Home People Cytosim Publications Misc


Julio Belmonte


I am funded by an EIPOD fellowship between the Leptin and Nedelec groups. Development of multi-cellular organisms involves coordinated large-scale changes of tissues, where cells differentiate, change shape and produce local deforming forces that give rise to new structures. In my project I combine experimental and simulation techniques to understand how different cells in the Drosophila embryo generate and transmit forces during gastrulation.


Serge Dmitrieff


Membranes are what define the cells and their compartments as distinct biological units. However, they can also be seen as a ubiquitous trafficking platform. I study how the membrane mechanics play a role in intracellular transport. Transport phenomena also involve reorganization of the cytoskeleton, and we study the coupling of membrane with actin and microtubules.

Personal website

Aastha Mathur

Bridging postdoc

Across various cellular systems, cytoskeletal rearrangement is known to drive even the most drastic morphological changes. I work to gain mechanistic under- standing of such a process in platelets. Enucleate cell fragments of 2-3μm diameter, platelets play an important role in blood clotting. Combining dynamic informa- tion from live cell microscopy with structural information from electron tomogra- phy into a computational model in Cytosim, I want to elucidate how competitive forces between actin and microtubules maintain the resting shape as well as drive the changes in morphology during activation platelets.


Francois Nedelec

Group leader

Our long-term research objective is to understand cytoskeletal organization in living cells, with an emphasis on mitosis. We develop in-vitro assays, quantitative image analysis and cytosim, a computer simulation to study cellular architecture from a mechanistic perspective, modeling the interactions of fibers and associated proteins such as molecular motors. At the moment, I am finishing up the next version of Cytosim.


Manuel Lera Ramirez

PhD Student

Mitotic spindles are bipolar strucutres made of microtubules, that form in eukaryotic cells during mitosis to segregate chromosomes to the two daughter cells. Its correct assembly, positioning and timely movements are crucial to safeguard a normal outcome of mitosis. The work of many cell biologists, biophysicist in the past 50 years have given us a precise idea of the components of the spindle, but we still lack a model that can explain mechanistically how these components assemble to form the spindle.


Herve Turlier


My research is focused on the theoretical description of cell shapes dynamics. Using analytical and simulation methods, I’m particularly working on the morphogenesis of one to a few interacting cells in the early mouse embryo, in collaboration with the group of Takashi Hiiragi.