EMBO Conference Series

Day 1 - Saturday, 17 November 2012
13:00 - 15:00	Registration
15:00 - 15:05	Welcome address
15:05 - 19:05	Session I Chair: Eileen Furlong, EMBL Heidelberg, Germany
15:05 - 15:35	New insights into control of gene expression programs Richard Young, Whitehead Institute for Biomedical Research, USA
15:35 - 16:05	Post-transcriptional gene regulation by small RNAs and RNA binding proteins Nikolaus Rajewsky, Max-Delbrück-Centrum for Molecular Medicine, Germany
16:05 - 16:20	Regulation of yeast central metabolism by enzyme phosphorylation Ana Paula Oliveira, ETH Zurich, Switzerland
16:20 - 16:50	Genome sequencing of childhood medulloblastoma brain tumors links chromothripsis with TP53 mutations Jan Korbel, EMBL Heidelberg, Germany
16:50 - 17:20	COFFEE BREAK ATC Foyer
17:20 - 17:50	Quantitative proteomics and systems biology Rudolf Aebersold, ETH Zurich, IMSB, Switzerland
17:50 - 18:05	*Regulatory genomics – decoding Drosophila* regulatory sequences through STARR-seq** Alexander Stark, IMP, Austria
18:05 - 18:35	Designing biological systems for health and sustainability Pamela Silver, Harvard Medical School, United States of America
18:35 - 19:05	TRIP: a high-throughput method to study the influence of chromatin context on gene regulation Bas van Steensel, Netherlands Cancer Institute, The Netherlands
19:05 - 21:00	DINNER EMBL Canteen
21:00 - 23:00	DRINKS ATC Roof Top Lounge

Day 2 - Sunday, 18 November 2012
09:00 - 12:30	Session II Chair: Greg Wray, Duke University, United States of America
09:00 - 09:30	Exploring biological networks and pathways using yeast phenomics Brenda Andrews, University of Toronto, Canada
09:30 - 10:00	From systems microbiology to molecular mechanism Nassos Typas, EMBL Heidelberg, Germany
10:00 - 10:15	Coordination of the human antiviral transcriptional program by stochastic interchromosomal interactions Dimitris Thanos, Biomedical Research Foundation Academy Of Athens, Greece
10:15 - 10:45	Systems analyses of an expression-based genetic perturbation network Frank Holstege, University Medical Center Utrecht, The Netherlands
10:45 - 11:15	COFFEE BREAK ATC Foyer
11:15 - 11:45	Mechanism and reconstitution in vitro of germ cell development in mice Mitinori Saitou, Graduate School of Medicine, Kyoto University, Japan
11:45 - 12:00	Consecutive positive feedback loops create a bistable switch that controls preadipocyte-to-adipocyte conversion Mary Teruel, Stanford University, United States of America
12:00 - 12:30	A genetic interaction map of chromatin-related genes Michael Boutros, German Cancer Research Center (DKFZ) / Heidelberg University, Germany
12:30 - 14:00	LUNCH EMBL Canteen
14:00 - 15:45	Poster Session I: Odd numbers ATC Helix A & B
15:45 - 19:00	Session III Chair: Lucas Pelkmans, University of Zurich, Switzerland
15:45 - 16:00	Sequence-based discovery of transcriptional targets in human and Drosophila Stein Aerts, University of Leuven, Belgium
16:00 - 16:30	Temporal control of enhancer activity during development: It’s all in the timing Eileen Furlong, EMBL Heidelberg, Germany
16:30 - 16:45	Compartmentalization and cell-to-cell variability in caspase-8 activation Stefan Kallenberger, DKFZ Heidelberg, Germany
16:45 - 17:15	Extracting fine grained disease phenotypes and adverse drug reactions from electronic patient records Søren Brunak, Center for Biological Sequence Analysis, Denmark
17:15 - 17:45	COFFEE BREAK ATC Foyer
17:45 - 18:15	Quantitative analysis of Fission Yeast transcriptomes and proteomes in proliferating and quiescent cells Jürg Bähler, University College London, United Kingdom
18:15 - 18:30	Quantification and modeling of the stochastic activity of bacterial metabolic promoters at the single cell, single molecule level using fluorescence fluctuation microscopy Nathalie Declerck, CBS, France
18:30 - 19:00	Genome-wide interplay between chromatin and the transcription machinery Frank Pugh, Penn State University, United States of America
19:00 - 21:00	DINNER EMBL Canteen
21:00 - 23:00	DRINKS Roof Top Lounge

Day 3 - Monday, 19 November 2012
09:00 - 12:30	Session IV Chair: Nevan Krogan, University of California, San Francisco, United States of America
09:00 - 09:30	Causality and cell-to-cell variability in perturbations of endocytosis Lucas Pelkmans, University of Zürich, Switzerland
09:30 - 10:00	Expanding the interaction space; protein-lipids networks Anne-Claude Gavin, EMBL Heidelberg, Germany
10:00 - 10:15	Growth-rate-dependent protein production in bacteria Jules Matthieu, INRA, France
10:15 - 10:45	Gene networks in the real world: the impact of natural stressors on function Gregory Wray, Duke University, United States of America
10:45 - 11:15	COFFEE BREAK ATC Foyer
11:15 - 11:45	Dynamic re-wiring of signaling networks in the DNA damage response – using systems biology to optimize combination therapy for cancer Michael Yaffe, Massachusetts Institute of Technology, United States of America
11:45 - 12:00	Selective enrichment of newly synthesized proteins for quantitative secretome analysis Jeroen Krijgsveld, EMBL Heidelberg, Germany
12:00 - 12:30	Nutritional regulatory networks Marian Walhout, University of Massachusetts Medical Center, United States of America
12:30 - 14:00	LUNCH ATC Foyer
14:00 - 15:30	Poster Session II: Even numbers ATC Helix A & B
15:30 - 19:00	Session V Chair: Marian Walhout, University of Massachusetts Medical School, USA
15:30 - 16:00	Chromosomal duplication is a transient evolutionary solution to stress Yitzhak Pilpel, Weizmann Institute of Science, Israel
16:00 - 16:30	From high-throughput screens to biomedical knowlege Frank Buchholz, TU Dresden, Medical Faculty, Germany
16:30 - 16:45	Functional high-throughput screening identifies microRNAs inducing cardiac regeneration Miguel Mano, ICGEB - International Centre for Genetic Engineering and Biotechnology, Italy
16:45 - 17:15	Systems and synthetic biology of biological timings Hiroki Ueda, Laboratory for Systems Biology, Center for Developmental Biology, RIKEN, Japan
17:15 - 17:45	COFFEE BREAK ATC Foyer
17:45 - 18:15	On the road towards personalized therapy: Mapping tumor heterogeneity using forty markers at single cell resolution Dana Pe'er, Columbia University, United States of America
18:15 - 18:30	Chemical and genetic modulation of mitochondrial protein import rescues ATP synthase disorders Raeka Aiyar, EMBL Heidelberg, Germany
18:30 - 19:00	Promoter-proximally paused RNA polymerase II: a window for opportunity Karen Adelman, NIEHS/ NIH, United States of America
19:00 - 00:00	GALA DINNER AND PARTY EMBL Canteen and ATC Foyer

Day 4 - Tuesday, 20 November 2012
09:00 - 12:30	Session 6
09:00 - 09:30	Factors shaping the pluripotent genome Wouter de Laat, Hubrecht Institute, The Netherlands
09:30 - 10:00	Genetic dissection of quantitative epigenomic variation in yeast Gäel Yvert, CNRS / Ecole Normale Superieure de Lyon, France
10:00 - 10:15	Harnessing gene-environment interactions to identify functional targets for molecular intervention in phenotype Julien Gagneur, Gene Center, LMU, Germany
10:15 - 10:45	A top-down systems biology approach to complex human diseases Patrick Aloy, Institute for Research in Biomedicine, Spain
10:45 - 11:15	COFFEE BREAK ATC Foyer
11:15 - 11:45	Systemic analysis of the human gut microbiome: Association of microbial markers with disease and health Peer Bork, EMBL Heidelberg, Germany
11:45 - 12:00	Chromosomal translocations are guided by the spatial organization of the genome Rachel McCord, University of Massachusetts Medical School, United States of America
12:00 - 12:30	MicroRNA can dampen fluctuations in the levels of its target mRNAs Alexander van Oudenaarden, Hubrecht Institute, The Netherlands
12:30 - 12:35	CLOSING REMARKS ATC Auditorium
12:35 - 13:00	PACKED LUNCH ATC Foyer
13:00	Bus to Frankfurt Airport and downtown

From Functional Genomics to Systems Biology

Final Programme

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