EMBO Conference Series
Microtubules: Structure, Regulation and Functions
EMBL Heidelberg, Germany Wednesday 23 May - Saturday 26 May 2012
Programme
The programme for 2012 EMBO Conference Series Microtubules: Structure, Regulation and Functions is available below.
You can download HERE the programme of the meeting and the listing of posters.
| 11:00 - 14:00 | Registration |
|---|---|
| 12:30 - 14:00 | Welcome Buffet |
| 14:00 - 14:15 | Opening remarks |
| 14:15 - 16:00 |
Session 1: Complex microtubule assemblies
Chair: Renata Basto |
| 14:15 - 14:40 | “The flagellar length control system” Wallace F. Marshall, University of California, San Francisco, USA |
| 14:40 -15:05 | “Deconstructing doublet microtubule function using cryo-electron tomography and structural proteomics” Daniela Nicastro, Brandeis University, Waltham, USA |
| 15:05 - 15:30 | “Organization of cortical microtubule arrays in Arabidopsis” Takashi Hashimoto, NAIST, Osaka, Japan |
| 15:30 - 15:45 | “Do forces affect EB-mediated microtubule regulation?” Svenja-Marei Kalisch, AMOLF, The Netherlands |
| 15:45 - 16:00 | “Phragmoplast microtubule generation is predominantly stimulated by augmin” Gohta Goshima, Nagoya University, Japan |
| 16:00 – 16:40 | Coffee Break |
| 16:40 – 18:15 | Session 2: MT based transport Chair: Iva TolicNorrelykke |
| 16:40 - 17:05 | “Role of LIS1 in high-load cytoplasmic dynein function” Richard B. Vallee, Columbia University Medical Center, New York, USA |
| 17:05 - 17:30 | “Regulation of cytoplasmic dynein” Samara Reck-Peterson, Harvard University, Boston, USA |
| 17:30 - 17:45 | “X-ray crystal structure of the S. cerevisiae dynein motor domain at 3.3 Å” Helgo Schmidt, Laboratory of Molecular Biology, United Kingdom |
| 17:45 - 18:00 | “Microtubule aster migration is essential for syncytial nuclear separation” Ivo A. Telley, EMBL Heidelberg, Germany |
| 18:00 - 18:15 | “Identification of a widespread Kinesin-1 light chain binding signature in the human genome” Michael Way, Cancer Research UK, United Kingdom |
| 18:15 – 19:45 | Dinner in the EMBL Canteen |
| 19:45 – 20:45 |
Keynote lecture kindly sponsored by Open Biology Chair: Rebecca Heald “Beauty and complexity in the interaction of microtubules with kinetochore complexes” Eva Nogales, HHMI / University of California, Berkeley, USA |
| 20:45 – 23:30 | Wine & beer and free poster session |
| 09:30 - 11:15 |
Session 3: MT dynamics and regulation
Chair: Joe Howard |
|---|---|
| 09:30 - 09:55 | “Functions of microtubule acetylation” Maxence V. Nachury, Stanford University, San Francisco, USA |
| 09:55 - 10:20 | “Diverse roles for microtubule severing enzymes/depolymerases in cell migration” David J. Sharp, Albert Einstein College of Medicine, New York, USA |
| 10:20 - 10:45 | “Microtubule dynamics in directed cell migration” Gaudenz Danuser, Harvard Medical School, Boston, USA |
| 10:45 - 11:00 | “Microtubule length regulation by depolymerizing kinesins” Melissa Gardner, University of Minnesota, USA |
| 11:00 - 11:15 | “Structural basis of tubulin tyrosination by tubulin tyrosine ligase” Andrea Prota, Paul Scherrer Institut, Switzerland |
| 11:15 – 11:45 | Coffee Break |
| 11:45 – 12:25 | Landmarks in MT research 1: Chair: Michel Steinmetz “Taxol, Tubulin and Tumors” Susan Band Horwitz, Albert Einstein College of Medicine, New York, USA |
| 12:30 – 14:00 | Lunch in the ATC Foyer |
| 14:00 – 17:30 | Poster session 1 (odd numbers) |
| 17:30 | Free time: Buses to Heidelberg or option to stay at posters with beer & wine. Individual return to hotels. |
| 09:00 – 10:35 | Session 4: MTs in cell divison Chair: Marileen Dogterom |
|---|---|
| 09:00 - 09:25 | “Comparative genomic analysis of mitotic spindle assembly with and without centrosomes” Helder Maiato, University of Porto, Portugal |
| 09:25 - 09:50 | “Polymerases and spindle assembly” Anthony A. Hyman, MPI- CBG, Dresden, Germany |
| 09:50 - 10:05 | “The actin-binding protein Moesin modulates microtubule dynamics during cell division” Benjamin Kwok , University of Montreal, Canada |
| 10:05 - 10:20 | “A microtubule-membrane linker required for nuclear envelope dynamics” Anne-Lore Schlaitz, University of California at Berkeley, USA |
| 10:20 - 10:35 |
“Kinesin-5 and Kinesin-12 control mitotic chromosome movement by regulating a microtubule-dependent spindle matrix” |
| 10:35 – 11:05 | Coffee Break |
| 11:05 – 12:40 | Session 5: MT interactors Chair: Fred Chang |
| 11:05 - 11:30 | “Dissecting mechanisms of microtubule-based mRNA transport in vivo and in vitro” Simon Bullock, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom |
| 11:30 - 11:55 | “Force generation by passive microtubule crosslinkers” Stefan Diez, MPI- CBG, Dresden, Germany |
| 11:55 - 12:10 | “EB proteins recognize a nucleotide-dependent structural cap at growing microtubule ends” Sebastian Maurer, Cancer Research UK, United Kingdom |
| 12:10 - 12:25 | “Doublecortin recognizes the 13-protofilament microtubule cooperatively and tracks microtubule ends” Gary Brouhard , McGill University, Canada |
| 12:25 - 12:40 | “Characterization of dynein by single-molecule investigations in vivo” Vaishnavi Ananthanarayanan, Max Planck Institute of Molecular Cell Biology and Genetics, Germany |
| 12:40 – 14:00 | Lunch in the ATC Foyer |
| 14:00 – 17:30 | Poster session 2 (even numbers) |
| 17:30 – 19:05 |
Session 6: MTs in differentiated cells
Chair: Holly Goodson |
| 17:30 - 17:55 | “Cytoskeletal mechanisms of axonal growth and regeneration” Frank Bradke, DZNE, Bonn, Germany |
| 17:55 - 18:20 | “Control of neuronal polarity and plasticity - the role of microtubules and cargo trafficking” Casper Hoogenraad, Department of Cell Biology, Utrecht University, The Netherlands |
| 18:20 - 18:35 | “Collective organisation and role of microtubule networks in polarity switches during tissue morphogenesis” Céline Revenu , EMBL Heidelberg, Germany |
| 18:35 - 18:50 | “Polarisation of the Drosophila egg chamber: a dual relationship between microtubules and oocyte nucleus positioning” Antoine Guichet, Institut Jacques Monod - CNRS-University Paris 7, France |
| 18:50 - 19:05 | “Spectraplakin SHOT/ACF7 organises noncentrosomal microtubules” Dmitry Nashchekin, University of Cambridge, United Kingdom |
| 19:05 – 00:00 | BBQ on the canteen terrace and party in the ATC foyer |
| 09:30 – 11:15 |
Session 7: MTs in disease mechanisms
Chair: John Correia |
|---|---|
| 09:30 - 09:55 | “Huntingtin and mitotic spindle orientation” Sandrine Humbert, Institut Curie, Orsay, France |
| 09:55 - 10:20 | “Mutant tubulins and human neurological disease” Elizabeth C. Engle, Children's Hospital, Boston, USA |
| 10:20 - 10:45 | “Determining the role of the microcephaly associated protein Asp in spindle position and neuroepithelia morphogenesis” Renata Basto, Institute Curie, Paris, France |
| 10:45 - 11:00 | “Characterization of zampanolide as a microtubule-stabilizing agent: Investigation into its binding site on the microtubule” Jessica Field, Victoria University of Wellington, New Zealand |
| 11:00 - 11:15 | “Blood platelets, a simple but physiological system to study tubulin PTMs and their role in microtubule organisation” Karin Sadoul, CR Inserm U823, France |
| 11:15 – 11:45 | Coffee Break |
| 11:45 – 12:25 |
Landmarks in MT research 2
Chair: Thomas Surrey J. Richard McIntosh, University of Colorado at Boulder, USA |
| 12:30 – 14:00 | Lunch in the EMBL canteen |
| 14:00 – 15:00 |
Hot-topic session
Chair: Carsten Janke |
| 14:00 - 14:15 | “Microtubules in Bacteria: ancient tubulins build a five-protofilament homolog of the eukaryotic cytoskeleton” Martin Pilhofer, Caltech and HHMI, USA |
| 14:15 - 14:30 | “High resolution 3D structure of axonemal microtubule doublet and characterization of Microtubule inner proteins” Aditi Maheshwari, ETH Zurich, Switzerland |
| 14:30 - 14:45 | “Direct visualization of microtubule-dependent microtubule nucleation mediated by augmin” Sabine Petry, UCSF, USA |
| 14:45 - 15:00 | “A TOG:ab-tubulin complex reveals conformation-based mechanisms for a microtubule polymerase” Luke Rice, UT Southwestern Medical Center, USA |
| 15:00 – 15:10 | Poster prize announcement |
| 15:10 – 15:40 | Coffee Break |
| 15:40 – 17:25 |
Session 8: MT organisation in the mitotic spindle
Chair: Kenneth Sawin |
| 15:40 -16:05 | “Organizing the prophase mitotic bipolar spindle” Phong Tran, Institut Curie, Paris, France |
| 16:05 - 16:30 | “Examining the micromechanics of the cell division apparatus” Tarun Kapoor, Rockefeller University, New York, USA |
| 16:30 - 16:55 | “Physical aspects of spindle assembly” Daniel Needleman, Harvard University, Boston, USA |
| 16:55 - 17:10 |
“Targeting and sorting of the microtubule nucleator gammaTuRC in the mitotic spindle” |
| 17:10 - 17:25 | “Engineering principles in the design of the fission yeast spindle” Jonathan Ward, EMBL Heidelberg, Germany |
| 17:25 | Closing, short feedback on conference, proposals for conference in 2014 |