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Staff at EMBL

Dr. Carsten Sachse

Group Leader
Sachse Group

EMBL Heidelberg, Meyerhofstra├če 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 2007, University of Jena/FLI-Leibniz-Institute for Age Research and Brandeis University, Waltham, Massachusetts.
Postdoctoral research at Max Planck Research Unit for Enzymology of Protein Folding, Halle, and at MRC Laboratory of Molecular Biology, Cambridge.
Group leader at EMBL since 2010.


(19)F NMR screening of unrelated antimicrobial peptides shows that membrane interactions are largely governed by lipids. Afonin, S., Glaser, R.W., Sachse, C., Salgado, J., Wadhwani, P. & Ulrich, A.S. Biochim Biophys Acta. 2014 Sep;1838(9):2260-8. doi: 10.1016/j.bbamem.2014.03.017.Epub 2014 Mar 31. Europe PMC

Structural differences explain diverse functions of Plasmodium actins. Vahokoski, J., Bhargav, S.P., Desfosses, A., Andreadaki, M., Kumpula, E.P., Martinez, S.M., Ignatev, A., Lepper, S., Frischknecht, F., Siden-Kiamos, I., Sachse, C. & Kursula, I. PLoS Pathog. 2014 Apr 17;10(4):e1004091. doi: 10.1371/journal.ppat.1004091.eCollection 2014 Apr. Europe PMC

SPRING - an image processing package for single-particle based helical reconstruction from electron cryomicrographs. Desfosses, A., Ciuffa, R., Gutsche, I. & Sachse, C. J Struct Biol. 2014 Jan;185(1):15-26. doi: 10.1016/j.jsb.2013.11.003. Epub 2013Nov 21. Europe PMC

GTP regulates the microtubule nucleation activity of gamma-tubulin. Gombos, L., Neuner, A., Berynskyy, M., Fava, L.L., Wade, R.C., Sachse, C. & Schiebel, E. Nat Cell Biol. 2013 Nov;15(11):1317-27. doi: 10.1038/ncb2863. Epub 2013 Oct 27. Europe PMC

Cartwheel architecture of Trichonympha basal body. Guichard, P., Desfosses, A., Maheshwari, A., Hachet, V., Dietrich, C., Brune, A., Ishikawa, T., Sachse, C. & Gonczy, P. Science. 2012 Aug 3;337(6094):553. Epub 2012 Jul 12. Europe PMC

Structure of the immature retroviral capsid at 8 A resolution by cryo-electron microscopy. Bharat, T.A., Davey, N.E., Ulbrich, P., Riches, J.D., de Marco, A., Rumlova, M., Sachse, C., Ruml, T. & Briggs, J.A. Nature. 2012 Jul 19;487(7407):385-9. Europe PMC

Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals. Korkhov, V.M., Sachse, C., Short, J.M. & Tate, C.G. Structure. 2010 Jun 9;18(6):677-87. Europe PMC

Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy. Sachse, C., Grigorieff, N. & Fandrich, M. Angew Chem Int Ed Engl. 2010 Feb 8;49(7):1321-3. Europe PMC

Structure of a bacterial dynamin-like protein lipid tube provides a mechanism for assembly and membrane curving. Low, H.H., Sachse, C., Amos, L.A. & Lowe, J. Cell. 2009 Dec 24;139(7):1342-52. Europe PMC

Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures. Schmidt, M., Sachse, C., Richter, W., Xu, C., Fandrich, M. & Grigorieff, N. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19813-8. Epub 2009 Oct 20. Europe PMC

Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils. Meinhardt, J., Sachse, C., Hortschansky, P., Grigorieff, N. & Fandrich, M. J Mol Biol. 2009 Feb 27;386(3):869-77. Epub 2008 Nov 14. Europe PMC

Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy. Sachse, C., Fandrich, M. & Grigorieff, N. Proc Natl Acad Sci U S A. 2008 May 27;105(21):7462-6. Epub 2008 May 15. Europe PMC

A dose-rate effect in single-particle electron microscopy. Chen, J.Z., Sachse, C., Xu, C., Mielke, T., Spahn, C.M. & Grigorieff, N. J Struct Biol. 2008 Jan;161(1):92-100. Epub 2007 Oct 1. Europe PMC

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Habicht, G., Haupt, C., Friedrich, R.P., Hortschansky, P., Sachse, C., Meinhardt, J., Wieligmann, K., Gellermann, G.P., Brodhun, M., Gotz, J., Halbhuber, K.J., Rocken, C., Horn, U. & Fandrich, M. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19232-7. Epub 2007 Nov 27. Europe PMC

High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus. Sachse, C., Chen, J.Z., Coureux, P.D., Stroupe, M.E., Fandrich, M. & Grigorieff, N. J Mol Biol. 2007 Aug 17;371(3):812-35. Epub 2007 Jun 4. Europe PMC

Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide. Sachse, C., Xu, C., Wieligmann, K., Diekmann, S., Grigorieff, N. & Fandrich, M. J Mol Biol. 2006 Sep 15;362(2):347-54. Europe PMC

Concentration-dependent realignment of the antimicrobial peptide PGLa in lipid membranes observed by solid-state 19F-NMR. Glaser, R.W., Sachse, C., Durr, U.H., Wadhwani, P., Afonin, S., Strandberg, E. & Ulrich, A.S. Biophys J. 2005 May;88(5):3392-7. Epub 2005 Feb 4. Europe PMC

Orientation of the antimicrobial peptide PGLa in lipid membranes determined from 19F-NMR dipolar couplings of 4-CF3-phenylglycine labels. Glaser, R.W., Sachse, C., Durr, U.H., Wadhwani, P. & Ulrich, A.S. J Magn Reson. 2004 May;168(1):153-63. Europe PMC