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EMBO Conference Series

From Functional Genomics to Systems Biology

EMBL Heidelberg, Germany Saturday 13 November - Tuesday 16 November 2010
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Programme

Day One: Saturday  13 November 2010

13:00 - 15:00 Registration (EMBL Advanced Training Centre)
15:00 - 15:05 Welcome address
15:05 - 16:50 Session I - Chair: Rick Young, Whitehead Institute, USA ( Klaus Tschira Auditorium)
15:05 - 15:35 Jonathan Weissman, University of California San Francisco, USA - Nascent transcript sequencing visualizes transcription at nucleotide resolution
15:35 - 16:05 Susan Mango, University of Utah, USA - How do embryos form complex organs such as liver or eyes?
16:05 - 16:20 Mattias Alenius, Linkoping University, Sweden - A regulatory matrix controlling selective odorant receptor expression in drosophila
16:20 - 16:50 Lucas Pelkmans, ETH Zurich, Switzerland - Cell-to-cell variability modelling reveals complex RNAi phenotypes in virus infection
16:50 - 17:20 Coffee Break (ATC Foyer)
17:20 - 17:50 Jason Lieb, The University of North Carolina at Chapel Hill, USA - Transcription factor binding dynamics and chromatin-membrane interactions
17:50 - 18:05 JeanChristophe Andrau, CNRS, France  - Tips: Novel features of the genomic landscape
18:05 - 18:35 Luis Serrano, Center for Genomic Regulation, Spain - Genome-wide quantification of mRNA, protein levels and turnover in a bacterium
18:45 - 21:00 Dinner (Canteen)
20:00 - 22:30 After dinner drinks & socializing in the Rooftop Lounge

Day Two: Sunday 14 November 2010

09:00 - 12:30 Session II - Chair: Susan Mango, University of Utah, USA  (Klaus Tschira Auditorium)
09:00 - 09:30 Michael Snyder, Stanford University, USA - Extensive “in vivo” metabolite-protein interactions revealed by large-scale systematic analyses
09:30 - 10:00 Marian Walhout, UMASS Medical School, USA - Gene-centered regulatory networks
10:00 - 10:15 Bart Deplancke, EPFL, Switzerland - Structural variant-mediated, fine-grained partitioning of the Drosophila genome into regions of regulatory activity
10:15 - 10:45 Bing Ren, University of California San Diego, USA - Comprehensive analysis of cis-regulatory elements in the mouse genome
10:45 - 11:15 Coffee Break (ATC Foyer)
11:15 - 11:45 Mike Tyers, University of Edinburgh, UK - Deconstruction and modulation of cellular networks
11:45 - 12:00 Guillaume Filion, The Netherlands Cancer Institute, Netherlands - Systematic protein-genome interaction maps reveal 5 chromatin types in Drosophila
12:00 - 12:30 Eileen Furlong, EMBL Heidelberg, Germany - Linking transcription factor occupancy and chromatin state to regulatory activity in both space and time
12:30 - 14:00 Lunch (Canteeen)
14:00 - 15:30 Poster Session I: A - M
15:30 - 19:00 Session III - Chair: Stuart Kim,  Stanford University, USA (Klaus Tschira Auditorium)
15:30  - 16:00 Erin O’Shea, Harvard University, USA - Multi-signal encoding by modulation of transcription factor translocation dynamics
16:00 - 16:30 Job Dekker, UMASS Medical School, USA - Long-range gene regulatory architecture of the human genome
16:30 - 16:45 Johannes Jaeger, Center for Genomic Regulation, Spain - Shift happens: The developmental and evolutionary dynamics of the gap gene network
16:45 - 17:15 Frank Holstege, University Medical Center Utrecht, Netherlands - Understanding regulatory circuitry
 17:15- 17:45 Coffee Break (ATC Foyer)
17:45 - 18:15 Jan Korbel, EMBL Heidelberg, Germany - Structural variation in the genome: extent, origin, and functional impact
18:15 - 18:30 Polly Fordyce, University of California San Francisco, USA - De novo identification and biophysical characterization of transcription factor binding sites with microfluidic affinity analysis
18:30 - 19:00 Trey Ideker, University of California San Diego, USA - Biomarkers as networks, not individual loci
19:00 - 20:30 Dinner (Canteen)
20:00 - 22:00 After dinner drinks & socializing in the Rooftop Lounge

Day Three: Monday 15 November 2010

09.00 - 12:30 Session IV - Chair: Eileen Furlong, EMBL Heidelberg, UK (Klaus Tschira Auditorium)
09:00 - 09:30 Richard Young, Whitehead institute, USA - Gene control, chromosome structure and human disease
09:30 - 10:00 Alex Stark, IMP Vienna,. Austria - High conservation of transcription factor binding across six Drosophila species
10:00 - 10:15 Georgy Koentges, University of Warwick, UK - Single cell systems analysis of vertebrate cis-regulatory module function and promoter communication
10:15 - 10:45 Sandra Schmid, The Scripps Research institute, USA - Comprehensive and unbiased analysis of dynamic behavior or clathrin coated pits in vivo
10:45 - 11:15 Coffee Break (ATC Foyer)
11:15 - 11:45 John Hogenesch, University of Pennsylvannia, USA - Systematic and systems approaches to understanding the mammalian clock
11:45 - 12:00 Julien Mozziconacci, UPMC, France - Intra- and inter-chromosomal interactions correlate with CTCF binding genome wide
12:00 - 12:30

Ben Scheres, Utrecht University, Netherlands - Gene networks for plant stem cell specification

12:30 - 14:00 Lunch (ATC Foyer)
14:00 - 15:30 Poster Session II: M - Z
15:30 - 19:00 Session V: Chair - Job Dekker, UMASS Medical School, USA (Klaus Tschira Auditorium)
15:30 - 16:00 Patrick Cramer, University of Munich, Germany - Nascent transcriptome analysis reveals dynamics of mRNA synthesis and decay in yeast
16:00 - 16:30 Uwe Sauer, ETH Zurich, Switzerland - Transcriptional control of metabolic function and the governing principles behind it
16:30 - 16:45 Brian Oliver, NIH, USA - Primary and secondary transcriptional response to altered gene dose
16:45 - 17:15 Daphne Koller, Stanford University, USA - Understanding Gene Regulation: Networks and Perturbations
17:15 - 17:45 Coffee Break (ATC Foyer)
17:45 - 18:15 Howard Chang, Stanford University, USA - Genome-wide views of RNA structural dynamics
18:15 - 18:30 Tali Raveh Sadka, Weizmann Institute of Science, Israel - Transcriptional Lego? Tuning expression levels in a predictable manner by manipulating promoter building blocks
18:30 - 19:00 Philippe Bastiaens, MPI Dortmund, Germany - Spatial cycles in intracellular growth factor signaling
19:00 - 24:00 Gala Dinner & Party

Day Four: Tuesday 16 November  2010

09:00 - 12:30 Session VI: Chair - Frank Holstege,  University Medical Center Utrecht, Netherlands (Klaus Tschira Auditorium)
09:00 - 09:30 Matthias Mann, MPI Martinsried, Germanuy - Making precision proteomics’ a reality
09:30 - 10:00 Aviv Regev, Broad Institute, USA - Unbiased reconstruction of mammalian regulatory networks: lessons from the immune system
10:00 - 10:15 Thomas Sandmann, German Cancer Research Center, Germany - Mapping of signaling networks through synthetic genetic interaction analysis by RNAi
10:15 - 10:45 Paul Flicek, EMBL-EBI Hinxton, UK - Evolutionary dynamics of sequence-specific DNA binding protein interactions
10:45 - 11:15 Coffee Break (ATC Foyer)
11:15 - 11:45 Stuart Kim, Stanford University, USA - Developmental drift and aging stochasticity in C. elegans
11:45 - 12:00 Julia Schulze, University of Vancouver, Canada - Genome-wide analysis of H2B ubiquitination and deubiquitination in the context of histone H3 methylation
12:00 - 12:30 Lars Steinmetz, EMBL Heidelberg, Germany - Genome-wide implications of antisense non-coding transcription
12:30 - 12:35 Closing remarks
13:00 Bus shuttle to Frankfurt Airport