Staff at EMBL

Dr. Carsten Sachse

Group Leader
Sachse Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

PhD 2007, University of Jena/FLI-Leibniz-Institute for Age Research and Brandeis University, Waltham, Massachusetts.
Postdoctoral research at Max Planck Research Unit for Enzymology of Protein Folding, Halle, and at MRC Laboratory of Molecular Biology, Cambridge.
Group leader at EMBL since 2010.

Publications

Cartwheel architecture of Trichonympha basal body. Guichard, P., Desfosses, A., Maheshwari, A., Hachet, V., Dietrich, C., Brune, A., Ishikawa, T., Sachse, C. & Gonczy, P. Science. 2012 Aug 3;337(6094):553. Epub 2012 Jul 12. PubMed

Structure of the immature retroviral capsid at 8 A resolution by cryo-electron microscopy. Bharat, T.A., Davey, N.E., Ulbrich, P., Riches, J.D., de Marco, A., Rumlova, M., Sachse, C., Ruml, T. & Briggs, J.A. Nature. 2012 Jul 19;487(7407):385-9. PubMed

Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals. Korkhov, V.M., Sachse, C., Short, J.M. & Tate, C.G. Structure. 2010 Jun 9;18(6):677-87. PubMed

Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy. Sachse, C., Grigorieff, N. & Fandrich, M. Angew Chem Int Ed Engl. 2010 Feb 8;49(7):1321-3. PubMed

Structure of a bacterial dynamin-like protein lipid tube provides a mechanism for assembly and membrane curving. Low, H.H., Sachse, C., Amos, L.A. & Lowe, J. Cell. 2009 Dec 24;139(7):1342-52. PubMed

Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures. Schmidt, M., Sachse, C., Richter, W., Xu, C., Fandrich, M. & Grigorieff, N. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19813-8. Epub 2009 Oct 20. PubMed

Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils. Meinhardt, J., Sachse, C., Hortschansky, P., Grigorieff, N. & Fandrich, M. J Mol Biol. 2009 Feb 27;386(3):869-77. Epub 2008 Nov 14. PubMed

Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy. Sachse, C., Fandrich, M. & Grigorieff, N. Proc Natl Acad Sci U S A. 2008 May 27;105(21):7462-6. Epub 2008 May 15. PubMed

A dose-rate effect in single-particle electron microscopy. Chen, J.Z., Sachse, C., Xu, C., Mielke, T., Spahn, C.M. & Grigorieff, N. J Struct Biol. 2008 Jan;161(1):92-100. Epub 2007 Oct 1. PubMed

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Habicht, G., Haupt, C., Friedrich, R.P., Hortschansky, P., Sachse, C., Meinhardt, J., Wieligmann, K., Gellermann, G.P., Brodhun, M., Gotz, J., Halbhuber, K.J., Rocken, C., Horn, U. & Fandrich, M. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19232-7. Epub 2007 Nov 27. PubMed

High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus. Sachse, C., Chen, J.Z., Coureux, P.D., Stroupe, M.E., Fandrich, M. & Grigorieff, N. J Mol Biol. 2007 Aug 17;371(3):812-35. Epub 2007 Jun 4. PubMed

Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide. Sachse, C., Xu, C., Wieligmann, K., Diekmann, S., Grigorieff, N. & Fandrich, M. J Mol Biol. 2006 Sep 15;362(2):347-54. PubMed

Concentration-dependent realignment of the antimicrobial peptide PGLa in lipid membranes observed by solid-state 19F-NMR. Glaser, R.W., Sachse, C., Durr, U.H., Wadhwani, P., Afonin, S., Strandberg, E. & Ulrich, A.S. Biophys J. 2005 May;88(5):3392-7. Epub 2005 Feb 4. PubMed

Orientation of the antimicrobial peptide PGLa in lipid membranes determined from 19F-NMR dipolar couplings of 4-CF3-phenylglycine labels. Glaser, R.W., Sachse, C., Durr, U.H., Wadhwani, P. & Ulrich, A.S. J Magn Reson. 2004 May;168(1):153-63. PubMed