Staff at EMBL

Dr. Anne Ephrussi

Head of Unit, EICAT Coordinator and Senior Scientist
Developmental Biology Ephrussi Group EMBL International Centre for Advanced Training (EICAT)

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

PhD 1985, Massachusetts Institute of Technology.
Postdoctoral research at Harvard University and Whitehead Institute, MIT, Cambridge, Massachusetts.
Group leader at EMBL since 1992.
Coordinator of EICAT since 2005.
Head of Unit since 2007.

Publications

A single Drosophila embryo extract for the study of mitosis ex vivo. Telley, I.A., Gaspar, I., Ephrussi, A. & Surrey, T. Nat Protoc. 2013 Jan 17;8(2):310-24. doi: 10.1038/nprot.2013.003. Epub 2013 Jan17. PubMed

A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization. Leibfried A., Müller S. & Ephrussi A. Development 140, 362-371 (2013) doi:10.1242/dev.089250

Aster migration determines the length scale of nuclear separation in the Drosophila syncytial embryo. Telley, I.A., Gaspar, I., Ephrussi, A. & Surrey, T. J Cell Biol. 2012 Jun 25;197(7):887-95. Epub 2012 Jun 18. PubMed

Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA. Ghosh, S., Marchand, V., Gaspar, I. & Ephrussi, A. Nat Struct Mol Biol. 2012 Mar 18;19(4):441-9. doi: 10.1038/nsmb.2257. PubMed

Dimerization of oskar 3' UTRs promotes hitchhiking for RNA localization in the Drosophila oocyte. Jambor, H., Brunel, C. & Ephrussi, A. RNA. 2011 Dec;17(12):2049-57. Epub 2011 Oct 25. PubMed

Drosophila Ge-1 Promotes P Body Formation and oskar mRNA Localization. Fan, S.J., Marchand, V. & Ephrussi, A. PLoS One. 2011;6(5):e20612. Epub 2011 May 31. PubMed

Myosin-V regulates oskar mRNA localization in the Drosophila oocyte. Krauss, J., Lopez de Quinto, S., Nusslein-Volhard, C. & Ephrussi, A. Curr Biol. 2009 Jun 23;19(12):1058-63. Epub 2009 May 28. PubMed

mRNA localization: gene expression in the spatial dimension. Martin, K.C. & Ephrussi, A. Cell. 2009 Feb 20;136(4):719-30. PubMed

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation. Besse, F., Lopez de Quinto, S., Marchand, V., Trucco, A. & Ephrussi, A. Genes Dev. 2009 Jan 15;23(2):195-207. Epub 2009 Jan 8. PubMed

The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo. Suyama, R., Jenny, A., Curado, S., Pellis-van Berkel, W. & Ephrussi, A. Development. 2009 Jan;136(1):95-105. Epub 2008 Nov 26. PubMed

Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules. Sung, H.H., Telley, I.A., Papadaki, P., Ephrussi, A., Surrey, T. & Rorth, P. Dev Cell. 2008 Dec;15(6):866-76. PubMed

Translational control of localized mRNAs: restricting protein synthesis in space and time. Besse, F. & Ephrussi, A. Nat Rev Mol Cell Biol. 2008 Dec;9(12):971-80. PubMed

The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses. Besse, F., Mertel, S., Kittel, R.J., Wichmann, C., Rasse, T.M., Sigrist, S.J. & Ephrussi, A. J Cell Biol. 2007 Jun 4;177(5):843-55. PubMed

Stimulation of endocytosis and actin dynamics by Oskar polarizes the Drosophila oocyte. Vanzo, N., Oprins, A., Xanthakis, D., Ephrussi, A. & Rabouille, C. Dev Cell. 2007 Apr;12(4):543-55. PubMed

Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis. Coutelis, J.B. & Ephrussi, A. Development. 2007 Apr;134(7):1419-30. Epub 2007 Feb 28. PubMed

Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila. Anne, J., Ollo, R., Ephrussi, A. & Mechler, B.M. Development. 2007 Jan;134(1):137-46. PubMed

A translation-independent role of oskar RNA in early Drosophila oogenesis. Jenny, A., Hachet, O., Zavorszky, P., Cyrklaff, A., Weston, M.D., Johnston, D.S., Erdelyi, M. & Ephrussi, A. Development. 2006 Aug;133(15):2827-33. PubMed

Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Chekulaeva, M., Hentze, M.W. & Ephrussi, A. Cell. 2006 Feb 10;124(3):521-33. PubMed

Gain-of-function screen for genes that affect Drosophila muscle pattern formation. Staudt, N., Molitor, A., Somogyi, K., Mata, J., Curado, S., Eulenberg, K., Meise, M., Siegmund, T., Hader, T., Hilfiker, A., Bronner, G., Ephrussi, A., Rørth, P., Cohen, S.M., Fellert, S., Chung, H.R., Piepenburg, O., Schafer, U., Jackle, H. & Vorbruggen, G. PLoS Genet 2005 Oct;1(4):e55. Epub 2005 Oct 28. PubMed

The Drosophila PAR-1 spacer domain is required for lateral membrane association and for polarization of follicular epithelial cells. Vaccari, T., Rabouille, C. & Ephrussi, A. Curr Biol 2005 Feb 8;15(3):255-61. PubMed

Par-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia. Riechmann, V. & Ephrussi, A. Development 2004 Dec;131(23):5897-907. PubMed

Drosophila development: RNA interference ab ovo. Chekulaeva, M. & Ephrussi, A. Curr Biol 2004 Jun 8;14(11):R428-30. PubMed

Hrp48, a Drosophila hnRNPA/B Homolog, Binds and Regulates Translation of oskar mRNA. Yano, T., De Quinto, S.L., Matsui, Y., Shevchenko, A., Shevchenko, A. & Ephrussi, A. Dev Cell 2004 May;6(5):637-48. PubMed

Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Hachet, O. & Ephrussi, A. Nature 2004 Apr 29;428(6986):959-63. PubMed

PKA-R1 spatially restricts Oskar expression for Drosophila embryonic patterning. Yoshida, S., Muller, H.A., Wodarz, A. & Ephrussi, A. Development 2004 Mar;131(6):1401-10. PubMed

Seeing is believing: the bicoid morphogen gradient matures. Ephrussi, A. & St Johnston, D. Cell 2004 Jan 23;116(2):143-52. PubMed

Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism. Teixeira, L., Rabouille, C., Rorth, P., Ephrussi, A. & Vanzo, N.F. Mech Dev 2003 Sep;120(9):1071-81. PubMed

Bruno regulates gurken during Drosophila oogenesis. Filardo, P. & Ephrussi, A. Mech Dev 2003 Mar;120(3):289-97. PubMed

Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte. Castagnetti, S. & Ephrussi, A. Development 2003 Mar;130(5):835-43. PubMed

The fusome and microtubules enrich Par-1 in the oocyte, Where it effects polarization in conjunction with Par-3, BicD, Egl, and Dynein. Vaccari, T. & Ephrussi, A. Curr Biol 2002 Sep 3;12(17):1524. PubMed

Oskar anchoring restricts pole plasm formation to the posterior of the Drosophila oocyte. Vanzo, N.F. & Ephrussi, A. Development 2002 Aug;129(15):3705-14. PubMed

A germline-specific gap junction protein required for survival of differentiating early germ cells. Tazuke, S.I., Schulz, C., Gilboa, L., Fogarty, M., Mahowald, A.P., Guichet, A., Ephrussi, A., Wood, C.G., Lehmann, R. & Fuller, M.T. Development 2002 May;129(10):2529-39. PubMed

Par-1 regulates stability of the posterior determinant Oskar by phosphorylation. Riechmann, V., Gutierrez, G.J., Filardo, P., Nebreda, A.R. & Ephrussi, A. Nat Cell Biol 2002 May;4(5):337-42. PubMed

Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport. Hachet, O. & Ephrussi, A. Curr Biol 2001 Oct 30;11(21):1666-74. PubMed

Axis formation during Drosophila oogenesis. Riechmann, V. & Ephrussi, A. Curr Opin Genet Dev 2001 Aug;11(4):374-83. PubMed

A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation. Tomancak, P., Piano, F., Riechmann, V., Gunsalus, K.C., Kemphues, K.J. & Ephrussi, A. Nat Cell Biol 2000 Jul;2(7):458-460 PubMed

Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis. Mata, J., Curado, S., Ephrussi, A. & Rorth, P. Cell 2000 May 26;101(5):511-22 PubMed

Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Jimenez, G., Guichet, A., Ephrussi, A. & Casanova, J. Genes Dev 2000 Jan 15;14(2):224-31 PubMed

Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries. Castagnetti, S., Hentze, M.W., Ephrussi, A. & Gebauer, F. Development 2000;127(5):1063-1068 PubMed

Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNA. Gunkel, N., Yano, T., Markussen, F.H., Olsen, L.C. & Ephrussi, A. Genes Dev 1998 Jun 1 12(11) 1652-1664 PubMed

Oocyte polarity depends on regulation of gurken by Vasa. Tomancak, P., Guichet, A., Zavorszky, P. & Ephrussi, A. Development 1998 May 125(9) 1723-1732 PubMed

Cytoplasmic flows localize injected oskar RNA in Drosophila oocytes. Glotzer, J.B., Saffrich, R., Glotzer, M. & Ephrussi, A. Curr Biol 1997 May 1 7(5) 326-337 PubMed

The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors. Guichet, A., Copeland, J.W., Erdelyi, M., Hlousek, D., Zavorszky, P., Ho, J., Brown, S., Percival-Smith, A., Krause, H.M. & Ephrussi, A. Nature 1997 Feb 6;385(6616):548-52. PubMed

Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene. Florence, B., Guichet, A., Ephrussi, A. & Laughon, A. Development 1997 Feb;124(4):839-47. PubMed

Efficient translation and phosphorylation of Oskar require Oskar protein and the RNA helicase Vasa. Markussen, F.H., Breitwieser, W. & Ephrussi, A. Cold Spring Harb Symp Quant Biol 1997 62 13-17 PubMed

Analysis of RNA distribution during Drosophila oogenesis using fluorescent in situ hybridization. Glotzer, J.B. & Ephrussi, A. In "A Comparative Methods Approach to the Study of Oocytes and Embryos", Richter, J. (ed.), 1997, Oxford University Press, New York

Oskar protein interaction with Vasa represents an essential step in polar granule assembly. Breitwieser, W., Markussen, F.H., Horstmann, H. & Ephrussi, A. Genes Dev 1996 Sep 1 10(17) 2179-2188 PubMed

mRNA localization and the cytoskeleton. Glotzer, J.B. & Ephrussi, A. Seminars in Cell and Developmental Biology 1996 7 357-365

Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly. Markussen, F.H., Michon, A.M., Breitwieser, W. & Ephrussi, A. Development 1995 Nov 121(11) 3723-3732 PubMed

Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization Erdelyi, M., Michon, A.M., Guichet, A., Glotzer, J.B. & Ephrussi, A. Nature 1995 Oct 12 377(6549) 524-527 PubMed

Germ plasm formation and germ cell determination in Drosophila. Lehmann, R. & Ephrussi, A. Ciba Found Symp 1994;182:282-96; discussion 296-300. PubMed

Induction of germ cell formation by oskar Ephrussi, A. & Lehmann, R. Nature 1992 Jul 30 358(6385) 387-392 PubMed

Oskar organizes the germ plasm and directs localization of the posterior determinant nanos. Ephrussi, A., Dickinson, L.K. & Lehmann, R. Cell 1991 Jul 12;66(1):37-50. PubMed