This is an unofficial site for getting compiled clustalw and clustalx binaries for Mac-X.

Note:You should convert all your sequence files from 'mac' to 'unix' format. The difference is in the way the new lines are represented. You can

  1. Try to converty them with BBedit.
  2. Try with 'tr' unix command. If you have bunch of sequences, then this is the best way.
     /usr/bin/tr '\015' '\n' < myseq.mac > myseq.macX
    
     WARNING  Do not use the same name for input and output file. You will loose your input file!
    

    Clustal qt is available from Des Higgins qt Clustal web site.
    Clustalx and Clustalw 1.83 (MacOS X native) Latest... as on Nov 10th, 2004

    After downloading, gunzip and untar (tar -xvf) or don't care, the stuffit/expander will take care and move the ~/Applications/Clustalx folder from ~/Desktop to either /Applications or ~/Applications

    mv ~/Desktop/Applications/Clustalx /Applications

    OR

    mv ~/Desktop/Applications/Clustalx ~/Applications

    You will find clustalx and clustalw binaries, help files there.

    run clustalw through a terminal window

    and for clustalx you know what to do, or just click on the icon... (if you are still in a terminal window, try open . command to open the current folder, you will see clustalx binary with this icon icon )

    And finally

    Send me the bugs, suggestions ! ( email: chenna at embl dot de )

    Now download Clustalx-1.83.1-MacOS-X.tar.gz    (10th November, 2004: Diwali release :-) New!

    Minor bug fix release. Clustalx was unable to read sequence files from different Volumes. Now it should (otherwise complain me again!!), note that this archive will create a Clustal_install folder instead of Application folder as mentioned above!


    For Mac OS X Tiger

    I got few complains about clustalx crashing with Tiger OS. This release should fix that. Please let me know if you come across any problem.

    Clustalx-1.83.1-MacOS-X-Tiger.gz     (11th October, 2005, Mac X Tiger)


    Now download Clustalx-1.83-MacOS-X.tar.gz May, 2003 This one is OLD, try downloding above link...

    Reference:
    Multiple sequence alignment with the Clustal series of programs.
    Chenna Ramu, Sugawara H, Koike T, Lopez R, Gibson TJ, Higgins DG, Thompson JD.
    Nucleic Acids Res. 2003 Jul 1;31(13):3497-500.

    After the installation try testing with the sample input file globin.pep

    Clustalx 1.81-alpha (MacOS X native)
    This one is compiled on my ibook with Mac OS X Version 10.2.1.
    (GCC version 1151, based on gcc version 3.1, prerelease )

    This release is based on the clustalx1.81 code, with few enhancements!

    You should have Stuffit Expander to unstuff the archive.

    The Stuffit Expander should create a clustalx1.81-alpha folder on your Desktop (folder).

    Locate the clustalx1.81-alpha folder, open it and click on the clustalx icon!

    New features
    • keyboard control for menus
    • save alignment in fasta format
    • saving range of sequence alignments with range numbers (useful for protein motif makers )
    • create percentage identity matrix PIM's
    • choosing color parameter file through file selection menu
    • ....... etc.,

    Now download clustalx1.81-alpha.darwin.hqx

    Clustalx 1.81 (for XDarwin)          
    The bundle contains clustalx and clustalw binaries. To run clustalx, you should have installed XDarwin, and lesstiff (needed by ncbi vibrant toolkit).

    To use clustalx, you should run XDarwin first.

    Installation:
    Open terminal window and type

    gunzip clustal_mac_x.tar.gz
    tar clustal_mac_x.tar
    

    Now download clustal-mac-x.tar.gz

    Clustalx 1.82 (MacOS X native)
    This one is compiled on my ibook with Mac OS X Version 10.2.1.
    (GCC version 1151, based on gcc version 3.1, prerelease )

    The good news is that you do not need lesstif/motif libraries!

    You should have Stuffit Expander to unstuff the archive. I could not make a tar archive since the tar is unable to archive the 'resource fork' :-(.

    The Stuffit Expander should create a clustalx1.82 folder on your Desktop (folder).

    Locate the clustalx1.82 folder, open it and click on the clustalx icon!

     OR 
    
    Open a terminal window, cd to 
    
    /Users/blabla/Desktop/clustalx1.82/clustalx.app/Contents/MacOs/
    
    ./clustalx
    
    Should pop-up the familiar.
    

    Now download clustalx1.82.darwin.hqx


    Chenna Ramu
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