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Staff at EMBL

David Will

Head of Medicinal Chemistry Section
Chemical Biology Core Facility

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Biography

PhD 1992, University of Edinburgh.
Postdoctoral research at Hoechst AG in Frankfurt.
Visiting Scientist at EMBL, Heidelberg 1994.
Medicinal Chemistry Lab Head, Sanofi-Aventis in Frankfurt 1994-2012.
Head of Medicinal Chemistry Section at EMBL since 2013.

Publications

Publications

Total: 36 publication(s)

2012

Nazaré M, Matter H, Will DW, Wagner M, Urmann M, Czech J, Schreuder H, Bauer A, Ritter K, Wehner V. (2012)
Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes
Angew. Chem. Int. Ed. Engl. 51(4):905-911. doi:10.1002/anie.201107091
Europe PMC | doi


2009

Matter H, Nazaré M, Güssregen S, Will DW, Schreuder H, Bauer A, Urmann M, Ritter K, Wagner M, Wehner V. (2009)
Evidence for C-Cl/C-Br...pi interactions as an important contribution to protein-ligand binding affinity
Angew Chem Int Edit 48(16):2911-2916. doi:10.1002/anie.200806219
Europe PMC | doi


2005

Nazaré M, Will DW, Matter H, Schreuder H, Ritter K, Urmann M, Essrich M, Bauer A, Wagner M, Czech J, Lorenz M, Laux V, Wehner V. (2005)
Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography
J. Med. Chem. 48(14):4511-4525. doi:10.1021/jm0490540
Europe PMC | doi

Matter H, Will DW, Nazaré M, Schreuder H, Laux V, Wehner V. (2005)
Structural requirements for factor Xa inhibition by 3-oxybenzamides with neutral P1 substituents: combining X-ray crystallography, 3D-QSAR, and tailored scoring functions
J. Med. Chem. 48(9):3290-3312. doi:10.1021/jm049187l
Europe PMC | doi

Will DW, Breipohl G, Gourvest JF, Ruxer JM, Doucet B, Auberval M, Baron R, Gaillard M, Gadek TR, Knolle J, Stilz HU, Peyman A. (2005)
alpha(v)beta(3) antagonists based on a central benzoic acid scaffold
Pol J Chem 79(3):567-572.


2004

Dickopf S, Frank M, Junker HD, Maier S, Metz G, Ottleben H, Rau H, Schellhaas N, Schmidt K, Sekul R, Vanier C, Vetter D, Czech J, Lorenz M, Matter H, Schudok M, Schreuder H, Will DW, Nestler HP. (2004)
Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa
Anal. Biochem. 335(1):50-57. doi:10.1016/j.ab.2004.08.033
Europe PMC | doi

Nazare M, Essrich M, Will DW, Matter H, Ritter K, Urmann M, Bauer A, Schreuder H, Dudda A, Czech J, Lorenz M, Laux V, Wehner V. (2004)
Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral PI substituents
Bioorg Med Chem Lett 14(16):4191-4195. doi:10.1016/j.bmcl.2004.06.020
doi

Nazaré M, Schneider C, Lindenschmidt A, Will DW. (2004)
A flexible, palladium-catalyzed indole and azaindole synthesis by direct annulation of chloroanilines and chloroaminopyridines with ketones
Angew. Chem. Int. Ed. Engl. 43(34):4526-4528. doi:10.1002/anie.200460122
Europe PMC | doi

Nazaré M, Essrich M, Will DW, Matter H, Ritter K, Urmann M, Bauer A, Schreuder H, Dudda A, Czech J, Lorenz M, Laux V, Wehner V. (2004)
Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents
Bioorg. Med. Chem. Lett. 14(16):4191-4195. doi:10.1016/j.bmcl.2004.06.020
Europe PMC | doi

Nazaré M, Essrich M, Will DW, Matter H, Ritter K, Urmann M, Bauer A, Schreuder H, Czech J, Lorenz M, Laux V, Wehner V. (2004)
Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand
Bioorg. Med. Chem. Lett. 14(16):4197-4201. doi:10.1016/j.bmcl.2004.06.019
Europe PMC | doi

Nazaré M, Matter H, Klingler O, Al-Obeidi F, Schreuder H, Zoller G, Czech J, Lorenz M, Dudda A, Peyman A, Nestler HP, Urmann M, Bauer A, Laux V, Wehner V, Will DW. (2004)
Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand
Bioorg. Med. Chem. Lett. 14(11):2801-2805. doi:10.1016/j.bmcl.2004.03.059
Europe PMC | doi


2002

Uhlmann E, Peyman A, Will DW. (2002)
Antisense: Medicinal Chemistry
In: Bertino JR (ed.), Encyclopedia of Cancer, vol 1. 2 edn. Academic Press, New York. pp 103-117.doi:10.1016/B0-12-227555-1/00012-5
doi


2001

Peyman A, Scheunemann K, Will DW, Knolle J, Wehner V, Breipohl G, Stilz HU, Carniato D, Ruxer J, Gourvest J, Auberval M, Doucet B, Baron R, Gaillard M, Gadek TR, Bodary S. (2001)
alpha(v)beta(3) Antagonists based on a central thiophene scaffold
Bioorg. Med. Chem. Lett. 11(15):2011-2015. doi:10.1016/s0960-894x(01)00357-2
Europe PMC | doi


2000

Rait A, Pirollo K, Will DW, Peyman A, Rait V, Uhlmann E, Chang EH. (2000)
3 '-end conjugates of minimally phosphorothioate-protected oligonucleotides with 1-O-hexadecylglycerol: Synthesis and anti-ras activity in radiation-resistant cells
Bioconjugate Chem 11(2):153-160. doi:10.1021/bc990106n
Europe PMC | doi

Rait A, Uhlmann E, Peyman A, Will DW, Chang EH. (2000)
Inhibition of Ras p21 synthesis by antisense undecamers with uniform and specifically arranged phosphorothioate linkages
Anticancer Drugs 11(3):181-191. doi:10.1097/00001813-200003000-00006
Europe PMC | doi


1999

Lutz MJ, Will DW, Breipohl G, Benner SA, Uhlmann E. (1999)
Synthesis of a monocharged peptide nucleic acid (PNA) analog and its recognition as substrate by DNA polymerases
Nucleos Nucleot 18(3):393-401. doi:10.1080/15257779908043084
Europe PMC | doi


1998

Peyman A, Uhlmann E, Wagner K, Augustin S, Weiser C, Hein S, Langner D, Breipohl G, Will DW. (1998)
DNA-PHONA-PNA chimeric molecules: Contributions to binding against complementary DNA
Nucleos Nucleot 17(9-11):1997-2001. doi:10.1080/07328319808004739
doi

Uhlmann E, Peyman A, Breipohl G, Will DW. (1998)
PNA: Synthetic polyamide nucleic acids with unusual binding properties
Angew Chem Int Edit 37(20):2797-2823. doi:10.1002/(SICI)1521-3773(19981102)37:203.0.CO;2-K
doi

Uhlmann E, Hornung L, Will DW, Grafe U. (1998)
Synthesis of novel oligodeoxynucleotide conjugates containing the anionophoric moiety of pamamycin
Nucleos Nucleot 17(1-3):309-316. doi:10.1080/07328319808005179
doi


1997

Breipohl G, Will DW, Peyman A, Uhlmann E. (1997)
Novel synthetic routes to PNA monomers and PNA-DNA linker molecules
Tetrahedron 53(43):14671-14686. doi:10.1016/S0040-4020(97)01044-2
doi

Schmidt A, Sindermann J, Peyman A, Uhlmann E, Will DW, Müller JG, Breithardt G, Buddecke E. (1997)
Sequence-specific antiproliferative effects of antisense and end-capping-modified antisense oligodeoxynucleotides targeted against the 5'-terminus of basic-fibroblast-growth-factor mRNA in coronary smooth muscle cells
Eur. J. Biochem. 248(2):543-549. doi:10.1111/j.1432-1033.1997.00543.x
Europe PMC | doi

Uhlmann E, Peyman A, Will DW. (1997)
Antisense: Chemical Modifications
In: Bertino JR (ed.), Encyclopedia of Cancer, vol 1. 1 edn. Academic Press, San Diego. pp 64-81.

Uhlmann E, Hornung L, Hein S, Augustin S, Peyman A, Will DW, Helsberg M, Sagi J, Otvos L, Ojwang JO, Mustain S, Rando RF. (1997)
Enhanced biological activity of antisense oligonucleotides containing 5-(1-hexynyl)-substituted pyrimidine nucleotides
Nucleos Nucleot 16(7-9):1717-1720. doi:10.1080/07328319708006262
doi

Peyman A, Ragg H, Ulshofer T, Will DW, Uhlmann E. (1997)
Enhanced specificity of minimally modified anti-c-myc oligonucleotides
Nucleos Nucleot 16(7-9):1215-1219. doi:10.1080/07328319708006161
doi

Peyman A, Uhlmann E, Wagner K, Augustin S, Weiser C, Will DW, Breipohl G. (1997)
PHONA-PNA co-oligomers: Nucleic acid mimetics with interesting properties
Angew Chem Int Edit 36(24):2809-2812. doi:10.1002/anie.199728091
doi

Uhlmann E, Will DW, Breipohl G, Peyman A, Langner D, Knolle J, OMalley G. (1997)
Synthesis of polyamide nucleic acids (PNAs), PNA/DNA-chimeras and phosphonic ester nucleic acids (PHONAs)
Nucleos Nucleot 16(5-6):603-608. doi:10.1080/07328319708002923
doi


1996

Peyman A, Uhlmann E, Wagner K, Augustin S, Breipohl G, Will DW, Schafer A, Wallmeier H. (1996)
Phosphonic ester nucleic acids (PHONAs): Oligonucleotide analogues with an achiral phosphonic acid ester backbone
Angew Chem Int Edit 35(22):2636-2638. doi:10.1002/anie.199626361
doi

Uhlmann E, Will DW, Breipohl G, Langner D, Ryte A. (1996)
Synthesis and properties of PNA/DNA chimeras
Angew Chem Int Edit 35(22):2632-2635. doi:10.1002/anie.199626321
doi

Breipohl G, Will DW, Langner D, Knolle J, Uhlmann E. (1996)
Synthesis of polyamide nucleic acids using a new protection scheme which is fully compatible with oligonucleotide synthesis
In: Epton R (ed.), Innovations and Perspectives in Solid Phase Synthesis and Combinatorial Libraries. Mayflower Scientific, Birmingham, UK. pp 61-64.

Will DW, Breipohl G, Langner D, Uhlmann E. (1996)
Solid-phase synthesis of PNA-DNA chimeric oligomers
In: Epton R (ed.), Innovations and Perspectives in Solid Phase Synthesis and Combinatorial Libraries. Mayflower Scientific, Birmingham, UK. pp 65-68.


1995

Will DW, Breipohl G, Langner D, Knolle J, Uhlmann E. (1995)
The synthesis of polyamide nucleic acids using a novel monomethoxytrityl protecting-group strategy
Tetrahedron 51(44):12069-12082. doi:10.1016/0040-4020(95)00766-2
doi


1993

Teigelkamp S, Ebel S, Will DW, Brown T, Beggs JD. (1993)
Branched poly-labelled oligonucleotides: enhanced specificity of fork-shaped biotinylated oligoribonucleotides for antisense affinity selection.
Nucleic Acids Res. 21(19):4651-4652. doi:10.1093/nar/21.19.4651
Europe PMC | doi

Grzybowski J, Will DW, Randall RE, Smith CA, Brown T. (1993)
Synthesis and antibody-mediated detection of oligonucleotides containing multiple 2,4-dinitrophenyl reporter groups
Nucleic Acids Res 21(8):1705-1712. doi:10.1093/nar/21.8.1705
Europe PMC | doi


1992

MacKellar C, Graham D, Will DW, Burgess S, Brown T. (1992)
Synthesis and physical properties of anti-HIV antisense oligonucleotides bearing terminal lipophilic groups
Nucleic Acids Res 20(13):3411-3417. doi:10.1093/nar/20.13.3411
Europe PMC | doi

Will DW, Brown T. (1992)
Attachment of vitamin E derivatives to oligonucleotides during solid-phase synthesis
Tetrahedron Lett 33(19):2729-2732. doi:10.1016/S0040-4039(00)79068-X
doi


1991

Will DW, Pritchard CE, Brown T. (1991)
The synthesis of oligonucleotides that contain 2,4-dinitrophenyl reporter groups
Carbohydr. Res. 216:315-322. doi:10.1016/0008-6215(92)84170-w
Europe PMC | doi