Uncovering the Hidden World of Giant Viruses in the Sea!
We have a broad interest in characterizing the ecological and evolutionary significance of eukaryotic viruses in the oceans with a special focus on large viruses. On our planet, there are viruses that are as complex as cellular organisms. The amoeba-infecting Mimivirus with a genome encoding 1000 genes is the prototype of such giant viruses. Recent studies from our group suggest that related giant viruses play crucial roles in oceanic ecosystems. Through in silico data mining, we are studying the species and genomic diversity of giant viruses to discover new genes of fundamental interest, to investigate host-virus interactions and to get better insights into the role of viruses in the functioning and evolution of the biosphere. Together with other teams of the consortium, we develop new computational tools and statistical methods to enhance the analysis of the uniquely comprehensive TARA OCEANS plankton data sets.
- Ogata H., Ray J., Toyoda K., Sandaa R.-A., Nagasaki K., Bratbak G., Claverie J.-M. Two new subfamilies of DNA mismatch repair proteins (MutS) specifically abundant in the marine environment. ISME J., 5, 1143-1151 (2011).
- Claverie J.-M., Ogata H. Ten good reasons not to exclude giruses from the evolutionary picture. Nat. Rev. Microbiol., 7, 615 (2009).
- Monier A., Pagarete A., de Vargas C., Allen M.J., Read B., Claverie J.-M., Ogata H. Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus. Genome Res., 19, 1441-1449 (2009).
- Ogata H., Claverie J.-M. How to infect a Mimivirus. Science, 321, 1305-1306 (2008).
- Monier A., Claverie J.-M., Ogata H. Taxonomic distribution of large DNA viruses in the sea. Genome Biol., 9, R106 (2008)
1 postdoc to work on the Biogeography of giant marine viruses and virus-host interactions using bioinformatics analysis of high-throughput metagenomic datasets and in vitro experimental giant virus biology.
For application, please send your CV to Pascal.