Protein Evolution
Friday 30th January 2009
Aidan
Budd and Francesca Diella
Activity 2: Exploring Protein Structure and Function
In many cases, one can infer general characteristics of the function of
a protein just by examining its structure.
Below is a list of PyMOL files describing the structure of proteins,
each of which has a rather different function - represented are
- an enzyme
- a DNA-binding transcription factor
- a protein forming a rigid, rod-like support structure (collagen)
- a signaling molecule that binds to calcium (calmodulin)
Struct1 Struct2 Struct3 Struct4
By examining the structures of these proteins, try and decide which
structure corresponds to which of these four functions.
If there is time, you might want to explore more information about the
structures of these proteins as provided by the PDBsum database. For example,
you might want to identify, for some of these structures:
- the organism the protein comes from
- the names of any diseases it is known to be involved in
- the sequence of the protein
Follow the links below to the UniProt and PDBsum records for these
entries:
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