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Staff at EMBL

Dr. Beate Neumann

Senior Scientific Officer
Advanced Light Microscopy Facility

EMBL Heidelberg, Meyerhofstra├če 1, 69117 Heidelberg, Germany

E-mail: send a mail

Publications

The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy. Asteriti, I.A., Di Cesare, E., De Mattia, F., Hilsenstein, V., Neumann, B., Cundari, E., Lavia, P. & Guarguaglini, G. Oncotarget. 2014 Aug 15;5(15):6229-6242. Europe PMC

Dynamical modelling of phenotypes in a genome-wide RNAi live-cell imaging assay. Pau, G., Walter, T., Neumann, B., Heriche, J.K., Ellenberg, J. & Huber, W. BMC Bioinformatics. 2013 Oct 16;14:308. doi: 10.1186/1471-2105-14-308. Europe PMC

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Gudjonsson, T., Altmeyer, M., Savic, V., Toledo, L., Dinant, C., Grofte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, S., Mailand, N., Neumann, B., Heriche, J.K., Shearer, R., Saunders, D., Bartek, J., Lukas, J. & Lukas, C. Cell. 2012 Aug 17;150(4):697-709. doi: 10.1016/j.cell.2012.06.039. Epub 2012 Aug9. Europe PMC

Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Simpson, J.C., Joggerst, B., Laketa, V., Verissimo, F., Cetin, C., Erfle, H., Bexiga, M.G., Singan, V.R., Heriche, J.K., Neumann, B., Mateos, A., Blake, J., Bechtel, S., Benes, V., Wiemann, S., Ellenberg, J. & Pepperkok, R. Nat Cell Biol. 2012 Jun 3;14(7):764-74. doi: 10.1038/ncb2510. Europe PMC

Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1. Moudry, P., Lukas, C., Macurek, L., Neumann, B., Heriche, J.K., Pepperkok, R., Ellenberg, J., Hodny, Z., Lukas, J. & Bartek, J. Cell Death Differ. 2012 May;19(5):798-807. doi: 10.1038/cdd.2011.150. Epub 2011Nov 11. Europe PMC

Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. Stadler, C., Hjelmare, M., Neumann, B., Jonasson, K., Pepperkok, R., Uhlen, M. & Lundberg, E. J Proteomics. 2012 Apr 3;75(7):2236-51. doi: 10.1016/j.jprot.2012.01.030. Epub2012 Feb 15. Europe PMC

Automated High-Throughput RNAi Screening in Human Cells Combined with Reporter mRNA Transfection to Identify Novel Regulators of Translation. Casanova, C.M., Sehr, P., Putzker, K., Hentze, M.W., Neumann, B., Duncan, K.E. & Thoma, C. PLoS One. 2012;7(9):e45943. doi: 10.1371/journal.pone.0045943. Epub 2012 Sep 27. Europe PMC

Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases. Ritzerfeld, J., Remmele, S., Wang, T., Temmerman, K., Brugger, B., Wegehingel, S., Tournaviti, S., Strating, J.R., Wieland, F.T., Neumann, B., Ellenberg, J., Lawerenz, C., Hesser, J., Erfle, H., Pepperkok, R. & Nickel, W. Genome Res. 2011 Nov;21(11):1955-68. doi: 10.1101/gr.116087.110. Epub 2011 Jul27. Europe PMC

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Lukas, C., Savic, V., Bekker-Jensen, S., Doil, C., Neumann, B., Solvhoj Pedersen, R., Grofte, M., Chan, K.L., Hickson, I.D., Bartek, J. & Lukas, J. Nat Cell Biol. 2011 Mar;13(3):243-53. Epub 2011 Feb 13. Europe PMC

CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging. Held, M., Schmitz, M.H., Fischer, B., Walter, T., Neumann, B., Olma, M.H., Peter, M., Ellenberg, J. & Gerlich, D.W. Nat Methods. 2010 Sep;7(9):747-54. doi: 10.1038/nmeth.1486. Epub 2010 Aug 8. Europe PMC

High-throughput microscopy using live mammalian cells. Terjung, S., Walter, T., Seitz, A., Neumann, B., Pepperkok, R. & Ellenberg, J. Cold Spring Harb Protoc. 2010 Aug 1;2010(7):pdb.top84. doi: 10.1101/pdb.top84. Europe PMC

Automatic identification and clustering of chromosome phenotypes in a genome wide RNAi screen by time-lapse imaging. Walter, T., Held, M., Neumann, B., Heriche, J.K., Conrad, C., Pepperkok, R. & Ellenberg, J. J Struct Biol. 2010 Apr;170(1):1-9. doi: 10.1016/j.jsb.2009.10.004. Epub 2009 Oct23. Europe PMC

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Neumann, B., Walter, T., Heriche, J.K., Bulkescher, J., Erfle, H., Conrad, C., Rogers, P., Poser, I., Held, M., Liebel, U., Cetin, C., Sieckmann, F., Pau, G., Kabbe, R., W├╝nsche, A., Satagopam, V., Schmitz, M.H., Chapuis, C., Gerlich, D.W., Schneider, R., Eils, R., Huber, W., Peters, J.M., Hyman, A.A., Durbin, R., Pepperkok, R. & Ellenberg, J. Nature. 2010 Apr 1;464(7289):721-7. Europe PMC

Work flow for multiplexing siRNA assays by solid-phase reverse transfection in multiwell plates. Erfle, H., Neumann, B., Rogers, P., Bulkescher, J., Ellenberg, J. & Pepperkok, R. J Biomol Screen. 2008 Aug;13(7):575-80. Epub 2008 Jul 3. Europe PMC

EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase. Tegha-Dunghu, J., Neumann, B., Reber, S., Krause, R., Erfle, H., Walter, T., Held, M., Rogers, P., Hupfeld, K., Ruppert, T., Ellenberg, J. & Gruss, O.J. J Cell Sci. 2008 May 15;121(Pt 10):1718-26. Epub 2008 Apr 29. Europe PMC

Reverse transfection on cell arrays for high content screening microscopy. Erfle, H., Neumann, B., Liebel, U., Rogers, P., Held, M., Walter, T., Ellenberg, J. & Pepperkok, R. Nat Protoc. 2007;2(2):392-9. Europe PMC

High-throughput RNAi screening by time-lapse imaging of live human cells. Neumann, B., Held, M., Liebel, U., Erfle, H., Rogers, P., Pepperkok, R. & Ellenberg, J. Nat Methods. 2006 May;3(5):385-90. Europe PMC

Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Sonnichsen, B., Koski, L.B., Walsh, A., Marschall, P., Neumann, B., Brehm, M., Alleaume, A.M., Artelt, J., Bettencourt, P., Cassin, E., Hewitson, M., Holz, C., Khan, M., Lazik, S., Martin, C., Nitzsche, B., Ruer, M., Stamford, J., Winzi, M., Heinkel, R., Roder, M., Finell, J., Hantsch, H., Jones, S.J., Jones, M., Piano, F., Gunsalus, K.C., Oegema, K., Gonczy, P., Coulson, A., Hyman, A.A. & Echeverri, C.J. Nature 2005 Mar 24;434(7032):462-9. Europe PMC

RGD-mutants of B-lymphotropic polyomavirus capsids specifically bind to alpha(v)beta3 integrin. Langner, J., Neumann, B., Goodman, S.L. & Pawlita, M. Arch Virol 2004 Oct;149(10):1877-96. Europe PMC