robinson, C.V. Structure. 2011 Jan 12;19(1):90-100. Europe PMC

Human importin alpha and RNA do not compete for binding to influenza A virus nucleoprotein. Boulo, S., Akarsu, H., Lotteau, V., Muller, C.W., Ruigrok, R.W. & Baudin, F. Virology. 2011 Jan 5;409(1):84-90. Epub 2010 Oct 25. Europe PMC

A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Gallego, O., Betts, M.J., Gvozdenovic-Jeremic, J., Maeda, K., Matetzki, C., Aguilar-Gurrieri, C., Beltran-Alvarez, P., Bonn, S., Fernandez-Tornero, C., Jensen, L.J., Kuhn, M., Trott, J., Rybin, V., Muller, C.W., Bork, P., Kaksonen, M., Russell, R.B. & Gavin, A.C. Mol Syst Biol. 2010 Nov 30;6:430. doi: 10.1038/msb.2010.87. Europe PMC

Full repression of RNA polymerase III transcription requires interaction between two domains of its negative regulator Maf1. Gajda, A., Towpik, J., Steuerwald, U., Muller, C.W., Lefebvre, O. & Boguta, M. J Biol Chem. 2010 Nov 12;285(46):35719-27. Epub 2010 Sep 3. Europe PMC

Solving the NES problem. Mattaj, I.W. & Muller, C.W. Nat Struct Mol Biol. 2010 Nov;17(11):1288-9. Europe PMC

Conformational flexibility of RNA polymerase III during transcriptional elongation. Fernandez-Tornero, C., Bottcher, B., Rashid, U.J., Steuerwald, U., Florchinger, B., Devos, D.P., Lindner, D. & Muller, C.W. EMBO J. 2010 Nov 17;29(22):3762-72. Epub 2010 Oct 22 Europe PMC

Structural basis of TBX5-DNA recognition: the T-box domain in its DNA-bound and -unbound form. Stirnimann, C.U., Ptchelkine, D., Grimm, C. & Muller, C.W. J Mol Biol. 2010 Jul 2;400(1):71-81. Epub 2010 May 5. Europe PMC

WD40 proteins propel cellular networks. Stirnimann, C.U., Petsalaki, E., Russell, R.B. & Muller, C.W. Trends Biochem Sci. 2010 Oct;35(10):565-74. Epub 2010 May 5. Review Europe PMC

A novel key element in post-meiotic male genome reprogramming Rousseaux, S., Petosa, C., Muller, C.W. & Khochbin, S. Med Sci (Paris). 2010 Feb;26(2):130-2. Europe PMC

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. Moriniere, J., Rousseaux, S., Steuerwald, U., Soler-Lopez, M., Curtet, S., Vitte, A.L., Govin, J., Gaucher, J., Sadoul, K., Hart, D.J., Krijgsveld, J., Khochbin, S., Muller, C.W. & Petosa, C. Nature. 2009 Oct 1;461(7264):664-8. Europe PMC

Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt. Grimm, C., Matos, R., Ly-Hartig, N., Steuerwald, U., Lindner, D., Rybin, V., Muller, J. & Muller, C.W. EMBO J. 2009 Jul 8;28(13):1965-77. Epub 2009 Jun 4. Europe PMC

Structural basis for LEAFY floral switch function and similarity with helix-turn-helix proteins. Hames, C., Ptchelkine, D., Grimm, C., Thevenon, E., Moyroud, E., Gerard, F., Martiel, J.L., Benlloch, R., Parcy, F. & Muller, C.W. EMBO J. 2008 Oct 8;27(19):2628-37. Epub 2008 Sep 11. Europe PMC

Structure of the Drosophila nucleosome core particle highlights evolutionary constraints on the H2A-H2B histone dimer. Clapier, C.R., Chakravarthy, S., Petosa, C., Fernandez-Tornero, C., Luger, K. & Muller, C.W. Proteins. 2008 Apr;71(1):1-7. Europe PMC

Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg. Grimm, C., de Ayala Alonso, A.G., Rybin, V., Steuerwald, U., Ly-Hartig, N., Fischle, W., Muller, J. & Muller, C.W. EMBO Rep. 2007 Nov;8(11):1031-7. Epub 2007 Oct 12. Europe PMC

Insights into transcription initiation and termination from the electron microscopy structure of yeast RNA polymerase III. Fernandez-Tornero, C., Bottcher, B., Riva, M., Carles, C., Steuerwald, U., Ruigrok, R.W., Sentenac, A., Muller, C.W. & Schoehn, G. Mol Cell. 2007 Mar 23;25(6):813-23. Europe PMC

Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly. Mylona, A., Fernandez-Tornero, C., Legrand, P., Haupt, M., Sentenac, A., Acker, J. & Muller, C.W. Mol Cell. 2006 Oct 20;24(2):221-32. Europe PMC

HDAC6-p97/VCP controlled polyubiquitin chain turnover. Boyault, C., Gilquin, B., Zhang, Y., Rybin, V., Garman, E., Meyer-Klaucke, W., Matthias, P., Muller, C.W. & Khochbin, S. EMBO J. 2006 Jul 26;25(14):3357-66. Epub 2006 Jun 29. Europe PMC

Karyopherin flexibility in nucleocytoplasmic transport. Conti, E., Muller, C.W. & Stewart, M. Curr Opin Struct Biol. 2006 Apr;16(2):237-44. Epub 2006 Mar 29. Europe PMC

Expression, purification, crystallization and preliminary X-ray analysis of a C-terminal fragment of the Epstein-Barr virus ZEBRA protein. Morand, P., Budayova-Spano, M., Perrissin, M., Müller, C.W. & Petosa, C. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt3):210-4. Epub 2006 Feb 10. Europe PMC

Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein. Petosa, C., Morand, P., Baudin, F., Moulin, M., Artero, J.B. & Muller, C.W. Mol Cell. 2006 Feb 17;21(4):565-72. Europe PMC

Expression, proteolytic analysis, reconstitution, and crystallization of the tau60/tau91 subcomplex of yeast TFIIIC. Mylona, A., Acker, J., Fernandez-Tornero, C., Sentenac, A. & Muller, C.W. Protein Expr Purif. 2006 Feb;45(2):255-61. Epub 2005 Jul 26. Europe PMC

The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions. Hartlepp, K.F., Fernandez-Tornero, C., Eberharter, A., Grune, T., Müller, C.W. & Becker, P.B. Mol Cell Biol 2005 Nov;25(22):9886-96. Europe PMC

Interaction of influenza virus proteins with nucleosomes. Garcia-Robles, I., Akarsu, H., Müller, C.W., Ruigrok, R.W. & Baudin, F. Virology 2005 Feb 5;332(1):329-36. Europe PMC

Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex. Petosa, C., Schoehn, G., Askjaer, P., Bauer, U., Moulin, M., Steuerwald, U., Soler-Lopez, M., Baudin, F., Mattaj, I.W. & Muller, C.W. Mol Cell 2004 Dec 3;16(5):761-75. Europe PMC

The histone octamer is invisible when NF-kappaB binds to the nucleosome. Angelov, D., Lenouvel, F., Hans, F., Muller, C.W., Bouvet, P., Bednar, J., Moudrianakis, E.N., Cadet, J. & Dimitrov, S. J Biol Chem 2004 Oct 8;279(41):42374-82. Epub 2004 Jul 21. Europe PMC

Structure of an activated Dictyostelium STAT in its DNA-unbound form. Soler-Lopez, M., Petosa, C., Fukuzawa, M., Ravelli, R.B.G., Williams, J.G. & Müller, C.W. Mol Cell 2004 Mar 26;13(6):791-804. Europe PMC

Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2). Akarsu, H., Burmeister, W.P., Petosa, C., Petit, I., Muller, C.W., Ruigrok, R.W. & Baudin, F. EMBO J 2003 Sep 15;22(18):4646-55. Europe PMC

Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI. Grune, T., Brzeski, J., Eberharter, A., Clapier, C.R., Corona, D.F., Becker, P.B. & Müller, C.W. Mol Cell 2003 Aug;12(2):449-60. Europe PMC

Solution study of the NF-kappaB p50-DNA complex by UV laser protein-DNA cross-linking. Angelov, D., Charra, M., Muller, C.W., Cadet, J. & Dimitrov, S. Photochem Photobiol 2003 Jun;77(6):592-6. Europe PMC

Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition. Cohen, S.X., Moulin, M., Hashemolhosseini, S., Kilian, K., Wegner, M. & Müller, C.W. EMBO J 2003 Apr 15;22(8):1835-45. Europe PMC

X-ray crystal structure of STAT proteins and structure-activity relationships. Muller, C.W., Soler-Lopez, M., Gewinner, C., & Groner, B. In "Signal Transducers and Activators of Transcription (STATs): Activation and Biology." P.B. Sehgal, D.E. Levy, & T. Hirano (Eds). Kluwer Academic Publishers, Dordrecht, The Netherlands.

The GCM domain is a Zn-coordinating DNA-binding domain. Cohen, S.X., Moulin, M., Schilling, O., Meyer-Klaucke, W., Schreiber, J., Wegner, M. & Muller, C.W. FEBS Lett 2002 Sep 25;528(1-3):95-100. Europe PMC

Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome. Coll, M., Seidman, J.G. & Muller, C.W. Structure (Camb) 2002 Mar;10(3):343-56. Europe PMC

Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. Michel, F., Soler-Lopez, M., Petosa, C., Cramer, P., Siebenlist, U. & Muller, C.W. EMBO J 2001 Nov 15;20(22):6180-90. Europe PMC

Comparison of ARM and HEAT protein repeats. Andrade, M.A., Petosa, C., O'Donoghue, S.I., Muller, C.W. & Bork, P. J Mol Biol 2001 May 25;309(1):1-18. Europe PMC

Transcription factors: global and detailed views. Müller, C.W. Curr Opin Struct Biol 2001 Feb;11(1):26-32. Europe PMC

DNA recognition by NF kappa B and STAT transcription factors. Muller, C.W. Ernst Schering Res Found Workshop 2001;(34):143-66. Europe PMC

Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association. Cingolani, G., Lashuel, H.A., Gerace, L. & Muller, C.W. FEBS Lett 2000 Nov 10;484(3):291-8 Europe PMC

Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA. Cramer, P., Varrot, A., Barillas-Mury, C., Kafatos, F.C. & Muller, C.W. Structure Fold Des 1999 Jul 15;7(7):841-52 Europe PMC

Structure of importin-beta bound to the IBB domain of importin-alpha Cingolani, G., Petosa, C., Weis, K. & Müller, C.W. Nature 1999 May 20;399(6733):221-9 Europe PMC

Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations. Basson, C.T., Huang, T., Lin, R.C., Bachinsky, D.R., Weremowicz, S., Vaglio, A., Bruzzone, R., Quadrelli, R., Lerone, M., Romeo, G., Silengo, M., Pereira, A., Krieger, J., Mesquita, S.F., Kamisago, M., Morton, C.C., Pierpont, M.E., Muller, C.W., Seidman, J.G. & Seidman, C.E. Proc Natl Acad Sci U S A 1999 Mar 16;96(6):2919-24 Europe PMC

A firm hand on NFkappaB: structures of the IkappaBalpha-NFkappaB complex. Cramer, P. & Muller, C.W. Structure Fold Des 1999 Jan 15;7(1):R1-6 Europe PMC

Expression of a tyrosine phosphorylated, DNA binding Stat3beta dimer in bacteria. Becker, S., Corthals, G.L., Aebersold, R., Groner, B. & Muller, C.W. FEBS Lett 1998 Dec 11;441(1):141-7. Europe PMC

Three-dimensional structure of the Stat3beta homodimer bound to DNA. Becker, S., Groner, B. & Muller, C.W. Nature 1998 Jul 9;394(6689):145-51. Europe PMC

Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution. Cramer, P., Larson, C.J., Verdine, G.L. & Muller, C.W. EMBO J 1997 Dec 1;16(23):7078-90. Europe PMC

Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor. Muller, C.W. & Herrmann, B.G. Nature 1997 Oct 23;389(6653):884-8. Europe PMC

Structure of the NF-kappa B p50 homodimer bound to DNA. Muller, C.W., Rey, F.A., Sodeoka, M., Verdine, G.L. & Harrison, S.C. Nature 1995 Jan 26;373(6512):311-7. Europe PMC