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Exploring Modular Protein Architecture

EMBL Heidelberg, Germany Tuesday 19 January - Friday 22 January 2010 Application closed
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Over the last few years a new paradigm has been emerging concerning the nature of Eukaryotic regulatory proteins - contrasting with the nice neat globular protein view expounded by biochemical and cell biological textbooks. Instead, many proteins have a remarkable number of architecture modules - including long natively disordered segments and short linear motifs that are awkward to investigate computationally and experimentally.

The course will set the scene by introducing the biological concepts behind these architecture modules and provide extensive hands-on application of the relevant bioinformatics tools with appropriate example proteins. The power - but also the limitations, which remain substantial - of the currently available software will be examined. 

 

Topics:

  • Introduction to Common Bioinformatic Tools (optional initial half day at no extra cost)
  • Multiple Sequence Alignment
  • Protein-Protein Interaction Networks
  • Predicting Globular Domains and Native Disorder

Heidelberg, Germany, 19 - 22 January 2010


Aims

Over the last few years a new paradigm has been emerging concerning the nature of Eukaryotic regulatory proteins - contrasting with the nice neat globular protein view expounded by biochemical and cell biological textbooks. Instead, many proteins have a remarkable number of architecture modules - including long natively disordered segments and short linear motifs that are awkward to investigate computationally and experimentally.

The course will set the scene by introducing the biological concepts behind these architecture modules and provide extensive hands-on application of the relevant bioinformatics tools with appropriate example proteins. The power - but also the limitations, which remain substantial - of the currently available software will be examined.

Topics

- Introduction to Common Bioinformatic Tools (optional initial half day at no extra cost)
- Multiple Sequence Alignment
- Protein-Protein Interaction Networks
- Predicting Globular Domains and Native Disorder
- Exploring Regulatory Protein Motifs
- 3D Structures of Proteins and Protein-Protein Interactions
- Bioinformatic Resource Integration

Programme

A downloadable draft version of the programme is available
HERE

Teachers

Nigel Brown, University of Heidelberg, Germany
Ricardo Rodriguez de la Vega, EMBL, Heidelberg, Germany
Francesca Diella, Biobyte Solutions GmbH, Heidelberg, Germany
Niall Haslam, Complex and Adaptive Systems Laboratory, University College Dublin, Germany
Lars Juhl Jensen, Novo Nordisk Foundation Center for Protein Research, Denmark
Philip McDermott , University of Manchester, United Kingdom
Sean O'Donoghue, EMBL, Heidelberg, Germany
Steve Pettifer, University of Manchester, United Kingdom
Venkata Satagopam, EMBL, Heidelberg, Germany
Andrea Schafferhans-Fuhrmann, TU Muenchen, Germany
David Thorne, University of Manchester, United Kingdom

Registration

Registration deadline is 4 December 2009.


Registration Link: Academia incl. registration


Attendance Fee:
250 Euros including twin room accommodation (for 2 or 3 nights, depending whether you apply for the optional initial introductory half-day), meals, local transport and course material.


The number of participants is limited to 20.

After the registration deadline expired, a selection will take place and everybody will be informed about the outcome.

After registering you will be asked to submit your motivation letter. This should contain a statement about current research and a justification of interest in the course.

You can submit a motivation letter using the account you've created (email + password).
The motivation letter submission link will be found in the confirmation page/ e-mail you will receive after registration.

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Scientific Organisers

Aidan Budd, EMBL, Heidelberg, Germany
Toby Gibson, EMBL, Heidelberg, Germany

Conference Organisers

Adela Valceanu, EMBL, Heidelberg, Germany

Hotel

A place in a twin room is included in the participation fee for 2 or 3 nights, depending whether you apply for the optional initial introductory half-day(19 Jan). The default dates are 19, 20, 21 Jan.
Rooms have been reserved at the ISG Hotel.
All additional nights will be charged extra at the hotel.(approx. EUR 75 per night).


Local Transport

There will be shuttle buses running from the ISG hotel to EMBL and back, mornings and evenings.
A detailed schedule will be available 2 weeks before the meeting.

Travel

The meeting will take place at EMBL, Heidelberg (Computer Teach. Lab - Room 6.51a).
For instructions on how to reach the institute, please click here.

Contact

For inquiries regarding the Sponsoring Options or the Sponsorship Order Form, please contact :
Antje Seeck - Marketing Officer

For other administrative issues please contact:
Adela Valceanu - Course & Conference Office

Institutional Sponsors

EMBRACE