>gi|198428656|ref|XP_002125658.1| PREDICTED: similar to cysteine rich protein 61 [Ciona intestinalis]
------------------------MRSTSFLIYSLSL-VAAFLHF-----V---------------------
-------------SIVNGMCPLVC--DCSNAP-TRCPSGVSLVTDGCNC-CKVCAKQTGEECNDQEKVCDPH
RDLFCDYSGS-RSGDWGVCRAQ-DGRPCVHEGTRISSGTMFQPTCKLRCWCMDGADACTSLC-PHEIQVPLP
HVCPHARLQPIPGQCCSAWVC-D-----APSGES--AVLPMDRFWNEYVSEHEPTDISS-SVLPLATVEELG
SNVADDVVYESDGGPDGDEIIDYQLRYVDSPQIDVGDEDSWSETNLIPGEVTRGRSLAGNRKS-GCRQQASM
WSYCTKSCGLGVSTRVSNANAECKLRREVRLCEVRSCNQEESLTP-K-------------HGRRCMKQRRAP
RKEHIVYS----GCTSVRSYRPRHCGLC-VHGRCCTPRSTRTTTVRFECEDGRA--FYKRMMVIKSCKCHRH
-C--TDVMIWNGLPGSHSARSHLAVDS-
>gi|312283673|ref|NP_001186030.1| WNT1 inducible signaling pathway protein 2 [Danio rerio]
------------------------MDRLLRDKRTGELVAWTLLFY-----L---------------------
-----------SSQVCCQQCGSSC--QCQGSV-PSCPEGVPLILDGCQC-CQVCARQQGEACSEVFP-CDGQ
RGLQCDYSAS-FPGEPGECVSQ-KELGCELNGVSYQEGQVFQPSCSLQCQCSGGGVTCVPQC-REDVLLPTP
D-CPHPRRVQPPGKCCKEWVC-------ENLDNT--VLQDAHIASKSDLTLPADSGYQT-RVVS--------
----------------------------------------------------------------NCIDQSSE
WSACSRTCGSGISVRVSNQNPSCVLEMQMRLCMIRPCQPVLHRSPQW-------------SRRKCQPSYRSA
TPVRLFHQ----GCYSTRFYRPRYCGSC-TDNRCCTPYQTGTAMVTFRCPGGRL--LNHAVMTINSCICHYN
-CPYSSR----GTSFWG-----------
>gi|198435966|ref|XP_002131922.1| PREDICTED: similar to connective tissue growth factor [Ciona intestinalis]
MFGYSVLKVSHPTIYIFCFTSNYVVFPFSEIKKWIIVFFVENIKMLFSVYIVMMIVTSQFYLSMATPNFDLR
RSNQSTEGDFYPARSEARECQ-DC--TCPDTP-GTCPPGVSRIMDGCDC-CKMCAKQLNEPCDVRMR-CDHH
KGLYCDMSA-------GLCKAS-PGVACYVGGSWYDNGQTFQLSCKVTCSCIDGDIACMPTCLPHK---PSI
RECRHPRLIHRRGECCEEWVC---------TRNG--RLDPGIEL---QEHEVKERPVQP-VVFRE-------
----------------------------------------------------------------NCMVQTTE
WSDCSKSCGFGVSNRVSNDNADCKLKKEMRLCNIRPCSMTESTVI-T-------------RRRSCRKTIRHS
SRVRFSLS----GCLSRDTYRQKYCGFC--TGKCCGPKVSKTIKVQFNCESGTN--FTRNMMMIKKCSCSS-
-CPNDFLN---LSTYNRAMVGDMVRST-
>gi|198419990|ref|XP_002127157.1| PREDICTED: similar to connective tissue growth factor [Ciona intestinalis]
------------------------MPATNYVLILSFL-VCMTLGVTEGQIR---------------------
-----------AFTTESPECRRKC-NNCPPT--PTCAYGVSLIPGKCGC-CKQCARQLDETCNDDMK-CDPH
RNLYCSYSG--VDEHEGVCVAK-PGRACLSSGLTYLNGESFLIGCKVKCTCMDGVLACENTC-PLTITARAP
KNCRHPQLVKKPNQCCSEWIC-S-----GETLSNNNTTNTRPSSSHSQIRRRHPNTFRP-RVIAMAANRRT-
------------------------------------------------------PISITVRAKDKCNVQTTE
WSACSKTCGWGVSERVTNDNKACKLRKQSRLCQIRPCSSSFVDNI-K-------------RGKKCIRTVKAQ
RRVQYSFS----GCQS-KVYTPKYCGAC-TDGRCCAPKHTVTKPIKFTCDGGFQ--FKKRMMVIKSCSCSRR
-CVGEN-----SFFSYRRMGGDT--WQE
>gi|260810877|ref|XP_002600149.1| hypothetical protein BRAFLDRAFT_276379 [Branchiostoma floridae]
-----------------------MKVTQSSVAAVVVF-LTCLVHA-----L---------------------
-------------PEGKGGCDGTC--ACPAQP-VTCVPGVRLLEDRCGCRCKVCASLLGEECSEMAP-CDDT
VGLYCDYSAD---KPTGICKATFQ-TPCVFQGKVYQSGESFELSCRETCVCQNGAVGCMPLC-PQEVRMPSD
D-CPFPQLEKVPGKCCKQWMC-DAK---PKELSAKGPMPMIAGK----LERKPETEYPE-------------
--------------------------------------------------------------PVACLLQATS
WSQCSVTCGMGVSTRVSNHNPECRMQVEKRICQMRPCDLQYLNHI-KVRTSLFIKSRGGWDGKKCRSTIRSM
EPSKITFSWYNTRCTTVKAYKWRWCGGCTISGRCCTPYKVKTTTMDFICEDRTP--IKQDVAWIHSCTCHRN
-CPLA-----------------------
>gi|4507921|ref|NP_003873.1| WNT1-inducible-signaling pathway protein 1 isoform 1 precursor [Homo sapiens]
----------MRWFLPWTLAAVTAAAASTVLATALSP-APTTMDFTPAPLE---------------------
-----------DTSSRPQFCKWPC--ECPPSP-PRCPLGVSLITDGCEC-CKMCAQQLGDNCTEAAI-CDPH
RGLYCDYSGDRPRYAIGVC-AQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLC--LRVRPPRL
W-CPHPRRVSIPGHCCEQWVCED-----DAKRPR--KTAPRDTG-----------AFDAVGEVEAWHR----
----------------------------------------------------------------NCIAYTSP
WSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLI-K-------------AGKKCLAVYQPE
ASMNFTLA----GCISTRSYQPKYCGVC-MDNRCCIPYKSKTIDVSFQCPDGLG--FSRQVLWINACFCNLS
-CRNPNDIFA-DLESYP-DFSEIAN---
>gi|261259961|ref|NP_001159702.1| WNT1 inducible signaling pathway protein 1a [Danio rerio]
---------MSWILMWSLLSARAPQIHSASAQDSSNL-LSTEEPITPQ--P---------------------
-------------YNRSQYCQWPC--KCPKTP-PMCPPGVSLLMDGCDC-CRACAKQVREACNEKEN-CDHH
RGLYCDYSADKPRYEKGVCAFL-PGTGCEHNGVIYRNGQSFQPNCKYQCLCVNGAIGCVPLC--NESQPPRV
W-CQNPQRVKVHGQCCELWIC-D-----ESRRGR--KTAPRHTM--------AALSSVK-KNWHK-------
----------------------------------------------------------------NCVAQTTS
WSPCSKTCGRGVSLRITNNNKKCEMVNESRLCNIRPCNVDITKHI-K-------------PGKKCLNIYRAE
KPQNFTIS----GCTSTNTYRPKYCGVC-TDERCCIPYKSKTIEVDFQCPNGPG--FTWQVMWINACFCNLS
-CKNPNDIFT-DLEQYH-EKREI-----
>gi|260081535|gb|ACX31196.1| WNT1 inducible signaling pathway protein 1b [Danio rerio]
----------------MWRLLSWILLTSSLHQASFHN-STDSPPMTTELDP---------------------
-------------YNRNRYCKWPC--KCPKSA-LVCPHGVSLLTDGCDC-CKACAKQAGETCNERDI-CDYH
KGLYCDYSADKPRYEKGVCAYV-MGTGCEYNGVIYRNGQSFQPNCKYRCLCVNGAIGCVPLC-TDSLP-PRV
W-CQSPKRVKIPGQCCEKWIC-E-----ESRKPR--KTNPRHAP------------AEV-STNDIWHN----
----------------------------------------------------------------NCIAQTTP
WSPCSKTCGRGISLRISNENAGCVMEKESRLCNLRPCEVDITKHF-R-------------PGKKCLNIYREP
EFQNFTIS----GCVSKKPYWPKYCGVC-TDERCCIPYKSKTIEVEFECPDGAL--LTWKYMWINACFCNLS
-CRNPNDIFADLEQYYE--FNEIVN---
>gi|260081541|gb|ACX31199.1| cysteine-rich angiogenic inducer 61 protein-like protein 2 [Danio rerio]
--------------------MHSGRNQRTRTHTWVVL-LFVVCSA-----D---------------------
-------------GEMSRGCPGPC--SCPPSP-PSCPRGVSRVWDNCGC-CKVCAQQFNQDCGSDLP-CDHI
KGLHCHLGAG-GDPQRGLCRAEAHGRPCEFSGRVYQHGEDFQTGCEHQCSCIDGVVGCVPLC-PLLVPLPGS
H-CTNPRLETPTGHCCQRWVC-DSDNSIREEESL--PKHTPQYNHISKLLQEHRSRPAA-QEWSSAPVSEI-
-----------------------------------------------------------PFPSPGCFSQTTD
WSECSASCGFGVSSRVTNSNAQCRLIRETRLCQITPCDATPHL---K-------------KGKKCRRTTRPR
KPELITFA----GCSTVRRYRPRSCGSC-VDDRCCQPRSTRTVRMRFRCPDGEN--ITRSVMWIQTCRCSKS
FCRAKRGR---SSPAVS-LHNDIHTFTH
>gi|260081539|gb|ACX31198.1| cysteine-rich angiogenic inducer 61 protein-like protein 1 [Danio rerio]
----------------------MSPLRIILRQGHFFT-LVLLSWA-----T---------------------
-------------AEVQGGCPLKC--SCPSAP-PSCPPGISSVLDHCGC-CRVCARQFNQDCSPTEP-CDHI
KGLRCHLGAE-GDPDRGLCRAEAQGRPCELDGRIYQHGEDFQPSCEHQCTCVDGVVGCLPLC-PHHISLPDW
R-CARRRLIRKPERCCPEWVCDD-----DNRIAEVNPVPEAHPAEHTHLTGNELLVTPS-ASWDSSAGAPYQ
EWIS----------------------------SSKS----------------------RPIAPATCLLQITD
WSPCSATCGMGVSSRVTNSNPECRLVSETRLCQIRECGVNTAPSL-K-------------KGKKCERSTRPQ
KPVQISFA----GCSTTRRYRLRSCGFC-SDGRLCVPSATRTVRLHFYCPEAERHDFTRSLMWIQRCSCRHT
---HSRRGLNTPAELFN-LPNDIHTYTH
>gi|48146981|emb|CAG33713.1| NOV [Homo sapiens]
-------------------MQSVQSTSFCLRKQCLCL-TFLLLHL-----L---------------------
-----------GQVAATQRCPPQCPGRCPATP-PTCAPGVRAVLDGCSC-CLVCARQRGESCSDLEP-CDES
SGLYCDRSAD-PSKQTGICTAV-EGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRC-QLDVLLPEP
N-CPAPRKVEVPGECCEKWIC-G-----PDEEDS--LGGLTLAA----YRPEATLGVEV-SDSSV-------
----------------------------------------------------------------NCIEQTTE
WTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDK-------------KGKKCLRTKKSL
KAIHLQFK----NCTSLHTYKPRFCGVC-SDGRCCTPHNTKTIQAEFQCSPGQI--VKKPVMVIGTCTCHTN
-CPKNNEAFLQELELKT-TRGKI-----
>gi|147905087|ref|NP_001079127.1| protein NOV homolog precursor [Xenopus laevis]
--------------------------MTPHLALCFIL-LIQ-------------------------------
-------------QVASQKCPSQC-DQCPEEP-PSCAPSVLLILDGCGC-CPVCARQEGESCSHLNP-CQED
KGLYCEFNAD-PRMETGTCMAL-EGNSCVFDGVVYRNRESFQPSCKYHCTCLNGHIGCVPRC-NLDLLLPGP
D-CPFPRRVKVPGECCEKWVC-D-----SKEEMA--IGGFAMAA----YRPEATLGIDA-SDTSF-------
----------------------------------------------------------------ACIAQTTE
WSACSKTCGMGVSSRVTNRNARCEMQKQIRLCMVRSCEEEPGWHVEK-------------KGKKCVRVRKTT
KPIHFHYK----NCTSVQPYKPKFCGQC-SDGRCCTPHSTKTMHVEFVCPQKRI--VKKPVMVISTCVCHYN
-CPQDSSLLQVENARFPGLKTNL-----
>gi|148725541|emb|CAN87751.1| novel protein similar to vertebrate connective tissue growth factor (CTGF) [Danio rerio]
-------------------------MTGTAFTRACIA-LSLLIH----------------------------
-------------TAICQDCSQPC--DCPDES-PLCPVGTSLVLDGCSC-CKVCARQAGEPCSFLEP-CDHH
KGLYCDYSVL-SDTETGICMAQ-EGQTCDLGGVIYRSGETFQPSCKHQCVCMNGEIGCVPTC-ATIIRLPSP
D-CPYPRRVQIPGKCCEEWVC-D-----QIPQED--TFQSAVAGRSIAYREISAHGLQP-ESARD-------
----------------------------------------------------------------NCIVQTTE
WSECSATCGMGVSSRVTNDNEQCQLERQTRMCMIRPCHADLEKDI-K-------------RGKKCVRTPKSQ
SGMRFELS----GCQSIRLYKPKFCGVC-TDDRCCTPQSTITAEVEFRCPEGDS--FRKKMMFIKTCSCHHN
-CPRENDIF--LASNSRRMIGDYENDM-
>gi|62632756|ref|NP_001015041.1| connective tissue growth factor [Danio rerio]
--------------------------MFSGMTQSVIA-LLFLTFL-----R---------------------
-------------WAVAQECSGQC--HCPEVP-PQCSPGVSLVLDTCGC-CRVCAKQLGELCTERDV-CDPH
KGLYCDYGSP-SNRRIGVCTAR-DGATCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLC-GMDIRLPSP
D-CPMPRRVKVPGKCCEEWVC-D-----SPRQNT--FVGSALAA----YREEETYGPDP-SMMRE-------
----------------------------------------------------------------NCLVQTTE
WSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESHLEEKI-R-------------KGKKCIRTPRVS
KPMKFEIS----GCTTTKSYRPKFCGVC-TDGRCCTPHRTATLPMEFKCPDGQV--MKKQMMFIKTCACHYN
-CPGENDIF--ESMYYKKMVGDMA----
>gi|147899003|ref|NP_001081697.1| connective tissue growth factor [Xenopus laevis]
--------------------------MSAGKVTAVLL-FALFCWV---------------------------
--------------SDAQECNGEC--QCPNKV-PVCDPGVSLVQDGCGC-CKVCSKQLGELCTERDV-CDPH
KGLFCDFGSR-VNRKIGVCTAR-EGAPCVFGGTVYRSGESFQSSCKYQCTCIDGGVGCVPLC-SMDIRLPSP
E-CPFPRRVKLPGKCCEEWVC-D-----QPQERT--LVGPALPA----FRMEETYGPDP-SLIRA-------
----------------------------------------------------------------NCLVQTTE
WSACSKTCGMGISTRVTNDNEHCRLEKQSRLCMVRPCEADLEENI-K-------------KGKKCIRTPKIS
KPVKFEFS----GCTSVKTYRAKFCGVC-TDGRCCTPHRTATLPVEFKCPDGEV--MKKNMMFIKTCACHFN
-CPGDNDIF--EAMYYRKMYGDMA----
>gi|116241320|sp|P29279.2|CTGF_HUMAN RecName: Full=Connective tissue growth factor; AltName: Full=CCN family member 2; AltName: Full=Hypertrophic chondrocyte-specific protein 24; AltName: Full=Insulin-like growth factor-binding protein 8; Short=IBP-8; Short=IGF-binding protein 8; Short=IGFBP-8; Flags: Precursor
-----------------------MTAASMGPVRVAFV-VLLALCS-----R---------------------
-------------PAVGQNCSGPC--RCPDEPAPRCPAGVSLVLDGCGC-CRVCAKQLGELCTERDP-CDPH
KGLFCHFGSP-ANRKIGVCTAK-DGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLC-SMDVRLPSP
D-CPFPRRVKLPGKCCEEWVC-D-----EPKDQT--VVGPALAA----YRLEDTFGPDP-TMIRA-------
----------------------------------------------------------------NCLVQTTE
WSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENI-K-------------KGKKCIRTPKIS
KPIKFELS----GCTSMKTYRAKFCGVC-TDGRCCTPHRTTTLPVEFKCPDGEV--MKKNMMFIKTCACHYN
-CPGDNDIF--ESLYYRKMYGDMA----
>gi|169154010|emb|CAQ13700.1| novel protein similar to vertebrate cysteine-rich, angiogenic inducer, 61 (CYR61) [Danio rerio]
--------------------------MKMKDFMCLLV-LVGIFC----------------------------
-------------TSGGWGCPQVC--RCPVKR-PVCPAGVSAVPDACGC-CKVCAAQLNDDCHEGKP-CDHH
KGLECNYGND-VSSLHGICRAKLEGRSCEYNGRMYQNGENFRAGCKHQCTCIDGAVGCVPLC-PTDIPLSSP
S-CPKPRLVKIPGQCCLSLDCHG-----ESPVLP--PVFRRPQPPPFLLPDPHTFKKPP-AKPKYSLSNEL-
--ME----------------------------VEKR--------------------WDKPRSRKHLPAQTTS
WTSCSRSCGMGVSSRVTNENRQCKLMKETRLCNIRPCSSAA-VPI-K-------------KGRKCSRTQKSP
EPLRLRYA----GCRSTRLYRPNYCGMC-LDGRCCSPRRTRTVPVLFSCPTGER--FERAVMFVQSCKCNDD
-CGSLNDA---SLPPQRWLYGDMHKFID
>gi|148226312|ref|NP_001085010.1| hypothetical protein LOC432074 [Xenopus laevis]
----------------------MRSLAALLPLLQLAA-LICTGTS-----G---------------------
-------------KLMEASCPTQC--VCPKEV-QSCPPGISLLTDSCGC-CKVCARQYNQDCGLNHP-CDHI
KGLHCDYGAD-PFSPRGICRAKSEGRPCEFFGQIYQNGENFQPNCKHQCTCMDGVVGCMPLC-PQEMALPGV
D-CINPRLVKVPGQCCEVWQC-DSNHISEDSGDT--TTGDGEDP----VRSSEEIG-EL-ADIEPVSSNEL-
--IS----------------------------LVRNGFRVENGLAPLPHPGKT-----------TCAIQTTE
WSQCSKSCNMGVSTRITNDNPHCKLMKETRLCEIRPCQDPFPTMS-K-------------NGKKCVRTKKAK
QAVHIPYA----GCTSVRQYKPLYCGSC-TDGRCCTPSKTRTMRVRFRCEDGDT--FQKSMMWVQKCKCHQD
-CPYHSEL---SYPHYR-LHNDIHKFKD
>gi|147904503|ref|NP_001079908.1| cysteine-rich, angiogenic inducer, 61 [Xenopus laevis]
--------------------------MSFLALNPVLA-IALLSGF-----I---------------------
-------------DLAVSSCPAVC--QCPVEV-PKCAPGVGLVLDGCGC-CKICAKQLNEDCSKTHP-CDHT
KGLECNFGAS-SRAIKGICRAKSEGRPCEYNSKIYQNGESFQPNCKHQCTCIDGAVGCLPLC-PQELSLPNL
G-CPNPRLVKVPGQCCEEWVC-D-----EA--KD--PVDEMDDF----F--NKEFGMDT-NEGELTRKNEF-
--VA----------------------------VIKG------GLKMLPVFGSDPQ--SHVVENSKCIVQTTS
WSQCSKTCGTGISTRVTNDNSNCRLVRETRICEVRPCGQPSYTSL-K-------------KGKKCTKTKKSQ
APVRYTYA----GCSSVKKYRPKYCGSC-VDGRCCTPQQTRTVKIRFRCEDGET--FTKNVMMIQSCRCNYN
-CPHTNE----AYPYYR-LFNDIHKFRD
>gi|62898331|dbj|BAD97105.1| cysteine-rich, angiogenic inducer, 61 variant [Homo sapiens]
--------------------------MSSRIARALAL-VVTLLHL-----T---------------------
-------------RLALSTCPAAC--HCPLEA-PKCAPGVGLVRDGCGC-CKVCAKQLNEDCSKTQP-CDHT
KGLECNFGAS-STALKGICRAQSEGRPCEYNSRIYQNGESFQPSCKHQCTCIDGAVGCIPLC-PQELSLPNL
G-CPNPRLVKVTGQCCEEWVC-D-----EDSIKD--PMEDQDGL----L--GKELGFDA-SEVELTRNNEL-
--IA----------------------------VGKG-----SSLKRLPVFGMEPRILYNPLQGQKCIVQTTS
WSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSL-K-------------KGKKCSKTKKSP
EPVRFTYA----GCLSVKKYRPKYCGSR-VDGRCCTPQLTRTVKMRFRCEDGET--FSKNVMMIQSCKCNYN
-CPHANEA---AFPFYR-LFNDIHKFRG