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EMBO Conference Series

From Functional Genomics to Systems Biology

EMBL Heidelberg, Germany Saturday 17 November - Tuesday 20 November 2012 Registration closed
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Final Programme

 
Day 1 - Saturday, 17 November 2012
13:00 - 15:00 Registration
15:00 - 15:05 Welcome address

15:05 - 19:05

Session I

Chair: Eileen Furlong, EMBL Heidelberg, Germany

15:05 - 15:35 New insights into control of gene expression programs

Richard Young, Whitehead Institute for Biomedical Research, USA

15:35 - 16:05

Post-transcriptional gene regulation by small RNAs and RNA binding proteins

Nikolaus Rajewsky, Max-Delbrück-Centrum for Molecular Medicine, Germany

16:05 - 16:20

Regulation of yeast central metabolism by enzyme phosphorylation

Ana Paula Oliveira, ETH Zurich, Switzerland

16:20 - 16:50

Genome sequencing of childhood medulloblastoma brain tumors links chromothripsis with TP53 mutations

Jan Korbel, EMBL Heidelberg, Germany

16:50 - 17:20 COFFEE BREAK

ATC Foyer

17:20 - 17:50 Quantitative proteomics and systems biology

Rudolf Aebersold, ETH Zurich, IMSB, Switzerland

17:50 - 18:05

Regulatory genomics – decoding Drosophila regulatory sequences through STARR-seq

Alexander Stark, IMP, Austria

18:05 - 18:35

Designing biological systems for health and sustainability

Pamela Silver, Harvard Medical School, United States of America

18:35 - 19:05

TRIP: a high-throughput method to study the influence of chromatin context on gene regulation

Bas van Steensel, Netherlands Cancer Institute, The Netherlands

19:05 - 21:00 DINNER

EMBL Canteen

21:00 - 23:00 DRINKS

ATC Roof Top Lounge

 
Day 2 - Sunday, 18 November 2012
09:00 - 12:30 Session II

Chair: Greg Wray, Duke University, United States of America

09:00 - 09:30

Exploring biological networks and pathways using yeast phenomics

Brenda Andrews, University of Toronto, Canada

09:30 - 10:00

From systems microbiology to molecular mechanism

Nassos Typas, EMBL Heidelberg, Germany

10:00 - 10:15

Coordination of the human antiviral transcriptional program by stochastic interchromosomal interactions

Dimitris Thanos, Biomedical Research Foundation Academy Of Athens, Greece

10:15 - 10:45

Systems analyses of an expression-based genetic perturbation network

Frank Holstege, University Medical Center Utrecht, The Netherlands

10:45 - 11:15 COFFEE BREAK

ATC Foyer

11:15 - 11:45

Mechanism and reconstitution in vitro of germ cell development in mice
Mitinori Saitou, Graduate School of Medicine, Kyoto University, Japan

11:45 - 12:00

Consecutive positive feedback loops create a bistable switch that controls preadipocyte-to-adipocyte conversion

Mary Teruel, Stanford University, United States of America

12:00 - 12:30

A genetic interaction map of chromatin-related genes
Michael Boutros, German Cancer Research Center (DKFZ) / Heidelberg University, Germany

12:30 - 14:00 LUNCH

EMBL Canteen

14:00 - 15:45 Poster Session I: Odd numbers

ATC Helix A & B

15:45 - 19:00

Session III

Chair: Lucas Pelkmans, University of Zurich, Switzerland

15:45 - 16:00

Sequence-based discovery of transcriptional targets in human and Drosophila
Stein Aerts, University of Leuven, Belgium

16:00 - 16:30 Temporal control of enhancer activity during development: It’s all in the timing
Eileen Furlong, EMBL Heidelberg, Germany

16:30 - 16:45

Compartmentalization and cell-to-cell variability in caspase-8 activation
Stefan Kallenberger, DKFZ Heidelberg, Germany
16:45 - 17:15 Extracting fine grained disease phenotypes and adverse drug reactions from electronic patient records
Søren Brunak, Center for Biological Sequence Analysis, Denmark
17:15 - 17:45 COFFEE BREAK

ATC Foyer

17:45 - 18:15

Quantitative analysis of Fission Yeast transcriptomes and proteomes in proliferating and quiescent cells

Jürg Bähler, University College London, United Kingdom

18:15 - 18:30

Quantification and modeling of the stochastic activity of bacterial metabolic promoters at the single cell, single molecule level using fluorescence fluctuation microscopy

Nathalie Declerck, CBS, France

18:30 - 19:00

Genome-wide interplay between chromatin and the transcription machinery

Frank Pugh, Penn State University, United States of America

19:00 - 21:00 DINNER

EMBL Canteen

21:00 - 23:00 DRINKS

Roof Top Lounge

 
Day 3 - Monday, 19 November 2012

09:00 - 12:30

Session IV

Chair: Nevan Krogan, University of California, San Francisco, United States of America

09:00 - 09:30

Causality and cell-to-cell variability in perturbations of endocytosis

Lucas Pelkmans, University of Zürich, Switzerland

09:30 - 10:00

Expanding the interaction space; protein-lipids networks

Anne-Claude Gavin, EMBL Heidelberg, Germany

10:00 - 10:15

Growth-rate-dependent protein production in bacteria

Jules Matthieu, INRA, France

10:15 - 10:45

Gene networks in the real world: the impact of natural stressors on function
Gregory Wray, Duke University, United States of America

10:45 - 11:15 COFFEE BREAK
ATC Foyer

11:15 - 11:45

Dynamic re-wiring of signaling networks in the DNA damage response – using systems biology to optimize combination therapy for cancer
Michael Yaffe, Massachusetts Institute of Technology, United States of America
11:45 - 12:00 Selective enrichment of newly synthesized proteins for quantitative secretome analysis
Jeroen Krijgsveld, EMBL Heidelberg, Germany

12:00 - 12:30

Nutritional regulatory networks
Marian Walhout, University of Massachusetts Medical Center, United States of America
12:30 - 14:00 LUNCH
ATC Foyer
14:00 - 15:30 Poster Session II: Even numbers
ATC Helix A & B

15:30 - 19:00

Session V
Chair: Marian Walhout, University of Massachusetts Medical School, USA

15:30 - 16:00

Chromosomal duplication is a transient evolutionary solution to stress
Yitzhak Pilpel, Weizmann Institute of Science, Israel

16:00 - 16:30

From high-throughput screens to biomedical knowlege
Frank Buchholz, TU Dresden, Medical Faculty, Germany

16:30 - 16:45

Functional high-throughput screening identifies microRNAs inducing cardiac regeneration
Miguel Mano, ICGEB - International Centre for Genetic Engineering and Biotechnology, Italy

16:45 - 17:15

Systems and synthetic biology of biological timings
Hiroki Ueda, Laboratory for Systems Biology, Center for Developmental Biology, RIKEN, Japan

17:15 - 17:45

COFFEE BREAK

ATC Foyer

17:45 - 18:15

On the road towards personalized therapy: Mapping tumor heterogeneity using forty markers at single cell resolution
Dana Pe'er, Columbia University, United States of America

18:15 - 18:30

Chemical and genetic modulation of mitochondrial protein import rescues ATP synthase disorders
Raeka Aiyar, EMBL Heidelberg, Germany

18:30 - 19:00

Promoter-proximally paused RNA polymerase II: a window for opportunity
Karen Adelman, NIEHS/ NIH, United States of America
19:00 - 00:00 GALA DINNER AND PARTY

EMBL Canteen and ATC Foyer

 
Day 4 - Tuesday, 20 November 2012
09:00 - 12:30 Session 6

09:00 - 09:30

Factors shaping the pluripotent genome
Wouter de Laat, Hubrecht Institute, The Netherlands

09:30 - 10:00

Genetic dissection of quantitative epigenomic variation in yeast
Gäel Yvert, CNRS / Ecole Normale Superieure de Lyon, France

10:00 - 10:15

Harnessing gene-environment interactions to identify functional targets for molecular intervention in phenotype
Julien Gagneur, Gene Center, LMU, Germany

10:15 - 10:45

A top-down systems biology approach to complex human diseases
Patrick Aloy, Institute for Research in Biomedicine, Spain
10:45 - 11:15 COFFEE BREAK

ATC Foyer

11:15 - 11:45

Systemic analysis of the human gut microbiome: Association of microbial markers with disease and health
Peer Bork, EMBL Heidelberg, Germany

11:45 - 12:00

Chromosomal translocations are guided by the spatial organization of the genome
Rachel McCord, University of Massachusetts Medical School, United States of America
12:00 - 12:30 MicroRNA can dampen fluctuations in the levels of its target mRNAs
Alexander van Oudenaarden, Hubrecht Institute, The Netherlands
12:30 - 12:35 CLOSING REMARKS

ATC Auditorium

12:35 - 13:00 PACKED LUNCH

ATC Foyer

13:00 Bus to Frankfurt Airport and downtown