CLUSTAL W (1.7) multiple sequence alignment HS8_139_PE19 --M-RWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLED-----TSS-------- MOUSE15_70_PE1 --M-RWLLPWTLAAVAVLRVGNILATALSPTPTTMTFTPAPLEE-----TTT-------- CHICK2_151_PE14 --------------------------AIAQTSTTMTPTIPAAKE-----AYT-------- XENTR496_1_PE19 ------------------------------------------------------------ TETNG21_1_PE42 ---MSWLLLWILTAAGIQQVGTKASPASSHNLTAVPAVASAAPD-----AHS-------- DANRE16_31_PE15 ----------------MWRLLSWILLTSSLHQASFHNSTDSPPMTTELDPYN-------- DANRE19_35_PE7 ------------------------------------TEEPITPQ-----PYN-------- DANRE20_1_PE8 --S-FWVRRAPLQAVYDAITTVLVSADLSESVLFLHALQGADSRREGTGPAD-------- CHICK3_71_PE3 --------------------CRAQAHRPQPRPGGKHPESSEAQP---------------- HS6_118_PE4 ------MNKRRLLYPSGWLHGPSDMQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPG MOUSE10_41_PE4 MRR-LLFCTLLMTGLTQQTKLCCRTQGSAPQDSTPGGRPGAALE-----VYQ-------- BRAFL_PE22461 ------------------------------------------------------------ BRAFL_PE49250 ----------------MKVTQSSVAAVVVFLTCLVHALPEGKGG---------------- DANRE23_26_PE17 ------------------------------------------------------------ DANRE5_32_PE16 ----------------MSPLRIILRQGHFFTLVLLSWATAEVQG-----G---------- DANRE8_56_PE23 -----------------------------------------VSR-----G---------- TETNG8_6_PE12 ----------------------MSERALFVLLFTAQVLTLAWSQ-----D---------- XENTR330_1_PE18 -------------------------MTPCLALCFILLLQQVASQ-----R---------- CHICK2_146_PE4 -------------------METGGGQGLPVLLLLLLLLRPCEAT-----VSG-------- HS8_125_PE3 ------------MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAAT-----QR--------- MOUSE15_57_PE3 ------------------MSLFLRKRCLCLGFLLFHLLSQVSAS-----LR--------- DANRE5_69_PE7 --------------------MTGTAFTRACIALSLLIHTAICQD---------------- XENTR200_2_PE6 --------------------MSAGKVTAVLLFALFCWVSDAQE----------------- HS6_138_PE20 ----------------MTAASMGPVRVAFVVLLALCSRPAVGQN---------------- CHICK3_62_PE8 ------------------------------------------------------------ MOUSE10_26_PE4 -----------------MLASVAGPISLALVLLALCTRPAMGQD---------------- TETNG14_7_PE75 --------------------TISTKEEKMEKMLFLTFLSQAAAQ-----E---------- DANRE20_26_PE5 --------------------MFSGMTQSVIALLFLTFLRWAVAQ-----E---------- XENTR667_1_PE24 ------------------------------------------------------------ DANRE21_14_PE1 ----------------------MKMKDFMCLLVLVGIFCTSGGW-----G---------- DANRE23_45_PE13 ------------------------MFAWAVIVIFIAHFNMVSSS---------------- TETNG1_21_PE52 --------------------ITGDLFKMLMVTIAVLFIGSLNV----------------- HS1_91_PE6 -------------------MSSRIARALALVVTLLHLTRLALST---------------- MOUSE3_149_PE17 -------------------MSSSTFRTLAVAVTLLHLTRLALST---------------- CHICK8_18_PE4 ------------------------------------------------------------ XENTR6_3_PE16 --------------------MSFLALNPILAVALLSGIIDLAVS-----S---------- TETNG9_11_PE17 ------------------------------------------------------------ XENTR48_3_PE12 ------------------MAMDPGILNRYLLLLGYCILPQICAQ---------------- CHICK20_6_PE35 --------------------MRLRLEKQLLILSLLCILSKVCSQ-----L---------- HS20_43_PE43 --------------------MRGTPKTHLLAFSLLCLLSKVRTQ-----L---------- MOUSE2_167_PE11 --------------------MRGNPLIHLLAISFLCILSMVYAQ-----L---------- HS8_139_PE19 -------RPQFCKWPC--ECPPSP-PRCPLGVSLITDGCEC-CKMCAQQLGDNCTEAAIC MOUSE15_70_PE1 -------RPEFCKWPC--ECPQSP-PRCPLGVSLITDGCEC-CKICAQQLGDNCTEAAIC CHICK2_151_PE14 -------RTQYCKWPC--ECPKSP-PRCSIGVSLVTDGCDC-CKMCAKQRGENCTEADTC XENTR496_1_PE19 ---------QFCKWPC--DCPQVP-PACPAGVSLLTDGCDC-CKTCAKQRGENCTEADTC TETNG21_1_PE42 -------RTQYCKWPC--VCPDAP-PTCPPGVSLLVDGCDC-CKTCARQVGEGCDEAATC DANRE16_31_PE15 -------RNRYCKWPC--KCPKSA-LVCPHGVSLLTDGCDC-CKACAKQAGETCNERDIC DANRE19_35_PE7 -------RSQYCQWPC--KCPKTP-PMCPPGVSLLMDGCDC-CRACAKQVREACNEKENC DANRE20_1_PE8 -------KRQFCSWPC--KCGVR--PLCAPGVSSILDGCGC-CKTCAQQIGESCNERDIC CHICK3_71_PE3 -------RTELCHWPC--QCPPV--PTCSPGVSLLKDGCGC-CKACAKQAGEVCNEVDIC HS6_118_PE4 EVSDAPQRKQFCHWPC--KCPQQK-PRCPPGVSLVRDGCGC-CKICAKQPGEICNEADLC MOUSE10_41_PE4 -------RTEVCRWPC--RCPPQR-PTCPPGVSLVRDGCGC-CKVCAKQPGDTCNEAEIC BRAFL_PE22461 ------------------------------------------------------------ BRAFL_PE49250 -----------CDGTC--ACPAQP-VTCVPGVRLLEDRCGCRCKVCASLLGEECSEMAPC DANRE23_26_PE17 ------------------------------------------------------------ DANRE5_32_PE16 -----------CPLKC--SCPSTP-PSCPPGISSVLDHCGC-CRVCARQFNQDCSPTEPC DANRE8_56_PE23 -----------CPGPC--SCPPSP-PSCPRGVSRVWDNCGC-CKVCAQQFNQDCGSDLPC TETNG8_6_PE12 -----------CPRRC--QCPDEP-PTCPPAVPLILDDCAC-CLVCARQRGQACSDMSPC XENTR330_1_PE18 -----------CPSQC-DQCPEEP-PSCAPSVPLVLDGCAC-CPVCARQEGESCSEMHPC CHICK2_146_PE4 -------REAACPRPCGGRCPAEP-PRCAPGVPAVLDGCGC-CLVCARQRGESCSPLLPC HS8_125_PE3 -----------CPPQCPGRCPATP-PTCAPGVRAVLDGCSC-CLVCARQRGESCSDLEPC MOUSE15_57_PE3 -----------CPSRCPPKCPSIS-PTCAPGVRSVLDGCSC-CPVCARQRGESCSEMRPC DANRE5_69_PE7 -----------CSQPC--DCPDES-PLCPVGTSLVLDGCSC-CKVCARQAGEPCSFLEPC XENTR200_2_PE6 -----------CNGEC--QCPHKV-PVCDPGVSLVQDGCGC-CKVCAKQLGELCTERDVC HS6_138_PE20 -----------CSGPC--RCPDEPAPRCPAGVSLVLDGCGC-CRVCAKQLGELCTERDPC CHICK3_62_PE8 ------------------------------------------------------------ MOUSE10_26_PE4 -----------CSAQC--QCAAEAAPHCPAGVSLVLDGCGC-CRVCAKQLGELCTERDPC TETNG14_7_PE75 -----------CGKPC--SCPSAP-PQCPPGVSLVLDGCGC-CRVCAKQMGELCTERDVC DANRE20_26_PE5 -----------CSGQC--HCPEVP-PQCSPGVSLVLDTCGC-CRVCAKQLGELCTERDVC XENTR667_1_PE24 ------------------------------------------------------------ DANRE21_14_PE1 -----------CPQVC--RCPVKR-PVCPAGVSAVPDACGC-CKVCAAQLNDDCHEGKPC DANRE23_45_PE13 -----------CPAVC--SCAPDA-PQCPPGVGLQRDACGC-CLVCARQLNEDCSRSEPC TETNG1_21_PE52 -----------CPAMC--ECPLEM-PHCAPGVSVVLDGCGC-CKVCARQLNEDCSLTEPC HS1_91_PE6 -----------CPAAC--HCPLEA-PKCAPGVGLVRDGCGC-CKVCAKQLNEDCSKTQPC MOUSE3_149_PE17 -----------CPAAC--HCPLEA-PKCAPGVGLVRDGCGC-CKVCAKQLNEDCSKTQPC CHICK8_18_PE4 ------------------------------------------------------------ XENTR6_3_PE16 -----------CPAVC--QCPVEV-PKCAPGVGMVLDGCGC-CKVCAKQLNEDCSKTHPC TETNG9_11_PE17 ---------QLCDSPC--ACPSAA-PRCPPGVALVPDGCRC-CSVCARQRGEPCTDRFPC XENTR48_3_PE12 ----------LCRTPC--FCSWIP-PRCPPGVPVIVDGCGC-CRICARQLGESCDHLYLC CHICK20_6_PE35 -----------CRRPC--YCSQML-PRCPRGSPLVLDGCGC-CRICARRLGEPCDFLHVC HS20_43_PE43 -----------CPTPC--TCPWPP-PRCPLGVPLVLDGCGC-CRVCARRLGEPCDQLHVC MOUSE2_167_PE11 -----------CPAPC--ACPWTP-PQCPPGVPLVLDGCGC-CRVCARRLGESCDHLHVC HS8_139_PE19 DPHRGLYCDYSGDRPRYAI-GVCAQV-VGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAV MOUSE15_70_PE1 DPHRGLYCDYSGDRPRYAI-GVCAQV-VGVGCVLDGVRYTNGESFQPNCRYNCTCIDGTV CHICK2_151_PE14 DFHRGLYCDYSGDRPRYEI-GVCSQI-VGVGCVLNGVRYNNGDTFQPNCKYNCTCINGAV XENTR496_1_PE19 DTHKGLYCDYSGDSPRYEV-GVCGQM-TGVGCVLNGIRYVNGQSFQPNCKYNCTCVNGDV TETNG21_1_PE42 DHHRGLYCDYSADKPRYEK-GVCAYM-AGSGCEHDGVIYRNGQSFAPSCKYQCVCVNGAI DANRE16_31_PE15 DYHKGLYCDYSADKPRYEK-GVCAYV-MGTGCEYNGVIYRNGQSFQPNCKYRCLCVNGAI DANRE19_35_PE7 DHHRGLYCDYSADKPRYEK-GVCAFL-PGTGCEHNGVIYRNGQSFQPNCKYQCLCVNGAI DANRE20_1_PE8 DPHKSMYCDFSKDQPRYEV-GICAYL-MGVGCDLNGAHYDNGQAFQPNPLYKCTCISGSI CHICK3_71_PE3 DPHKGLYCDYSQDEPRYET-GVCAYL-VAVGCELNGIYYLNGQNFQPNPLYKCLCISGAI HS6_118_PE4 DPHKGLYCDYSVDRPRYET-GVCAYL-VAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAI MOUSE10_41_PE4 DPHKGLYCDYSGDTPRYET-GVCAYL-VAVGCEFNRVYYQNGQVFQPHPLFSCLCVSGAI BRAFL_PE22461 ------------------------------------------------------------ BRAFL_PE49250 DDTVGLYCDYSADKPT----GICKAT-FQTPCVFQGKVYQSGESFELSCRETCVCQNGAV DANRE23_26_PE17 ------------------------------------------------------------ DANRE5_32_PE16 DHIKGLRCHLGAE-GDPDR-GLCRAEAQGRPCELDGRIYQHGEDFQPSCEHQCTCVDGVV DANRE8_56_PE23 DHIKGLHCHLGAG-GDPQR-GLCRAEAHGRPCEFSGRVYQHGEDFQTGCEHQCSCIDGVV TETNG8_6_PE12 DTRKGLRCDYAKD-VRKRT-GLCVAH-GGHVCVLDGSVYQNGQTFIPSCKYQCMCWDGQI XENTR330_1_PE18 QEDKGLYCEFNAD-PRTEA-GICMAL-EGNNCIFDGVVYRNRATFQPSCKYHCTCLNGHI CHICK2_146_PE4 DESGGLYCDRGPE-DGGGA-GICMVL-EGDNCVFDGMIYRNGETFQPSCKYQCTCRDGQI HS8_125_PE3 DESSGLYCDRSAD-PSNQT-GICTAV-EGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQI MOUSE15_57_PE3 DQSSGLYCDRSAD-PNNQT-GICMVP-EGDNCVFDGVIYRNGEKFEPNCQYFCTCRDGQI DANRE5_69_PE7 DHHKGLYCDYSVL-SDTET-GICMAQ-EGQTCDLGGVIYRSGETFQPSCKHQCVCMNGEI XENTR200_2_PE6 DPHKGLFCDFGSR-VNRKI-GVCTAR-EGAPCVFGGTVYRSGESFQSSCKYQCTCIDGGV HS6_138_PE20 DPHKGLFCHFGSP-ANRKI-GVCTAK-DGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAV CHICK3_62_PE8 ------------X-ANRRI-GVCTAR-DGAPCVFSGMVYRSGESFQSSCKYQCTCLDGAV MOUSE10_26_PE4 DPHKGLFCDFGSP-ANRKI-GVCTAK-DGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAV TETNG14_7_PE75 DPHKGLYCDFGAR-INRRI-GVCTAR-DGATCVFGGAVYKSGETFQSSCKYQCTCLDGAM DANRE20_26_PE5 DPHKGLYCDYGSP-SNRRI-GVCTAR-DGATCVFGGMVYRSGESFQSSCKYQCTCLDGAV XENTR667_1_PE24 ------------------------AKSEGRPCEFFGQIYQNGENFQPNCKHQCTCMDGVV DANRE21_14_PE1 DHHKGLECNYGND-VSSLH-GICRAKLEGRSCEYNGRMYQNGENFRAGCKHQCTCIDGAV DANRE23_45_PE13 DHSKGLECNYGAS-HGATR-GICRAKSEGRPCEYSSRIYQNGESFQPNCKHQCTCMDGAV TETNG1_21_PE52 DHTKGLECNFGASFAGATTRGICRAKSEGRPCEYSSRIYQNGESFQPNCKHQCTCIDGAV HS1_91_PE6 DHTKGLECNFGAS-STALK-GICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAV MOUSE3_149_PE17 DHTKGLECNFGAS-STALK-GICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAV CHICK8_18_PE4 -----------AS-PAATN-GICRAQSEGRPCEYNSKIYQNGESFQPNCKHQCTCIDGAV XENTR6_3_PE16 DHTKGLECNFGAS-SRAIK-GICRAKSEGRPCEYNSKIYQNGESFQPNCKHQCTCIDGAV TETNG9_11_PE17 DPHRGLRCDYSASFPGEP--GECVGE-DELGCELNGVTYHEGQEFQPSCDTLCRCRGGGV XENTR48_3_PE12 DESKELLCDYPTGSNGR---GTCNYNYDG-SCEYDGKEYKDGEVFQPNCKFQCKCIDGGI CHICK20_6_PE35 DRSQGLICDYSSGTG-----GTCNFEDNEEGCEVNGRLYRDGEVFQPSCKLQCRCLDGGF HS20_43_PE43 DASQGLVCQPGAG-PGGRG-ALCLLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGF MOUSE2_167_PE11 DPSQGLVCQPGAG-PSGRG-AVCLFEEDDGSCEVNGRRYLDGETFKPNCRVLCRCDDGGF HS8_139_PE19 GCTPLC-LRVRPPRLWCPHP--RRVSIPGHCCEQWVCED---DAKRPRKTAPRDTGA--- MOUSE15_70_PE1 GCTPLC-LSPRPPRLWCRQP--RHVRVPGQCCEQWVCDD---DARRPRQTALLDTRA--- CHICK2_151_PE14 GCIPMC-TNSRPPLVWCPNP--KLIKMAGKCCEQWVCDD---SK---KIRKTSPRHI--- XENTR496_1_PE19 GCVPLC-TNSRPPLVWCQNP--KRVKMTGKCCEQWICDD---FK---RVRKTSPRHI--A TETNG21_1_PE42 GCVGLCAESQPPPRVWCQAP--RRVKVPGQCCERWICDE---AR---RGRKTAPRHA--- DANRE16_31_PE15 GCVPLC-TDSLPPRVWCQSP--KRVKIPGQCCEKWICEE---SR---KPRKTNPRHA--- DANRE19_35_PE7 GCVPLCNES-QPPRVWCQNP--QRVKVHGQCSLSSVKKN--------------------- DANRE20_1_PE8 GCTPA--FIQKPTGMLSPAA--LQGQLPAG-----LKSS---RNPKNQQDTTYRTMS--- CHICK3_71_PE3 GCTPI--FTPKLAASPCSSG--MGRKKNGQT----VCGP---GQNKQLQSVNYRLMS--- HS6_118_PE4 GCTPL--FIPKLAGSHCSGA------KGGKKSDQSNCSL---EPLLQQLSTSYKTMP--- MOUSE10_41_PE4 GCTPL--FIPKLAGSNCSAAKGRRKTDPPNCGR---------GTLQQQNSASYKTMS--- BRAFL_PE22461 -----------MPSDDCPFP--RLEKVPGKCCKQWMCDS---KPKELSAKGPMPMIA--G BRAFL_PE49250 GCMPLCPQEVRMPSDDCPFP--QLEKVPGKCCKQWMCDA---KPKELSAKGPMPMIA--G DANRE23_26_PE17 -----SKSDLTLPADSGYQT--RVVS---------------------------------- DANRE5_32_PE16 GCLPLCPHHISLPDWRCARR--RLIRKPERCCPEWVCDD---DNRIAEVNPVPEAHP--A DANRE8_56_PE23 GCVPLCPLLVPLPGSHCTNP--RLETPTGHCCQRWVCDS---DNSIREEEPLPKHTPQYN TETNG8_6_PE12 TCVPRCNLDMMLPGPDCPMP--RRVQVPGECCEKWVCDP---QAE--ASALGGFAMA--- XENTR330_1_PE18 GCVPRCNLDLMLPGPDCPFP--RRVKVPGECCEKWVCDS---KE---EMAIGGFAMA--- CHICK2_146_PE4 GCLPRCNLGLLLPGPDCPFP--RKIEVPGECCEKWVCDP---RD---EVLLGGFAMA--- HS8_125_PE3 GCVPRCQLDVLLPEPNCPAP--RKVEVPGECCEKWICGP---DE---EDSLGGLTLA--- MOUSE15_57_PE3 GCLPRCQLDVLLPGPDCPAP--RKVAVPGECCEKWTCGS---DEQGTQGTLGGLALP--- DANRE5_69_PE7 GCVPTCATIIRLPSPDCPYP--RRVQIPGKCCEEWVCDQIP-QEDTFQSAVAGRSIG--- XENTR200_2_PE6 GCVPLCSMDIRLPSPECPFP--RRVKLPGKCCEEWVCDQ---PQ---ERTLVGPALP--- HS6_138_PE20 GCMPLCSMDVRLPSPDCPFP--RRVKLPGKCCEEWVCDE---PK---DQTVVGPALA--- CHICK3_62_PE8 GCVPLCSMDVRLPSPDCPYP--RRVKLPGKCCEEWVCDE---AK---EQTAVGPALA--- MOUSE10_26_PE4 GCVPLCSMDVRLPSPDCPFP--RRVKLPGKCCEEWVCDE---PK---DRTAVGPALA--- TETNG14_7_PE75 GCVPLCSVNVRLPSPDCPMP--RRVKVPGKCCEEWECDS---PN---KNSFVGSALA--- DANRE20_26_PE5 GCVPLCGMDIRLPSPDCPMP--RRVKVPGKCCEEWVCDS---PR---QNTFVGSALA--- XENTR667_1_PE24 GCMPLCPQEMALPGPDCINP--RLVKVPGQCCEAWQCDSNHIPEDSGDTTAGDREDPVRS DANRE21_14_PE1 GCVPLCPTDIPLSSPSCPKP--RLVKIPGQCCLSLDCHG---ESPVLPPVFRRPQPP--- DANRE23_45_PE13 GCVPLCPQELSLPALGCANP--RLVKVPGRCCEEWVCDD---EQQGGKLIESANKMP--G TETNG1_21_PE52 GCVPLCPQELSLPNLGCANP--RLVKVAGQCCEEWVCDD---GKQTDVLERIFGKDV--- HS1_91_PE6 GCIPLCPQELSLPNLGCPNP--RLVKVTGQCCEEWVCDE---DSIKDPMEDQDGLLG--- MOUSE3_149_PE17 GCIPLCPQELSLPNLGCPNP--RLVKVSGQCCEEWVCDE---DSIKDSLDDQDDLLG--- CHICK8_18_PE4 GCIPLCPQELSLPNLGCPSP--RLVKVPGQCCEEWVCDE---SKDALEELEGFFSKE--- XENTR6_3_PE16 GCLPLCPQELSLPNLGCPNP--RLVKVPGQCCEEWVCDE---AKDPVDEIVDFFNKE--- TETNG9_11_PE17 TCVPACPLHGRRPTPDCPNP--QHVRLPGECCKKWVCES---LENTVFQDAITAMRRTRL XENTR48_3_PE12 TCTPLCSENVLIATPECPFP--RRVEIPGRCCPEWICDE---DQQSPVSNSLGKERE--- CHICK20_6_PE35 TCVPLCQEDVRLPTPDCPHP--RRVDIPGKCCPEWVCEA---GERHLLQSTGAGNTG--- HS20_43_PE43 TCVPLCSEDVRLPSWDCPHP--RRVEVLGKCCPEWVCGQ--------GGGLGTQPLP--- MOUSE2_167_PE11 TCLPLCSEDVRLPSWDCPRP--RRIQVPGRCCPEWVCDQ---AVMQPAIQPSSAQGH--- HS8_139_PE19 ----FDAVGEVEAWHR---------------------------------NCIAYTSPWSP MOUSE15_70_PE1 ----FAASGAVEQRYE---------------------------------NCIAYTSPWSP CHICK2_151_PE14 --SSAAYEGEDEAWQK---------------------------------NCIVHTSPWSP XENTR496_1_PE19 SPASVAYGGESESWHN---------------------------------NCIVQTTSWSP TETNG21_1_PE42 ---IEAAPAETRSWHR---------------------------------NCIPQTSSWSP DANRE16_31_PE15 ----PAEVSANDIWHN---------------------------------NCIAQTTPWSP DANRE19_35_PE7 -------------WHK---------------------------------NCVAQTTSWSP DANRE20_1_PE8 ------------AWKK---------------------------------NCLVQTTAWSP CHICK3_71_PE3 -----AYRNLPLVLKK---------------------------------KCLVQATPWTP HS6_118_PE4 -----AYRNLPLIWKK---------------------------------KCLVQATKWTP MOUSE10_41_PE4 -----AYRNLPLTWRK---------------------------------KCLVQATKWTP BRAFL_PE22461 KLERKPEREQDTKQEKSPYYQMDS-YLGLIPSHGAEYPEPV--------ACLLQATSWSQ BRAFL_PE49250 KLERKPETEYPEPV-----------------------------------ACLLQATSWSQ DANRE23_26_PE17 -------------------------------------------------NCIDQSSEWSA DANRE5_32_PE16 EHTHLTGNELLVTPSASWDSSAGAPYQEWISSSKSRPIAPA--------TCLLQITDWSP DANRE8_56_PE23 HISKLLQEHRSRPAAQEWSSAPVSEIPFPSP------------------GCFSQTTDWSE TETNG8_6_PE12 -AYRQEETVRFDAWDSSL-------------------------------NCIEQTTEWGA XENTR330_1_PE18 -AYRPEATLGIDASDMF--------------------------------TCIAQTTEWSA CHICK2_146_PE4 -AYRQEATLGIDVSDSSA-------------------------------NCIEQTTEWSA HS8_125_PE3 -AYRPEATLGVEVSDSSV-------------------------------NCIEQTTEWTA MOUSE15_57_PE3 -AYRPEATVGVEVSDSSI-------------------------------NCIEQTTEWSA DANRE5_69_PE7 -KEISAHGLQPESARD---------------------------------NCIVQTTEWSE XENTR200_2_PE6 -AFRMEETYGPDPSLIRA-------------------------------NCLVQTTEWSA HS6_138_PE20 -AYRLEDTFGPDPTMIRA-------------------------------NCLVQTTEWSA CHICK3_62_PE8 -AYRLEDTYGPDPTMMRA-------------------------------NCLVQTTEWSA MOUSE10_26_PE4 -AYRLEDTFGPDPTMMRA-------------------------------NCLVQTTEWSA TETNG14_7_PE75 -AYREEETFGPDLSMMRE-------------------------------NCLVQTTEWSA DANRE20_26_PE5 -AYREEETYGPDPSMMRE-------------------------------NCLVQTTEWSA XENTR667_1_PE24 SEEIGEQADMEPVSSNELISLVRNGFRVENGEWVAPII-----------ALPGAVTSWDW DANRE21_14_PE1 -PFLLPDPHTFKKPPAKPKYSLSNELMEVEKRWDKPRSRK---------HLPAQTTSWTS DANRE23_45_PE13 NKEVGGDSEKELTNKNELISVIMNTKLKSLPAFRSHQME----------KCIVQTTGWSQ TETNG1_21_PE52 ---LTDELERDLTNKNELISVVNGGGLKSLAAFRPQPEVQL--FD--NHKCIVQTTPWSQ HS1_91_PE6 KELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQ--GQKCIVQTTSWSQ MOUSE3_149_PE17 ----LDASEVELTRNNELIAIGKGSSLKRLPVFGTEPRVLFNPLHAHGQKCIVQTTSWSQ CHICK8_18_PE4 --FGLDASEGELTRNNELIAIVKG-GLKMLPVFGSEPQSRA--FE--NPKCIVQTTSWSQ XENTR6_3_PE16 --FGMDTSEGELTRKNEFVAVVKG-GLKMLPVFGSDPQSHV--VE--NSKCIVQTTSWSQ TETNG9_11_PE17 LPSLPQHHPLNTPVPPGP-------------------------------ACPEKSTQWSP XENTR48_3_PE12 ------AKGRSQVKPF---------------------------------ACAEWSTQWST CHICK20_6_PE35 -LQSLSPLLCFHPARAVPY------------------------------PCQPWGTEWSA HS20_43_PE43 -AQGPQFSGLVSSLPPGV-------------------------------PCPEWSTAWGP MOUSE2_167_PE11 ---QLSALVTPASADG---------------------------------PCPNWSTAWGP HS8_139_PE19 CSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDI-HTLIK-------------AGK MOUSE15_70_PE1 CSTTCGLGISTRISNVNARCWPEQESRLCNLRPCDVDI-QLHIK-------------AGK CHICK2_151_PE14 CSKTCGLGISTRISNDNDQCRLLKESRLCNMRPCEVDI-TKHIK-------------PGK XENTR496_1_PE19 CSKTCGLGISTRISNENDKCRLRKERRLCDMRPCDVDI-TQHIR-------------TGK TETNG21_1_PE42 CSRSCGRGLSLRVSNANERCELVKESRLCNLRPCEVNI-TGYIK-------------PGK DANRE16_31_PE15 CSKTCGRGISLRISNENAGCVMEKESRLCNLRPCEVDI-TKHFR-------------PGK DANRE19_35_PE7 CSKTCGRGVSLRITNNNKKCEMVNESRLCNIRPCNVDI-TKHIK-------------PGK DANRE20_1_PE8 CSRSCGIGISVRVNNDNSKCEMRKERRLCLLRPCDKNT-LKRLKMP-----------KGK CHICK3_71_PE3 CSRTCGIGISSRVTNENKKCEMKKEKRLCFIQPCLTNI-LKTVKIP-----------KGK HS6_118_PE4 CSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNI-LKTIKIP-----------KGK MOUSE10_41_PE4 CSRTCGMGISNRVTNDNANCEMRKERRLCYIQPCSRNT-SQAVKIP-----------RGE BRAFL_PE22461 CSVTCGMGVSTRVSNHNPECRMQVEKRICQMRPCDLEY-LNHIK-------------DGK BRAFL_PE49250 CSVTCGMGVSTRVSNHNPECRMQVEKRICQMRPCDLQY-LNHIKVRTSLFIKSRGGWDGK DANRE23_26_PE17 CSRTCGSGISVRVSNQNPSCVLEMQMRLCMIRPCQPVLHRSPQW-------------SRR DANRE5_32_PE16 CSATCGIGVSSRVTNSNPECRLVSETRLCQIRECGVNT-APSMK-------------KGK DANRE8_56_PE23 CSASCGFGVSSRVTNSNAQCRLIRETRLCQITPCDA---TPHLK-------------KGK TETNG8_6_PE12 CSQTCGVGVSTRVTNKNRRCEMVKQTRLCMIRPCADQL-DRTRL-------------RGS XENTR330_1_PE18 CSKTCGMGVSSRVTNRNPRCEMQKQIRLCMVRPCEEEPGWHMEK-------------KGK CHICK2_146_PE4 CSKSCGMGFSTRVTNRNQQCEMVKQTRLCMMRPCENE--EPSDK-------------KGK HS8_125_PE3 CSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDK-------------KGK MOUSE15_57_PE3 CSKSCGMGVSTRVTNRNRQCEMVKQTRLCIVRPCEQEPEEVTDK-------------KGK DANRE5_69_PE7 CSATCGMGVSSRVTNDNEQCQLERQTRMCMIRPCHADL-EKDIK-------------RGK XENTR200_2_PE6 CSKTCGMGISTRVTNDNEHCRLEKQSRLCMVRPCEADL-EENIK-------------KGK HS6_138_PE20 CSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADL-EENIK-------------KGK CHICK3_62_PE8 CSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADL-EENIK-------------KGK MOUSE10_26_PE4 CSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADL-EENIK-------------KGK TETNG14_7_PE75 CSKSCGLGISTRVTNDNRECRLEKQTRLCMVRPCESQL-EQSIR-------------KGK DANRE20_26_PE5 CSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESHL-EEKIR-------------KGK XENTR667_1_PE24 SPPTAAMSIYTGTESVDKSAKTLTDGNNCSCFPTQQPR-YWGMQ-------------TGK DANRE21_14_PE1 CSRSCGMGVSSRVTNENRQCKLMKETRLCNIRPCSSA--AVPIK-------------KGR DANRE23_45_PE13 CSRSCGTGISTRITNNNAECKLMKESRICEVRPCSQSP-HTSLK-------------KGK TETNG1_21_PE52 CSKSCGTGISTRVTNHNSECKLVKETRLCEVRPCTQSP-YSSLK-------------KGK HS1_91_PE6 CSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPV-YSSLK-------------KGK MOUSE3_149_PE17 CSKSCGTGISTRVTNDNPECRLVKETRICEVRPCGQPV-YSSLK-------------KGK CHICK8_18_PE4 CSKTCGTGISTRVTNDNPDCKLIKETRICEVRPCGQPS-YASLK-------------KGK XENTR6_3_PE16 CSKTCGTGISTRVTNDNSNCRLVRETRICEVRPCGQPS-YTSLK-------------KGK TETNG9_11_PE17 CSQSCGAGVSTRVSNQNPACKLQMETRLCKVRPCYSVQPAPKPA-------------AGQ XENTR48_3_PE12 CSVSCGVGLSLRVSNRNPLCRLKAQTRLCMVRPCR----YSPAT-------------EGV CHICK20_6_PE35 CSATCGVGFSTRVSNQNPYCRLETQRRLCVLRPC-------------------------- HS20_43_PE43 CSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCP------------------------- MOUSE2_167_PE11 CSTTCGLGIATRVSNQNRFCQLEIQRRLCLSRPCL------------------------- HS8_139_PE19 --KCLAVYQPEASMNFTLA----GCISTRSYQPKYCGVCM-DNRCCIPYKSKTIDVSFQC MOUSE15_70_PE1 --KCLAVYQPEEATNFTLA----GCVSTRTYRPKYCGVCT-DNRCCIPYKSKTISVDFQC CHICK2_151_PE14 --KCLAVYRTNEPMNYTIS----GCMSKSPYRPKYCGICT-DNRCCTPYKSKTIEVRFEC XENTR496_1_PE19 --KCLSVYREAEPKNFTIS----GCLSKRPYRPKYCGVCT-DDRCCIPYKSKTIQVEFEC TETNG21_1_PE42 --KCLNIYREELPSNLTIS----GCTSKRPYRPKYCGVCT-DERCCIPYKSRTVEVEFQC DANRE16_31_PE15 --KCLNIYREPEFQNFTIS----GCVSKKPYWPKYCGVCT-DERCCIPYKSKTIEVEFEC DANRE19_35_PE7 --KCLNIYRAEKPQNFTIS----GCTSTNTYRPKYCGVCT-DERCCIPYKSKTIEVDFQC DANRE20_1_PE8 --TCKPKFQASKAEKLSLS----GCTSVKKHRPTYCGVCT-DKRCCVPNKSKMVNVEFHC CHICK3_71_PE3 --TCQPTFQLPRAEKLFFS----GCSTTQSYKLTFCGVCV-DKRCCVPNKSKMITLQFEC HS6_118_PE4 --TCQPTFQLSKAEKFVFS----GCSSTQSYKPTFCGICL-DKRCCIPNKSKMITIQFDC MOUSE10_41_PE4 --TCQPTFQLPKAEKFVFS----GCSSTQSYRPTFCGICL-DKRCCVPNKSKMITVRFDC BRAFL_PE22461 --KCRSTIRSMEPSKITFSWYNTRCTTVKAYKWRWCGGCTISGRCCTPYKVKTTTMDFIC BRAFL_PE49250 --KCRSTIRSMEPSKITFSWYNTRCTTVKAYKWRWCGGCTISGRCCTPYKVKTTTMDFIC DANRE23_26_PE17 --KCQPSYRSATPVRLFHQ----GCYSTRFYRPRYCGSCT-DNRCCTPYQTGTAMVTFRC DANRE5_32_PE16 --KCERSTRPQKPVQISFA----GCSTTRRYRLRSCGFCS-DGRLCVPSATRTVRLHFHC DANRE8_56_PE23 --KCRRTTRPRKPELITFA----GCSTVRRYRPRSCGSCV-DDRCCQPRSTRTVRMRFRC TETNG8_6_PE12 --KCQRVVRSGTAVRLSHK----NCTSIQAYTPRYCGSCT-DGRCCTPHRTKTALVDFQC XENTR330_1_PE18 --RCVRMRKTTKPIHLHYK----NCSSVQPYKPKFCGQCS-DGRCCTPHTTKTMHVEFEC CHICK2_146_PE4 --KCIRTKKSMKAVRFEYK----NCTSVQTYKPRYCGLCN-DGRCCTPHNTKTIQVEFRC HS8_125_PE3 --KCLRTKKSLKAIHLQFK----NCTSLHTYKPRFCGVCS-DGRCCTPHNTKTIQAEFQC MOUSE15_57_PE3 --KCLRTKKSLKAIHLQFE----NCTSLYTYKPRFCGVCS-DGRCCTPHNTKTIQVEFQC DANRE5_69_PE7 --KCVRTPKSQSGMRFELS----GCQSIRLYKPKFCGVCT-DDRCCTPQSTITAEVEFRC XENTR200_2_PE6 --KCIRTPKISKPVKFEIS----GCTSVKTYRAKFCGVCT-DGRCCTPHRTATLPVEFKC HS6_138_PE20 --KCIRTPKISKPIKFELS----GCTSMKTYRAKFCGVCT-DGRCCTPHRTTTLPVEFKC CHICK3_62_PE8 --KCIRTPKISKPIKFELS----GCTSVKTYRAKFCGVCT-DGRCCTPHRTATLPVEFKC MOUSE10_26_PE4 --KCIRTPKIAKPVKFELS----GCTSVKTYRAKFCGVCT-DGRCCTPHRTTTLPVEFKC TETNG14_7_PE75 --KCIRTPRVSKPMKFEIS----GCTTTKSYRPKFCGVCL-DGRCCTPHRTTTLPMEFKC DANRE20_26_PE5 --KCIRTPRVSKPMKFEIS----GCTTTKSYRPKFCGVCT-DGRCCTPHRTATLPMEFKC XENTR667_1_PE24 --KCARTRKAPQAAPLTYA----GCASLRQYKPLHCGSCA-DGRCCTPSKTRTLRVRFRC DANRE21_14_PE1 --KCSRTQKSPEPLRLRYA----GCRSTRLYRPNYCGMCL-DGRCCSPRRTRTVPVLFSC DANRE23_45_PE13 --KCNRTKKSVTPVKFSYA----GCSSLKKYRPRFCGSCV-DGRCCSPQNTRTIRVKFRC TETNG1_21_PE52 --KCSRTKKSSQPVKFTYA----GCSSLKKYRPKYCGACV-DGRCCSPHVTRTIRVKFRC HS1_91_PE6 --KCSKTKKSPEPVRFTYA----GCLSVKKYRPKYCGSCV-DGRCCTPQLTRTVKMRFRC MOUSE3_149_PE17 --KCSKTKKSPEPVRFTYA----GCSSVKKYRPKYCGSCV-DGRCCTPLQTRTVKMRFRC CHICK8_18_PE4 --KCTKTKKSPSPVRFTYA----GCSSVKKYRPKYCGSCV-DGRCCTPQQTRTVKIRFRC XENTR6_3_PE16 --KCTKTKKSQAPVRYTYA----GCSSVKKYRPKYCGSCV-DGRCCTPQQTRTVKIRFRC TETNG9_11_PE17 QGRCEASDASPGPIRLLHQ----GCVSTRAFRLRYCGGCT-DWRCCVPHQTSTAEVTFRC XENTR48_3_PE12 --TCTPTVHSALRLRYKTD----DCISIREFRPTFCGTC--PMKHCAPYQTENDLVAFHC CHICK20_6_PE35 ---------PALPA-------------------------------ASP----------AV HS20_43_PE43 -----------------------------------------PSRGRSPQNSA-----F-- MOUSE2_167_PE11 -----------------------------------------ASRSHGSWNSA-----F-- HS8_139_PE19 PDGLG--FSRQVLWINACFCNLSCRN-----PNDIF---ADLESYPDFSEIAN MOUSE15_70_PE1 PEGPG--FSRQVLWINACFCNLSCRN-----PNDIF---ADLESYPDFEEIAN CHICK2_151_PE14 PDGTE--ISWKIMWINACFCNLNCKN-----PNDIF---ADLAHYHDYSEIAN XENTR496_1_PE19 PDGSG--FTWNVMWINACFCNLSCRK-----PNDIF---ADLQSYHDYTEIV- TETNG21_1_PE42 PNGTG--FSWKMLWIQACFCNLSCRN-----PNDIF---TELDSYYGYSEIVN DANRE16_31_PE15 PDGAL--LTWKYMWINACFCNLSCRN-----PNDIF---ADLEQYYEFNEIVN DANRE19_35_PE7 PNGPG--FTWQVMWINACFCNLSCKN-----PNDIF---TDLEQYHEKREI-- DANRE20_1_PE8 KGGSN--VRWKMQWITSCVCQRKCSN-----ADDMF---SELHLI-------- CHICK3_71_PE3 PNEGF--FKWKMMWITSCVCQRICSD-----PGDIF---SELKIL-------- HS6_118_PE4 PNEGS--FKWKMLWITSCVCQRNCRE-----PGDIF---SELKIL-------- MOUSE10_41_PE4 PSEGS--FKWQMLWVTSCVCQRDCRE-----PGDIF---SELRIL-------- BRAFL_PE22461 EDRTP--IKQDVAWIHSCTCHRNCPL-----A--------------------- BRAFL_PE49250 EDRTP--IKQDVAWIHSCTCHRNCPL-----A--------------------- DANRE23_26_PE17 PGGRL--LNHAVMTINSCICHYNCPY-----SSRGT------SFWG------- DANRE5_32_PE16 PEAERHDFTRSLMWIQRCSCRHTHSRRGLNTPAELF------NLPNDIHTYTH DANRE8_56_PE23 PDGEN--ITRSVMWIQTCRCSKSFCR-----AKRGR-SSPAVSLHNDIHTFTH TETNG8_6_PE12 TNGKS--ARRPVMVILTCVCHTHCPR-----DNAVW----------------- XENTR330_1_PE18 PQKRI--IKKPVMVVSTCVCHYNCPR-----DASLL--QVDNARFPGLNTNL- CHICK2_146_PE4 PQGKF--LKKPMMLINTCVCHGNCPQ-----SNNAF--FQPLDPMSSEAKI-- HS8_125_PE3 SPGQI--VKKPVMVIGTCTCHTNCPK-----NNEAF--LQELELKTTRGKM-- MOUSE15_57_PE3 LPGEI--IKKPVMVIGTCTCYSNCPQ-----NNEAF--LQDLELKTSRGEI-- DANRE5_69_PE7 PEGDS--FRKKMMFIKTCSCHHNCPR-----ENDIFLASNSRRMIGDYENDM- XENTR200_2_PE6 PDGEI--MKKNMMFIKTCACHSNCPG-----DNDIFEAMYYRKMYGDMA---- HS6_138_PE20 PDGEV--MKKNMMFIKTCACHYNCPG-----DNDIFESLYYRKMYGDMA---- CHICK3_62_PE8 PDGEI--MKRKMMFIKTCACHYNCPG-----DNDIFESLYYRKMYGDMA---- MOUSE10_26_PE4 PDGEI--MKKNMMFIKTCACHYNCPG-----DNDIFESLYYRKMYGDMA---- TETNG14_7_PE75 PDGQV--MKKHMMFIKSCACHYNCPG-----ENDIFESMYYKKMVGDMA---- DANRE20_26_PE5 PDGQV--MKKQMMFIKTCACHYNCPG-----ENDIFESMYYKKMVGDMA---- XENTR667_1_PE24 DDGDT--FQKSVMWVQKCKCHRDCPY-----PSQLS--YPHYRLHNDIHTFTD DANRE21_14_PE1 PTGER--FERAVMFVQSCKCNDDCGS-----LNDAS-LPPQRWLYGDMHKFID DANRE23_45_PE13 QDGET--FNKNVMMIESCKCTKHCPH-----ASEAG--FPFYRLYNDIHKFTD TETNG1_21_PE52 EDGET--FNKNIMVIESCKCTYNCPH-----VNEAS--YPFYRLSNDIHKFRD HS1_91_PE6 EDGET--FSKNVMMIQSCKCNYNCPH-----ANEAA--FPFYRLFNDIHKFRD MOUSE3_149_PE17 EDGEM--FSKNVMMIQSCKCNYNCPH-----PNEAS--FRLYSLFNDIHKFRD CHICK8_18_PE4 DDGET--FTKSVMMIQSCRCNYNCPH-----ANEAY---PFYRLVNDIHKFRD XENTR6_3_PE16 EDGET--FTKNVMMIQSCRCNYNCPH-----ANEAY---PYYRLFNDIHKFRD TETNG9_11_PE17 LTGVL--IRRPVMMIHSCVCGDTC----------------------------- XENTR48_3_PE12 RGGLT---WKQMMSIISCVCY-------------------------------- CHICK20_6_PE35 SDG-------------------------------------------------- HS20_43_PE43 ----------------------------------------------------- MOUSE2_167_PE11 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