Personal Homepage of Thorsten Henrich

トルステン　ヘンリｯヒ

Thorsten Henrich, PhD
Staff Member, Computational Biologist
EMBL Heidelberg
Meyerhofstr. 1
69117 Heidelberg
Germany

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Tel +49-6221-387-516
Fax +49-6221-387-166
henrich@embl.de
Currently I am working in the Centre for Computational Biology, in which I am responsible for developing a cross species gene experssion pattern database named 4DXpress:

In the major animal model species like mouse, fish or fly, detailed spatial information on gene expression over time can be acquired through whole mount in situ hybridisation experiments. In these species expression patterns of many genes have been studied and data has been integrated into dedicated model organism databases like ZFIN for zebrafish, MEPD for medaka, BDGP for drosophila or GXD for mouse. However, a central repository that allows users to query and compare gene expression patterns across different species has not yet been established. Therefore we have integrated expression patterns for zebrafish, drosophila, medaka and mouse into a central public repository called 4DXpress (expression database in 4 dimensions). Users can query anatomy ontology based expression annotations across species and quickly jump from one gene to the orthologs in other species. Genes are linked to public microarray data in ArrayExpress. We have mapped developmental stages between the species to be able to compare developmental time-phases. We store the largest collection of gene expression patterns available to date in an individual resource, reflecting 13300 annotated genes. 4DXpress will be an invaluable tool for developmental as well for computational biologists interested in gene regulation and evolution. 4DXpress is available at http://ani.embl.de/4DXpress

Author: Thorsten Henrich
Last change: 6 Feb 2008
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