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Heidelberg, 19 April 2018 Dog microbiome closer to humans' than expected Dog and human gut microbiomes have more similar genes and responses to diet than previously thought, according to a study by EMBL scientist Luis Pedro Coelho and colleagues from the Bork group, published in Microbiome on April 19.
Rome, 26 March 2018 Captured on film for the first time: microglia nibbling on brain synapses Laetitia Weinhard, Cornelius Gross, and colleagues from EMBL Rome and the Schwab team have captured microglia nibbling on brain synapses. Their findings show that the special glial cells help synapses grow and rearrange, demonstrating the essential role of microglia in brain development. Nature Communications publishes the results on March 26.
Heidelberg, 22 March 2018 LifeTime - a visionary proposal for an EU Flagship Reliably predicting the onset and trajectory of a disease might seem like a distant dream. But a European consortium is aiming to achieve exactly this using a set of emerging technologies with the analysis of single cells at their core. Leading scientists - amongst whom several from EMBL - have now submitted the proposal for a FET Flagship called LifeTime.
Heidelberg, 19 March 2018 Molecular cuisine for gut bacteria Scientific recipes to successfully grow and study gut bacteria in the lab: that’s what EMBL scientists from the Bork, Patil, and Typas groups are publishing in Nature Microbiology on March 19. They report on the nutritional preferences and growth characteristics of 96 diverse gut bacterial strains. Their results will help scientists worldwide advance our understanding of the gut microbiome.
Heidelberg, 19 March 2018 Commonly used drugs affect our gut bacteria One in four drugs with human targets inhibit the growth of bacteria in the human gut. These drugs cause antibiotic-like side-effects and may promote antibiotic resistance, EMBL researchers from the Bork, Patil, Typas, and Zeller groups report in Nature on March 19.
Heidelberg, 15 March 2018 Potential new way to limit antibiotic resistance spreading One of the biggest current threats to global health is the rise of multi-drug resistant bacteria, caused by the spreading of antibiotic resistance amongst them. In an attempt to help fight this threat, EMBL researchers Anna Rubio-Cosials, Orsolya Barabas, and colleagues have unraveled the molecular basis of a major antibiotic resistance transfer mechanism. They also developed molecules and a proof-of-principle for blocking this transfer. Cell publishes their results on March 15.
Heidelberg, 14 March 2018 Chromatin usage in individual cells reveals developmental trajectories Both cell type and developmental stage can be deduced from chromatin accessibility measurements in thousands of single cells, researchers from the Furlong group at EMBL and the University of Washington show. They used this approach to uncover how cells in developing embryos regulate their identity as they decide what kind of cell to become. Nature publishes the results on March 14.
Heidelberg, 7 March 2018 Accelerating antibody discovery New EMBL spinoff company Velabs Therapeutics strives to speed up the discovery of new and better therapeutic antibodies, by making a new microfluidics platform - developed by EMBL group leader Christoph Merten - available to the global antibody research community.
Heidelberg, 22 February 2018 Synchronised waves control embryonic patterning During an embryo’s journey from a single cell to a complex organism, countless patterning processes make sure that the right cells develop in exactly the right location and at the right time. Cells activate specific genes in a rhythmic manner during this early development, resulting in waves of activation sweeping through the embryo. Scientists from the Aulehla and Merten labs at EMBL now show that the rhythm between two specific sets of waves – controlled by the Wnt and Notch pathways – enables the formation of new segments. The journal Cell published their results on February 22.
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