Top image

Staff at EMBL

Tobias Rausch

Bioinformatician
Genomics Core Facility Korbel Group

EMBL Heidelberg, Meyerhofstra├če 1, 69117 Heidelberg, Germany

E-mail: send a mail
Web page: http://www.embl.de/~rausch/

Publications

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse. Bandapalli, O.R., Schuessele, S., Kunz, J.B., Rausch, T., Stutz, A.M., Tal, N., Geron, I., Gershman, N., Izraeli, S., Eilers, J., Vaezipour, N., Kirschner-Schwabe, R., Hof, J., von Stackelberg, A., Schrappe, M., Stanulla, M., Zimmermann, M., Koehler, R., Avigad, S., Handgretinger, R., Frismantas, V., Bourquin, J.P., Bornhauser, B., Korbel, J.O., Muckenthaler, M.U. & Kulozik, A.E. Haematologica. 2014 Jun 27. pii: haematol.2014.104992. Europe PMC

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Kool, M., Jones, D.T., Jager, N., Northcott, P.A., Pugh, T.J., Hovestadt, V., Piro, R.M., Esparza, L.A., Markant, S.L., Remke, M., Milde, T., Bourdeaut, F., Ryzhova, M., Sturm, D., Pfaff, E., Stark, S., Hutter, S., Seker-Cin, H., Johann, P., Bender, S., Schmidt, C., Rausch, T., Shih, D., Reimand, J., Sieber, L., Wittmann, A., Linke, L., Witt, H., Weber, U.D., Zapatka, M., Konig, R., Beroukhim, R., Bergthold, G., van Sluis, P., Volckmann, R., Koster, J., Versteeg, R., Schmidt, S., Wolf, S., Lawerenz, C., Bartholomae, C.C., von Kalle, C., Unterberg, A., Herold-Mende, C., Hofer, S., Kulozik, A.E., von Deimling, A., Scheurlen, W., Felsberg, J., Reifenberger, G., Hasselblatt, M., Crawford, J.R., Grant, G.A., Jabado, N., Perry, A., Cowdrey, C., Croul, S., Zadeh, G., Korbel, J.O., Doz, F., Delattre, O., Bader, G.D., McCabe, M.G., Collins, V.P., Kieran, M.W., Cho, Y.J., Pomeroy, S.L., Witt, O., Brors, B., Taylor, M.D., Schuller, U., Korshunov, A., Eils, R., Wechsler-Reya, R.J., Lichter, P. & Pfister, S.M. Cancer Cell. 2014 Mar 17;25(3):393-405. doi: 10.1016/j.ccr.2014.02.004. Europe PMC

Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia. Kminkova, J., Mraz, M., Zaprazna, K., Navrkalova, V., Tichy, B., Plevova, K., Malcikova, J., Cerna, K., Rausch, T., Benes, V., Brychtova, Y., Doubek, M., Mayer, J. & Pospisilova, S. Carcinogenesis. 2014 May;35(5):992-1002. doi: 10.1093/carcin/bgt396. Epub 2013Dec 4. Europe PMC

The genomic and transcriptomic landscape of a HeLa cell line. Landry, J.J., Pyl, P.T., Rausch, T., Zichner, T., Tekkedil, M.M., Stutz, A.M., Jauch, A., Aiyar, R.S., Pau, G., Delhomme, N., Gagneur, J., Korbel, J.O., Huber, W. & Steinmetz, L.M. G3 (Bethesda). 2013 Aug 7;3(8):1213-24. doi: 10.1534/g3.113.005777. Europe PMC

Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. Grosch, M., Gruner, B., Spranger, S., Stutz, A.M., Rausch, T., Korbel, J.O., Seelow, D., Nurnberg, P., Sticht, H., Lausch, E., Zabel, B., Winterpacht, A. & Tagariello, A. Matrix Biol. 2013 May 9. pii: S0945-053X(13)00070-X. doi:10.1016/j.matbio.2013.05.001. Europe PMC

Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency. Greil, J., Rausch, T., Giese, T., Bandapalli, O.R., Daniel, V., Bekeredjian-Ding, I., Stutz, A.M., Drees, C., Roth, S., Ruland, J., Korbel, J.O. & Kulozik, A.E. J Allergy Clin Immunol. 2013 May;131(5):1376-83.e3. doi:10.1016/j.jaci.2013.02.012. Epub 2013 Apr 3. Europe PMC

Impact of genomic structural variation in Drosophila melanogaster based on population-scale sequencing. Zichner, T., Garfield, D.A., Rausch, T., Stutz, A.M., Cannavo, E., Braun, M., Furlong, E.E. & Korbel, J.O. Genome Res. 2013 Mar;23(3):568-79. doi: 10.1101/gr.142646.112. Epub 2012 Dec 6. Europe PMC

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Weischenfeldt, J., Simon, R., Feuerbach, L., Schlangen, K., Weichenhan, D., Minner, S., Wuttig, D., Warnatz, H.J., Stehr, H., Rausch, T., Jager, N., Gu, L., Bogatyrova, O., Stutz, A.M., Claus, R., Eils, J., Eils, R., Gerhauser, C., Huang, P.H., Hutter, B., Kabbe, R., Lawerenz, C., Radomski, S., Bartholomae, C.C., Falth, M., Gade, S., Schmidt, M., Amschler, N., Hass, T., Galal, R., Gjoni, J., Kuner, R., Baer, C., Masser, S., von Kalle, C., Zichner, T., Benes, V., Raeder, B., Mader, M., Amstislavskiy, V., Avci, M., Lehrach, H., Parkhomchuk, D., Sultan, M., Burkhardt, L., Graefen, M., Huland, H., Kluth, M., Krohn, A., Sirma, H., Stumm, L., Steurer, S., Grupp, K., Sultmann, H., Sauter, G., Plass, C., Brors, B., Yaspo, M.L., Korbel, J.O. & Schlomm, T. Cancer Cell. 2013 Feb 11;23(2):159-70. doi: 10.1016/j.ccr.2013.01.002. Europe PMC

Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Richter J., Schlesner M., Hoffmann S., Kreuz M., Leich E., Burkhardt B., Rosolowski M., Ammerpohl O., Wagener R., Bernhart S.H., Lenze D., Szczepanowski M., Paulsen M., Lipinski S., Russell R.B., Adam-Klages S., Apic G., Claviez A., Hasenclever D., Hovestadt V., Hornig N., Korbel J.O., Kube D., Langenberger D., Lawerenz C., Lisfeld J., Meyer K., Picelli S., Pischimarov J., Radlwimmer B., Rausch T., Rohde M., Schilhabel M., Scholtysik R., Spang R., Trautmann H., Zenz T., Borkhardt A., Drexler H.G., Moller P., Macleod R.A., Pott C., Schreiber S., Trumper L., Loeffler M., Stadler P.F., Lichter P., Eils R., Kuppers R., Hummel M., Klapper W., Rosenstiel P., Rosenwald A., Brors B., Siebert R. Nat Genet. 2012 Nov 11;44(12):1316-1320. doi: 10.1038/ng.2469. Epub 2012 Nov 11. Europe PMC

An integrated map of genetic variation from 1,092 human genomes. 1000 Genomes Project Consortium Nature. 2012 Nov 1;491(7422):56-65. doi: 10.1038/nature11632. Europe PMC

DELLY: structural variant discovery by integrated paired-end and split-read analysis. Rausch, T., Zichner, T., Schlattl, A., Stutz, A.M., Benes, V. & Korbel, J.O. Bioinformatics. 2012 Sep 15;28(18):i333-i339. Europe PMC

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations. Rausch, T., Jones, D.T., Zapatka, M., Stutz, A.M., Zichner, T., Weischenfeldt, J., Jager, N., Remke, M., Shih, D., Northcott, P.A., Pfaff, E., Tica, J., Wang, Q., Massimi, L., Witt, H., Bender, S., Pleier, S., Cin, H., Hawkins, C., Beck, C., von Deimling, A., Hans, V., Brors, B., Eils, R., Scheurlen, W., Blake, J., Benes, V., Kulozik, A.E., Witt, O., Martin, D., Zhang, C., Porat, R., Merino, D.M., Wasserman, J., Jabado, N., Fontebasso, A., Bullinger, L., Rucker, F.G., Dohner, K., Dohner, H., Koster, J., Molenaar, J.J., Versteeg, R., Kool, M., Tabori, U., Malkin, D., Korshunov, A., Taylor, M.D., Lichter, P., Pfister, S.M. & Korbel, J.O. Cell. 2012 Jan 20;148(1-2):59-71. Europe PMC