ELM   Currently 128 Elms in ELM database.

o Summary of features reported by ELM. (Mouseover the matches for details.)

TRG_ENDOCYTIC_2LIG_CYCLIN_1MOD_TYR_ITSMMOD_GSK3_1LIG_APCC_Dbox_1MOD_CK1_1LIG_MAPK_1LIG_14-3-3_3LIG_SH2_STAT5LIG_FHA_1LIG_SH2_SRC Submit to SmartSubmit to PfamMOD_ProDKin_1LIG_ULM_U2AF65_1MOD_PKA_2MOD_CK2_1LIG_SH3_3MOD_PKB_1MOD_PIKK_1Submit to GlobPlotLIG_PDZ_3LIG_WW_4LIG_BRCT_BRCA1_1HelpHelpHelpHelpHelpHelpHelpHelpHelpHelpHelpTRG_ENDOCYTIC_2: [143,146] YDKLTRG_ENDOCYTIC_2: [234,237] YPDVTRG_ENDOCYTIC_2: [296,299] YQPITRG_ENDOCYTIC_2: [326,329] YSALTRG_ENDOCYTIC_2: [354,357] YSCMLIG_CYCLIN_1: [19,22] RPLPLIG_CYCLIN_1: [44,48] RILQVMOD_TYR_ITSM: [230,237] ERTHYPDVMOD_GSK3_1: [184,191] GENTNSISMOD_GSK3_1: [276,283] RQASNTPS
[285,292] IPISSSFS
[286,293] PISSSFST
[287,294] ISSSFSTSMOD_GSK3_1: [300,307] PQPTTPVS
[301,308] QPTTPVSS
[304,311] TPVSSFTSMOD_GSK3_1: [320,327] TALTNTYSMOD_GSK3_1: [346,353] PVPSQTSS
[348,355] PSQTSSYSMOD_GSK3_1: [376,383] HMQTHMNS
[385,392] PMGTSGTT
[386,393] MGTSGTTS
[391,398] TTSTGLIS
[395,402] GLISPGVSLIG_APCC_Dbox_1: [102,107] IRDRLLLIG_APCC_Dbox_1: [202,207] MRLQLKLIG_APCC_Dbox_1: [239,244] ARERLAMOD_CK1_1: [119,125] SVSSINRMOD_CK1_1: [155,161] SWGTRPGMOD_CK1_1: [189,195] SISSNGEMOD_CK1_1: [289,295] SSFSTSV
[290,296] SFSTSVYMOD_CK1_1: [307,313] SSFTSGS
[308,314] SFTSGSMMOD_CK1_1: [349,355] SQTSSYS
[352,358] SSYSCMLMOD_CK1_1: [368,374] SYDTYTPMOD_CK1_1: [389,395] SGTTSTGLIG_MAPK_1: [240,249] RERLAAKIDLLIG_14-3-3_3: [77,82] RVATPELIG_SH2_STAT5: [372,375] YTPPLIG_FHA_1: [61,67] YETGSIRLIG_FHA_1: [78,84] VATPEVVLIG_FHA_1: [185,191] ENTNSISLIG_FHA_1: [301,307] QPTTPVSLIG_FHA_1: [392,398] TSTGLISLIG_SH2_SRC: [296,299] YQPISmart: PAX: 
[4,128] SHSGVNQLGGVFVNGRPLPD
STRQKIVELAHSGARPCDIS
RILQVSNGCVSKILGRYYET
GSIRPRAIGGSKPRVATPEV
VSKIAQYKRECPSIFAWEIR
DRLLSEGVCTNDNIPSVSSI
NRVLRSmart: low_complexity_region: 
[174,185] QDGCQQQEGGGESmart: HOX: 
[210,272] LQRNRTSFTQEQIEALEKEF
ERTHYPDVFARERLAAKIDL
PEARIQVWFSNRRAKWRREE
KLRSmart: low_complexity_region: 
[281,294] TPSHIPISSSFSTSSmart: low_complexity_region: 
[387,395] GTSGTTSTGSmart: low_complexity_region: 
[398,412] SPGVSVPVQVPGSEPMOD_ProDKin_1: [77,83] RVATPEVMOD_ProDKin_1: [278,284] ASNTPSHMOD_ProDKin_1: [301,307] QPTTPVSMOD_ProDKin_1: [358,364] LPTSPSVMOD_ProDKin_1: [370,376] DTYTPPHMOD_ProDKin_1: [395,401] GLISPGVLIG_ULM_U2AF65_1: [261,266] RRAKWRMOD_PKA_2: [213,219] NRTSFTQMOD_CK2_1: [189,195] SISSNGELIG_SH3_3: [75,81] KPRVATPLIG_SH3_3: [166,172] TSVPGQPLIG_SH3_3: [292,298] STSVYQP
[299,305] IPQPTTPLIG_SH3_3: [327,333] SALPPMPLIG_SH3_3: [339,345] NNLPMQP
[342,348] PMQPPVPLIG_SH3_3: [356,362] CMLPTSPLIG_SH3_3: [398,404] SPGVSVP
[402,408] SVPVQVPMOD_PKB_1: [103,111] RDRLLSEGVMOD_PIKK_1: [170,176] GQPTQDGMOD_PIKK_1: [215,221] TSFTQEQMOD_PIKK_1: [346,352] PVPSQTSMOD_PIKK_1: [380,386] HMNSQPMMOD_PIKK_1: [412,418] PDMSQYWDisOrder: [2,22] QNSHSGVNQLGGVFVNGRPL
PDisOrder: [66,76] IRPRAIGGSKPDisOrder: [150,195] NGQTGSWGTRPGWYPGTSVP
GQPTQDGCQQQEGGGENTNS
ISSNGEDisOrder: [280,418] NTPSHIPISSSFSTSVYQPI
PQPTTPVSSFTSGSMLGRTD
TALTNTYSALPPMPSFTMAN
NLPMQPPVPSQTSSYSCMLP
TSPSVNGRSYDTYTPPHMQT
HMNSQPMGTSGTTSTGLISP
GVSVPVQVPGSEPDMSQYWGlobDom: [196,279] DSDEAQMRLQLKRKLQRNRT
SFTQEQIEALEKEFERTHYP
DVFARERLAAKIDLPEARIQ
VWFSNRRAKWRREEKLRNQR
RQASLIG_PDZ_3: [81,84] PEVVLIG_PDZ_3: [103,106] RDRL
[108,111] SEGVLIG_PDZ_3: [114,117] NDNILIG_PDZ_3: [143,146] YDKLLIG_PDZ_3: [219,222] QEQI
[222,225] IEALLIG_PDZ_3: [240,243] RERLLIG_PDZ_3: [268,271] EEKLLIG_WW_4: [77,82] RVATPELIG_WW_4: [278,283] ASNTPSLIG_WW_4: [301,306] QPTTPVLIG_WW_4: [358,363] LPTSPSLIG_WW_4: [370,375] DTYTPPLIG_WW_4: [395,400] GLISPGLIG_BRCT_BRCA1_1: [287,291] ISSSF F9SD_RaNNgY.png

o Filtering summary

User supplied cellular location(s): nucleus, cytosol
User supplied taxon: Homo sapiens

(An ELM is listed as filtered when all its matching instances have been filtered out.)

ElmsInstances
retained1462
Species filtered15
Smart filtered726
Cellular location
filtered
822
all found
(before filtering)
29110
   
Query sequence:
>unknown MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRY
YETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV
SSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQ
EGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFAR
ERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIP
QPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPT
SPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPR
LQ


o Globular domains/ TM domains and signal peptide detected by the SMART server

Domain Start End
PAX 4 128
HOX 210 272


o Results of ELM motif search after globular domain filtering and context filtering.

All matches falling inside SMART/PFAM domains are excluded from this list.

Elm Name Instances
(Matched Sequence)
Positions PHI-Blast Instance Mapping Elm Description Cell Compartment Pattern
LIG_APCC_Dbox_1
MRLQLK
202-207
- An RXXL motif that binds to the Cdh1 and Cdc20 components of APC/C thereby targeting the protein for destruction in a cell cycle dependent manner nucleus,
cytosol
.R..L.
LIG_BRCT_BRCA1_1
ISSSF
287-291
- Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with low affinity nucleus,
BRCA1-BARD1 complex
.S..F
LIG_FHA_1
ENTNSIS
QPTTPVS
TSTGLIS
185-191
301-307
392-398
- Phosphothreonine motif binding a subset of FHA domains that show a preference for a large aliphatic amino acid at the pT+3 position. nucleus ..(T)..[ILV].
LIG_WW_4
ASNTPS
QPTTPV
LPTSPS
DTYTPP
GLISPG
278-283
301-306
358-363
370-375
395-400
- Class IV WW domains interaction motif; phosphorylation-dependent interaction. nucleus,
cytosol
...[ST]P.
MOD_CK1_1
SWGTRPG
SISSNGE
SSFSTSV
SFSTSVY
SSFTSGS
SFTSGSM
SQTSSYS
SSYSCML
SYDTYTP
SGTTSTG
155-161
189-195
289-295
290-296
307-313
308-314
349-355
352-358
368-374
389-395
- CK1 phosphorylation site nucleus,
cytosol
S..([ST])...
MOD_CK2_1
SISSNGE
189-195
- CK2 phosphorylation site nucleus,
cytosol,
protein kinase CK2 complex
...([ST])..E
MOD_GSK3_1
GENTNSIS
RQASNTPS
IPISSSFS
PISSSFST
ISSSFSTS
PQPTTPVS
QPTTPVSS
TPVSSFTS
TALTNTYS
PVPSQTSS
PSQTSSYS
HMQTHMNS
PMGTSGTT
MGTSGTTS
TTSTGLIS
GLISPGVS
184-191
276-283
285-292
286-293
287-294
300-307
301-308
304-311
320-327
346-353
348-355
376-383
385-392
386-393
391-398
395-402
- GSK3 phosphorylation recognition site nucleus,
cytosol
...([ST])...[ST]
MOD_PIKK_1
GQPTQDG
PVPSQTS
HMNSQPM
PDMSQYW
170-176
346-352
380-386
412-418
- (ST)Q motif which is phosphorylated by PIKK family members nucleus ...([ST])Q..
MOD_ProDKin_1
ASNTPSH
QPTTPVS
LPTSPSV
DTYTPPH
GLISPGV
278-284
301-307
358-364
370-376
395-401
- Proline-Directed Kinase (e.g. MAPK) phosphorylation site in higher eukaryotes. nucleus,
cytosol
...([ST])P..
LIG_PDZ_3
YDKL
143-146
- Class III PDZ domains binding motif cytosol,
plasma membrane,
membrane
.[DE].[IVL]
LIG_SH2_SRC
YQPI
296-299
- Src-family Src Homology 2 (SH2) domains binding motif. cytosol Y[QDEVAIL][DENPYHI][IPVGAHS]
LIG_SH2_STAT5
YTPP
372-375
- STAT5 Src Homology 2 (SH2) domain binding motif. cytosol Y[VLTFIC]..
LIG_SH3_3
TSVPGQP
STSVYQP
IPQPTTP
SALPPMP
NNLPMQP
PMQPPVP
CMLPTSP
SPGVSVP
SVPVQVP
166-172
292-298
299-305
327-333
339-345
342-348
356-362
398-404
402-408
- This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity cytosol,
plasma membrane,
focal adhesion
...[PV]..P
TRG_ENDOCYTIC_2
YDKL
YQPI
YSAL
YSCM
143-146
296-299
326-329
354-357
- Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex cytosol,
plasma membrane,
clathrin-coated endocytic vesicle
Y..[LMVIF]


o List of excluded ELMs falling inside SMART/PFAM domains.

Matches in this list are only likely to be of interest if they are in surface-exposed loops.
Consult the SMART or PFAM entries for useful links to solved 3D structures.

Elm Name Positions PHI-Blast Instance Mapping Elm Description Cell Compartment Pattern
LIG_14-3-3_3
77-82
- Consensus derived from natural interactors which do not exactly match the mode1 and mode2 ligands nucleus,
cytosol,
internal side of plasma membrane
[RHK][STALV].[ST].[PESRDIF]
LIG_APCC_Dbox_1
102-107
239-244
- An RXXL motif that binds to the Cdh1 and Cdc20 components of APC/C thereby targeting the protein for destruction in a cell cycle dependent manner nucleus,
cytosol
.R..L.
LIG_CYCLIN_1
19-22
44-48
- Substrate recognition site that interacts with cyclin and thereby increases phosphorylation by cyclin/cdk complexes. Predicted protein should have the MOD_CDK site. Also used by cyclin inhibitors. nucleus,
cytosol
[RK].L.{0,1}[FYLIVMP]
LIG_FHA_1
61-67
78-84
- Phosphothreonine motif binding a subset of FHA domains that show a preference for a large aliphatic amino acid at the pT+3 position. nucleus ..(T)..[ILV].
LIG_MAPK_1
240-249
- MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. The classic motif approximates (R/K)xxxx#x# where # is a hydrophobic residue. nucleus,
cytosol
[KR]{0,2}[KR].{0,2}[KR].{2,4}[ILVM].[ILVF]
LIG_ULM_U2AF65_1
261-266
- Pattern encompassing the ULMs in SF1 and SAP155 which bind to the UHM of U2AF65 nucleus,
spliceosome complex
[kr]{1,4}[kr].[kr]w.
LIG_WW_4
77-82
- Class IV WW domains interaction motif; phosphorylation-dependent interaction. nucleus,
cytosol
...[ST]P.
MOD_CK1_1
119-125
- CK1 phosphorylation site nucleus,
cytosol
S..([ST])...
MOD_PIKK_1
215-221
- (ST)Q motif which is phosphorylated by PIKK family members nucleus ...([ST])Q..
MOD_ProDKin_1
77-83
- Proline-Directed Kinase (e.g. MAPK) phosphorylation site in higher eukaryotes. nucleus,
cytosol
...([ST])P..
LIG_PDZ_3
81-84
103-106
108-111
114-117
219-222
222-225
240-243
268-271
- Class III PDZ domains binding motif cytosol,
plasma membrane,
membrane
.[DE].[IVL]
LIG_SH3_3
75-81
- This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity cytosol,
plasma membrane,
focal adhesion
...[PV]..P
MOD_PKA_2
213-219
- PKA phosphorylation site cytosol .R.([ST])...
MOD_PKB_1
103-111
- PKB Phosphorylation site cell,
cytosol
R.R..([ST])...
MOD_TYR_ITSM
230-237
- ITSM (immunoreceptor tyrosine-based switch motif). This motif is present in the cytoplasmic region of the CD150 subfamily within the CD2 family and it enables these receptors to bind to and to be regulated by SH2 adaptor molecules, as SH2DIA. cytosol ..T.(Y)..[IV]
TRG_ENDOCYTIC_2
234-237
- Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex cytosol,
plasma membrane,
clathrin-coated endocytic vesicle
Y..[LMVIF]