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Staff at EMBL

CP-60010188

Dr. Carsten Sachse

Group Leader
Sachse Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Biography

PhD 2007, University of Jena/FLI-Leibniz-Institute for Age Research and Brandeis University, Waltham, Massachusetts.
Postdoctoral research at Max Planck Research Unit for Enzymology of Protein Folding, Halle, and at MRC Laboratory of Molecular Biology, Cambridge.
Group leader at EMBL since 2010.

Publications

Total: 18 publication(s)

2014

Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Sidén-Kiamos I, Sachse C, Kursula I. (2014)
Structural differences explain diverse functions of Plasmodium actins.
PLoS Pathog. 10(4) doi:10.1371/journal.ppat.1004091
Europe PMC | doi

Afonin S, Glaser RW, Sachse C, Salgado J, Wadhwani P, Ulrich AS. (2014)
(19)F NMR screening of unrelated antimicrobial peptides shows that membrane interactions are largely governed by lipids
Biochim. Biophys. Acta 1838(9):2260-2268. doi:10.1016/j.bbamem.2014.03.017
Europe PMC | doi

Desfosses A, Ciuffa R, Gutsche I, Sachse C. (2014)
SPRING - an image processing package for single-particle based helical reconstruction from electron cryomicrographs
J. Struct. Biol. 185(1):15-26. doi:10.1016/j.jsb.2013.11.003
Europe PMC | doi


2013

Gombos L, Neuner A, Berynskyy M, Fava LL, Wade RC, Sachse C, Schiebel E. (2013)
GTP regulates the microtubule nucleation activity of γ-tubulin
Nat. Cell Biol. 15(11):1317-1327. doi:10.1038/ncb2863
Europe PMC | doi


2012

Guichard P, Desfosses A, Maheshwari A, Hachet V, Dietrich C, Brune A, Ishikawa T, Sachse C, Gönczy P. (2012)
Cartwheel architecture of Trichonympha basal body
Science 337(6094):553. doi:10.1126/science.1222789
Europe PMC | doi

Bharat TA, Davey NE, Ulbrich P, Riches JD, de Marco A, Rumlova M, Sachse C, Ruml T, Briggs JA. (2012)
Structure of the immature retroviral capsid at 8 A resolution by cryo-electron microscopy
Nature 487(7407):385-389. doi:10.1038/nature11169
Europe PMC | doi


2010

Korkhov VM, Sachse C, Short JM, Tate CG. (2010)
Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals
Structure 18(6):677-687. doi:10.1016/j.str.2010.03.001
Europe PMC | doi

Sachse C, Grigorieff N, Fändrich M. (2010)
Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy
Angew. Chem. Int. Ed. Engl. 49(7):1321-1323. doi:10.1002/anie.200904781
Europe PMC | doi


2009

Low HH, Sachse C, Amos LA, Löwe J. (2009)
Structure of a bacterial dynamin-like protein lipid tube provides a mechanism for assembly and membrane curving
Cell 139(7):1342-1352. doi:10.1016/j.cell.2009.11.003
Europe PMC | doi

Schmidt M, Sachse C, Richter W, Xu C, Fändrich M, Grigorieff N. (2009)
Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures
Proc. Natl. Acad. Sci. U.S.A. 106(47):19813-19818. doi:10.1073/pnas.0905007106
Europe PMC | doi

Meinhardt J, Sachse C, Hortschansky P, Grigorieff N, Fändrich M. (2009)
Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils
J. Mol. Biol. 386(3):869-877. doi:10.1016/j.jmb.2008.11.005
Europe PMC | doi


2008

Sachse C, Fändrich M, Grigorieff N. (2008)
Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy
Proc. Natl. Acad. Sci. U.S.A. 105(21):7462-7466. doi:10.1073/pnas.0712290105
Europe PMC | doi

Chen JZ, Sachse C, Xu C, Mielke T, Spahn CM, Grigorieff N. (2008)
A dose-rate effect in single-particle electron microscopy
J. Struct. Biol. 161(1):92-100. doi:10.1016/j.jsb.2007.09.017
Europe PMC | doi


2007

Habicht G, Haupt C, Friedrich RP, Hortschansky P, Sachse C, Meinhardt J, Wieligmann K, Gellermann GP, Brodhun M, Götz J, Halbhuber KJ, Röcken C, Horn U, Fändrich M. (2007)
Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils
Proc. Natl. Acad. Sci. U.S.A. 104(49):19232-19237. doi:10.1073/pnas.0703793104
Europe PMC | doi

Sachse C, Chen JZ, Coureux PD, Stroupe ME, Fändrich M, Grigorieff N. (2007)
High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus
J. Mol. Biol. 371(3):812-835. doi:10.1016/j.jmb.2007.05.088
Europe PMC | doi


2006

Sachse C, Xu C, Wieligmann K, Diekmann S, Grigorieff N, Fändrich M. (2006)
Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide
J. Mol. Biol. 362(2):347-354. doi:10.1016/j.jmb.2006.07.011
Europe PMC | doi


2005

Glaser RW, Sachse C, Dürr UH, Wadhwani P, Afonin S, Strandberg E, Ulrich AS. (2005)
Concentration-dependent realignment of the antimicrobial peptide PGLa in lipid membranes observed by solid-state 19F-NMR
Biophys. J. 88(5):3392-3397. doi:10.1529/biophysj.104.056424
Europe PMC | doi


2004

Glaser RW, Sachse C, Dürr UH, Wadhwani P, Ulrich AS. (2004)
Orientation of the antimicrobial peptide PGLa in lipid membranes determined from 19F-NMR dipolar couplings of 4-CF3-phenylglycine labels
J. Magn. Reson. 168(1):153-163. doi:10.1016/j.jmr.2004.02.008
Europe PMC | doi