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Staff at EMBL

CP-60002630

Dr. Jonathon Blake

Bioinformatician
Genomics Core Facility

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Publications

Total: 23 publication(s)

2014

Blake J, Riddell A, Theiss S, Gonzalez AP, Haase B, Jauch A, Janssen JW, Ibberson D, Pavlinic D, Moog U, Benes V, Runz H. (2014)
Sequencing of a patient with balanced chromosome abnormalities and neurodevelopmental disease identifies disruption of multiple high risk loci by structural variation
PLoS ONE 9(3):e90894. doi:10.1371/journal.pone.0090894
Europe PMC | doi


2013

Frühmesser A, Blake J, Haberlandt E, Baying B, Raeder B, Runz H, Spreiz A, Fauth C, Benes V, Utermann G, Zschocke J, Kotzot D. (2013)
Disruption of EXOC6B in a patient with developmental delay, epilepsy, and a de novo balanced t(2;8) translocation
Eur. J. Hum. Genet. 21(10):1177-1180. doi:10.1038/ejhg.2013.18
Europe PMC | doi

Bettencourt P, Marion S, Pires D, Santos LF, Lastrucci C, Carmo N, Blake J, Benes V, Griffiths G, Neyrolles O, Lugo-Villarino G, Anes E. (2013)
Actin-binding protein regulation by microRNAs as a novel microbial strategy to modulate phagocytosis by host cells: the case of N-Wasp and miR-142-3p
Front Cell Infect Microbiol 3:19. doi:10.3389/fcimb.2013.00019
Europe PMC | doi


2012

Riedmaier I, Benes V, Blake J, Bretschneider N, Zinser C, Becker C, Meyer HH, Pfaffl MW. (2012)
RNA-sequencing as useful screening tool in the combat against the misuse of anabolic agents
Anal. Chem. 84(15):6863-6868. doi:10.1021/ac301433d
Europe PMC | doi

Simpson JC, Joggerst B, Laketa V, Verissimo F, Cetin C, Erfle H, Bexiga MG, Singan VR, Hériché JK, Neumann B, Mateos A, Blake J, Bechtel S, Benes V, Wiemann S, Ellenberg J, Pepperkok R. (2012)
Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway
Nat. Cell Biol. 14(7):764-774. doi:10.1038/ncb2510
Europe PMC | doi

Baay-Guzman GJ, Huerta-Yepez S, Vega MI, Aguilar-Leon D, Campillos M, Blake J, Benes V, Hernandez-Pando R, Teran LM. (2012)
Role of CXCL13 in asthma: novel therapeutic target
Chest 141(4):886-894. doi:10.1378/chest.11-0633
Europe PMC | doi

Rausch T, Jones DT, Zapatka M, Stütz AM, Zichner T, Weischenfeldt J, Jäger N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Blake J, Benes V, Kulozik AE, Witt O, Martin D, Zhang C, Porat R, Merino DM, Wasserman J, Jabado N, Fontebasso A, Bullinger L, Rücker FG, Döhner K, Döhner H, Koster J, Molenaar JJ, Versteeg R, Kool M, Tabori U, Malkin D, Korshunov A, Taylor MD, Lichter P, Pfister SM, Korbel JO. (2012)
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
Cell 148(1-2):59-71. doi:10.1016/j.cell.2011.12.013
Europe PMC | doi


2011

Sanchez M, Galy B, Schwanhaeusser B, Blake J, Bähr-Ivacevic T, Benes V, Selbach M, Muckenthaler MU, Hentze MW. (2011)
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins
Blood 118(22):e168-79. doi:10.1182/blood-2011-04-343541
Europe PMC | doi


2010

Trougakos IP, Chondrogianni N, Amarantos I, Blake J, Schwager C, Wirkner U, Ansorge W, Gonos ES. (2010)
Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines
Cancer Genet. Cytogenet. 196(2):109-118. doi:10.1016/j.cancergencyto.2009.09.012
Europe PMC | doi


2009

Hose D, Rème T, Meissner T, Moreaux J, Seckinger A, Lewis J, Benes V, Benner A, Hundemer M, Hielscher T, Shaughnessy JD Jr, Barlogie B, Neben K, Krämer A, Hillengass J, Bertsch U, Jauch A, De Vos J, Rossi JF, Möhler T, Blake J, Zimmermann J, Klein B, Goldschmidt H. (2009)
Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma
Blood 113(18):4331-4340. doi:10.1182/blood-2008-09-178350
Europe PMC | doi

Wagner W, Bork S, Horn P, Krunic D, Walenda T, Diehlmann A, Benes V, Blake J, Huber FX, Eckstein V, Boukamp P, Ho AD. (2009)
Aging and replicative senescence have related effects on human stem and progenitor cells
PLoS ONE 4(6):e5846. doi:10.1371/journal.pone.0005846
Europe PMC | doi

Lowery AJ, Miller N, Devaney A, McNeill RE, Davoren PA, Lemetre C, Benes V, Schmidt S, Blake J, Ball G, Kerin MJ. (2009)
MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer
Breast Cancer Res. 11(3):R27. doi:10.1186/bcr2257
Europe PMC | doi


2008

Denger S, Bähr-Ivacevic T, Brand H, Reid G, Blake J, Seifert M, Lin CY, May K, Benes V, Liu ET, Gannon F. (2008)
Transcriptome profiling of estrogen-regulated genes in human primary osteoblasts reveals an osteoblast-specific regulation of the insulin-like growth factor binding protein 4 gene
Mol. Endocrinol. 22(2):361-379. doi:10.1210/me.2007-0292
Europe PMC | doi

Wagner W, Horn P, Castoldi M, Diehlmann A, Bork S, Saffrich R, Benes V, Blake J, Pfister S, Eckstein V, Ho AD. (2008)
Replicative senescence of mesenchymal stem cells: a continuous and organized process
PLoS ONE 3(5):e2213. doi:10.1371/journal.pone.0002213
Europe PMC | doi


2006

Wagner W, Feldmann RE Jr, Seckinger A, Maurer MH, Wein F, Blake J, Krause U, Kalenka A, Bürgers HF, Saffrich R, Wuchter P, Kuschinsky W, Ho AD. (2006)
The heterogeneity of human mesenchymal stem cell preparations--evidence from simultaneous analysis of proteomes and transcriptomes
Exp. Hematol. 34(4):536-548. doi:10.1016/j.exphem.2006.01.002
Europe PMC | doi

Blake J, Schwager C, Kapushesky M, Brazma A. (2006)
ChroCoLoc: an application for calculating the probability of co-localization of microarray gene expression
Bioinformatics 22(6):765-767. doi:10.1093/bioinformatics/btk022
Europe PMC | doi


2005

Wagner W, Wein F, Seckinger A, Frankhauser M, Wirkner U, Krause U, Blake J, Schwager C, Eckstein V, Ansorge W, Ho AD. (2005)
Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood
Exp. Hematol. 33(11):1402-1416. doi:10.1016/j.exphem.2005.07.003
Europe PMC | doi

Wagner W, Saffrich R, Wirkner U, Eckstein V, Blake J, Ansorge A, Schwager C, Wein F, Miesala K, Ansorge W, Ho AD. (2005)
Hematopoietic progenitor cells and cellular microenvironment: behavioral and molecular changes upon interaction
Stem Cells 23(8):1180-1191. doi:10.1634/stemcells.2004-0361
Europe PMC | doi

Wagner W, Laufs S, Blake J, Schwager C, Wu X, Zeller JW, Ho AD, Fruehauf S. (2005)
Retroviral integration sites correlate with expressed genes in hematopoietic stem cells
Stem Cells 23(8):1050-1058. doi:10.1634/stemcells.2005-0006
Europe PMC | doi

Schwager C, Blake J. (2005)
Bloader--a batch loader application for MIAMExpress
Bioinformatics 21(8):1727-1729. doi:10.1093/bioinformatics/bti231
Europe PMC | doi


2004

Wagner W, Ansorge A, Wirkner U, Eckstein V, Schwager C, Blake J, Miesala K, Selig J, Saffrich R, Ansorge W, Ho AD. (2004)
Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis
Blood 104(3):675-686. doi:10.1182/blood-2003-10-3423
Europe PMC | doi

Almstrup K, Hoei-Hansen CE, Wirkner U, Blake J, Schwager C, Ansorge W, Nielsen JE, Skakkebaek NE, Rajpert-De Meyts E, Leffers H. (2004)
Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling
Cancer Res. 64(14):4736-4743. doi:10.1158/0008-5472.can-04-0679
Europe PMC | doi


1997

Blake J, Salinas PC, Hughes SM. (1997)
n beta geo, a combined selection and reporter gene for retroviral and transgenic studies.
BioTechniques 23(4):690-695.
Europe PMC