EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

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  • PhD 2007, University of Jena/FLI-Leibniz-Institute for Age Research and Brandeis University, Waltham, Massachusetts.
    Postdoctoral research at Max Planck Research Unit for Enzymology of Protein Folding, Halle, and at MRC Laboratory of Molecular Biology, Cambridge.
    Group leader at EMBL since 2010.


Total: 21 publication(s)


Ehebauer MT, Zimmermann M, Jakobi AJ, Noens EE, Laubitz D, Cichocki B, Marrakchi H, Lanéelle MA, Daffé M, Sachse C, Dziembowski A, Sauer U, Wilmanns M. (2015)

Characterization of the Mycobacterial Acyl-CoA Carboxylase Holo Complexes Reveals Their Functional Expansion into Amino Acid Catabolism.

PLoS Pathog. 11(2) doi:10.1371/journal.ppat.1004623
Europe PMC | doi


Fromm SA, Bharat TA, Jakobi AJ, Hagen WJ, Sachse C. (2014)

Seeing tobacco mosaic virus through direct electron detectors.

J Struct Biol doi:10.1016/j.jsb.2014.12.002
Europe PMC | doi

Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L. (2014)

The dynamic conformational landscape of γ-secretase.

J. Cell. Sci.
Europe PMC

Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Sidén-Kiamos I, Sachse C, Kursula I. (2014)

Structural differences explain diverse functions of Plasmodium actins.

PLoS Pathog. 10(4) doi:10.1371/journal.ppat.1004091
Europe PMC | doi

Afonin S, Glaser RW, Sachse C, Salgado J, Wadhwani P, Ulrich AS. (2014)

(19)F NMR screening of unrelated antimicrobial peptides shows that membrane interactions are largely governed by lipids

Biochim. Biophys. Acta 1838(9):2260-2268. doi:10.1016/j.bbamem.2014.03.017
Europe PMC | doi

Desfosses A, Ciuffa R, Gutsche I, Sachse C. (2014)

SPRING - an image processing package for single-particle based helical reconstruction from electron cryomicrographs

J. Struct. Biol. 185(1):15-26. doi:10.1016/j.jsb.2013.11.003
Europe PMC | doi


Gombos L, Neuner A, Berynskyy M, Fava LL, Wade RC, Sachse C, Schiebel E. (2013)

GTP regulates the microtubule nucleation activity of γ-tubulin

Nat. Cell Biol. 15(11):1317-1327. doi:10.1038/ncb2863
Europe PMC | doi


Guichard P, Desfosses A, Maheshwari A, Hachet V, Dietrich C, Brune A, Ishikawa T, Sachse C, Gönczy P. (2012)

Cartwheel architecture of Trichonympha basal body

Science 337(6094):553. doi:10.1126/science.1222789
Europe PMC | doi

Bharat TA, Davey NE, Ulbrich P, Riches JD, de Marco A, Rumlova M, Sachse C, Ruml T, Briggs JA. (2012)

Structure of the immature retroviral capsid at 8 A resolution by cryo-electron microscopy

Nature 487(7407):385-389. doi:10.1038/nature11169
Europe PMC | doi


Korkhov VM, Sachse C, Short JM, Tate CG. (2010)

Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals

Structure 18(6):677-687. doi:10.1016/j.str.2010.03.001
Europe PMC | doi

Sachse C, Grigorieff N, Fändrich M. (2010)

Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy

Angew. Chem. Int. Ed. Engl. 49(7):1321-1323. doi:10.1002/anie.200904781
Europe PMC | doi


Low HH, Sachse C, Amos LA, Löwe J. (2009)

Structure of a bacterial dynamin-like protein lipid tube provides a mechanism for assembly and membrane curving

Cell 139(7):1342-1352. doi:10.1016/j.cell.2009.11.003
Europe PMC | doi

Schmidt M, Sachse C, Richter W, Xu C, Fändrich M, Grigorieff N. (2009)

Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures

Proc. Natl. Acad. Sci. U.S.A. 106(47):19813-19818. doi:10.1073/pnas.0905007106
Europe PMC | doi

Meinhardt J, Sachse C, Hortschansky P, Grigorieff N, Fändrich M. (2009)

Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils

J. Mol. Biol. 386(3):869-877. doi:10.1016/j.jmb.2008.11.005
Europe PMC | doi


Sachse C, Fändrich M, Grigorieff N. (2008)

Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy

Proc. Natl. Acad. Sci. U.S.A. 105(21):7462-7466. doi:10.1073/pnas.0712290105
Europe PMC | doi

Chen JZ, Sachse C, Xu C, Mielke T, Spahn CM, Grigorieff N. (2008)

A dose-rate effect in single-particle electron microscopy

J. Struct. Biol. 161(1):92-100. doi:10.1016/j.jsb.2007.09.017
Europe PMC | doi


Habicht G, Haupt C, Friedrich RP, Hortschansky P, Sachse C, Meinhardt J, Wieligmann K, Gellermann GP, Brodhun M, Götz J, Halbhuber KJ, Röcken C, Horn U, Fändrich M. (2007)

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

Proc. Natl. Acad. Sci. U.S.A. 104(49):19232-19237. doi:10.1073/pnas.0703793104
Europe PMC | doi

Sachse C, Chen JZ, Coureux PD, Stroupe ME, Fändrich M, Grigorieff N. (2007)

High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus

J. Mol. Biol. 371(3):812-835. doi:10.1016/j.jmb.2007.05.088
Europe PMC | doi


Sachse C, Xu C, Wieligmann K, Diekmann S, Grigorieff N, Fändrich M. (2006)

Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide

J. Mol. Biol. 362(2):347-354. doi:10.1016/j.jmb.2006.07.011
Europe PMC | doi


Glaser RW, Sachse C, Dürr UH, Wadhwani P, Afonin S, Strandberg E, Ulrich AS. (2005)

Concentration-dependent realignment of the antimicrobial peptide PGLa in lipid membranes observed by solid-state 19F-NMR

Biophys. J. 88(5):3392-3397. doi:10.1529/biophysj.104.056424
Europe PMC | doi


Glaser RW, Sachse C, Dürr UH, Wadhwani P, Ulrich AS. (2004)

Orientation of the antimicrobial peptide PGLa in lipid membranes determined from 19F-NMR dipolar couplings of 4-CF3-phenylglycine labels

J. Magn. Reson. 168(1):153-163. doi:10.1016/j.jmr.2004.02.008
Europe PMC | doi