Heidelberg, 13 December 2013 Without rings, chromosome arms get broken You hop on the train, turn around to say goodbye, and the announcement sounds: ‘doors closing’. If you ignore the warning for the sake of one last wave to a friend on the platform, the doors may bruise you, but they won’t cut off your arm. Dividing yeast cells, are more ruthless, the Haering group at EMBL Heidelberg have discovered.
Heidelberg, 5 December 2013 Light at the ends of the tunnel When scientists in the Beck group at EMBL Heidelberg determined what one of the nuclear pore’s main building blocks – Nup107 – looks like and how it is arranged, they found clues to the flexibility of this tunnel into the nucleus. Their study was recently featured on the cover of Cell.
Heidelberg, 1 December 2013 Chance and influence Whether a cell in a mammal’s embryo develops into the animal’s body or becomes the placenta and accompanying tissues isn’t sealed at the start, scientists at EMBL Heidelberg have discovered. Starting with random variation, cells gradually change until they split into the two populations that will become either the body or ‘extra-embryonic’ tissues.
Heidelberg, 19 November 2013 Growing bubbles Scientists now have a new tool to study interactions between proteins and the lipids that form the cell's membranes, by producing tiny ‘bubbles’ of artificial membrane. The new technique, recently published in Nature Methods, was developed by Anne-Claude Gavin and colleagues at EMBL Heidelberg.
Heidelberg, 16 September 2013 Playing ‘Who’s who?’ with atoms In the Carlomagno group’s molecular version of ‘Who’s who’, Alexander Marchanka at EMBL Heidelberg has devised a whole new suite of ‘questions’ to enable researchers to identify the atoms in an RNA molecule by solid-state NMR. The work is featured on the cover of Angewandte Chemie.
Heidelberg, 4 September 2013 It's not just noise Scientists at EMBL Heidelberg have shown that specific exons – parts our genes are broken up into – are important to the functioning of human organs. The findings, published in PNAS, highlight finely tuned, crucial events within a seemingly chaotic landscape and provide a rich resource for the study of genetics relating to human health and disease.
Heidelberg, 7 August 2013 HeLa genome online The genome of a HeLa cell line, sequenced by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, is now available to scientists online, following an agreement between the National Institutes of Health (NIH), in the USA, and representatives of the Lacks family.
Heidelberg, 18 July 2013 GSK joins EMBL’s Corporate Partnership Programme GSK/Cellzome, a subsidiary of global healthcare company GlaxoSmithKline, and the European Molecular Biology Laboratory (EMBL) have signed a corporate partnership agreement whereby GSK will support the EMBL Advanced Training Centre in Heidelberg for three years with funding for conferences and training. In return, GSK will gain access to EMBL’s state-of-the-art training facilities and may take on an advisory role to identify topics for future conferences, seminars and workshops.
Heidelberg/Hinxton, 5 June 2013 EMBL joins Global Alliance for sharing genomic and clinical data EMBL have joined the Global Alliance, a large-scale, international effort to enable the secure sharing of genomic and clinical data, by establishing an evidence base for genomic research and medicine that adheres to the highest standards of ethics and privacy.
Heidelberg, 16 May 2013 Strengthening EMBL-Argentine relations On 9 May, the Argentinean flag flew over EMBL’s headquarters in Heidelberg, Germany, as the laboratory welcomed Lino Barañao, Argentine Minister of Science, Technology and Productive Innovation, and Agueda Menvielle, National Directress of International Relations. The visit took place in the context of a continuing commitment by EMBL and the Argentine Republic to enhance strategic scientific cooperation.
Hinxton, 11 April 2013 Perfect proteins preferred Uncontrolled inflammation has been linked to the onset of many diseases, from rheumatoid arthritis to certain cancers. One of the key enzymes in triggering inflammation, the Tank-binding kinase I (TBKI), is attracting an increasing attention as a potential drug-target in the fight against several diseases. Researchers at EMBL Grenoble have published the high-resolution 3D structure of this enzyme, both in its active and its inactive forms, in Cell Reports. This finding could have widespread consequences for the design of new drug-candidates.
Grenoble, 18 March 2013 Zooming in on inflammation Uncontrolled inflammation has been linked to the onset of many diseases, from rheumatoid arthritis to certain cancers. One of the key enzymes in triggering inflammation, the Tank-binding kinase I (TBKI), is attracting an increasing attention as a potential drug-target in the fight against several diseases. Researchers at EMBL Grenoble have published the high-resolution 3D structure of this enzyme, both in its active and its inactive forms, in Cell Reports. This finding could have widespread consequences for the design of new drug-candidates.
Heidelberg, 25 February 2013 Yeast’s fusional relationships Yeast get involved in preliminaries too: cells of opposite mating types ‘tickle’ each other with pheromones to trigger attraction and prepare for mating. They then fuse their external membranes to yield one cell with two nuclei, and there is no going back: the two nuclei must come together to become one, so the resulting yeast cell can inherit the genetic information from its two ‘parents’. Researchers at EMBL have elucidated a crucial mechanism of this two-step relationship: how the two nuclei move and get close enough to be able to fuse. Their findings were published in February 2013 in Genes & Development.