Hinxton, 16 July 2018 Europe PMC now indexes preprints Europe PMC, the discovery platform for life science literature, based at the European Bioinformatics Institute (EMBL-EBI), will include preprint abstracts in the search results, alongside peer-reviewed content, to make science reported in preprints readily discoverable. To begin with, over 37 000 preprints will be available in Europe PMC from July 10, 2018.
Heidelberg, 12 July 2018 Parental chromosomes kept apart during embryo’s first division It was long thought that during an embryo’s first cell division, one spindle is responsible for segregating the embryo’s chromosomes into two cells. EMBL scientists from the Ellenberg group now show that there are actually two spindles, one for each set of parental chromosomes, meaning that the genetic information from each parent is kept apart throughout the first division. Science publishes the results – bound to change biology textbooks – on 12 July 2018.
Hinxton, 10 July 2018 Leukaemia roots detectable years before diagnosis Researchers in the Gerstung group at EMBL-EBI and collaborators have discovered that it is possible to identify people at high risk of developing acute myeloid leukaemia (AML) years before they suddenly develop the disease. Published in Nature, the study found that blood tests looking for changes in DNA code can reveal the roots of AML in healthy people. Further research could allow earlier detection and monitoring of people at risk of AML in the future, and open the prospect of developing ways to reduce the likelihood of developing this cancer.
Heidelberg, 6 July 2018 Melting bacteria to decipher antibiotic resistance With antibiotic resistance spreading worldwide, there is a strong need for new technologies to study bacteria. EMBL researchers from the Savitski and Typas groups have adapted an existing technique to study the melting behaviour of proteins so that it can be used for the study of bacteria. Molecular Systems Biology published their results – allowing researchers worldwide to start using the technique – on July 6.
Heidelberg, 4 July 2018 Combining antibiotics changes their effectiveness The effectiveness of antibiotics can be altered by combining them with each other, non-antibiotic drugs or even with food additives. Depending on the bacterial species, some combinations stop antibiotics from working to their full potential whilst others begin to defeat antibiotic resistance, report EMBL researchers from the Typas group and collaborators in Nature on July 4.
Heidelberg, 29 June 2018 Algal nuclear pore complex revealed Researchers from the Beck group at EMBL, and collaborators have revealed the structure of the NPC of the alga Chlamydomonas reinhardtii, in a paper published in Nature Communications. Their research reveals that there are striking differences between the human and the algal NPC.
Grenoble, 26 June 2018 Flu’s response to new drug explored The new influenza drug Xofluza was approved for clinical use in Japan in February 2018. Scientists from the Cusack group at EMBL Grenoble have now investigated the drug’s mode of action in detail, and uncovered possible mechanisms by which viral resistance to it could emerge. Scientific Reports published the results of this collaboration between scientists from EMBL and Japanese pharmaceutical company Shionogi on 25 June.
Heidelberg, 22 June 2018 Miniature testing of drug pairs on tumour biopsies Combinations of cancer drugs can be quickly and cheaply tested on tumour cells using a novel device developed by EMBL scientists from the Merten group. The research, reported in Nature Communications on June 22, marks the latest advancement in the field of personalised medicine.