Introduction to Multiple Sequence Alignment

Thursday 17th February 2011

EMBL Hamburg, Germany

Aidan Budd and Toby Gibson

Sequence alignment lies at the core of many bioinformatics tools - particularly in the field of protein bioinformatics. Thus, an awareness of:
are all useful for biologists who need to critically interpret alignments, and calculate/build them for their own analyses

This half-day course aims to provide an introduction to these issues for biologists who either have no (or limited) previous experience using alignments.


12.00 - 13.00
  • Introduction
  • Alternative interpretations of alignments
    • structural
    • evolutionary
    • situations where interpretations are not equivalent
13.00 - 14.00 Lunch
14.00 - 15.30
  • Examining multiple sequence alignments (MSAs)
  • A work-flow for building an MSA from A-Z
15.30 - 16.00 Coffee
16.00 - 17.30
  • A work-flow for building an MSA from A-Z (cont.)
  • Features of difficult-to-align sequence sets



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