>gi|74959793|sp|O61213.2|DUOX1_CAEEL RecName: Full=Dual oxidase 1; Short=DUOX1; AltName: Full=NADPH thyroid oxidase 1; AltName: Full=Blistered cuticle protein 3; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MRSKHVLYIAILFSSIF ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------GG KGI-----------------------------------QQNEE------FQRYD------ -GWYN------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------NLANSEWGSAGSR--------------LHRDARSYY SDGVYSVNN----------SLPSARELSDILFKGE--SGIPN-TRGCTTLLAFFSQVVAY EIMQSNGVSCPLETLKIQVPLCDNVFDKECEGKTEIP---------------------FT R----AKYDKAT--GNGLNS----------PREQINERTSW-IDGSFIYGTTQPWVSSLR SF--KQGRLAEGV------PGYPPL-NNPHIP-LNNPAPPQVHRLMSPDRLFMLGD---- SRVNENPGLLSFGL------------------ILFRWHNYNANQIH-------------- REHPDWT--DEQIFQAARRLVI------------------------ASMQKIIAYDFVP- --GLLGEDVRLSN----------YTKYM------PHVPPGISHAFGAAAFRFPHSIV--- -----------------PPAMLLRKR------GNKCEFRTEVGGYP------ALRLCQNW WNAQDIVKEYSVDEIILGMASQIAER---DDNIV----VEDLRDYIFGPMHFSRLDVVAS SIMRGRDNGVPPYNELRRTFGLAP-KTWETMNEDFYKKHTAKVEKLKELYGGNILYLDAY VGGMLEGGENGP---------------------------------------------GEL FKEIIKDQFT-------------------------------------------------- ------------------RIRDGDRFWFENKLNGLFTDEEVQMIHSITLRDIIKATTDID ETMLQKDVFFFKEGDPCPQPFQVNTTGLEPCVPFMQSTYWTDNDTTYVFTLIGLACVPLI CYGIGRYLVNRRIAIGHNSACDSLTTDFANDDCGAKGDIYGVNALEWLQEEYIRQV---- ------------------------------------------------------------ --------------------------------------------------RIEIENTTLA VKKPRGGILRKIRFETGQKIELFHSMPNPSAMHGPFVLLSQKNNHHLVIRLSSDRDLSKF LDQIRQAASGINAEVIIKDEENSILLSQAITKERRQDRLDLFFREAYAKAFNDSELQDSE TSFDSSNDDILNETISREELASAMGMKANNEFVKRMFAMTAKHNEDSLSFNEFLTVLREF VNAPQKQKLQTLFKMCDLEGKNKVLRKDLAELVKSLNQTAGVHITESVQLRLFNEVLHYA GVSNDAKYLTYDDFNALFSDIPDKQPVGLPFNRKNYQPSIGETSSLNSFAVVDRSINSSA PLTLIHKVSAFLETYRQHVFIVFCFVAINLVLFFERFWHYRYMAENRDLRRVMGAGIAIT RGAAGALSFCMALILLTVCRN--------------------------------------- ----------------------------IITLLRETVIAQYIPFDSAIAFHKIVALFAAF WATLHTVGHCVNF--YHVGTQSQEGLACLFQEAFFGSNFLPSISYWFFSTITGLTGIALV AVMCIIYVFALPCFIKRAYHAFRLTHLLNIAFYALTLLHGLPKLLDSPKFGYYVVGPIVL FVIDRIIGLMQYYKKLEIVNAEILPSDIIYIEYRRPR---------------EFKYKSGQ WVTVSSPSISCTFNESHAFSIASSPQDENMKLYIKAVGPWTWKLRSELIRSLNTGSPFPL IHMKGPYGDGNQEWMDYEVAIMVGAGIGVTPYASTLVDLVQRTSSDSFHRVRCRKVYFLW VCSTHKNYEWFVDVLKNVEDQARSGILETHIFVTQTFHKFDLRTTMLYICEKHFRATNSG ISMFTGLHAKNHFGRPNFKAFFQFIQSEHKEQSKIGVFSCGPVNLNESIAEGCADANRQR DAPSFAHRFETF >gi|75047044|sp|Q8HZK2.2|DUOX2_PIG RecName: Full=Dual oxidase 2; AltName: Full=NADH/NADPH thyroid oxidase p138-tox; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ML-----------------------------------C--------------------- ------------------------------------------------------------ -----IRP---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------E ALVLLGALLTVPLDPVGGQDALSLTWEVQRYDGWFNN--LRQHEHGAAGSPLRRLVPANY ADGVYQALG--------EPLLPNPRQLSHTTMRGP--AGLRS-IRNRTVLGVFFGYHVLS DLVSIEKPGCPAEFLNIHIPPGDPVFDPHKSGDVVLP---------------------FQ R----SRWDP----NTGQSP--------SNPRDLTNEVTGW-LDGSAIYGSSHSWSDELR SF--SGGQLASGP-----DPAFPR--QAQDPL-FMWTPPDPATGQRGPQGLYAFGA---- EQGNREPFLQALGL------------------LWFRYHNLCAQKLA-------------- REHPLWG--DEELFQHARKRVI------------------------ATYQSITMYEWLP- -------SFLQQT-----PPNYTEYRPF--------LDPSISPEFLAASEQFFSTMV--- -----------------PPGVYMR--------NASCHFQMVLNESYGSFPALRVCNSYWI RENPNLNSAEAVNQLLLGMASQISEL---EDWIV----VEDLRDYWPGPGKFSRTDYVAS SIQRGRDMGLPSYTQALQALGLNTPKNWSDFNPN---VDPQVLEATAALYNQDLSRLELF SGGLLESYGDP----------------------------------------------GPL FSTIVLDQFV-------------------------------------------------- ------------------RLRDGDRYWFENTKNGLFSKEEIAEIRSTTLRDVLVAVTNVS SSALQPNVFIWNEDSPCPQPQQLTTEDLPHCVPLTVIQYFE------------------- ---------GSGPG--------------------------FGITIVALCCLPLMSL---- -LISGVVAYFRSRERKKLQKRGKESVKKEADKDGVSAMEWPGPKERSYPVSIQLLPDRHL QVLDRHLSVLRTIQLRPRHRVNLILSNNLGRRTLLLKIPKEYDLVLLFNSEDERGAFVQH LQGFCASCALGLDIDEMGESELFRKAVTKQQRGRILEIFFRHLFAQVLDIDQADAGALPL DSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDVLVVFM KGSPEDKSRLMFTMYDLDGNGFLSKDEFFTMIRSFIEISNNCLSKAQLTEVVESMFREAG FQDKQELTWEDFHFMLRDHDSELRHTQLCVKGGGGGVGVIFKPDISSRVSFIIRTPEERS SPQGVRLPASEASELGGPVL------------KKRFGKKAVVPPPRLYTEALQEKKQRGF LAQKLQQYKRFVENYRRHIVCVAIFSAICAGLFVERAYYYAFVSPPSGIAETTFVGIILS RGTAASVSFMFSYILLTMCRN--------------------------------------- ----------------------------LITFLRETFLNHYVPFDAAVDFHRWIAMAALV LAILHSVGHVVNVYIFSVSPLSLLACVFPSVFVNDGSKLPQKFYWWFFQTIPGMTGVLLL VVLAIMYVFASPYFRRRSFRGFWLTHHFYILLYVLLIIHGSFALIQLPRFHIFFLVPALI YVGDKLVSLSRKKVEISVVKAELLPSGVTHLQFQRPQ-----------------GFEYKS GQWVRIACLGLGTNEYHPFTLTSAPHE-DTLSLHIRAVGPWTTRLREIYSHPMGDGYARY PKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIW VTRTQRQFEWLADIIREVEENDHRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNR SLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKTCQLINRQDQ THFVHHYENF-- >gi|81866480|sp|Q8CIY2.1|DUOX1_RAT RecName: Full=Dual oxidase 1; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MAVYSAVAWILLF ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GV-----------------------------------LASLG----------------- ------------------------------------------------------------ ----------A------------------------------------------------- ----------------QNPVSW-------EVQRFDG---------------WYN------ ------------------------------------------------------------ ------------------------NLMEHRWGSKGSR--------------LQRLVPASY ADGVYQPLR--------EPYLPNPRHLSNRVMRGP--AGQPS-LRNRTVLGVFFGYHVLS DLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLP---------------------FQ R----SRWDR----STGQSP--------SNPRDLTNQVTGW-LDGSAIYGSSHSWSDTLR SF--SGGQLASGP-----DPAFPR--NSQNSL-LMWMAPDPATGQGGPQGLYAFGA---- QRGNREPFLQALGL------------------LWFRYHNLCAKRLA-------------- QEHPHWG--DEELFQHARKRVI------------------------ATYQNIAMYEWLP- -------SFLKQT-----PPEYPGYHPF--------LDPSISPEFVVASEQFLSTMV--- -----------------PPGVYMR--------NASCHFQGIANRNSSVSGALRVCNSYWS RENPKLQRAEDVDALLLGMASQIAER---EDHLV----VEDVQDFWPGPLKFSRTDYLAS CLQRGRDLGLPSYTKAREALGLPPVSHWQDINPALSRSNGTVLEATAALYNQDLSRLELL AGGLLESHGDP----------------------------------------------GPL FSAIVLDQFV-------------------------------------------------- ------------------RLRDGDRYWFENNRNGLFSKEEIAEIRNTSLRDILVAVTNVD PSALQPSVFFWLAGDPCPQPSQLSTQGLPACAPLFVRDYFK------------------- ---------GSGFG--------------------------FGLTIGTLCCFPLVSL---- --LSAWIVARLRMRNFKRLQRQDRQSIMCEKLVGGVEALEWQGRKEPCRPVLVHLQPGQI RVVDGRLTVLRTIQLRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVEN IRAALKENGLSFQEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPL DSSTKVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFM KGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKDQLAEVVESMFRESG FQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQE--KICPSP RMSAHCARNNTKTASSPQRLQCPVDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSR RHQTVQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILS RGTAASISFMFSYILLTMCRN--------------------------------------- ----------------------------LITFLRETFLNRYIPFDAAVDFHRFIASTAII LTVLHSAGHVVNVYLFSISPLSVLSCLFPDLFHDDGSEFPQKYYWWFFQTVPGLTGVLLL LALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAII YVGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQ-----------------GFEYKS GQWVRIACLALGTTEYHPFTLTSAPHE-DTLSLHIRAAGPWTTRLREIYSPPTGDTCARY PKLYLDGPFGEGHQEWHKFEVSVLVGAGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIW VTRTQRQFEWLADIIREVEENDSRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNR SLFTGLRSVTHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINKQDR THFSHHYENF-- >gi|75047045|sp|Q8HZK3.1|DUOX1_PIG RecName: Full=Dual oxidase 1; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MGF-----------------------------------RLALA----------------- ----------------------------------------------------WTLLVGP- -----WMPMGA------------------------------------------------- ----------------RNSISW-------EVQRFDG---------------WYN------ ------------------------------------------------------------ ------------------------NLMEHKWGSKGSR--------------LQRLVPASY ADGVYQPLG--------EPHLPNPRDLSNTAMRGP--AGQAS-LRNRTVLGVFFGYHVLS DLVSIEKPGCPAEFLNIHIPPGDPVFDPHKSGDVVLP---------------------FQ R----SRWDP----NTGQSP--------SNPRDLTNEVTGW-LDGSAIYGSSHSWSDELR SF--SGGQLASGP-----DPAFPR--QAQDPL-FMWTPPDPATGQRGPQGLYAFGA---- EQGNREPFLQALGL------------------LWFRYHNLCAQKLA-------------- REHPLWG--DEELFQHARKRVI------------------------ATYQSITMYEWLP- -------SFLRKM-----PQEYTGYRPF--------LDPSISPEFLAASEQFFSTMV--- -----------------PPGVYMR--------NASCHFQGVINRNSSVSRALRVCNSYWS REHPNLQRAEDVDALLLGMASQIAER---EDHMV----VEDVQDFWPGPLKFSRTDHLAS CLQRGRDLGLPSYTKARARLGLPPVTRWQDINPALSRSDGIVLEATAALYNQDLSRLELL PGGLLESYGDP----------------------------------------------GPL FSTIVLDQFV-------------------------------------------------- ------------------RLRDGDRYWFENTKNGLFSEKEIAEIRNTSLRDVLVAVTNMT PGALQPNVFFWHAGDPCPQPRQLSTKDLPACAPLIMRDYFK------------------- ---------GSGFG--------------------------FGVTIGTLCCFPLVSL---- --LSAWIVAQLRRRNFKRLQVQNRQSIMCEKLVGGMKALEWQGRKEPCRPVLVHLQSGQI HVMDGRLSVLRTIQLRPPQQVNLILSSNHGRRTLLLKIPKEYDLVLMFDLEEERQVMVEN LQSALKESGLSFQEWELREQELMRAAVTREQRSHLLETFFRHLFSQVLDIDQADAGALPL DSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFM KGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLTEVVESMFREAG FQDKQELTWEDFHFMLRDHDSELRFTQLCVKGVEVPEVIKDLCRRASYISQEKLCPSPRV SAHCPRSNVDVEVELTPWKLQCPTDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSR RHQTVQQFKRFVENYRRHIGCLAVFYTIAGGLFLERAYYYAFAAHHMGITDTTRVGIILS RGTAASISFMFSYILLTMCRN--------------------------------------- ----------------------------LITFLRETFLNRYVPFDAAVDFHRLIASTAII LTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDNGSEFPQKYYWWFFQTVPGLTGVMLL LILAIMYVFASHHFRRCSFRGFWLTHHLYILLYMLLIIHGSFALIQLPRFHIFFLVPALI YVGDKLVSLSRKKVEISVVKAELLPSGVTHLQFQRPQ-----------------GFEYKS GQWVRIACLALGTTEYHPFTLTSAPHE-DTLSLHIRAAGPWTTRLREIYSPPTDDNCAKY PKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIW VTRTQRQFEWLADIIREVEENDHRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNR SLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDR THFSHHYENF-- >gi|75050486|sp|Q9MZF4.1|DUOX1_CANFA RecName: Full=Dual oxidase 1; AltName: Full=NADPH thyroid oxidase 1; Short=Thyroid oxidase 1; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MGF-----------------------------------CLALT----------------- ----------------------------------------------------WTFLVGS- -----WTSMGA------------------------------------------------- ----------------QKPISW-------EVQRFDG---------------WYN------ ------------------------------------------------------------ ------------------------NLMEHKWGSKGSR--------------LQRLVPASY ADGVYQPLG--------EPHLPNPRDLSNAAMRGP--AGQAS-LRNRTVLGVFFGYHVLS DLVSVETPGCPAEFLNIRIPPGDPVFDPNGRGDVVLP---------------------FQ R----SRWDP----ESGQSP--------SNPRDLTNAVTGW-LDGSAIYGSSHSWSDALR SF--SGGQLASGP-----DPAFPR--NAQPPL-LMWSAPDPASGQRGPGGLYAFGA---- ERGNRDPFLQALGL------------------LWFRYHNLCAQRLA-------------- RQHPHWG--DEELFQHARKRVI------------------------ATYQNIALYEWLP- -------SFLQQA-----PVKYAGYNPF--------LDPSISPEFLVASEQFFSTMV--- -----------------PPGIYMR--------NASCHFQEVINRNSSISRALRVCNSYWS RKHPNLRRAEDVDALLLGMASQIAER---EDHVV----VEDVLDFWPGSLKFSRTDHVAG CLQRGRDLGLPSYTKARAALGLPPITRWQDINPALSQNNHTVLEATAALYNQDLSQLELL PGGLLESHGDP----------------------------------------------GPL FSAIVLNQFV-------------------------------------------------- ------------------RLRDGDRYWFENTRNGLFSEEEIAEIRNTSLRDVLVAVTNMN PSTLQPNVFFWHMGDPCPQPRQLSTQGLPACAPSTMQDYFE------------------- ---------GSGFG--------------------------FGVTIGTLCCFPLVSL---- --LSAWIVARLRKKNFKKLQGQDRKSVMSEKLVGGMEALEWQGHKEPCRPVLVHLQPGQI CVVDGRLSVLRTIQLRPPQQVNLILSGNRGRRALLLKIPKEYDLVLLFNLEEERQVLVEN LRGALKESGLKFQEWELREQELMRTAVTRQQRSHLLETFFRHLFSQVLDIDQADAGTLPL DSSQKVQEALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFM KGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLTEVVESMFRESG FQDKEELTWEDFHFMLRDHDSELRFTQLCVRGVEVPEVIKDLCRRASYISQEKICPSPRV SARCPHSN--TEVEWTPQRLQCPVDTDPPQEIRRRFGKKVTSFQPLLFTEAQREKFQRSR RHQTLQQFKRFIENYRRHIGCVAVFYAITGGLFLERAYYYAFGAHHMGITDTTRVGIILS RGTAASISFMFSYILLTMCRN--------------------------------------- ----------------------------LITFLRETFLNRYVPFDAAVDFHRLIASTAIV LTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHNDGSEFPQKYYWWFFQTVPGLTGVMLL LVLAIMYVFASHHFRRHSFRGFWLTHHLYILLYVLLIIHGSFGLIQLPRFHIFFLVPALI YVGDKLVSLSRKKVEISVVKAELLPSGVTHLQFQRPQ-----------------GFEYKS GQWVQIACLALGTTEYHPFTLTSAPHE-DTLSLHIRAAGPWTTRLREIYSPPTGDGCAKY PKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIW VTRTQRQFEWLADIIREVEENDCQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNR SLFTGLRSITHFGRPPFEPFFKSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDR THFSHHYENF-- >gi|548478|sp|P35419.1|PERT_MOUSE RecName: Full=Thyroid peroxidase; Short=TPO; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MRTLGAMAIMLVVMGTVIF LSFIL----------------------------------------------RSRDILCGK T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MK SHV-----------------------------------ISAVE-TSQLMVDHAVYNTMKR -NLKKRE------------------------------VLSPAQL--------LSFFKLPE STSGAISR--A------------------------------------------------- ----------------AEIMET-------SIQVMKR------------------------ ----------EQS------------------QFSTDALSAD------------------I LGTIANLSGCLPFMLPPRCPDTCLANKYRPITGACNN--RDHPRWGASNTALARWLPPVY EDGFSQPKGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTED--DQYSDFLPVWGQYIDH DIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSSGTTACLP-----------FY R----SSAAC----GTGDQGALFGNLSAANPRQQMNGLTSF-LDASTVYGSSPGVEKQLR NWSSSAGLLRVNTLHLDAGRAYLP--FATAAC-APEPGTPR----TNRTPCFLAGD---- GRASEVPALAAVHT------------------LWLREHNRLASAFK-------------- AINKHWS--ANTAYQEARKVVG------------------------ALHQIITMRDYIP- --KILGPDAFRQYV----GPYEGYNPTV---------NPTVSNIFSTAAFRFGHATV--- ----------------HPLVRRLNTDFQEHTELPRLQLRDVF--FR-------------- --PWRLIQEGGLDPIVRGLLARAAKLQVQGQLMN----EELTERLFVLSNVG-TLDLASL NLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAI--ANRSMVNKIMDLYK-HADNIDVW LGGLAEKFL-P----------------------------------------------GAR TGPLFACIIG-------------------------------------------------- -----------------------------KQMKALRDG---------------------- -------------------------------DR----FWWE------------------- ---------NTNVF--------------------------TDAQRQELEKHSLPRV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICDN--------------------------------------- ------------------------------------------------------------ -----TGLTRVPV----------------------------------------------- ------------------------------------------------------------ ------------------------------DAFRIGK----------------------- --FPQDFESCEDIPSMDLELWRETFPQ-DDKCVFPEEVDNGNFVHCEESGKLVLVYSCFH GYKLQGQEQVTCTQKGWDSEPPVCKDVNECADLTHPPCHPSAQCKNTKGSFQCVCTDPYV LGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLTWIVICRWTHADKKATLPITERVTT QSGCRKSQGRGISPHKAAAQDTGQEPASGSRVLLCE------------------------ ------------ >gi|129832|sp|P14650.1|PERT_RAT RecName: Full=Thyroid peroxidase; Short=TPO; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MRTLGAMAVMLVVMGTAIF LPFLLRSRDILGG--------------------------------------KTMTSHVIS V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------V---------------------------------ET SQL-----------------------------------LVDNA-----VYNTMKRNLKKR -GVLSPA----------------------------QLLSFS-KL--------PESTSGA- -----ISR--A------------------------------------------------- ----------------AEIMET-------SIQVMKR------------------------ -----------EQS-----------------QFSTDALSAD------------------I LATIANLSGCLPFMLPPRCPDTCLANKYRPITGVCNN--RDHPRWGASNTALARWLPPVY EDGFSQPRGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTED--DQYSDFLPVWGQYIDH DIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSSRTTACLP-----------FY R----SSAAC----GTGDQGALFGNLSAANPRQQMNGLTSF-LDASTVYGSSPGVEKQLR NWSSSAGLLRVNTLHLDSGRAYLP--FASAAC-APEPGAPH----ANRTPCFLAGD---- GRASEVPALAAVHT------------------LWLREHNRLATAFK-------------- AINTHWS--ANTAYQEARKVVG------------------------ALHQIITMRDYIP- --KILGPDAFRQYV----GPYEGYNPTV---------NPTVSNVFSTAAFRFGHATV--- ----------------HPLVRRLNTDFQDHTELPRLQLHDVF--FR-------------- --PWRLIQEGGLDPIVRGLLARPAKLQVQEQLMN----EELTERLFVLSNVG-TLDLASL NLQRGRDHGLPGYNEWREFCGLSRLDTGAELNKAI--ANRSMVNKIMELYK-HADNIDVW LGGLAEKFL-P----------------------------------------------GAR TGPLFACIIG-------------------------------------------------- --------------------------------KQMKAL---------------------- -----R-----------------------DGDR----FWWE------------------- ---------NSHVF--------------------------TDAQRQELEKHSLPRV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICDN--------------------------------------- ------------------------------------------------------------ -----TGLTRVPV----------------------------------------------- ------------------------------------------------------------ ------------------------------DAFRIGK----------------------- --FPQDFESCEEIPSMDLRLWRETFPQ-DDKCVFPEKVDNGNFVHCEESGKLVLVYSCFH GYKLQGQEQVTCTQNGWDSEPPVCKDVNECADLTHPPCHSSAKCKNTKGSFQCVCTDPYM LGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLSWTVICRWTHADKKSTLLITERVTM ESGFRKSQESGISPQKAEVQDAEQEPAYGSRVLLCE------------------------ ------------ >gi|12643419|sp|P22079.2|PERL_HUMAN RecName: Full=Lactoperoxidase; Short=LPO; AltName: Full=Salivary peroxidase; Short=SPO; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MRVLLHLPALLASLI LL-------------------------------------------------QAAASTTRA Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TT RTS-----------------------------------AISDT------VSQAKVQVNKA ---FLDS---------------------------------------------RTRLKTA- -----MSS---------------------------------------------------- ----------------ETPTSR-------QLSEYLKHAKGRTRTAIRNGQVWEE------ ---------SLKRLRQKASLT----------NVTDPSL---------------------D LTSLSLEVGCGAPAPVVRCDP---CSPYRTITGDCNN--RRKPALGAANRALARWLPAEY EDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLD--QNRSLLFMQWGQIVDH DLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMP--------FF R----AGFVCP---TPPYKS---------LAREQINALTSF-LDASFVYSSEPSLASRLR NLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSP-CEFINT------TARVPCFLAGD---- SRASEHILLATSHT------------------LFLREHNRLARELK-------------- RLNPQWD--GEKLYQEARKILG------------------------AFVQIITFRDYLP- --ILLGDHMQKWI-----PPYQGYSESV---------DPRISNVFTFAFRFGHLEVP--- -----------------SSMFRLDENYQPWGPEPELPLHTLF--FN-------------- --TWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMT----GELRNKLFQPTHRIHGFDLAAI NTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVL--KSKMLAKKLLGLYG-TPDNIDIW IGAIAEPLV-E----------------------------------------------RGR VGPLLACLLG-------------------------------------------------- -----------------------------KQFQQIRDG---------------------- -------------------------------DR----FWWE------------------- ---------NPGVF--------------------------TNEQKDSLQKMSFSRL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCDN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TRITKV---------------PRDPFWANS YPYDFVDCSAIDKLDLSPWASVKN------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|129826|sp|P11247.1|PERM_MOUSE RecName: Full=Myeloperoxidase; Short=MPO; Contains: RecName: Full=Myeloperoxidase light chain; Contains: RecName: Full=Myeloperoxidase heavy chain; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MKLLLALAGLLAPLAM LQTSNGATPALL---------------------------------------GEVENSVVL S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------CMEE------------------------------AK QLV-----------------------------------DRAYK------ERRESIKRTLQ SGSASPT------------------------------ELLF-YF--------KQPVAGT- -----RTAVRA------------------------------------------------- ----------------ADYLHV-------ALDLLKR----------KLQPLWPR------ ----------PFNV-----------------TDVLTPA---------------------Q LNLLSVSSGCAYQDVGVTCPP---NDKYRTITGHCNN--RRSPTLGASNRAFVRWLPAEY EDGVSMPFGWTPGVNRNGFKVPLARQVSNAIVRFPNDQLTKD--QERALMFMQWGQFLDH DITLTPEPATRFSFFTGLNCETSCLQQPPCFPLKIPPNDPRIKNQKDCIP--------FF R----SCPAC----TRNNIT----------IRNQINALTSF-VDASGVYGSEDPLARKLR NLTNQLGLLAVNTRFQDNGRALMPFDSLHDDPCLLTNRSAR----IP---CFLAGD---- MRSSEMPELTSMHT------------------LFVREHNRLATQLK-------------- RLNPRWN--GEKLYQEARKIVG------------------------AMVQIITYRDYLP- --LVLGPAAMKKY-----LPQYRSYND--------SVDPRIANVF-TNAFRYGHTLI--- ----------------QPFMFRLNNQYRPTAANPRVPLSKVF--FA-------------- --SWRVVLEGGIDPILRGLMATPAKLNRQNQIVV----DEIRERLFEQVMRI-GLDLPAL NMQRSRDHGLPGYNAWRRFCGLPQPSTVGELGTVL--KNLELARKLMAQYG-TPNNIDIW MGGVSEPLE-P----------------------------------------------NGR VGQLLACLIG-------------------------------------------------- -----------------------------TQFRKLR------------------------ -----------------------------DGDR----FWWE------------------- --------NPGVFS--------------------------KQQ-RQALASISLPRL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICDN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TGITTVS--------------KNNIFMSNT YPRDFVSCNTLPKL--NLTSWKET------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|74871953|sp|Q9VZZ4.1|PXDN_DROME RecName: Full=Peroxidasin; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MRFMLLMLQLLGLLLLLAGGVQSVYCPAGCTCLE RTVRCIRAKLSAVPKLPQDTQTLDLRFNHIEELPANAFSGLAQLTTLFLNDNELAYLQDG ALNGLTALRFVYLNNNRLSRLPATIFQRMPRLEAIFLENNDIWQLPAGLFDNLPRLNRLI MYNNKLTQLPVDGFNRLNNLKRLRLDGNAIDCNCGVYSLWRRWHLDVQRQLVSISLTCAA PQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSCEVTGLPRPQITWMHNTQ ELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVRLVVNGGNHPLDS PIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQIVALHGSGHVLLDCAASGWP QPDIQWFVNGRQLLQSTPSLQLQANGSLILLQPNQLSAGTYRCEARNSLGSVQATARIEL KELPEILTAPQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQL-----EN ENT-----------------------------------ELVVGAARQEHAGVYRCTAHNE NGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPCQADQPEDGLQISWRHDGRL- -----IDPNVQLAEKYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRASASALVTIRNNV DLAPGDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSDKAPPNYGELLRVFRFPTGEARQL ARAAEIYERTLVNIRKHVQEGDNLTMKSEEYEF-RDLLSRE------------------H LHLVAELSGCMEHREMPNCTDMCFHSRYRSIDGTCNN--LQHPTWGASLTAFRRLAPPIY ENGFSMPVGWTKGMLYSGHAKPSARLVSTSLVATK--EITPD--ARITHMVMQWGQFLDH D-LDHAIPSVSSESWDGIDCKKSCEMAPPCYPIEVPPNDPRVRNRRCID---------VV R----SSAIC----GSGMTS---LFFDSVQHREQINQLTSY-IDASQVYGYSTAFAQELR NLTSQEGLLRVGVHFPRQKDMLPF--AAPQDG-MDCRRNLD----ENTMSCFVSGD---- IRVNEQVGLLAMHT------------------IWMREHNRIASKLK-------------- QINSHWD--GDTLYQEARKIVG------------------------AQMQHITFKQWLPL IIGESGMEMMGEY--------QGYNPQL---------NPSIANEFATAALRFGHTII--- ----------------NPILHRLNETFQPIPQGHLLLHKAFFAPWR-------------- -----LAYEGGVDPLMRGFLAVPAKLKTPDQNLN-----TELTEKLFQTAHAVALDLAAI NIQRGRDHGMPGYNVYRKLCNLTVAQDFEDLAGEI--SSAEIRQKMKELYG-HPDNVDVW LGGILEDQV-E----------------------------------------------GGK VGPLFQCLLV-------------------------------------------------- -----------------------------EQFRRLRDGDR-------------------- -------------------------------------LYYE------------------- --------NPGVF---------------------------SPEQLTQIKQANFGRV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------LCDV--------------------------------------- -------------------------GDNFDQVTENVFILAKHQGGYKKCEDIIGINLYLW QECGRCNSPPAIFDSYIPQTYTKRSNRQKRDLGKENDEVATAESYDSPLE---------- ------------------------------------------------------------ ------------------------------SLYDVNEERVSGLEELIGSFQKELKKLHKK LRKLEDSCNSADSEPVAQVVQLAAAPPQLVSKPKRSHCVDDKGTTRLNNEVWSPDVCTKC NCFHGQVNCLRERCGEVSCPPGVDPLTPPEACCPHCPMVK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|187471091|sp|A1KZ92.2|PXDNL_HUMAN RecName: Full=Peroxidasin-like protein; AltName: Full=Vascular peroxidase 2; AltName: Full=Cardiac peroxidase; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFK STVRCMHLMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRN AFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLF LHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEY PRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNH SLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSF VIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRD HGRFT------------------------------------------------------- ------------------------CHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEE HAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSS LGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITE SGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESS ILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIR ERVKQGLTVDLEGK-----------------EFRYNDLVSPR-----------------S LSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNN--LQQPTWGAALTAFARLLQPAY RDGIRAPRG-LGLPVGSRQPLPPPRLVATVWARAA--AVTPD--HSYTRMLMHWGWFLEH DLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCML---------FA R----SSPAC----ASGRPS---ATVDSVYAREQINQQTAY-IDGSNVYGSSERESQALR DPSVPRGLLKTGFPWPPSGKPLLP--FSTGPP-TECARQEQ------ESPCFLAGD---- HRANEHLALAAMHT------------------LWFREHNRVATELS-------------- ALNPHWE--GNTVYQEARKIVG------------------------AELQHITYSHWLP- --KVLG------------DPGTRMLRGY--RGYNPNVNAGIINSFATAAFRFGHTLI--- ----------------NPILYRLNATLGEISEGHLPFHKALF------------------ -SPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLS-----PELTQRLFSAAYSAAVDSAAT IIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEI--KDSEIRQKLRKLYG-SPGDIDLW PALMVEDLI-P----------------------------------------------GTR VGPTLMCLFV-------------------------------------------------- -----------------------------TQFQRLRDG---------------------- -----D-------------------------------RFWY------------------- -------ENPGVF---------------------------TPAQLTQLKQASLSRV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------LCDN--------------------------------------- -------------------------GDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVW QDCCADCRSRGQFRAVTQESQKKRS----------------------------------- ------------------------------------------------------------ ------------------------------AQYSYP---------------VDKDMELSH LRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALREQINKLEARLRQAGC TDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPELVKGTCCPVCRDRGM PSDSPEKR---------------------------------------------------- ------------------------------------------------------------ ------------ >gi|172045828|sp|Q92626.2|PXDN_HUMAN RecName: Full=Peroxidasin homolog; AltName: Full=Vascular peroxidase 1; AltName: Full=Melanoma-associated antigen MG50; AltName: Full=p53-responsive gene 2 protein; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ----------------MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFR TTVRCMHLLLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSG AFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLF LHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEY PRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNN ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ GDSGEYA----------------------------------------------------- ------------------------CSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEG QTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNI IGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTE SGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATS IVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQLIQ EHVQHGLMVDLNGT-----------------SYHYNDLVSPQ-----------------Y LNLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNN--LQHPMWGASLTAFERLLKSVY ENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTE--TVTPD--EQFTHMLMQWGQFLDH DLDSTVVALSQARFSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMF--------FV R----SSPVC----GSGMTS---LLMNSVYPREQINQLTSY-IDASNVYGSTEHEARSIR DLASHRGLLRQGI-VQRSGKPLLP--FATGPP-TECMRDEN----ESPIPCFLAGD---- HRANEQLGLTSMHT------------------LWFREHNRIATELL-------------- KLNPHWD--GDTIYYETRKIVG------------------------AEIQHITYQHWLP- --KILGEVGMRTL-----GEYHGYDPGI---------NAGIFNAFATAAFRFGHTLV--- ----------------NPLLYRLDENFQPIAQDHLPLHKAFFSPFR-------------- -----IVNEGGIDPLLRGLFG-----VAGKMRVPSQLLNTELTERLFSMAHTVALDLAAI NIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEI--KNPEIREKLKRLYG-STLNIDLF PALVVEDLV-P----------------------------------------------GSR LGPTLMCLLS-------------------------------------------------- -----------------------------TQFKRLRDG---------------------- -----D-------------------------------RLWY------------------- -------ENPGVF---------------------------SPAQLTQIKQTSLARI---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------LCDN--------------------------------------- -------------------------ADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVW QDCCEDCRTRGQF----------------------------------------------- ------------------------------------------------------------ ------------------------------NAFSYHFRGRRSLEFSYQEDKPTKKTRPRK IPSVGRQGEHLSNSTSAFSTRSDASGTNDFREFVLEMQKTITDLRTQIKKLESRLSTTEC VDAGGESHANNTKWKKDACTICECKDGQVTCFVEACPPATCAVPVNIPGACCPVCLQKRA EEKP-------------------------------------------------------- ------------------------------------------------------------ ------------ >gi|123788303|sp|Q3UQ28.1|PXDN_MOUSE RecName: Full=Peroxidasin homolog; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ -------------------MAVRPTRRCLLALLLCFAWWAMAVVASKQGAGCPSRCLCFR TTVRCMHLLLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRSLNTLLLNNNQIKKIPNG AFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPESFQHLPKLERLF LHNNRITHLVPGTFSQLESMKRLRLDSNALHCDCEILWLADLLKTYAQSGNAQAAATCEY PRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNN ELSMKTDSRLNLLDDGTLMIQNTQEADEGVYQCMAKNVAGEAKTQEVTLRYLGSPARPTF VIQPQNTEVLVGESVTLECSATGHPLPQITWTRGDRTPLPIDPRVNITPSGGLYIQNVAQ SDSGEYTCFASNSVDSIHATAFIIVQALPQFTVTPQSRVVIEGQTVDFQ----------- ------------------------CAAKGHPQPVIAWTKGGSQLSVDRRHLVLSSGTLRI SGV-----------------------------------ALHDQ-------GQYECQAVNI IGSQKVVAHLTVQPRVTPVFASIPSDMTVEVGTNVQLPCSSQGEQEPAITWNKDGVQVTE SGKFHISPEGFLTINDVGTADAGRYECVARNTIGYASVSMVLSVNVPDVSRNGDPYVATS IVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVGQARAGEIFERTLQLIQ EHVQHGLMVDLNGT-----------------SYHYNDLVSPQ-----------------Y LSLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNN--LQHPMWGASLTAFERLLKAVY ENGFNTPRGINSQRQYNGHVLPMPRLVSTTLIGTE--VITPD--EQFTHMLMQWGQFLDH DLDSTVVALSQARFSDGQHCSSVCSNDPPCFSVMIPPNDPRVRSGARCMF--------FV R----SSPVC----GSGMTS---LLMNSVYPREQINQLTSY-IDASNVYGSTDHEARSIR DLASHRGLLRQGI-VQRSGKPLLP--FATGPP-TECMRDEN----ESPIPCFLAGD---- HRANEQLGLTSMHT------------------LWFREHNRIAAELL-------------- KLNPHWD--GDTVYHETRKIVG------------------------AEIQHITYRHWLP- --KILGEVGMKML-----GEYRGYDPSV---------NAGIFNAFATAAFRFGHTLI--- ----------------NPLLYRLDENFEPIPQGHVPLHKAFFSPFR-------------- -----IVNEGGIDPLLRGLFG-----VAGKMRIPSQLLNTELTERLFSMAHTVALDLAAI NIQRGRDHGIPPYHDYRVYCNLSAAYTFEDLKNEI--KSPVIREKLQRLYG-STLNIDLF PALMVEDLV-P----------------------------------------------GSR LGPTLMCLLS-------------------------------------------------- -----------------------------TQFRRLRDG---------------------- -----D-------------------------------RLWY------------------- -------ENPGVF---------------------------SPAQLTQLKQTSLARI---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------LCDN--------------------------------------- -------------------------SDNITRVQQDVFRVAEFPHGYSSCEDIPRVDLRVW QDCCEDCRTRGQF----------------------------------------------- ------------------------------------------------------------ ------------------------------NAFSYHFRGRRSLEFSYEDDKPT-KRARWR KALSVKHGKHLSNATSATHEHLEGPATNDLKEFVLEMQKIITDLRKQINSLESRLSTTEC VDDSGESHGGNTKWKKDPCTVCECKNGQITCFVEACQPAACPQPVKVEGACCPVCLKNTA EEKP-------------------------------------------------------- ------------------------------------------------------------ ------------ >gi|400748|sp|Q01603.1|PERO_DROME RecName: Full=Peroxidase; Short=DmPO; AltName: Full=Chorion peroxidase; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MIRARDLLLLALLG FIS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SA LGL-----------------------------------KVSSG--YHIVHNQPQSSFPNY HGFSYLQ------------------------------GSAPYVI--------GNSLPTSP APQNPFSSPAS------------------------------------------------- ----------------PPVSAY-------------G------------------------ -----------------------------------------------------------Y SFPTAGRVSCAAPPA--VCE----KTAYRTLDGSCNH--LEQPGLGVANSKYGRLLTPKY ADGISAPTR-----SVTGDELPSARLVSLVAFGE---QDVPD--PEFTLHNMQWGQIMTH D--MSMQAGGTQSKKHPTRCCTDDGRLIGLDTAHKTCFAIIVPPHDPAYSQVGTECLNFV RTLTDRDSNCQYQGGPAEQL----------------TVVTSYLDLSLVYGNSIQQNSDIR EF--QGGRMIVEE---RNGAKWLP--LSRNVT-GDCDAVDA------SEVCYRSGD---- VRVNQNPGLAILQT------------------ILLREHNRIADALS-------------- ALNPHYD--DRTLFQEARKINI------------------------AQYQQISYYEWLP- --IFLGGENMLKNRLIYKAPSGSYINDF-----DPNIDPSVLNEHATAAFRYFHSQI--- -----------------EGRLDLL-----------SELRQVLGSLT-------------- --LSDWFNRPGIIEVGDNFDSLTRGHATQPEELTDINFDRQIKHFLFRRNMPFGSDLRSL DIQRNRDHGLASYNDMREFCGLRRAHSWEGYGDL---ISPPILEKLKSLYP-SHEDVDLT VGASLEAHV-A----------------------------------------------GTL AGPTFLCILT-------------------------------------------------- ----------------------------EQFYRTRVGD---------------------- -----R-------------------------------FFFE------------------- ------NGDKLTGF--------------------------TPDQLEELRKASMARL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------LCDN--------------------------------------- ------------------------------------------------------------ ----------GNH----------------------------------------------- ------------------------------------------------------------ ------------------------------ISSMQPE-------------------AFRT VSHSNPIIPCSNIPQVDLTKWIDQKPYATVDPSHYGKK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|74947832|sp|Q9VEG6.2|PERC_DROME RecName: Full=Chorion peroxidase; AltName: Full=Peroxinectin-related protein; Short=Dpxt; Contains: RecName: Full=Chorion peroxidase light chain; Contains: RecName: Full=Chorion peroxidase heavy chain; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MSRILFILLLLIVT QLSELQAAAFSVRQNRFDEVPDLQTPAPLATSTESSKKPEKATSGLLKKCLPCSDGIRCV PQIQ-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------CPAHVRMESH------------------------EK PQI-----------------------------------CDLPA-------GKFGYCCETG QNHTAPK-----------------------------PETSPKER--------RSGFPTI- -----LSPAVL------------------------------------------DEARRNF EHLMHGVAQIPVRRGFPDFAHG-------LVFHSTA-----------KDDLHNFAISNSA IEQVMTTQLFGKKEQVPVE------------DFITNNVP--------------------I KFTETPLAHHCQPPP--VCGNI--RSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAY EDGIWTPRA----HSSDGTPLLGARKISRTLL-----SDVDRPHPKYNLMVMQFGQVLAH D-ISQTSSIRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAFGVRCLNFV RLSLVPSPDCQLSYGKQLTK-----------------VTHF-VDASPVYGSSDEASRSLR AF--RGGRLRMMN---DFGRDLLP--LTNDKK----ACPSE----EAGKSCFHSGKSLLS NVFLIINSLITYLTRLGDGRTNQIISLITLQILLAREHNRVAGALH-------------- ELNPSAS--DETLFQEARRIVI------------------------AEMQHITYNEFLP- --IIIGPQQMKRFRLVPLHQGYSHDYNV-------NVNPAITNEFSGAAYRMGHSSV--- -----------------DGKFQIRQEHGRI--DEVVNIPDVM--FN-------------- --PSRMRKREFYDDMLRTLYSQPMQQVDSSISQG-------LSRFLFRGDNPFGLDLAAI NIQRGRDQGLRSYNDYLELMGAPKLHSFEQFP-------IEIAQKLSRVYR-TPDDIDLW VGGLLEKAV-E----------------------------------------------GGV VGVTFAEIIA-------------------------------------------------- ----------------------------DQFARFKQGD---------------------- -------------------------------------RYYY------------------- --EYDNGINPGAF---------------------------NPLQLQEIRKVTLARL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------LCDN--------------------------------------- ------------------------------------------------------------ --SDRLTLQAVPL----------------------------------------------- ------------------------------------------------------------ ------------------------------AAFVRAD----------------------- ----------------HPGNQMIGCDDPNLPSVNLEAWRA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|166208492|sp|P82600.3|PERC_AEDAE RecName: Full=Chorion peroxidase; Contains: RecName: Full=Chorion peroxidase light chain; Contains: RecName: Full=Chorion peroxidase heavy chain; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MAKKVLLLSLYSAVLSTWFG FGYVQCKLPTSRSEIPNFDYTVAQQPDQSDACEQNEVCMVSVECILDAKKKAILKPCSTV P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SV DGV-----------------------------------CCPSS--------EYNGTSSRV QQNSEEH----------------------------AADHLVLQAIHEGRREYDEKLRFED EHRAVMTAKEK------------------------------------------------- ----------------PEAMFHRMFLPGGLKTHGKE--------------VVDA------ ----------EEQA-----------------NVYGHVFASRKYAELTNMTLKQRQGDRFA RIPRAIRKRCLPPVP---CNP---HSRYRTIDGSCNNPLPDRTSWGMEGYPFDRVLEPAY EDGVWAPRI----HSVTGNLLPSARVISVALFPD---EYRPD--PRLNILFMQMGQFISH D-FTLSRGFTTKHGQAIECCTPNCTAPLFGPHRHFACFPIEVPPNDPFYSRFGVRCLNLV RIRLAQGPEC----QLGYAK-------------QADLVTHF-LDASTVYGSTNDVAAELR AF--QQGRLKDSF---PNGIELLP--FARNRT-ACVPWARV---------CYEGGD---- IRTNQLLGLTMVHT------------------LFMREHNRLAVGLS-------------- KINPHWD--DERLYQEARRILI------------------------AEYQNVVYNEFLP- --ILLGHERVQQLGLA--DPFDTYTNYY-----DPNLRPMTLAEVGAAAHRYGHSLV--- -----------------EGFFRFLTRESP---PEDVFIKDIF------------------ NDPSKTLEPNSFDVMMFSFNQQPMEQMDRFLTYG----LT---RFLFKERKPFGSDLASL NIQRGRDFAVRPYNDYREWAGLGRITDFNQLG--------EVGALLAQVYE-SPDDVDLW PGGVLEPPA-E----------------------------------------------GAV VGSTFVALLS-------------------------------------------------- --------------------------------AGYTRY---------------------- -----K-----------------------RADR----YYFT------------------- ---NGPEVNPGAFT--------------------------LQQ-LGEIRRTTLAGI---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICAN--------------------------------------- ------------------------------------------------------------ ------ADHKEDF----------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------YQAQEALRQ SSADNVPVPCTRYDTVNLGLWREEGF---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|93140516|sp|Q7QH73.3|PERC_ANOGA RecName: Full=Chorion peroxidase; Contains: RecName: Full=Chorion peroxidase light chain; Contains: RecName: Full=Chorion peroxidase heavy chain; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MLPKGVLLFLVLIVLV QHFATVQTTNAIE--------------------------------------RPSAPSSQC T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------S---------------------------------SH ESC-----------------------------------VLRVMCEVEPRARTTLVPCLTA DGLEGVC------------------------------CSVAKEG--------KQRKKRS- -----LPFELS------------------------------------------------- ----------------QELFQN-------AVGEGHR--------------VYTRKLANID HHREVMRGGSVDTLVRQFHAPPGEPLGAEDPTAYEDMFVARSFANALNLSVAERLDLPEL TLDPALRRKRCLPPR--SCDP---HARYRSLDGSCNNPVPARSSWGAAGYPFERLLPPAY EDGVWAPRV---HSSVSGRLLASARDISVAVF-----PDVDRRDRKFNLLLMQFGQFMSH D--FTRSASVRIGQEEVQCCNAEHSGALRGEQAHFACMPIAVSPADPFYSRFGIRCLNFV RLALARDGKC----RLGYGK-------------QLNRVTHF-IDGSAVYGSNEALAASLR TF--EGGRLRSSF---PTGEELLP--FARTRA-ACEPWAKA---------CFRAGD---- DRVNQIVSLTEMHT------------------LFLREHNRVATALA-------------- ALNRHWD--DERLYQETRRIVG------------------------AVMQKIFYNEYLP- --SIVGHSKARQY-------GLLDSHGEQTDFYSPDVKPAVFNELSGAAFRFGHSTV--- -----------------DGAFLIQHRHRR---TELVPIQEVF--LN-------------- --PSRLLQRSFFDDFLFSLMDQPQQQLDDSITFG----LT---RLLFAGRNPFGSDLASL NIQRGRDHALRPYNDYRSWAGLERLTSFEQFG--------PVGARLASVYE-FPDDVDLW VGGLLEPPTQD----------------------------------------------GAL FGETFAAIIS-------------------------------------------------- --------------------------------EQFARL---------------------- -----K-----------------------FGDR----YYYT------------------- ---NGPRTNPGFFT--------------------------GEQ-LRELSKVSLASV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICAN--------------------------------------- ------------------------------------------------------------ --LDQADGFSAPR----------------------------------------------- ------------------------------------------------------------ ------------------------------DAFRQPS----------------------- --EHNPPVPCQTLVGMDLSAWRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|20138793|sp|Q9UUS2.1|LIDS_GAEGR RecName: Full=Linoleate diol synthase; AltName: Full=Linoleate (8R)-dioxygenase; Short=Linoleate 8-dioxygenase ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MTVSTHHDDSPGLSGRLRD LLHHVFG--------------------------------------------NQKSPTVYP N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------A---------------------------------P- -GN-----------------------------------SAKPV------PTGLADDIDKL -GFKDID-----------------------------------TL--------LIFLNSA- -----VKG--V------------------------------------------------- ----------------NDDQQF-------LLEKMIQ--------------LLAK------ ----------LPPA-----------------SREGKKL---------------------T DGLINDLWDSLDHPPVASLGK---GFSFREPDGSNNN--IHLPSLGAANTPYARSTKPLV FQ-NPNP--------------PDPATIFDTLMVRDPAKFRPH-PNKISSMLFYLATIITH D---------------------------------------------------------IF Q----TSPR-------DFNI----------------NLTSSYLDLSPLYGRNHDEQMAVR TG--KDGLLKPDT---FSSK---------------------------------------- RVIGFPPGVGAFLI------------------MFNRFHNYVVTQLAKINEGGRFKRPTTP DDTAGWETYDNSLFQTGRLITC------------------------GLYINIVLGDYVRT ILNLNRANTTWNL-----DPRTKEGKSLLSKPTPEAVGNQVSVEF--NLIYRWHCTISER DDKWTTNAMREALGGQDPATAKME--------DVMRALGMFE--KNIPDEPEKRTLAGLT RQSDGAFDDTELVKILQESIEDVAGAF-GPNHVP----AC-------------MRAIEIL GIKQSRTWNVATLNEFRQFIGLTPHDSFYHMN-----PDPKICKILAQMYD-SPDAVELY PGIMAEAAK-PPFSPGSGLCPPYTTSRAILSDAVSLVRGDRFYTVDYTPRNITNWGFNEA STDKAVDWGHVIYKLFFRAFPNHFLPNSVYAHFPFVVPSENKLIFEGLGAANKYSWDPPK ARAPIQFIRSHKAVLEVLSNQKDYKVTWGPAIKMLSGD---------------------- -----PATSFALAGDEPANAASRHHVIAALTAP----KQWRDEVRRFYEVTTRDLLRRHG APVHGVGAGPRTHE--------------------------VDVIRDVIGLAHARFM--AS L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------FSLPLKEEGKEEGAYGEHE LYRSLVTIFAAIFWDSDVCNS--------------------------------------- -----------LKLHQASKAAADKMSALIAEHVREMEAGTGFLGALGKLKDLITGNDVHA NGNGVYTNGNGVYTNGNGVHTNGNGVHTNGNG---------------------------- ------------------------------------------------------------ ------------------------------VPHAAPS--------LRSFGDQL-L-QRML SQDGRSIEETVSGTILPVVMAGTANQT-QLLAQCLDYYLGVGEKHLPEMKRLAMLNTSEA DEKLLK------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|198427709|ref|XP_002127674.1| PREDICTED: similar to prostaglandin-endoperoxide synthase 2 [Ciona intestinalis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MPAYYPNLALSSSLKRIVGFSIFKMVAAVTFLGVLT FLLLSNDASTNTD--------------------------------------VHYDPCCSF P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH QSV-----------------------------------CTSPD------MISYQCDCTGT -GYYGDE------------------------------CQHP-YL--------STRIKKW- -----IKP--S------------------------------------------------- ----------------KSTTHY-------ILTHFKW--------------VWTI------ ----------VNNV-----------------SWLRKTL---------------------M KAVLAMRVSSVTEPS--PYRG---LSSYPSWSAYIND--TM----------YVRTLPPVP TN-CPTPMG-----VKGKPELPEISVLLEKFFKRR--TFQPC-PQRTSVLFPFFAQHFTH M---------------------------------------------------------FF K----TDPMK----GMPYQW----------------GDQL--VDLSQIYGHGEKRQHELR SH--VNGKLKVSL---VDGHEFPP--LSNQTT-ANMSNINL----LPQEYQFVFGH---- QGFSLMPTFLIWST------------------IWLREHNRICDLIK-------------- EENPAWD--DERIFQTARLVLT------------------------GETIKVVIEDYVQ- --HLSGFHYKLLY-----DPELVQGGSH-------SFHNQIHVEF--QLLYHWHALM--- -----------------PDQIEFN--------GKSYTMKRLL--FN-------------- ---PEPVVKGGLKRTIEDLSNQWAGQVAGGKTQG----AA-------------TLHVAGL AIKNGRDLRMQSFNAYKEKFEMKKYTTFQELT-----GEEEMAAELQKLYG-DIDAVEYY IGIMLEKRR-S----------------------------------------------PQL FGETLTEMGS-----------------------PY------------------------- ------------------------------SLKGLYSN---------------------- -----P-----------------------INHK----DWWK------------------- ---------PSTFG--------------------------GQKIMDVIKNTNLQSL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICRT--------------------------------------- ------------------------------------------------------------ ------VEG-CPH----------------------------------------------- ------------------------------------------------------------ ------------------------------ASFTVPDGATYRLPSDKQDVEND-R-TSAI LIERARNADANKYMWTQDAKPNSIPDK-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|47221466|emb|CAG08128.1| unnamed protein product [Tetraodon nigroviridis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MKVLSVFACTVVSLL LLLESTPSAGDG---------------------------------------SAVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CVRYG------TDQYKCDCTRT -GYSGVN------------------------------CTDP-GF--------WAKVHTM- -----LKP--S------------------------------------------------- ----------------PQVQDY-------ILRHFEK--------------FWDY------ ----------VNN------------------SPLRDTF---------------------M RIVLTARIELXXXXX--XXXX---XXXXXXXXXXXXX--XX----------XXXXXXXXX XX-XXXXXX-----XXXXXXXXXXXXXXXXXXXXX--XXXXX-XXXXXXXXXXXXXXXXX X---------------------------------------------------------XX X----XXXXX----XXXXXX----------------XXXXX-XXXXXXXXXXXXXXXXXX XX--XXXXXXXXX---XXXXXXXX--XXXXXX-XXXXXXXX----XXXXXXXXXXX---- XXXXXXXXXXXXXX------------------XXXXXXXXXXXXXX-------------- XXXXXXX--XXXXXXXXXXXXX------------------------GETIKIIIEEYVQ- --QLSGYFFKLKF-----DPTLLFKEQF-------QYSNRIAVEF--DHLYHWHSLL--- -----------------PDSYLID--------GDEISATGFV--FN-------------- ---GSVLANYGVEKMVDSFSRQIAGQIGGGQNFH----ES-------------IIRVIRS LLHHGREVRLQPFNEYRKKFDQKPYESFSELT-----DNEEIAKGLEEAYG-DIDALEFF PGIMLEKTS-P----------------------------------------------GHI FGESMFQMGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----A-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GETGFNIIKTATLEKLFFEQ D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LYVQLFRQQVATETLQQAS SFQAVNPCCYYPCQHAGVCVRYGTDQYQCDCTGTGFYGDNCTVPEFWTNIYVMLKPSPPL VHFILKHFQWFWDFVNNSFLQDVFMRFVLTVRIKLIPIIPTYNTKYGYLNWESYYNTSYY TRILPPVPEDCPLPMGAIGETCSSGSWPVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVDGSNIYGDNLMRQ LQLRLLKDGKLKYQQLVNGEMYPPTVNKVSVYMMYPE--------------TV-P-PEQR LVIGHELFGLVPGLSLYATLWLREHNR-VCDILKEEHPTWDDEQLFQTARLIVIGETIKI IIEDYVQHLSGYLFKLKFDPSLLFKEQFQYSNRIALEFVHLYHWHSLMPDSFLIDGDDIS LPEFLYNSSILTHYGVEKLVDSFSRQRAGQVA---------------------------- ------------------------------------------------------------ ------------ >gi|198423377|ref|XP_002123273.1| PREDICTED: similar to prostaglandin-endoperoxide synthase 2b [Ciona intestinalis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MKSVLLQTAVLLVGC ILDKC----------------------------------------------ESYDPCCAF P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------KH SAI-----------------------------------CTTLK-------DDYECDCTGT -GFYGRN------------------------------CEYG-YF--------STYVTDL- -----FRP--S------------------------------------------------- ----------------RSTLHH-------YMTNYSL--------------LWKL------ ----------VNNI-----------------SWLQKKL---------------------M AVVLKIRTNYVYEPS--PYVG---MDSYPTWDSYINK--TV----------YARTLPPIP QD-CPTPMG-----TKGPKTLPDIKVLRSLLFQRN--KFEPC-PMRTNVFFAFFAQHFTH Q---------------------------------------------------------FF K----TNTIK----GMPFQW----------------G-EHS-VDLSHVYGHTIQRQHELR SH--IDGKLKVFE---TNGEVFPP--LTESAN-VTMS-GEK----LMRGRKFAIGH---- PGFGAFPSFFVIAT------------------LWLREHNRVCDILK-------------- DLHPDWD--DERLFQTARLILT------------------------GETLKIIVEDYVQ- --HVSGFHFQLSY-----DPEILHKSTF-------SYNNQIHAEF--HILYHWHMLM--- -----------------PDFIELG--------EHVYPLKELL--FN-------------- ---VDPVVEIGMETVLKQLSNQFAGKVVGGRNQG----PE-------------LVAVVEL ALKQTRQMRMCSFNKYRERFGMKPYTSFEELT-----GETEVAALLRNLYY-DIDALELF VGYFVEHRR-N----------------------------------------------RQV LGATMLEMGA-----------------------PY------------------------- ------------------------------SLKGVFGN---------------------- -----P-----------------------IGSP----AWWK------------------- ---------PSTFG--------------------------GEVGFNIIKTTNLKNF---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICRN--------------------------------------- ------------------------------------------------------------ ------VKG-CPD----------------------------------------------- ------------------------------------------------------------ ------------------------------ISFKVPQ--------------DV-P-YNSV EGKSSSPNTGIADVLISLTRPQVAQKS-QVKELKREEKTNEKSEL--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|197734865|gb|ACH73269.1| cyclooxygenase [Petromyzon marinus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------H Q---------------------------------------------------------FF N----TDPVR----GPAFTR----------------ALGHG-VDLNHIYGGTLERQHQLR LF--KDGKLKFQM---IDGEAYPP--VVRDAP-VHMVYPEH----VPASLRFAVGH---- EVYGLLPGLLVYAT------------------VWLREHNRVCDVLH-------------- ARHPRWD--DERLFQTARLILT------------------------GETMKIVIEEYVQ- --HLSGYNFHLKF-----DPTLLFGVNF-------QYSNRMSLEF--NHLYHWHPLM--- -----------------PDSLLID--------GRNYSYDEFL--FN-------------- ---PGLLADKKLMPLVRSFMRQRAGTVSGGRNIN----KN-------------LLHVATS IIEHGRTLRLQSLNQYRHRFNMRPFTSFLELT-----GDEAMAAEME------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|219498304|ref|XP_002245690.1| hypothetical protein BRAFLDRAFT_153094 [Branchiostoma floridae] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------FGIPPYKTFLELT--G--GDAEMADQLEEAYG-DVDAVELY VGLMVEQPA-P----------------------------------------------GSV TSETIIEMGG-----------------------PF------------------------- ------------------------------SVKGLLSN---------------------- -----P-----------------------LCSP----QWWK------------------- ---------PSTFG--------------------------GEAGFRMVKTATLKNL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------FCRN--------------------------------------- ------------------------------------------------------------ ------T----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|219485386|ref|XP_002239720.1| hypothetical protein BRAFLDRAFT_129952 [Branchiostoma floridae] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MNGAIIAICLTLLPVLI ---------------------------------------------------AAENPCCSM P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN MGV-----------------------------------CMREG-------DSYSCDCTRT -GYYGQN------------------------------CDIP-EF--------WTSIKVA- -----LKP--S------------------------------------------------- ----------------KKTTHH-------LLTNYKW--------------LWNI------ ----------VNRI-----------------PFLSKFI---------------------M RAVYKIRSATVDSPP--MYHT---GHDYTSWDTYADR--SY----------YTRALPPVP PG-CPTPMG-----TAGRKELPSPQYIAETFLARR--RFIPD-KRRTNVLFNFMAQHFTH Q---------------------------------------------------------FF K----TDFKK----GAGRTW----------------G-DHG-VDLSHIYGETVERQHQLR SF--TDGKLKFQR---VEGEVYPP--SLADAP-VHMIYPPY----VPEGKRFAIGH---- EFFGLLPGLFVYST------------------VWLREHNRVCDVMK-------------- ELHPDWD--DERLFQTARLILT------------------------GETINIIINEYVQ- --HLSGYNFDLFW-----DPELLFSDQF-------QYQNRIFVEF--NHLYHWHPLM--- -----------------PDQFHIN--------GSTYGMKDYL--FN-------------- ---TDLVFKHGFGTTVDAMSRQIAGQI-GPKNIG----PV-------------NLKVAVE TIKHERNLRMQGLNQYRKRFGIPPYKTFLELTG----GDAEMADQLEEAYG-DVDAVELY VGLMVEQPA-P----------------------------------------------GSV TSETIIEMGG-----------------------PF------------------------- ------------------------------SVKGLLSN---------------------- -----P-----------------------LCSP----QWWK------------------- ---------PSTFG--------------------------GEAGFRMVKTATLKDL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------FCRN--------------------------------------- ------------------------------------------------------------ ------TAGPCGL----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFAVPE--------------DVQPTGLPE EQDASSQGKGASQNDADLVPVNGVLSS-QDKHLHKEEKTSQDGSQDPETSSKVTANEKPV AKNEKLPKNGVAQKKEFQNGSPKNGRASKNDVPKNEPAPKNGLPTAFPKNGAAPRTYVNR TSCKQCDRIEL------------------------------------------------- ------------------------------------------------------------ ------------ >gi|219485392|ref|XP_002239723.1| hypothetical protein BRAFLDRAFT_285765 [Branchiostoma floridae] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN MGV-----------------------------------CMTEG-------DSYSCDCTRT -GYYGQN------------------------------CDIP-EF--------WTSIKVA- -----LKP--S------------------------------------------------- ----------------KKTTHH-------LLTNYKW--------------LWNI------ ----------VNRI-----------------PFLSNFI---------------------M RAVYKIRSATVDSPP--MYHT---GHDYTSWDTYADR--SY----------YTRALPPVP PG-CPTPMG-----TAGRKELPSPQYIAETFLARR--RFIPD-KRRTNVLFNFMAQHFTH Q---------------------------------------------------------FF K----TDFKK----GAGRTW----------------G-DHG-VDLSHIYGETVERQHQLR SF--TDGKLKFQR---VEGEVYPP--SLADAP-VHMIYPPY----VPEGKRFAIGH---- EFFGLLPGLFVYST------------------VWLREHNRVCDVMK-------------- ELHPDWD--DERLFQTARLILT------------------------GETINIIINEYVQ- --HLSGYNFDLFW-----DPELLFSDQF-------QYQNRIFVEF--NHLYHWHPLM--- -----------------PDQFHIN--------GSTYGMKEYL--FN-------------- ---TDLVFKHGFGTTVDAMSRQIAGQI-GPKNIG----PV-------------NLKVAVE TIKHERNLRMQGLNQYRKRFGIPPYKTFLELT--G--GDAEMADQLEEAYG-DVDAVELY VGLMVEQPA-P----------------------------------------------GSV TSETIIEMGG-----------------------PF------------------------- ------------------------------SVKGLLSN---------------------- -----P-----------------------LCSP----QWWK------------------- ---------PSTFG--------------------------GEAGFRMVKTATLKDL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------FCRN--------------------------------------- ------------------------------------------------------------ ------TAGPCGL----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFAVP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|197734867|gb|ACH73270.1| cyclooxygenase-c [Branchiostoma lanceolatum] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------H Q---------------------------------------------------------FF K----TDFKK----GAGRTW----------------G-DHG-VDLSHIYGETVERQHQLR SF--TDGKLKFQR---VEGEVYPP--SLADAP-VHMIYPPY----VPEGKRFAIGH---- EFFGLLPGLFVYST------------------VWLREHNRVCDVMK-------------- ELHPDWD--DERLFQTARLILT------------------------GETINIIINEYVQ- --HLSGYNFDLFW-----DPELLFSDQF-------QYQNRIFVEF--NHL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|219429310|ref|XP_002212444.1| hypothetical protein BRAFLDRAFT_161760 [Branchiostoma floridae] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SY----------YTRALPPVP ED-CPTPMG-----TKGHKELPSPEYLAQTFLART--TFLPDTRRRTNVLFGFMAQHFTH Q---------------------------------------------------------FF K----TDFKK----GPGRTW----------------S-DHA-VDMSQVYGETVGRQQQLR TF--KDGKLKHQL---VDGEVFPP--SLQDAP-V-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|219415825|ref|XP_002205720.1| hypothetical protein BRAFLDRAFT_68307 [Branchiostoma floridae] MVYSLSGAPCWLQAGSRIGGQSAGSNIRLTNMAGLLKFGKLHHSQERYSASFRALMAVVE TRKDMYQMSYEANIPDCTLCEPGADLRVLGIGSGSGETDSAILKKLLQRHSSVYNRVVEP SGEMIGRYKTAEEYFQTKDDTKFHLIHAVHVLYYVEDLDATLRNLWEQLGDGGYMLVAIQ SDKGGWGGLRHKLWEKFGQGDRVMTWCSTSGDVKQCLDTRGISYVTSVDEININVSECFK DDSEAGKLLLDFLTHTPYVSSEPEIKSTALEYIRGLLKLGKLMHHSPGWYSVNFRAFLAA LEMSKDMYQMYGPKVPDLTLCELGADLRVLGIGSGSERYSESFRALIAAVETSRYQMSYG PKVPDSTLCEPGTDLRVLGIGSGSGKGDWGGLRHKLWEKFGQGDRDRCSTSDDVKQCLDR RGISYVTSFDTTNINVSECFKENSENGKLLLDFLTHTPYVSSEPEIKSTALQYIRGRVPV LGHLLALGRAPHLELTAWRRQYGDVFTIRLGMEDIVVLNGYTAVKDALVDRSELFASRPQ SYLLDSTVGFEKADVDCLEVPLDDLSIVHLRATSASLTPAEIVRNLRLFCIRSTHSQAQE ELDAVVGESLPTLSHRSQLPYVNACLLEVMRIRTLIPVTIHATTQDVEVQGYDIPKGSRN MGV-----------------------------------CMREG-------GGYTCDCTRT -GYYGQTRTAKYCNSHHIYISSVKSYEMHQADRCMSLSCTA-EL--------LTALGAA- -----LKP--S------------------------------------------------- ----------------DEMIDH-------LLFNYKW--------------LWHI------ ----------INNT-----------------QSLRNFL---------------------M RLLSKLSVGQVDSPP--LYHT---GHDYTSWDTYSAR--SY----------YTRALPPVP AD-CPTPMG-----TKGPKELPSPEYLAETFLARR--TFLPDTRRRTNVLFGFMAQHFTH Q---------------------------------------------------------FF K----TDFKK----GPGHTW-----------------SDHA-VDMSHVYGETTERQHQLR SF--QDGKLKYQL---VDGEVFPP--SLQDAP-VHMIYPPN----VPEDKRFALGH---- EFFGHLPGLFVWAT------------------VWLREHNRVCDVMK-------------- KVHPDWD--DERLFQTARLILI------------------------GETIKIVIEEYVQ- --HLAGNNFQLVW-----DPELLFEERL-------QYQNRISVEF--NHLYHWHMLM--- -----------------PDHFDIN--------GTMYTMEDYL--FN-------------- ---NDIVLKHGLNATVDAMSRQIAGRVSATY----------------------LGHCIYN IIRAP--------------------------------GDAEMAAQLEEAYG-DIDAVELY VGWAMENPMPA----------------------------------------------GNV LSEMFVRMGS-----------------------TF------------------------- ------------------------------SFTGMLSN---------------------- -----P-----------------------ICSP----GWWK------------------- ---------PSTFG--------------------------GEVGFNLLKTTTLKDL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------FCRN--------------------------------------- ------------------------------------------------------------ ------MNGPCGL----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFSVPE------------DVEPTGMPEAV EPAGLPEAEEPTGLPTDEGASQDKHTS-QNQEL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|219481257|ref|XP_002237803.1| hypothetical protein BRAFLDRAFT_162714 [Branchiostoma floridae] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------FGMAPYRTFLELTA----GDAEMAAQLEEAYG-DIDAVELY VGWAMENPMPA----------------------------------------------GNV LSEMFVRMGS-----------------------TF------------------------- ------------------------------SFTGMLSN---------------------- -----P-----------------------ICSP----GWWK------------------- ---------PSTFG--------------------------GEVGFNLLKTTTLKDL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------FCRN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|219430282|ref|XP_002212929.1| hypothetical protein BRAFLDRAFT_75314 [Branchiostoma floridae] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MPRTVPSVPMLFSTFV ---------------------------------------------------CSDNLCCSF P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN MGV-----------------------------------CMREG-------DGYTCDCTGT -GYYGQN------------------------------CQTA-EF--------WTMLKTA- -----LRP--S------------------------------------------------- ----------------DQTIDH-------LTKNYKW--------------LWHI------ ----------INNT-----------------QALRNFL---------------------M RLFSKLYVDKVDSPP--LYHT---GHDYTTWDTYSAR--SY----------YTRALPPVP KD-CPTPMG-----TKGHKELPSPEYVAETSLGAQ--NVPPGHETTHQHALRLHGAALHS S---------------------------------------------------------VL Q----NRLQE----GTWSHL------------ERPCGKFLF-VDMSHVYGETVERQRQLR SF--QDGKLKYQL---VNGEAFPP--SLQDAS-VHMIYPPD----VPEEKRFALGH---- EFFGLLPGLFVWAT------------------VWLREHNRVCDVMK-------------- DLHPDWD--DERLFQTARLILI------------------------GETINIVIGEYVQ- --HLAGKNFQLFW-----DPELLFEEQL-------QYQNSIFVEF--NHLYHWHVLM--- -----------------PDQFHIN--------GTMYDMEEYL--YN-------------- ---NDIVLKHGLNTTVDAMSRQIAGR------------------------------VAVE TIKHERELRMQPLNQYRKRFGMPPYRTFLELTA----GDTEMAAQLEEAYG-DIDAVELY VGWAIENPM-P----------------------------------------------GSV HSETIVRMGS-----------------------TF------------------------- ------------------------------SFKGMLAN---------------------- -----P-----------------------ICSP----GWWK------------------- ---------PSTFG--------------------------GEVGFNLLKTTTLKDL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------FCRN--------------------------------------- ------------------------------------------------------------ ------MNGPCGL----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFTVPE---------------------DV EPTGLTEDVESVGVPRKEGISRDKQTSQNQEL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|197734869|gb|ACH73271.1| cyclooxygenase-d [Branchiostoma lanceolatum] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------H Q---------------------------------------------------------FF K----TDFKK----GPGRTW-----------------SDHA-VDMSHVYGETVERQRQLR SF--QDGKLKYQL---VDGEAFPP--SLQDAS-VHMIYPPD----VPEKKRFALGH---- EFFGLLPGLFVWAT------------------VWLREHNRVCDVMK-------------- DLHPDWD--DERLYQTARLILI------------------------SETINIVIGEYVQ- --HLAGKNFQLFW-----DPELLFEEQX-------QYQNSIFVEF--NHL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|197734858|gb|ACH73266.1| cyclooxygenase-1a [Fundulus heteroclitus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NL--SY----------YTRLLPPVP KD-CPLPMG-----TKGKPVLPDIKEISERYFKRT--EFRPD-PQGTNLMFAFMAQHFTH Q---------------------------------------------------------FF K----TSHKV----DAGFTK----------------ALGHG-VDASNIYGEELERQHQLR LH--KDGKLKYQL---INGEMYPP--TVSEVP-VHMVYPEG----FPAEQRLAIGQ---- EVFGLVPGLTVYAT------------------IWLREHNRVCDILK-------------- GEHPTWD--DEQLFQTARLIII------------------------GEIINIIIEEYVQ- --HLSGYYLKLKY-----DPSLLFGVRF-------QYTNRIALEF--CYLYHWHPLM--- -----------------PDSFLID--------GDELPYSQFL--YN-------------- ---TSILMHYGVEKLVDAFSRQPAGQIGGGRNIH----QA-------------VLRVAEM VIRDSRAARLQPFNQYRKRFNLKPYSSFYELT-----GDEEMARGLEELYG-DIDALEFY PGLLLEKTR-P----------------------------------------------SSI FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------INSP----EYWK------------------- ---------PSTFG--------------------------GETGFNIIKTSTLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TKW-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VDFHVPR--------------NE-E----- ---------------------ERKPST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|47210129|emb|CAF95578.1| unnamed protein product [Tetraodon nigroviridis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------LVSDAF LS-------------------------------------------------SPVNPCCYL P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH WGV-----------------------------------CVRYG------LDQYQCDCTRT -GYYGEN------------------------------CTVP-EF--------WTRVRLL- -----LRP--S------------------------------------------------- ----------------PDGAHY-------ILTHFQW--------------LWDI------ ----------VNH------------------TFLRDFL---------------------M RLVITVRSNLVPYPP--TYNS---KYGYLNWESMSNL--SY----------YTRILPPVP ED-CPTPMG-----VKGKEELPDPELLVERLLRRR--TFRPD-PQGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TYNRM----GLGFTK----------------ALDHG-VGAGHIYGDTLDRQLQLR LH--KDGKLKFQV---LEGEVYPP--SGMDVP-IRMNYPSR----IPPEKTFAIGQ---- EMFGIIPGLTMYAT------------------LWLREHNRVCDILK-------------- AEHPTWD--DEQLFQTSRLIIIGEKGWTAVFLPYGTSCLTAALPLAGETIKIVIEEYVQ- --QLSGYLLDLKF-----DPAMLFNTQF-------QYGNRIALEF--TQLYHWHPLM--- -----------------PDRFLID--------GDEVLYEQFL--YN-------------- ---TSVLIHYGVDKMVEAFSLQAAGQIGGGHNVP----AM-------------LTDVAVR TIKESRQLRLQPFNEYRKRFNLQPYTSFREFT-----DNEEIARELEEFYG-DIDALEYY PGLMLEKTR-P----------------------------------------------GAI FGESMVEMGA-----------------------PY------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GKVGFDIVNSATLKDL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCYN--------------------------------------- ------------------------------------------------------------ ------TKT-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFRVPK----------------------- ----------------------------EAQ----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|197734856|gb|ACH73265.1| cyclooxygenase-1b [Fundulus heteroclitus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MRASVLGSVCALLV LL--------------------REPGCQGDE---VTT--------------STVNPCCYL P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------KH WSV-----------------------------------CVRYG------EDKYECDCTHT -GYYGEN------------------------------CSIP-EL--------WTRVRQF- -----LKP--S------------------------------------------------- ----------------PDVVHY-------ILTHFHW--------------LWDI------ ----------INN------------------TFLRNVL---------------------M RLVITARSNLIPSPP--TFNS---KYNYLSWESYYNL--SY----------YTRILPPVP ED-CPTPLG-----VKGRNGLPDPQVLFERLLKRR--TFRPD-PQGSNIMFAFFAQHFTH Q---------------------------------------------------------FF K----TYNRM----GLGFTK----------------ALSHG-VDAGHIYGDSLERQHLLR LF--RDGKLKYQL---IDGEVYPP--SVTDAP-VRMSYPPG----IPVEKQMAIGQ---- EVFGLLPGLSLYAT------------------LWLREHNRVCDILK-------------- AEHPTWD--DEQLFQTTRLIII------------------------GETIRIVIEEYVQ- --HLSGYLLQLKF-----DPTLLFNSNF-------QYGNRIALEF--SQLYHWHPLM--- -----------------PDSFHIS--------GDELSYSQFL--FN-------------- ---TSVLTHYGVEKLVDAFSRQAAGQIGGGHNIN----AV-------------ITKVIVG TIEESRQLRIQPFNEYRKRFNLEPYTSFRDFT-----DSEEIASTLEELYG-DIDTLEFY PGLLLEKTR-P----------------------------------------------GAI FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----QYWK------------------- ---------PSTFG--------------------------GKVGFDIVNSASLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------SRT-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFSVPA--------------EE-E----- ----------------PGRNDGKERSS-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|197734871|gb|ACH73272.1| cyclooxygenase-1b [Myoxocephalus octodecemspinosus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MRSPVLGPVCALLL LL--------------------REPACRGDE---VTS--------------DTVNPCCYF P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH WGV-----------------------------------CVRYG------EDKYECDCTRT -GYTGGN------------------------------CTVP-EF--------WSRVHQF- -----LKP--S------------------------------------------------- ----------------PEVLHY-------ILTHFNW--------------LWDI------ ----------INH------------------TFLRDVL---------------------M RMVLTVRSNLIPSPP--TYNS---KYDYLSWESYYNL--SY----------YTRILPPVP KD-CPTPLG-----VKGKAGLPDPELLVERLLKRR--TFRPD-PQGSNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TYNRM----GVGFTK----------------ALAHG-VDAGHVYGDNLQRQLKLR LH--KDGKLKYQL---VDGQIYPP--SVVDAP-VKMSYPPG----VPPEAQMAICQ---- EVYGLLPGLGMFAT------------------LWLREHNRVCDILK-------------- AEHPTWD--DEQLFQTARFVII------------------------GETIKIVIEEYVQ- --QLSGYLLQLKF-----DPALLFNSNF-------QYGNRIALEF--SQLYHWHPLM--- -----------------PESFLIN--------GDELPYKRFL--FN-------------- ---NTVLTHYGIENLVTAFSRQVAGQIGGGFNIN----AA-------------VTKVSVL TIKESRKLRMQPFNEYRKRFNLKPYTSFREFT-----DNEEIARELEEFYG-DVDALEFY PGLLLERTR-E----------------------------------------------GSI FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----VYWK------------------- ---------PSTFG--------------------------GKVGFDIVNSATLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TRT-CSY----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFRVPT--------------EE-Q---LK ----------------TGNDDSKTRTD-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|139005800|dbj|BAF52621.1| cyclooxygenase-1 [Micropogonias undulatus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MRSSVLGSVWALLL LL--------------------REPACRGDE---VTS--------------STVNPCCYL P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH WGV-----------------------------------CVRYG------EDKYECDCTRT -GYFGEN------------------------------CTVP-EF--------WTRVRQF- -----LKP--S------------------------------------------------- ----------------PDVVHY-------ILTHFRW--------------LWDI------ ----------VNY------------------TYLRDVL---------------------M RLVLTARSTLIPSPP--TYNS---KYSYLSWESYYNL--SY----------YTRLLPPVP KD-CPTPLG-----VKGKAGLPDPELLVERLLKRR--TFRLD-PQGSNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TYNRM----GLGYTK----------------ALAHG-VDAGHIYGDSLKRQLQLR LH--KDGKLKYQL---IDGEIYPP--SIADAP-VRMNYPPG----IPPEKQFAIGQ---- EVFGLLPGLGMYAT------------------LWLREHNRVCDILK-------------- AAHPTWD--DDQLFQTSRLIII------------------------GETIKIVIEEYVQ- --HLSGYLLQLKF-----DPTLLFNSNF-------QYGNRIALEF--SQLYHWHPLM--- -----------------PDYFIIN--------GDEVSYTQFL--FN-------------- ---TSVLTHYGIDKLVDAFSRQNAGQIGGGHNIN----PV-------------VTKVAVG AIKESRQLRMQPFNEYRKRFNLKPYTSFREFT-----DNEEIARELEEFYG-DIDSVEFY PGLMLEKTR-S----------------------------------------------GAI FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GKVGFDIVNSATLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------SKR-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFRVPT--------------EE-Q---LQ ----------------RESDDSKKRPD-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|94574383|gb|AAI16576.1| Ptgs1 protein [Danio rerio] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MRECNFLLKWTVIL LL--------------------SVSFCAGEESPTSS---------------NTANPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN QGI-----------------------------------CVRYG------LERYECDCTRT -GYYGEN------------------------------CTIP-EL--------WTRVYRL- -----LKP--S------------------------------------------------- ----------------PNVVHY-------ILTHFDW--------------LWDL------ ----------INR------------------SFLRDWL---------------------M RKVLTVRANLIPSPP--TYNS---RYDYLNWEAYSNI--TY----------YTRILPPVP ND-CPTPMG-----TKGKIKLPDPKLLVEKFMLRR--NFRLD-PQGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----THNRV----GLGFTK----------------GLGHG-VDAGHIYGDSLDRQLELR LH--KDGKLKYQV---LNGDIYPP--TVLHAQ-VKMSYPPS----VPPEQQLAIGQ---- EVFGLLPGLGMYAT------------------LWLREHNRVCEILK-------------- QEHPTWG--DEQLFQTARLIII------------------------GETIRIVIEEYVQ- --HLSGYRLKLHF-----DPTLLFNSQF-------QYQNRISVEF--NQLYHWHPLM--- -----------------PDSFYID--------GDLIQYSKFI--FN-------------- ---TSILTHYGLEKLVEAFSIQPAGQIGGGHNIH----PV-------------VSGVAER VIVESRELRLQPFNEYRKRFNLKPYTSFAELT-----GEQEMSNELEELYG-HIDAMEFY PALLLEKTR-P----------------------------------------------GAV FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----DYWK------------------- ---------PSTFG--------------------------GKTGFDIVNSATLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TKW-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFHTPP----------------------- ----------------SDYKPQRTSHG-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|24119249|ref|NP_705942.1| prostaglandin-endoperoxide synthase 1 [Danio rerio] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MRECNFLLKWTVIL LL--------------------SVSFCAGEESPTSS---------------NTANPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN QGI-----------------------------------CVRYG------LERYECDCTRT -GYYGEN------------------------------CTIP-EL--------WTRVYRL- -----LKP--S------------------------------------------------- ----------------PNVVHY-------ILTHFDW--------------LWDL------ ----------INR------------------SFLRDWL---------------------M RKVLTVRANLIPSPP--TYNS---RYDYLNWEAYSNI--TY----------YTRILPPVP ND-CPTPMG-----TKGKIKLPDPKLLVEKFMLRR--NFRLD-PQGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----THNRV----GLGFTK----------------GLGHG-VDAGHIYGDSLDRQLELR LH--KDGKLKYQV---LNGDIYPP--TVLHAQ-VKMSYPPS----VPPEQQLAIGQ---- EVFGLLPGLGMYAT------------------LWLREHNRVCEILK-------------- QEHPTWG--DEQLFQTARLIII------------------------GETIRIVIEEYVQ- --HLSGYRLKLHF-----DPTLLFNSQF-------QYQNRISVEF--NQLYHWHPLM--- -----------------PDSFYID--------GDHIQYSKFI--FN-------------- ---TSILTHYGLEKLVEAFSIQPAGQIGGGHNIH----PV-------------VSGVAER VIVESRELRLQPFNEYRKRFNLKPYTSFAELT-----GEQEMSKELEELYG-HIDAMEFY PALLLEKTR-P----------------------------------------------GAV FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----DYWK------------------- ---------PSTFG--------------------------GKTGFDIVNSATLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TKW-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFHTPP----------------------- ----------------SDYKPQRTSHG-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|122890728|emb|CAM14110.1| prostaglandin-endoperoxide synthase 1 [Danio rerio] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MRECNFLLKWTVIL LL--------------------SVSFCAGEE-SPTSS--------------NTANPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN QGI-----------------------------------CVRYG------LDRYECDCTRT -GYYGEN------------------------------CTIP-EL--------WTRVYRL- -----LKP--S------------------------------------------------- ----------------PNVVHY-------ILTHFDW--------------LWDL------ ----------INR------------------SFLRDWL---------------------M RKVLTVRANLIPSPP--TYNS---RYDYLNWEAYSNI--TY----------YTRILPPVP ND-CPTPMG-----TKGKIKLPDPKLLVEKFMLRR--NFRLD-PQGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----THNRV----GLGFTK----------------GLGHG-VDAGHIYGDSLDRQLELR LH--KDGKLKYQV---L------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|6502967|gb|AAF14529.1|AF158374_1 prostaglandin endoperoxide synthase-1; cyclooxygenase-1 [Salvelinus fontinalis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MRGL-VVCVWACIL LQ--------------------RLPTCRGEEVKDVST--------------NVVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN WAL-----------------------------------CVRFG------IDRYECDCTRT -GFYGQN------------------------------CTIP-EF--------WTRIHQQ- -----LKP--S------------------------------------------------- ----------------PDVVHY-------ILTHFHW--------------LWNL------ ----------INR------------------TFMRDWL---------------------M RMVLTVRSNLIPSPP--TFNS---KYGYLSWESYSNV--SY----------YTRILPPVP ED-CPTPMG-----TKGKSVLPDPKLVVEKFLLRR--QFRPD-PKGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TRNSM----GLGFTS----------------ALGHG-VDAGNVYGDNLVRQLNLR LL--KDGKMKYQV---VKGEVYPP--TVAEAP-VNMRYPQG----TPVGQRMAIGQ---- EVFGLLPGLTMYAT------------------LWLREHNRVCDILK-------------- AEHPTWG--DEQLFQTARLIVI------------------------GETIRIVIEEYVQ- --HLSGYLLDLKF-----DPVLLFKSTF-------QYRNRIAVEF--NQLYHWHPLM--- -----------------PDSFHID--------GDVVSYSQFI--FN-------------- ---TSIVTHYGVEKLVDAFSRQYAGQIGGGRNIH----PV-------------VTKVAEG VIEESRTLRLQPFNEYRKRFNLKPYTSFSDFT-----GEEEMARELEELYG-DIDALEFY PALMLEKTR-P----------------------------------------------NAI FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GQTGFDIVNSASLERL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TNW-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFNVPP--------------AG-Q----- ------------------EPPPRKQST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|213513266|ref|NP_001133846.1| Prostaglandin G/H synthase 1 [Salmo salar] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MREC-VVCVWACIL LQ--------------------RLPTCPGEEGKDAST--------------NVVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN WGV-----------------------------------CVRFG------IDRNECDCTRT -GFYGQN------------------------------CTIP-EF--------WTRIHQQ- -----LKP--S------------------------------------------------- ----------------PDVVHY-------ILTHFHW--------------LWNL------ ----------INR------------------TFMRDWL---------------------M RVVLTVRSNLIPSPP--TFNS---KYGYLSWESYSNV--SY----------YTRILPPVP ED-CPTPMG-----TKGKSVLPDPKLVVEKFLLRR--QFRRD-PKGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TRNSM----GLGFTR----------------ALGHG-VDAGNVYGDNLERQLSLR LL--KDGKMKYQV---VKGEVYPP--TVAEAP-VNMRYPQG----TPVGHRMAIGQ---- EVFGLLPGLTMYAT------------------LWLREHNRVCDILK-------------- AEHPTWG--DEQLFQTARLIVI------------------------GETIRIVIEEYVQ- --HLSGYLLDLKF-----DPVLLFKSTF-------QYRNRIAVEF--KQLYHWHPLM--- -----------------PDSFHID--------GDVVPYSQFM--FN-------------- ---TSIVTHYGVEKLVDAFSRQYAGQIGGGRNIH----PV-------------VTNVAEG VIEESRTLRLQPFNEYRKRFNLKPYTSFSDFT-----GEEEIARELEELYG-DIDALEFY PAIMLEKTR-P----------------------------------------------NAI FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GQTGFDIVNSASLERL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TNW-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFNVPP--------------AG-Q----- ------------------EEPPRKQST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|185133942|ref|NP_001117833.1| cyclooxygenase-1 [Oncorhynchus mykiss] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MSAAYIIFALLYWEDAPAEGAYAVNLTMREC-VVWVWACIL LQ--------------------RLPTCRGEEVEDAST---------------VVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN WGV-----------------------------------CVRFG------IDRYECDCTRT -GFYGQN------------------------------CTIP-EF--------WTRVHQQ- -----LKP--S------------------------------------------------- ----------------PDVVHY-------ILTHFHW--------------LWNL------ ----------INR------------------TFMRDWL---------------------M RVVLTVRSNLIPSPP--TFNS---KYGYLSWESYSNV--SY----------YTRILPPVP ED-CPTPMG-----TKGKSVLPDPKLVVEKFLLRR--QFRRD-PRGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TRNSM----GLGFTR----------------ALGHG-VDAGNVYGDNLVRQLNLR LL--KDGKMKYQV---VKGEVYPP--TVAEAA-VNMRYPQE----TPVGQRMAIGQ---- EVFGLLPGLTMYAT------------------LWLREHNRVCDILK-------------- AEHPTWG--DEQLFQTARLIVI------------------------GETIRIVIEEYVQ- --HLSGYLLDLKF-----DPVLLFKSTF-------QYRNRIAVEF--KQLYHWHPLM--- -----------------PDSFHID--------GDEVPYSQFI--FN-------------- ---TSIVTHYGVEKLVDAFSRQCAGQIGGGRNIH----PV-------------VTNVAEG VIEESRTLRLQPFNEYRKRFNLKPYTSFSDFT-----GEEEMARELEELYG-DIDALEFY PAIMLEKTR-P----------------------------------------------NAI FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GQTGFDIVNSASLERL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TNW-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFNVPP--------------AG-Q----- ------------------EEPPRKQST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|15384976|emb|CAC59825.1| cyclooxygenase-1 [Oncorhynchus mykiss] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------H Q---------------------------------------------------------FF K----TRNSM----GLGFTR----------------ALGHG-VDAGNVYGDNLVRQLNLR LL--KDGKMKYQV---VKGEVYPP--TVAEAA-VNMRYPQE----TPVGQRMAIGQ---- EVFGLLPGL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|213626869|gb|AAI70301.1| Cyclooxygenase 1 [Xenopus laevis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MAGLCLTMLFMIVT SSYSLEVS-------------------------------------------TKVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH KGV-----------------------------------CVRFE------MEEYQCDCTRT -GYYGTN------------------------------CTIP-EW--------WTKFREL- -----IRP--S------------------------------------------------- ----------------PAFYHY-------ILTRFKW--------------FWDI------ ----------INS------------------TFIRDFI---------------------V RLVLTVRSNLIPSPP--TYNS---EYGYISWEAYSNV--SY----------FTRVLPPVP HD-CPTPMG-----TKGKKELPDATFLVETFLKRE--KFIPD-PQGTNLLFAFFAQHFTH Q---------------------------------------------------------FF K----TYGRM----GRGFIK----------------GFGHG-VDLSHIYGDSLERQHILR LF--KDGKLKYQI---INGETYPP--TVVEAP-VHMIYPEN----VPKEKQFAVGQ---- EVFGLLPGLMMYAT------------------LWLREHNRVCDVLK-------------- KEHPTWD--DEQLFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYYLKLKF-----DPELLFGVQF-------QYRNRIAVEF--NQLYHWHPLM--- -----------------PEKFKII--------EDEFGYSSFI--YN-------------- ---TSIILDYGVEALVESFTKQIAGKIGGGKNHP----PS-------------LLKVAAG VIEESRNLRLQPFNEYRKRFGLKAYKSFRDLT-----GEEKMAAQLEEFYG-DIDALEFY VGLLLEKPN-P----------------------------------------------NSI FGESMVEIGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GETGFNIVKTASIQKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------VKT-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFHVPD----------------------- ------------------VLPTLKKSD-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|147906023|ref|NP_001091389.1| cyclooxygenase 1 [Xenopus laevis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MAGLCLTMLFMIVT SSYSLEVS-------------------------------------------TKVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH KGV-----------------------------------CVRFE------MEEYQCDCTRT -GYYGTN------------------------------CTIP-EW--------WTKFREL- -----IRP--S------------------------------------------------- ----------------PAFYHY-------ILTRFKW--------------FWDI------ ----------INS------------------TFIRDFI---------------------V RLVLTVRSNLIPSPP--TYNS---EYGYISWEAYSNV--SY----------FTRVLPPVP HD-CPTPMG-----TKGKKELPDATFLVETFLKRE--KFIPD-PQGTNLLFAFFAQHFTH Q---------------------------------------------------------FF K----TYGRM----GRGFIK----------------GFGHG-VDLSHIYGDSLERQQILR LF--KDGKLKYQI---INGETYPP--TVVEAP-VHMIYPEN----VPKEKQFAVGQ---- EVFGLLPGLMMYAT------------------LWLREHNRVCDVLK-------------- KEHPTWD--DEQLFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYYLKLKF-----DPELLFGVQF-------QYRNRIAVEF--NQLYHWHPLM--- -----------------PEKFKII--------EDEFGYSSFI--YN-------------- ---TSIILDYGVEALVESFTKQIAGKIGGGKNHP----PS-------------LLKVAAG VIEESRNLRLQPFNEYRKRFGLKAYKSFRDLT-----GEEKMAAQLEEFYG-DIDALEFY VGLLLEKPN-P----------------------------------------------NSI FGESMVEIGA-----------------------PF------------------------- ------------------------------PLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GETGFNIVKTASIQKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------VKT-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFHVPD----------------------- ------------------VLPTLKKSD-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|118099456|ref|XP_425326.2| PREDICTED: similar to Prostaglandin G/H synthase 1 precursor (Cyclooxygenase-1) (COX-1) (Prostaglandin-endoperoxide synthase 1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) [Gallus gallus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MEGLQSGAGGRSSVSHTCGHPAGF LLGVEVAVARQDTLTAPWLGRAALPHPTALLGSSKVPNAVAPRVDGDLSSLSAVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH QGV-----------------------------------CVRVG------LEGYECDCTRT -GYFGAN------------------------------CTSP-EL--------WTRLRDL- -----LKP--S------------------------------------------------- ----------------PTFYHF-------VLTHFRW--------------FWDI------ ----------INS------------------TFIRDTL---------------------M RLVLTVRANLIPSPP--TFNS---QYGYISWEAYANV--SY----------YTRILPPVP EE-CPTPMG-----TKGKQQLPDAQLLAQRFLLRH--KFEAD-PRGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TSGKM----GRGFTK----------------ALGHG-VDLGHLYGDNLQRQHQLR LF--QDGKLKFQV---VNGEVYPP--SVTEVP-VHMVYPPA----IPKEKQLAMGQ---- EVFGLLPGLCMYAT------------------LWLREHNRVCDILK-------------- QEHPTWG--DEQLFQTARLILI------------------------GETIKIVIEDYVQ- --HLSGYFLNLKF-----DPELLFEQQF-------QYRNRIAVEF--NQLYHWHALM--- -----------------PDSFTIQ--------GQEYSYEQFL--YN-------------- ---TSMLMDYGVEALAESFSMQTAGRIGGGQNIN----AN-------------VLGVAVG VIEESRQLRLQPFNEYRKRFGLKPYTSFQELT-----GEEDKAAELEELYG-DIDALEFY PGLLLEKPQ-P----------------------------------------------NGI FGESMVEIGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GATGFEIVKTASLEKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------VKK-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFHVPD--------------AA-A-AGET ----------------DSGHAGGASST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|129900|sp|P22437.1|PGH1_MOUSE RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin-endoperoxide synthase 1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MSRRSLSLW--FPLLL LL---------------L----LPPTPSVLLADPGVP--------------SPVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN QGV-----------------------------------CVRFG------LDNYQCDCTRT -GYSGPN------------------------------CTIP-EI--------WTWLRNS- -----LRP--S------------------------------------------------- ----------------PSFTHF-------LLTHGYW--------------LWEF------ ----------VNA------------------TFIREVL---------------------M RLVLTVRSNLIPSPP--TYNS---AHDYISWESFSNV--SY----------YTRILPSVP KD-CPTPMG-----TKGKKQLPDVQLLAQQLLLRR--EFIPA-PQGTNILFAFFAQHFTH Q---------------------------------------------------------FF K----TSGKM----GPGFTK----------------ALGHG-VDLGHIYGDNLERQYHLR LF--KDGKLKYQV---LDGEVYPP--SVEQAS-VLMRYPPG----VPPERQMAVGQ---- EVFGLLPGLMLFST------------------IWLREHNRVCDLLK-------------- EEHPTWD--DEQLFQTTRLILI------------------------GETIKIVIEEYVQ- --HLSGYFLQLKF-----DPELLFRAQF-------QYRNRIAMEF--NHLYHWHPLM--- -----------------PNSFQVG--------SQEYSYEQFL--FN-------------- ---TSMLVDYGVEALVDAFSRQRAGRIGGGRNFD----YH-------------VLHVAVD VIKESREMRLQPFNEYRKRFGLKPYTSFQELT-----GEKEMAAELEELYG-DIDALEFY PGLLLEKCQ-P----------------------------------------------NSI FGESMIEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GDVGFNLVNTASLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TKT-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFRVPD--------------YP-G----- ----------------DDGSVLVRRST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|3914292|sp|Q63921.2|PGH1_RAT RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin-endoperoxide synthase 1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MSRRSLSLQ--FPLLL LL---------------L----LLPPPPVLLTDAGVP--------------SPVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN QGV-----------------------------------CVRFG------LDHYQCDCTRT -GYSGPN------------------------------CTIP-EI--------WTWLRSS- -----LRP--S------------------------------------------------- ----------------PSFTHF-------LLTHGYW--------------IWEF------ ----------VNA------------------TFIREVL---------------------M RLVITVRSNLIPSPP--TYNT---AHDYISWESFSNV--SY----------YTRILPSVP KD-CPTPMG-----TKGKKQLPDIHLLAQRLLLRR--EFIPG-PQGTNVLFAFFAQHFTH Q---------------------------------------------------------FF K----TSGKM----GPGFTK----------------ALGHG-VDLGHIYGDSLERQYHLR LF--KDGKLKYQV---LDGEVYPP--SVEQAS-VLMRYPPG----VPPEKQMAVGQ---- EVFGLLPGLMLFST------------------IWLREHNRVCDLLK-------------- EEHPTWD--DEQLFQTTRLILI------------------------GETIKIIIEEYVQ- --HLSGYFLQLKF-----DPELLFRAQF-------QYRNRIALEF--NHLYHWHPLM--- -----------------PDSFQVG--------SQEYSYEQFL--FN-------------- ---TSMLVDYGVEALVDAFSRQRAGRIGGGRNFD----YH-------------VLHVAED VIKESREMRLQSFNEYRKRFGLKPYTSFQEFT-----GEKEMAAELEELYG-DIDALEFY PGLMLEKCQ-P----------------------------------------------NSL FGESMIEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GDVGFNIVNTASLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TKT-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFRVPD--------------YP-G----- ----------------DDGSVFVRPST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|75039091|sp|O97554.1|PGH1_RABIT RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin-endoperoxide synthase 1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MSRSSPSLR--LPVLL LL---------------LLLLLLPPPPPVLPADPGAP--------------APVNPCCYF P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH QGV-----------------------------------CVRVA------LDRYQCDCTRT -GYSGPN------------------------------CTVP-DL--------WTWLRSS- -----LRP--S------------------------------------------------- ----------------PTFVHY-------LLTHVRW--------------FWEF------ ----------VNA------------------TFIRDTL---------------------M RLVLTVRSNLIPSPP--TYNL---DYDYISWEAFSNV--SY----------YTRVLPSVP KD-CPTPMG-----TKGKKQLPDAQVLAHRFLLRR--TFIPD-PQGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TSGKM----GPGFTK----------------ALGHG-VDLGHIYGDSLERQYHLR LF--KDGKLKYQV---LDGEVYPP--SVEEAP-VLMHYPRG----VPPRSQMAVGQ---- EVFGLLPGLMLYAT------------------LWLREHNRVCDLLK-------------- AEHPTWD--DEQLFQTTRLILI------------------------GETIKIVIEEYVQ- --QLSGYFLQLKF-----DPEMLFSVQF-------QYRNRIAMEF--NHLYHWHPLM--- -----------------PDSFQVG--------SQEYSYEQFL--FN-------------- ---TSMLVDYGVEALVDAFSRQSAGRIGGGRNID----HH-------------VLHVAVE VIKESREMRLQPFNEYRKRFGLKPYASFQELT-----GETEMAAELEELYG-DIDALEFY PGLLLEKCQ-P----------------------------------------------NSI FGESMIEIGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GEVGSNLIKTATLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TKT-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFRVPR--------------SS-G----- ----------------DDGPAAERRST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|129899|sp|P23219.1|PGH1_HUMAN RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin-endoperoxide synthase 1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MSR-SLLLR--FLLFL LL---------------L------PPLPVLLADPGAP--------------TPVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH QGI-----------------------------------CVRFG------LDRYQCDCTRT -GYSGPN------------------------------CTIP-GL--------WTWLRNS- -----LRP--S------------------------------------------------- ----------------PSFTHF-------LLTHGRW--------------FWEF------ ----------VNA------------------TFIREML---------------------M RLVLTVRSNLIPSPP--TYNS---AHDYISWESFSNV--SY----------YTRILPSVP KD-CPTPMG-----TKGKKQLPDAQLLARRFLLRR--KFIPD-PQGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TSGKM----GPGFTK----------------ALGHG-VDLGHIYGDNLERQYQLR LF--KDGKLKYQV---LDGEMYPP--SVEEAP-VLMHYPRG----IPPQSQMAVGQ---- EVFGLLPGLMLYAT------------------LWLREHNRVCDLLK-------------- AEHPTWG--DEQLFQTTRLILI------------------------GETIKIVIEEYVQ- --QLSGYFLQLKF-----DPELLFGVQF-------QYRNRIAMEF--NHLYHWHPLM--- -----------------PDSFKVG--------SQEYSYEQFL--FN-------------- ---TSMLVDYGVEALVDAFSRQIAGRIGGGRNMD----HH-------------ILHVAVD VIRESREMRLQPFNEYRKRFGMKPYTSFQELV-----GEKEMAAELEELYG-DIDALEFY PGLLLEKCH-P----------------------------------------------NSI FGESMIEIGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GEVGFNIVKTATLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TKT-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFRVPD--------------AS-Q----- ----------------DDGPAVERPST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|548481|sp|P05979.2|PGH1_SHEEP RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin-endoperoxide synthase 1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MSRQSISLR--FPLLL LL---------------L------SPSPVFSADPGAP--------------APVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH QGI-----------------------------------CVRFG------LDRYQCDCTRT -GYSGPN------------------------------CTIP-EI--------WTWLRTT- -----LRP--S------------------------------------------------- ----------------PSFIHF-------MLTHGRW--------------LWDF------ ----------VNA------------------TFIRDTL---------------------M RLVLTVRSNLIPSPP--TYNI---AHDYISWESFSNV--SY----------YTRILPSVP RD-CPTPMG-----TKGKKQLPDAEFLSRRFLLRR--KFIPD-PQGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TSGKM----GPGFTK----------------ALGHG-VDLGHIYGDNLERQYQLR LF--KDGKLKYQM---LNGEVYPP--SVEEAP-VLMHYPRG----IPPQSQMAVGQ---- EVFGLLPGLMLYAT------------------IWLREHNRVCDLLK-------------- AEHPTWG--DEQLFQTARLILI------------------------GETIKIVIEEYVQ- --QLSGYFLQLKF-----DPELLFGAQF-------QYRNRIAMEF--NQLYHWHPLM--- -----------------PDSFRVG--------PQDYSYEQFL--FN-------------- ---TSMLVDYGVEALVDAFSRQPAGRIGGGRNID----HH-------------ILHVAVD VIKESRVLRLQPFNEYRKRFGMKPYTSFQELT-----GEKEMAAELEELYG-DIDALEFY PGLLLEKCH-P----------------------------------------------NSI FGESMIEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------ASTFG--------------------------GEVGFNLVKTATLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TKT-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFHVPD--------------PR-Q----- ----------------EDRPGVERPPT-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|166897622|sp|O62664.2|PGH1_BOVIN RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin-endoperoxide synthase 1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MSRQGISLR--FPLLL LL---------------L------SPSPVLPADPGAP--------------APVNPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QH QGI-----------------------------------CVRFG------LDRYQCDCTRT -GYYGPN------------------------------CTIP-EI--------WTWLRTT- -----LRP--S------------------------------------------------- ----------------PSFVHF-------LLTHGRW--------------LWDF------ ----------VNA------------------TFIRDKL---------------------M RLVLTVRSNLIPSPP--TYNV---AHDYISWESFSNV--SY----------YTRILPSVP RD-CPTPMG-----TKGKKQLPDAEFLSRRFLLRR--KFIPD-PQGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TSGKM----GPGFTK----------------ALGHG-VDLGHIYGDNLERQYQLR LF--KDGKLKYQM---LNGEVYPP--SVEEAP-VLMHYPRG----IPPQSQMAVGQ---- EVFGLLPGLMVYAT------------------IWLREHNRVCDLLK-------------- AEHPTWG--DEQLFQTARLILI------------------------GETIKIVIEEYVQ- --QLSGYFLQLKF-----DPELLFGAQF-------QYRNRIAMEF--NQLYHWHPLM--- -----------------PDSFRVG--------PQDYSYEQFL--FN-------------- ---TSMLVDYGVEALVDAFSRQPAGRIGGGRNID----HH-------------ILHVAVD VIKESRELRLQPFNEYRKRFGMKPYTSFQELT-----GEKEMAAELEELYG-DIDALEFY PGLLLEKCH-P----------------------------------------------NSI FGESMIEMGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------ASTFG--------------------------GDVGFNLVKTATLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------TKT-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFHVPD--------------PH-R----- ----------------EDRPGVERPPT-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|17226311|gb|AAL37727.1|AF420317_1 cyclooxygenase [Squalus acanthias] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MEAARIILLLLPLC FLKMADT--------------------------------------------TAINPCCYY P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN KGI-----------------------------------CVNVG------KEGYECDCTRT -GYYGVN------------------------------CTFP-FS--------WSRVHKF- -----LKP--S------------------------------------------------- ----------------PSSMHH-------VLTHYKW--------------LWYI------ ----------INNI-----------------SFFSDTL---------------------M RLVLTVRANIIPSPP--TYNS---DYTYVSWEGYSNI--SY----------LTRLLPPVP KD-CPTPTG-----TQGYKKLPDSEQLAEEFLLRR--KFIPD-PQGSNLMFAFFAQHFTH Q---------------------------------------------------------FF R----TDLDR----GPGFTK----------------ALGHG-VDLTHIYGDSLERQHHLR LF--KDGKLKYQV---VNGEVFPP--SVKEAP-IQMKYPST----LPEEKRLAIGH---- DTFGLIPGLMMYAT------------------IWLREHNRVCDILK-------------- EEHPVWS--DEQLFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYNFRMMF-----NPELLFTEHF-------QYSNRIAVEF--DHLYHWHPLM--- -----------------PDSFIVK--------GQDFSYKDFL--FN-------------- ---TDILLNLGVDALVESFSKQIAGRIGGGRNIH----QS-------------LLHIAIA TIEHGRLLRFQPYNEYRKKLGLTPYKSFQELT-----GEREVAARLEKLYG-HIDAMEFY PALLLEAPN-K----------------------------------------------NSI FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----DYWK------------------- ---------PSTFG--------------------------GKTGFDIVNTATFEKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICLN--------------------------------------- ------------------------------------------------------------ ------VKK-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------VGFHVP------------------------ -YNVDNDYEREKGK----------PST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|197734863|gb|ACH73268.1| cyclooxygenase-2 [Myxine glutinosa] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MTSEVFVVLCVAVV FAG--AA--------------------------------------------AADDPCCGS P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------EN KGV-----------------------------------CVSVG------FEDYECDCTRT -GYYGSN------------------------------CTYP-ET--------WTWIVNM- -----LKP--L------------------------------------------------- ----------------PDTVHY-------FLTHFAP--------------FWSL------ ----------VNRA-----------------AFLRDRV---------------------M RHVLMSRAHMVSSPP--TYNA---DYGYKSWEAYSNL--SY----------FTRLLPPVP QG-CPTPMG-----RTGKKELPDAQKLXERFLLRR--TFIPD-PQGSNLLFAFFAQHFTH Q---------------------------------------------------------FF K----TDFKR----GPGFTK----------------ALGHG-VDLSHIYGDTLDKQHKLR LH--NNGKLKFQM---IDGEVFPP--LVSEAP-VDMIYPPH----VPEAARFAVGH---- EAFGLVPGLMLYGT------------------LWLREHNRVCDVLD-------------- VDHPEWD--DERIFQTARLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPKLLFGQPF-------QYSNRISVEF--NHLYHWHGLN--- -----------------PDAFRVG--------TQEYQYSQFL--FN-------------- ---NTILLNHGVRGLLEAFNVQQAGRIGGGQNIH----GA-------------LLHVATA SIKHGRKMRFQSLNQYRKQFGLQPYQSFEQLT-----GETEMAADLAELYS-DINAMEFY LGLMVEKPR-Q----------------------------------------------GAL FGETMVEAGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----A-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GNRGFEIVNSASLRRL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------LQGPCPD----------------------------------------------- ------------------------------------------------------------ ------------------------------VAFHVPR---------------D-N-QQDV VVNVTGSQGGSDGVTTTPHYVADQQSR-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|24119251|ref|NP_705943.1| prostaglandin-endoperoxide synthase 2 [Danio rerio] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MNKLVCLVLLSSIW IFP-GEG----------------------------------------------YDPCCAQ P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN QGV-----------------------------------CLSKG------ADAYECDCTRT -GYYGEN------------------------------CTTP-EL--------LTRIKSA- -----LKP--R------------------------------------------------- ----------------PNVVHH-------ILTHYKS--------------IWDI------ ----------INSI-----------------SYLRDGI---------------------M RYILLSRSHLVESPP--TYNA---DYGYKSWEAYSNL--SY----------YTRTLAPLP QN-CPTP------------DLPNAKQVVEQVLLRK--QFIPD-PQRSSLMFAFFAQHFSH Q---------------------------------------------------------FF K----SDFKK----GPAFTK----------------ALGHG-VDLGHIYGETLEVQHKLR LF--KDGKLKYQV---VDGEVYPP--LVKDVQ-VEMHYPPH----IPEEQKFAVGH---- EAFGLVPGLMMYAT------------------IWLREHNRVCDIMK-------------- QEHPDWD--DERIFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYNFKLKF-----DPELIFSERF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDNFQIQ--------DQIYGYHQFV--FN-------------- ---NSIVTTHGIRNMVDSFTKQTAGRVSGGRNLP----PA-------------VQGVAVK VLEQTRQMRYQSFNAYRRRFNMKPYSSFEEMT-----GDKDLAAQLKELYG-HVDKVELY PGLLVEKSR-P----------------------------------------------NSV FGETMVEMGA-----------------------PY------------------------- ------------------------------SLKGLMGN---------------------- -----A-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GKVGFDIVNSASLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------ISGPCPM----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFQVPD--------------VK-F-QSSE NVNSSSVHSTVNNI--NPTVVLNERSS-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|38649358|gb|AAH63232.1| Prostaglandin-endoperoxide synthase 2a [Danio rerio] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MNKLVCLVLLSSIW IFP-GEG----------------------------------------------YDPCCAQ P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN QGV-----------------------------------CLSKG------ADAYECDCTRT -GYYGEN------------------------------CTTP-EL--------LTRIKSA- -----LKP--R------------------------------------------------- ----------------PNVVHH-------ILTHYKS--------------IWDI------ ----------INSI-----------------SYLRDGI---------------------M RYILLSRSHLVESPP--TYNA---DYGYKSWEAYSNL--SY----------YTRTLAPLP QN-CPTP------------DLPNAKQVVEQVLLRK--QFIPD-PQRSSLMFAFFAQHFSH Q---------------------------------------------------------FF K----SDFKK----GPAFTK----------------ALGHG-VDLGHIYGETLEVQHKLR LF--KDGKLKYQV---VDGEVYPP--LVKDVQ-VEMHYPPH----IPEEQKFAVGH---- EAFGLVPGLIMYAT------------------IWLREHNRVCDIMK-------------- QEHPDWD--DERIFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYNFKLKF-----DPELIFSERF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDNFQIQ--------DQIYGYHQFV--FN-------------- ---NSIVTTHGIRNMVDSFTKQTAGRVSGGRNLP----PA-------------VQGVAVK VLEQTRQMRYQSFNAYRRRFNMKPYSSFEEMT-----GDKDLAAQLKELYG-HVDKVELY PGLLVEKSR-P----------------------------------------------NSV FGETMVEMGA-----------------------PY------------------------- ------------------------------SLKGLMGN---------------------- -----A-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GKVGFDIVNSASLKKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCLN--------------------------------------- ------------------------------------------------------------ ------VSGPCPM----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFQVPD--------------VK-F-QSSE NVNSSSVHSTVNNI--NPTVVLNERSS-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|70887621|ref|NP_001020675.1| prostaglandin-endoperoxide synthase 2b [Danio rerio] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MKSSVLFIFLLLG FVV-CTG----------------------------------------------ANPCCSH P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CTEMG------SDAYECDCTRT -GYYGQN------------------------------CTTP-EF--------LTWVKVS- -----LKP--S------------------------------------------------- ----------------PNTVHY-------ILTHFKS--------------LWNI------ ----------INNV-----------------SFLRNGI---------------------M RYVLTSRAHLIDSPP--TFNA---DYGYKSWEAYSNL--SY----------YTRTLPPVP RD-CPTPMG-----VAGKKELPDVKMLAEKLLLRR--KFIPD-PQRTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----SDMKK----GPAFTT----------------ALNHG-VDLAHIYGQNLDRQHKLR LF--KDGKLRYQI---LDGEVYPP--TVSEVQ-VDMHYPPH----VPESRRFAVGH---- EAFGLVPGLMMYAT------------------IWLREHNRVCDILK-------------- QEHPDWD--DERLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYYFKLKF-----DPELLFNERF-------QYQNRISSEF--NTLYHWHPLM--- -----------------PDDFHIQ--------DEVYNYQQFL--FN-------------- ---TSILTDYGVNSLVESFNKQIAGRVAGGRNVA----PA-------------VLRVAIK SIENSRQMRYQSINAYRKRFNMKPYRSFEEMT-----GEKEMAAELEEMYG-DVDAVELY AGLLVEKPR-S----------------------------------------------NAI FGETMVEMGA-----------------------PY------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GKVGFEIVNSASLQNL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCNN--------------------------------------- ------------------------------------------------------------ ------VNGPCPM----------------------------------------------- ------------------------------------------------------------ ------------------------------ASFYVPN--------------VK-D-SLPT TINASTSQS-DRNV--NPTVLLKERTS-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|47222192|emb|CAG11618.1| unnamed protein product [Tetraodon nigroviridis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------TGNPCCSE P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CTPIG------KDSYECDCTLT -GYAGPN------------------------------CTTP-EF--------LTWVKVS- -----LKP--S------------------------------------------------- ----------------PNTVHY-------LLTHFKG--------------FWNI------ ----------VNNI-----------------SFLRDAI---------------------M RYVLTSRSHLIESPP--TFNA---DYDYKSWEAYSNL--SY----------YTRTLPPVS KD-CPTPMG-----VAGKKELPDSKVLAEKVLMRR--QFIPD-PQRTSLMFAFFAQHFTH Q---------------------------------------------------------FF K----TDSKK----GPAFTA----------------AQGHG-VDLGHIYGGDLERQHKLR LF--KDGKLQHQV---INGEVYPP--TVKDVG-VEMQYPPH----IPESERFAVGH---- EAFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- EVHPDWD--DERLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFKERF-------QYQNRIASEF--NTLYHWHPLM--- -----------------PDSFHIE--------EKEYSYKEFV--FN-------------- ---NSVVTRHGISHLVESFTKQLAGRVAGGRNVP----KS-------------LLYVSIK SIENSRQMRYQSLNAYRKRFSMKPYSSFEEMT-----GGTE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|48596662|emb|CAF74800.1| cyclo-oxygenase-2 [Dicentrarchus labrax] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MQLVLVLLLAASLI PT-------------------------------------------------YLAQPCCSI P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGA-----------------------------------CAGNG------FDNYECDCTRT -GYYGRN------------------------------CTTP-EF--------ITQLKP-- -----LKP--A------------------------------------------------- ----------------PNTAHY-------ILTHSKG--------------VWNV------ ----------INLI-----------------PFVRQVI---------------------M VYVLTGRSPLIDSPP--TYNV---EYGYKSWEAYSNL--SY----------YTRILPPVA RD-CPTPIG-----VVGKIALPDSKTAVEKLLRKR---FIPD-PQGTNIMFAFFAQHFTH Q---------------------------------------------------------FF K----SDMKK----GPAFTV----------------AKGHG-VDLSHIYGDKLERQHKLR LF--KDGKLKYQM---VNGEMYPP--TVKEVG-AEMHYPPH----VPEAHRFAVGH---- EAFGLVPGLMMYAT------------------IWLREHNRVCDILQ-------------- QEHPEWD--DELSFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNSRF-------QYQNRI-VEF--NTLYHWHPLL--- -----------------PDTFLIG--------EEVYSYGQFV--FN-------------- ---NSSAPEHGIKRLVSSFTNQIAGRVAGGRNIP----LA-------------LGPVATE VIDYSRDMRYQSLNVYRKRFELRPYSSFEDLT-----GEPEIAAELEPLYA-DADIVELY PALLVEKPR-P----------------------------------------------TAP FGETMVELGA-----------------------PY------------------------- ------------------------------SLKGLMGN---------------------- -----L-----------------------ICSP----LYWK------------------- ---------PSTFG--------------------------GVVGFSILNTASLESL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPI----------------------------------------------- ------------------------------------------------------------ ------------------------------ASFEVPD----------------------- -FTSYPAINVSDIEDINPTVLLKEKTS-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|33590221|gb|AAQ22672.1| cyclo-oxygenase-2 [Dicentrarchus labrax] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------AFFAQHFTH Q---------------------------------------------------------FF K----SDMKK----GPAFTV----------------AKGHG-VDLSHIYGDKLERQHKLR LF--KDGKLKYQM---VNGEMYPP--TVKEVG-AEMHYPPH----VPEAHRFAVGH---- EAFGLVPGLMMYAT------------------IWL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|185133473|ref|NP_001117820.1| cyclooxygenase-2 [Oncorhynchus mykiss] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MNRVICIILLLAVGLY FC-------------------------------------------------EGVDPCCAQ P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------EN RGL-----------------------------------CNSKG------FDNYECDCTRT -GYYGKN------------------------------CTTP-EF--------LTWIKIS- -----LKP--A------------------------------------------------- ----------------PNTIHY-------ILTHYKG--------------LWNV------ ----------INKI-----------------TFVRNAI---------------------M SYVLTPRSHLVDSPP--TYNA---DYGYKSWEAYSNL--FY----------YTRTLPPLP KD-CPTPMG-----TAGRAVLPDVKLVVEKVLLRK--RFIPD-PQGSNLMFAFFAQHFTH Q---------------------------------------------------------FF K----SDFMK----GPAFTK----------------ALGHG-VDLNHVYGDTLERQHKLR LF--KDGKLKYRV---LNGEVYPP--LVREVG-AEMHYPPQ----VPEEHRFAVGH---- EHFGLVPGLMMYAT------------------IWLREHNRVCDVLR-------------- QEHPEWD--DERIFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFQLKF-----DPELLFNQRF-------QYQNRIAAEF--NTLYHWHPLM--- -----------------PETFSIE--------DRAYTYPQFV--FN-------------- ---NSLVTEHGINNLVESFTKQIAGRVAGGRNLP----PA-------------LVGVAAK ALEHSRDMRYQSLNAYRKRFNMRVYTSFEDLT-----GETELAAELESLYG-DVDAVELY PGLLVERPR-P----------------------------------------------NAV FGETMVEMGA-----------------------PY------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWM------------------- ---------PSTFG--------------------------GSVGFDILNTASLERL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCNN--------------------------------------- ------------------------------------------------------------ ------VKGSCPM----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFQVPD-------------------FLRA FESASVNTSEAHLSDMNPGVLFKERTS-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|56967366|gb|AAW31868.1| cyclooxygenase 2 [Salmo salar] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ILTHYKG--------------LWNV------ ----------INKI-----------------TFVRNAI---------------------M SYVLTSRSHLVDSPP--TYNA---DYGYKSWEAYSNL--SY----------YTRTLPPLP KD-CPTPMG-----TAGRAVLPDAKLVVEKVLLRK--RFIPD-PQGSNLMFAFFAQHFTH Q---------------------------------------------------------FF K----SDFMK----GPA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|5639926|gb|AAD45896.1|AF158373_1 prostaglandin endoperoxide synthase-2; cyclooxygenase-2 [Salvelinus fontinalis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MNKVVCIILLLTVGLY FC-------------------------------------------------EGVDPCCAQ P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------EN RGL-----------------------------------CNSKG------FDNYECDCTRT -GYYGKN------------------------------CTTP-EF--------LTWIKIS- -----LKP--A------------------------------------------------- ----------------PNTVHY-------ILTHYKG--------------LWNV------ ----------INKI-----------------TFVRNAI---------------------M SYVLTSRSHLVDSPP--TYNA---DYGYKSWEAYSNL--SY----------YTRTLPPLP KD-CPTPMG-----TAGRAVLPDVKLVVEKVLLRK--RFIPD-PQGSNLMFAFFAQHFTH Q---------------------------------------------------------FF K----SDLKK----GPAFTK----------------ALGHG-VDLNHVYGDSLERQHKLR LF--KDGKLKYQV---LNGEVYPP--LVREVG-AEMHYPPQ----VPEEHRFAVGH---- EHFGLVPGLMMYAT------------------IWLREHNRVCDVLR-------------- QEHPEWD--DERIFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFQLKF-----DPELLFNQRF-------QYQNRIAAEF--NTLYHWHPLM--- -----------------PDTFSIE--------DRAYTYPQFV--FN-------------- ---NSLVTEHGITNLVESFTKQIAGRVAGGRNLP----PA-------------LVAVAAK ALEHSRDMRYQSLNAYRKRFNMRAYTSFEDLT-----GETELAAELESLYG-DVDAVELY PGLLVERPR-P----------------------------------------------NAV FGETMVEMGA-----------------------PY------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----EYWM------------------- ---------PSTFG--------------------------GSVGFDIVNTASLERL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCSN--------------------------------------- ------------------------------------------------------------ ------VKGSCPM----------------------------------------------- ------------------------------------------------------------ ------------------------------VSFQVPD-------------------FLRA FESASVNTSEAHLRGMNPGVVFKERTL-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|185135435|ref|NP_001118139.1| prostaglandin G/H synthase 2b [Oncorhynchus mykiss] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MNRIISALLFLPLG IIFVCEG----------------------------------------------GNPCCSQ P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------MN RGV-----------------------------------CTAMG------SEDYECDCTRT -GFYGHN------------------------------CTQP-EF--------FTWIKVS- -----LKP--T------------------------------------------------- ----------------PNTVHY-------LLTNYKG--------------VWNI------ ----------INSI-----------------SFLRDAI---------------------M RYVLTSRSHLIDSPP--TFNA---DYNYKSWEAYSNL--SY----------YTRTLPPLP KD-CPTPMG-----VVGKIELPDAKMLAEKLLIRR--KFIPD-PQGSSLMFAFFAQHFTH Q---------------------------------------------------------FF K----SDQKM----GPAFTK----------------AKGHG-VDLGHIYGENLERQHKLR LF--KDGKLKFQV---LDGEVYPP--TVKEVG-ADMHYPPH----VPESHRFAVGH---- EAFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- EVHPDWD--DDRLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYNFKLKF-----DPELLFKERF-------QYQNRISSEF--NTLYHWHPLM--- -----------------PDAFHIQ--------EQVYSYPQFV--FN-------------- ---TSVVTTHGISNLVASFTKQIAGRVAGGRNVP----PA-------------VMMVALK SIENSRQMRYQSLNAYRKRFSMKPYASFEDLT-----GEKEMAAELEEMYG-HVDAVELY PGLLVEKPR-T----------------------------------------------NAI FGETMVEMGA-----------------------PY------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GSVGFDIINTASLQRL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCSN--------------------------------------- ------------------------------------------------------------ ------VKGPCPV----------------------------------------------- ------------------------------------------------------------ ------------------------------ASFHVPD--------------VE-D-NRSN TINSSTAQSGSNDV--NPTVLLKEGTT-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|219808025|gb|ACL35628.1| cyclooxygenase-2 [Hippocampus kuda] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------WNI------ ----------INNI-----------------SFLRNAI---------------------M KYVLTSRSHMIDSPP--TYNA---DYHYKSWEAYSNL--SY----------YTRALPPVP QD-CPTPMG-----VVGKKELPDVKLLAEKLLTRR--KFIPD-PQGTSLMFAFFAQHFTH Q---------------------------------------------------------FF K----TDMKR----GPAFTM----------------AKGHG-VDLSHVYGDSLEKQHKLR LF--KDGKLRYQT---LDGEMYPP--TVKDVG-VDMHYPPH----VPDSHRFAVGH---- EAFGLVPGLMMYA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|47175549|gb|AAS21313.2| cyclooxygenase 2 [Fundulus heteroclitus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MNRITFAVFLLALC FSF-HKE--------------------------------------------VLGNACCSE P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CTAMG------SDSYECDCTRT -GYRGQN------------------------------CTTP-EF--------LTWIKIS- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------FWNI------ ----------INNI-----------------SFLRDAI---------------------M KYVLTSRSHMIDSPP--TYNA---DYGYKSWEAYSNL--SY----------YTRALPPVP ED-CPTPMG-----VVGKKELPDVKVLAEKLLVRR--RFIPD-PQGTSLMFAFFAQHFTH Q---------------------------------------------------------FF K----SDMKN----GPAFTV----------------AKGHG-VDLGHIYGENLEKQHKLR LF--KDGKLKYTM---VNGEVYPP--LVKDVG-VEMHYPPH----VPDSQRFAVGH---- EAFGLVPGLLMYAT------------------IWLREHNRVCDVLK-------------- GVHPDWD--DERLFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQRF-------QYQNRIASEF--NTLYHWHPLM--- -----------------PDSFHIE--------EKDYSYKEFV--FN-------------- ---TSVVTEHGINNLVDSFSKQIAGRVAGGRNVP----GP-------------IMYVAIK SIENSRKMRYQSLNAYRKRFSMKPYTSFEDLT-----GEKEMAAILEELYG-DVDAVELY PGLLVEKPR-T----------------------------------------------NAI FGETMVEMGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GTAGFDIVNTASLQRL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCNN--------------------------------------- ------------------------------------------------------------ ------VRGPCPV----------------------------------------------- ------------------------------------------------------------ ------------------------------ASFYVPD--------------VK-E-TGSM TINSSTSHSRDSNI--NPTVILKERTS-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|139005693|dbj|BAF52620.1| cyclooxygenase-2 [Micropogonias undulatus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MNKLTFAVFLLALG FLV-CEA----------------------------------------------GNPCCAE P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN KGV-----------------------------------CTSLG------AENYECDCTRT -GYFGQN------------------------------CTTP-EF--------LTWLKIT- -----LKP--S------------------------------------------------- ----------------PNTVHY-------LLTHFKG--------------FWNI------ ----------VNNI-----------------SFLRDGI---------------------M TYVLTSRSHMIDSPP--TFNA---DYSYKCWEAYSNL--SY----------YTRTLPPVP KD-CPTPMG-----VVGKKELPDAKVLAEKLLVRR--QFIPD-PQGTSLMFAFFAQHFTH Q---------------------------------------------------------FF K----SDMKN----GPAFTL----------------SKGHG-VDLSHIYGDNLERQHKLR LF--KDGKMKYQI---VDGEVYPP--TVQEVG-VHMHYPPH----VPDSHRFAVGH---- EAFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- EVHPDWD--DERLFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYNFKLKF-----DPQLLFNQRF-------QYQNRISSEF--NTLYHWHPLM--- -----------------PDSFQIE--------EKDYSYKQFV--FN-------------- ---TSVVTEHGISNLVESFSKQVAGRVAGGRNVP----GP-------------ILHVAIK SIEDSRKMRYQSLNAYRKRFSMKPYTSFEDMT-----GEKEMAAVLEEMYG-HIDAVELY PGLLVEKPR-S----------------------------------------------NAI FGETMVEMGA-----------------------PY------------------------- ------------------------------SFKGLMGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GSVGFDIVNTASLQKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCNN--------------------------------------- ------------------------------------------------------------ ------VQGPCPV----------------------------------------------- ------------------------------------------------------------ ------------------------------ASFHVPD--------------AP-M-TGSM IINSSTSHSRSSDI--NPTVILKERTT-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|156968376|gb|ABU98644.1| cyclooxygenase-2 [Epinephelus coioides] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------AFFSQHFTH Q---------------------------------------------------------FF K----SDMRE----GPAFTV----------------AKGHG-VDLGHIYGDNLERQHKLR LF--KDGKLKYQI---IDGEVYPP--TVKEVG-VDMHYPPH----VPDSDRFAVGH---- EAFGLVPGLMMYAP------------------IWL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|197734860|gb|ACH73267.1| cyclooxygenase-2b [Myoxocephalus octodecemspinosus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MYRFTFAVFLLALG VLV-CEG----------------------------------------------GNPCCSE P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CTALG------TDNYECDCTRT -GYHGHN------------------------------CTTP-EF--------LTWVKIS- -----LKP--S------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------FWNI------ ----------INSI-----------------SFFRDAI---------------------M RYVLTSRSHLIDSPP--TFNA---DYGYKSWEAYSNL--SY----------YTRTLPPVP ED-CPTPMG-----VVGKKELPDAKLLAEKLFMRR--QFIPD-PQGTSLMFAFFAQHFTH Q---------------------------------------------------------FF K----SDMKK----GPAFTL----------------ATGHG-VDLNHVYGGSMERQHKLR LR--QDGKLKYQV---LDGEVYPP--TVKEVG-ADMHYPPH----VPESHRFAVGH---- EAFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- EVHPDWD--DERLFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYNFKLKF-----DPELLFNQRF-------QYQNRIASEF--NTLYHWHPLM--- -----------------PDSFHIE--------EKDYSYKEFV--FN-------------- ---TSVVTEHGIGNLVESFTNQIAGRVAGGRNVP----GP-------------IMYVAIK SIENSRKMRYQSLNAYRKRFSMKPYSSFEDMT-----GEKEMAAILEEFYG-HVDAVELY PGLLVEKPR-S----------------------------------------------NAI FGETMVEMGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GSEGFNIVNTASLQRL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCNN--------------------------------------- ------------------------------------------------------------ ------VQGPCPV----------------------------------------------- ------------------------------------------------------------ ------------------------------ASFSGPD--------------VK-D-SGSM IINSSTS---NSDI--NPTVILKERTT-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|198401184|gb|ACH87388.1| cyclooxygenase-2 [Oplegnathus fasciatus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TH Q---------------------------------------------------------FF K----SDMKK----GPAFTV----------------AKGHG-VDLNHIYGDSLERQHKLR LL--KDGKLKYQI---LDGEVYPP--TVKEVG-VDMHYPPH----VPDSHRFAVGH---- EAFGLVPGLMMYAT------------------IWLREHNRACDVLK-------------- EVHPDWD--DERLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQRF-------QYQNRIASEF--NTLYHWHPLM--- -----------------PDSFHVE--------EQDYSYKQFV--FN-------------- ---TSVVTEHGISNLVESFTNQIAGRVAGGRNVP----GP-------------IMYVAIK SIENSRQMRYQSLNAYRKRFSMKPYSSFEDMT-----GEKEMAAVLEEMYG-HIDAVELY PGLLVEKPR-P----------------------------------------------NAI FGETMVEMGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GSVGFDIVNTASLQRL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------VCNN--------------------------------------- ------------------------------------------------------------ ------VRGPCPV----------------------------------------------- ------------------------------------------------------------ ------------------------------ASFHVPD--------------VK-D-TGSM IINSSTSHSRSSDI--NPTVILKERTT-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|71895727|ref|NP_001025697.1| prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [Xenopus (Silurana) tropicalis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MIVLPAAVFLSLLV FSQ-------------------------------------------------AANPCCSN P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CMTVG------HDRYECDCTRT -GFYGEN------------------------------CTKP-EF--------LSWLRLK- -----LKP--A------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------LWNI------ ----------VNNI-----------------SFLRDAI---------------------M RYVLTSRSHLIDSPP--TYNS---HYGYKSWEAFSNL--SY----------YTRTLPPVE RD-CPTPMG-----VKGMKELPSAKLVVEKFLMRR--KFIPD-PQGSNVMFAFFAQHFTH Q---------------------------------------------------------FF R----TDMAK----GAAFTK----------------ALGHG-VDLNHIYGESLERQHKLR LM--KGGKLKYQM---ISGEMYPP--TVKTTG-VDMVYPPH----IPDHLQFAVGQ---- EVFGLVPGLMMYST------------------IWLREHNRVCDILS-------------- NEHPEWD--DERIFQTARLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQKF-------QYQNRISAEF--NTLYHWHPLL--- -----------------PDTFAIS--------EKEYSYPQFL--YN-------------- ---NSVMLNHGLTEMVESFSRQTAGRVAGGRNFP----AA-------------ITRVAVA SIEHSREMRYQSLNEYRKRFMLKPFESFEELT-----GEKEMSAELEKLYG-DIDAMEFY PGLLVEQPR-P----------------------------------------------GAI FGETMVEIGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GSVGFDIVNSASLQKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VRD-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------TAFHVLK--------------SK-P-SEKD FINAS-SDSTLENV--KPSLILKEHAS-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|147903100|ref|NP_001086946.1| prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [Xenopus laevis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MIVLPAAVFLALLV FSQ-------------------------------------------------AANPCCSN P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN QGV-----------------------------------CMTVG------FDRYECDCTRT -GFYGEN------------------------------CTKP-EF--------LSWLRLK- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILSHFKG--------------VWNI------ ----------VNSM-----------------SFLRDAI---------------------M RYVLTSRSHLIDSPP--TYNS---HYTYKNWETYSNL--SY----------YTRSLPPVE RD-CPTPMG-----VKGLKELPSSKLVVEKFLMRR--KFIPD-PQGTNVMFAFFAQHFTH Q---------------------------------------------------------FF K----TDMAK----GAAFTK----------------ALGHG-VDLNHVYGESLERQHKLR LM--KGGKLKYQM---IDGDMYPP--TVKSSG-VDMAYPPH----VPEHVQFAVGQ---- EVFGLVPGLMMYST------------------IWLREHNRVCDILA-------------- GEHPEWD--DERIFQTARLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPQLLFNQRF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDTFAIN--------EKEYSYPQFL--YN-------------- ---NSVMIDHGLTQMVESFSRQSAGRVAGGRNFP----AA-------------ITRVAVA SIEHSREMRYQSLNEYRKRFMLKPFETFEELT-----GEKEMSAELEKLYG-DIDAMELY PGLLVEQPR-P----------------------------------------------GAI FGETMVEMGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GSVGFDIVNSASFQKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VRD-CPY----------------------------------------------- ------------------------------------------------------------ ------------------------------TAFHVLK--------------NK-P-SGKD FINAS-SDSTLENV--KPSLILKEHTS-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|129898|sp|P27607.1|PGH2_CHICK RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=PHS II; AltName: Full=Mitogen-inducible PGHS; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLLPCALLAALLA AGH-------------------------------------------------AANPCCSL P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CMTTG------FDRYECDCTRT -GYYGEN------------------------------CTTP-EF--------FTWLKLI- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------VWNI------ ----------INNI-----------------SFLRDTI---------------------M RYVLTSRSHLIDSPP--TYNS---DYSYKSWEAYSNL--SY----------YTRSLPPVG HD-CPTPMG-----VKGKKELPDSKLIVEKFLLRR--KFIPD-PQGTNVMFTFFAQHFTH Q---------------------------------------------------------FF K----TDHKK----GPGFTK----------------AYGHG-VDLNHIYGETLERQLKLR LR--KDGKLKYQM---IDGEMYPP--TVKDTQ-AEMIYPPH----VPEHLQFSVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- QEHPEWD--DEQLFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQRF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDTFQIH--------NQEYTFQQFL--YN-------------- ---NSIMLEHGLSHMVKSFSKQSAGRVAGGKNVP----AA-------------VQKVAKA SIDQSRQMRYQSLNEYRKRFMLKPFKSFEELT-----GEKEMAAELEELYG-DIDAMELY PGLLVEKPR-P----------------------------------------------GAI FGETMVEIGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----T-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GKVGFEIINTASLQKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------TAFHVLN--------------PE-P-TEA- TINVSTSNTAMEDI--NPTLLLKEQSA-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|50751211|ref|XP_422297.1| PREDICTED: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) isoform 2 [Gallus gallus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLLPCALLAALLA AGH-------------------------------------------------AANPCCSL P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CMTTG------FDRYECDCTRT -GYYGEN------------------------------CTTP-EF--------FTWLKLI- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------VWNI------ ----------INNI-----------------SFLRDTI---------------------M RYVLTSRSHLIDSPP--TYNS---DYSYKSWEAYSNL--SY----------YTRSLPPVG HD-CPTPMG-----VKGKKELPDSKLIVEKFLLRR--KFIPD-PQGTNVMFTFFAQHFTH Q---------------------------------------------------------FF K----TDHKK----GPGFTK----------------AYGHG-VDLNHIYGETLERQLKLR LR--KDGKLKYQM---IDGEMYPP--TVKDTQ-AEMIYPPH----VPEHLQFSVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- QEHPEWD--DEQLFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQRF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDTFQIH--------NQEYTFQQFL--YN-------------- ---NSIMLEHGLSHMVKSFSKQSAGRVAGGKNVP----AA-------------VQKVAKA SIDQSRQMRYQSLNEYRKRFMLKPFKSFEELT-----GEKEMAAELEELYG-DIDAMELY PGLLVEKPR-P----------------------------------------------GAI FGETMVEIGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----T-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GKVGFEIINTASLQKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------TAFHVLN--------------PE-P-TEA- TINVSTSNTAMEDI--NPTLLLKEQSA-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|118094249|ref|XP_001231379.1| PREDICTED: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) isoform 1 [Gallus gallus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MTTG------FDRYECDCTRT -GYYGEN------------------------------CTTP-EF--------FTWLKLI- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------VWNI------ ----------INNI-----------------SFLRDTI---------------------M RYVLTSRSHLIDSPP--TYNS---DYSYKSWEAYSNL--SY----------YTRSLPPVG HD-CPTPMG-----VKGKKELPDSKLIVEKFLLRR--KFIPD-PQGTNVMFTFFAQHFTH Q---------------------------------------------------------FF K----TDHKK----GPGFTK----------------AYGHG-VDLNHIYGETLERQLKLR LR--KDGKLKYQM---IDGEMYPP--TVKDTQ-AEMIYPPH----VPEHLQFSVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- QEHPEWD--DEQLFQTTRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQRF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDTFQIH--------NQEYTFQQFL--YN-------------- ---NSIMLEHGLSHMVKSFSKQSAGRVAGGKNVP----AA-------------VQKVAKA SIDQSRQMRYQSLNEYRKRFMLKPFKSFEELT-----GEKEMAAELEELYG-DIDAMELY PGLLVEKPR-P----------------------------------------------GAI FGETMVEIGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----T-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GKVGFEIINTASLQKL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------TAFHVLN--------------PE-P-TEA- TINVSTSNTAMEDI--NPTLLLKEQSA-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|3914302|sp|O62725.1|PGH2_MUSVI RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=PHS II; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLARAGLLCASLS PPH-------------------------------------------------AANPCCSN P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN QGV-----------------------------------CMSIG------FDQYMCDCSRT -GFYGEN------------------------------CSTP-EF--------LTRVKLL- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------VWNI------ ----------VNKI-----------------PFLADVI---------------------M KYVRTSRSHCIEPPP--TYNV---HYAYKSWEAFSNL--SY----------YTRALPPVA DD-CPTPMG-----VKGKKELPDSKEIVEKFLLRR--KFIPD-PQGTNMMFAFFAQHFTH Q---------------------------------------------------------FF K----TDHKR----GPGFTK----------------GLGHG-VDLSHVYGETLDRQHKLR LF--KDGKMKYQV---IDGEVYPP--TVKDTQ-VEMIYPPH----VPEHLRFAVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- QEQGEWD--DERLFRRSRLILI------------------------GETIKIVIEDYVR- --HLSGYHFSLKF-----DPELLFNQQF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDTLQID--------DQEYNFQQFV--YN-------------- ---NSILLEHGLTQFGESFSRQIAGRVAGGRNVP----AA-------------VQQEQRA SIDQSRQMKYQSLNEYRKRFSVKPYASFEELT-----GEKEMAGELKALYQ-DIDAMELY PALLVEKPR-P----------------------------------------------DAI FGETMVEIGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----DYWK------------------- ---------PSHFG--------------------------GEVGFKIINTASIQSL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------TAFSVQD--------------PQ-L-TKTV TINGSSSHSGLDDI--NPTVLLKERST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|3914301|sp|O62698.2|PGH2_BOVIN RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=PHS II; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLARALLLCAAVA LSG-------------------------------------------------AANPCCSH P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CMSVG------FDQYKCDCTRT -GFYGEN------------------------------CTTP-EF--------LTRIKLL- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------VWNI------ ----------VNKI-----------------SFLRNMI---------------------M RYVLTSRSHLIESPP--TYNV---HYSYKSWEAFSNL--SY----------YTRALPPVP DD-CPTPMG-----VKGRKELPDSKEVVKKVLLRR--KFIPD-PQGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TDFER----GPAFTK----------------GKNHG-VDLSHIYGESLERQHKLR LF--KDGKMKYQM---INGEMYPP--TVKDTQ-VEMIYPPH----VPEHLKFAVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- QEHPEWG--DEQLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQQF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDVFQID--------GQEYNYQQFI--YN-------------- ---NSVLLEHGLTQFVESFTRQRAGRVAGGRNLP----VA-------------VEKVSKA SIDQSREMKYQSFNEYRKRFLVKPYESFEELT-----GEKEMAAELEALYG-DIDAMEFY PALLVEKPR-P----------------------------------------------DAI FGETMVEAGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GEVGFKIINTASIQSL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICSN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------TSFSVQD--------------TH-L-TKTV TINASSSHSGLDDI--NPTVLLKERST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|3914304|sp|P79208.1|PGH2_SHEEP RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=PHS II; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLARALLLCAAV- VCG-------------------------------------------------AANPCCSH P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CMSVG------FDQYKCDCTRT -GFYGEN------------------------------CTTP-EF--------LTRIKLL- -----LKP--T------------------------------------------------- ----------------PDTVHY-------ILTHFKG--------------VWNI------ ----------VNKI-----------------SFLRNMI---------------------M RYVLTSRSHLIESPP--TYNV---HYSYKSWEAFSNL--SY----------YTRALPPVP DD-CPTPMG-----VKGRKELPDSKEVVKKVLLRR--KFIPD-PQGTNLMFAFFAQHFTH Q---------------------------------------------------------FF K----TDIER----GPAFTK----------------GKNHG-VDLSHVYGESLERQHNRR LF--KDGKMKYQM---INGEMYPP--TVKDTQ-VEMIYPPH----IPEHLKFAVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- QEHPEWG--DEQLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQQF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDVFQID--------GQEYNYQQFI--YN-------------- ---NSVLLEHGVTQFVESFTRQIAGRVAGRRNLP----AA-------------VEKVSKA SLDQSREMKYQSFNEYRKRFLLKPYESFEELT-----GEKEMAAELEALYG-DIDAMELY PALLVEKPA-P----------------------------------------------DAI FGETMVEAGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----EYWK------------------- ---------PSTFG--------------------------GEVGFKIINTASIQSL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICSN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------TSFSVQD--------------AH-L-TKTV TINASSSHSGLDDI--NPTVLLKERST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|3915797|sp|P35354.2|PGH2_HUMAN RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=PHS II; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLARALLLCAVLA LSH-------------------------------------------------TANPCCSH P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CMSVG------FDQYKCDCTRT -GFYGEN------------------------------CSTP-EF--------LTRIKLF- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------FWNV------ ----------VNNI-----------------PFLRNAI---------------------M SYVLTSRSHLIDSPP--TYNA---DYGYKSWEAFSNL--SY----------YTRALPPVP DD-CPTPLG-----VKGKKQLPDSNEIVEKLLLRR--KFIPD-PQGSNMMFAFFAQHFTH Q---------------------------------------------------------FF K----TDHKR----GPAFTN----------------GLGHG-VDLNHIYGETLARQRKLR LF--KDGKMKYQI---IDGEMYPP--TVKDTQ-AEMIYPPQ----VPEHLRFAVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- QEHPEWG--DEQLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNKQF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDTFQIH--------DQKYNYQQFI--YN-------------- ---NSILLEHGITQFVESFTRQIAGRVAGGRNVP----PA-------------VQKVSQA SIDQSRQMKYQSFNEYRKRFMLKPYESFEELT-----GEKEMSAELEALYG-DIDAVELY PALLVEKPR-P----------------------------------------------DAI FGETMVEVGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----V-----------------------ICSP----AYWK------------------- ---------PSTFG--------------------------GEVGFQIINTASIQSL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------TSFSVPD--------------PE-L-IKTV TINASSSRSGLDDI--NPTVLLKERST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|2498769|sp|P70682.1|PGH2_CAVPO RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=PHS II; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLARALLLCAALA LGQ-------------------------------------------------AANPCCSN P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGE-----------------------------------CLSVG------FDRYKCDCTRT -GYYGEN------------------------------CTTP-EF--------LTRIKLL- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------VWNI------ ----------VNNI-----------------PFLRNAI---------------------M IYVLTSRSHLIDSPP--TYNA---HYGYKSWEAFSNL--SY----------YTRALPPVA DD-CPTPMG-----VKGKKELPDSNEVLEKVLLRR--KFIPD-PQGTNMMFAFFAQHFTH Q---------------------------------------------------------FF K----SDQKR----GPAFTT----------------GLAHG-VDLSHIYGETLDRQHKLR LF--KDGKMKYQI---IDGEMYPP--TVKETQ-VEMMYPPY----IPEHARFAVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- QEHPEWD--DERLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQQF-------QYQNRIASEF--NTLYHWHPLL--- -----------------PDTFQID--------DQVYNFQQFL--YN-------------- ---NSILVEHGLTQFVESFTKQIAGRVAGGRNVP----LA-------------VQRVAKA SIEHSRKMKYQSLNEYRKRFLMKPYTSFEELT-----GEKEMAAGLEALYG-DIDAMELY PALLVEKPR-P----------------------------------------------DAI FGETMVEMGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----HYWK------------------- ---------PSTFG--------------------------GEVGFQIVNTASIQSL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPV----------------------------------------------- ------------------------------------------------------------ ------------------------------TAFNLPD--------------PQ-L-AKTV TINASASHSRLEDL--SPTVLLKGRST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|548483|sp|Q05769.1|PGH2_MOUSE RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=PHS II; AltName: Full=Glucocorticoid-regulated inflammatory cyclooxygenase; AltName: Full=Gripghs; AltName: Full=TIS10 protein; AltName: Full=Macrophage activation-associated marker protein P71/73; AltName: Full=PES-2; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLFRAVLLCAALG LSQ-------------------------------------------------AANPCCSN P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGE-----------------------------------CMSTG------FDQYKCDCTRT -GFYGEN------------------------------CTTP-EF--------LTRIKLL- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------VWNI------ ----------VNNI-----------------PFLRSLI---------------------M KYVLTSRSYLIDSPP--TYNV---HYGYKSWEAFSNL--SY----------YTRALPPVA DD-CPTPMG-----VKGNKELPDSKEVLEKVLLRR--EFIPD-PQGSNMMFAFFAQHFTH Q---------------------------------------------------------FF K----TDHKR----GPGFTR----------------GLGHG-VDLNHIYGETLDRQHKLR LF--KDGKLKYQV---IGGEVYPP--TVKDTQ-VEMIYPPH----IPENLQFAVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDILK-------------- QEHPEWG--DEQLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQQF-------QYQNRIASEF--NTLYHWHPLL--- -----------------PDTFNIE--------DQEYSFKQFL--YN-------------- ---NSILLEHGLTQFVESFTRQIAGRVAGGRNVP----IA-------------VQAVAKA SIDQSREMKYQSLNEYRKRFSLKPYTSFEELT-----GEKEMAAELKALYS-DIDVMELY PALLVEKPR-P----------------------------------------------DAI FGETMVELGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----QYWK------------------- ---------PSTFG--------------------------GEVGFKIINTASIQSL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------TSFNVQD--------------PQ-P-TKTA TINASASHSRLDDI--NPTVLIKRRST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|548484|sp|P35355.1|PGH2_RAT RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=PHS II; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLFRAVLLCAALA LSH-------------------------------------------------AANPCCSN P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGE-----------------------------------CMSIG------FDQYKCDCTRT -GFYGEN------------------------------CTTP-EF--------LTRIKLL- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------VWNI------ ----------VNNI-----------------PFLRNSI---------------------M RYVLTSRSHLIDSPP--TYNV---HYGYKSWEAFSNL--SY----------YTRALPPVA DD-CPTPMG-----VKGNKELPDSKEVLEKVLLRR--EFIPD-PQGTNMMFAFFAQHFTH Q---------------------------------------------------------FF K----TDQKR----GPGFTR----------------GLGHG-VDLNHVYGETLDRQHKLR LF--QDGKLKYQV---IGGEVYPP--TVKDTQ-VDMIYPPH----VPEHLRFAVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDILK-------------- QEHPEWD--DERLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQQF-------QYQNRIASEF--NTLYHWHPLL--- -----------------PDTFNIE--------DQEYTFKQFL--YN-------------- ---NSILLEHGLAHFVESFTRQIAGRVAGGRNVP----IA-------------VQAVAKA SIDQSREMKYQSLNEYRKRFSLKPYTSFEELT-----GEKEMAAELKALYH-DIDAMELY PALLVEKPR-P----------------------------------------------DAI FGETMVELGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----QYWK------------------- ---------PSTFG--------------------------GEVGFRIINTASIQSL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------ASFNVQD--------------PQ-P-TKTA TINASASHSRLDDI--NPTVLIKRRST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|3914296|sp|O02768.1|PGH2_RABIT RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=PHS II; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLARALLLCAAVA LSH-------------------------------------------------AANPCCSN P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CMTMG------FDQYKCDCTRT -GFYGEN------------------------------CSTP-EF--------LTRIKLL- -----LKP--T------------------------------------------------- ----------------PDTVHY-------ILTHFKG--------------VWNI------ ----------VNSI-----------------PFLRNSI---------------------M KYVLTSRSHMIDSPP--TYNV---HYNYKSWEAFSNL--SY----------YTRALPPVA DD-CPTPMG-----VKGKKELPDSKDVVEKLLLRR--KFIPD-PQGTNMMFAFFAQHFTH Q---------------------------------------------------------FF K----TDLKR----GPAFTK----------------GLGHG-VDLNHIYGETLDRQHKLR LF--KDGKMKYQV---IDGEVYPP--TVKDTQ-VEMIYPPH----IPAHLQFAVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- QEHPEWD--DEQLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQQF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDTFQID--------DQQYNYQQFL--YN-------------- ---NSILLEHGLTQFVESFTRQIAGRVAGGRNVP----PA-------------VQKVAKA SIDQSRQMKYQSLNEYRKRFLLKPYESFEELT-----GEKEMAAELEALYG-DIDAVELY PALLVERPR-P----------------------------------------------DAI FGESMVEMGA-----------------------PF------------------------- ------------------------------SLKGLMGN---------------------- -----P-----------------------ICSP----NYWK------------------- ---------PSTFG--------------------------GEVGFKIVNTASIQSL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------TSFNVPD--------------PQ-L-TKTV TINASASHSRLEDI--NPTVLLKGRST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >gi|3914297|sp|O19183.1|PGH2_HORSE RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=PHS II; Flags: Precursor ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MLARALLLCVALA LGH-------------------------------------------------AANPCCSN P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------C---------------------------------QN RGV-----------------------------------CMSVG------FDQYQCDCTRT -GFYGEN------------------------------CSTP-EF--------LTRIKLF- -----LKP--T------------------------------------------------- ----------------PNTVHY-------ILTHFKG--------------VWNI------ ----------VNSF-----------------PFLRNAV---------------------M KYVLVSRSHLIESPP--TYNA---QYGYKSWESFSNL--SY----------YTRALPPVA DG-CPTPMG-----VKGKKELPDSKEIVEKFLLRR--KFIPD-PQGTNMMFAFFAQHFTH Q---------------------------------------------------------FF K----TDPKR----GPAFTK----------------GLGHG-VDLSHIYGETLDRQHKLR LF--KDGKMKYQI---INGEVYPP--TVKDTQ-VEMIYPPH----IPEHLRFAVGQ---- EVFGLVPGLMMYAT------------------IWLREHNRVCDVLK-------------- QEHPEWD--DERLFQTSRLILI------------------------GETIKIVIEDYVQ- --HLSGYHFKLKF-----DPELLFNQQF-------QYQNRIAAEF--NTLYHWHPLL--- -----------------PDTFQID--------DQEYNFQQFL--YN-------------- ---NSILLEHGLTQFVESFSRQIAGRVAGGRNVP----AA-------------AQKIAKA SIDQSREMKYQSLNEYRKRFRLTPYKSFEELT-----GEKEMAAELEALYG-DIDAMELY PALLVEKPR-P----------------------------------------------DAI FGETMVELGA-----------------------PF------------------------- ------------------------------SLKGLLGN---------------------- -----P-----------------------ICSP----DYWK------------------- ---------PSTFG--------------------------GEVGFKIINTASIQSL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------ICNN--------------------------------------- ------------------------------------------------------------ ------VKG-CPF----------------------------------------------- ------------------------------------------------------------ ------------------------------TAFSVQD--------------PQ-L-SKAV TINASASHSGLDDV--NPTVLLKERST-EL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------