EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Personal Assistant
Kirsi Heerde
Room: 209-212
Tel: +49 6221 387- 8201
Fax: +49 6221 387- 8211
E-mail: dg-office@embl.org


  • PhD 1979, University of Leeds, UK.
    Postdoctoral work at the Friedrich Miescher Institute and the Biocenter, Basel, Switzerland.
    Group Leader at EMBL since 1985.
    Programme Coordinator since 1990.
    Scientific Director of EMBL 1999-2005.
    Director General since 2005.


Total: 239 publication(s)


Christodoulou A, Santarella-Mellwig R, Santama N, Mattaj IW. (2016)

Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells.

J. Cell. Sci. 129(8):1552-65-1565. doi: 10.1242/jcs.175273
Europe PMC | doi


Yokoyama H, Koch B, Walczak R, Ciray-Duygu F, González-Sánchez JC, Devos DP, Mattaj IW, Gruss OJ. (2014)

The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation.

Nat Commun 5:3270. doi: 10.1038/ncomms4270
Europe PMC | doi


Yokoyama H, Nakos K, Santarella-Mellwig R, Rybina S, Krijgsveld J, Koffa MD, Mattaj IW. (2013)

CHD4 is a RanGTP-dependent MAP that stabilizes microtubules and regulates bipolar spindle formation

Curr. Biol. 23(24):2443-2451. doi: 10.1016/j.cub.2013.09.062
Europe PMC | doi

Dekker J, Wysocka J, Mattaj I, Lieberman Aiden E, Pikaard C. (2013)

Nuclear biology: what's been most surprising?

Cell 152(6):1207-1208. doi: 10.1016/j.cell.2013.02.041
Europe PMC | doi

Santarella-Mellwig R, Pruggnaller S, Roos N, Mattaj IW, Devos DP. (2013)

Three-dimensional reconstruction of bacteria with a complex endomembrane system

PLoS Biol. 11(5):e1001565. doi: 10.1371/journal.pbio.1001565
Europe PMC | doi


Mall M, Walter T, Gorjánácz M, Davidson IF, Nga Ly-Hartig TB, Ellenberg J, Mattaj IW. (2012)

Mitotic lamin disassembly is triggered by lipid-mediated signaling

J. Cell Biol. 198(6):981-990. doi: 10.1083/jcb.201205103
Europe PMC | doi

Tooze J, Mattaj I, Rorth P, Pulverer B. (2012)

Evolution and revolution at The EMBO Journal

EMBO J 31(15):3231-3233. doi: 10.1038/emboj.2012.208

Asencio C, Davidson IF, Santarella-Mellwig R, Ly-Hartig TB, Mall M, Wallenfang MR, Mattaj IW, Gorjánácz M. (2012)

Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis

Cell 150(1):122-135. doi: 10.1016/j.cell.2012.04.043
Europe PMC | doi

Borrego-Pinto J, Jegou T, Osorio DS, Auradé F, Gorjánácz M, Koch B, Mattaj IW, Gomes ER. (2012)

Samp1 is a component of TAN lines and is required for nuclear movement

J. Cell. Sci. 125(Pt 5):1099-1105. doi: 10.1242/jcs.087049
Europe PMC | doi


Symens N, Walczak R, Demeester J, Mattaj I, De Smedt SC, Remaut K. (2011)

Nuclear inclusion of nontargeted and chromatin-targeted polystyrene beads and plasmid DNA containing nanoparticles

Mol. Pharm. 8(5):1757-1766. doi: 10.1021/mp200120v
Europe PMC | doi

Simons K, Mattaj IW. (2011)

Retrospective. Lennart Philipson (1929-2011)

Science 333(6043):711. doi: 10.1126/science.1210990
Europe PMC | doi

Mall M, Walter T, Gorjanacz M, Ellenberg J, Mattaj IW. (2011)

Mitotic Lamin disassembly is triggered by a lipid-mediated mitotic Lipin signaling pathway



Mattaj IW. (2010)

It's the Technology, Stupid

Mol. Biol. Cell 21(22):3805-3806. doi: 10.1091/mbc.e10-04-0342
Europe PMC | doi

Mattaj IW, Müller CW. (2010)

Solving the NES problem

Nat. Struct. Mol. Biol. 17(11):1288-1289. doi: 10.1038/nsmb1110-1288
Europe PMC | doi

Symens N, Walzack R, Demeester J, Mattaj I, De Smedt SC, Remaut K. (2010)

Nuclear inclusion of inert and chromatin-targeted polystyrene spheres and plasmid DNA containing nanoparticles

J Control Release 148(1):e96-8. doi: 10.1016/j.jconrel.2010.07.071
Europe PMC | doi

Yavuz S, Santarella-Mellwig R, Koch B, Jaedicke A, Mattaj IW, Antonin W. (2010)

NLS-mediated NPC functions of the nucleoporin Pom121

FEBS Lett. 584(15):3292-3298. doi: 10.1016/j.febslet.2010.07.008
Europe PMC | doi

Mattaj IW. (2010)

Coordinated action needed for Europe's research programmes

Nature 465(7301):1005. doi: 10.1038/4651005a
Europe PMC | doi

Santarella-Mellwig R, Franke J, Jaedicke A, Gorjanacz M, Bauer U, Budd A, Mattaj IW, Devos DP. (2010)

The compartmentalized bacteria of the planctomycetes-verrucomicrobia-chlamydiae superphylum have membrane coat-like proteins

PLoS Biol. 8(1):e1000281. doi: 10.1371/journal.pbio.1000281
Europe PMC | doi


Platani M, Santarella-Mellwig R, Posch M, Walczak R, Swedlow JR, Mattaj IW. (2009)

The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex

Mol. Biol. Cell 20(24):5260-5275. doi: 10.1091/mbc.e09-05-0377
Europe PMC | doi

Yokoyama H, Rybina S, Santarella-Mellwig R, Mattaj IW, Karsenti E. (2009)

ISWI is a RanGTP-dependent MAP required for chromosome segregation

J. Cell Biol. 187(6):813-829. doi: 10.1083/jcb.200906020
Europe PMC | doi

Gorjánácz M, Mattaj IW. (2009)

Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans

J. Cell. Sci. 122(Pt 12):1963-1969. doi: 10.1242/jcs.044750
Europe PMC | doi


Casanova CM, Rybina S, Yokoyama H, Karsenti E, Mattaj IW. (2008)

Hepatoma up-regulated protein is required for chromatin-induced microtubule assembly independently of TPX2

Mol. Biol. Cell 19(11):4900-4908. doi: 10.1091/mbc.e08-06-0624
Europe PMC | doi

Hawryluk-Gara LA, Platani M, Santarella R, Wozniak RW, Mattaj IW. (2008)

Nup53 is required for nuclear envelope and nuclear pore complex assembly

Mol. Biol. Cell 19(4):1753-1762. doi: 10.1091/mbc.e07-08-0820
Europe PMC | doi

Yokoyama H, Gruss OJ, Rybina S, Caudron M, Schelder M, Wilm M, Mattaj IW, Karsenti E. (2008)

Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate

J. Cell Biol. 180(5):867-875. doi: 10.1083/jcb.200706189
Europe PMC | doi

Galy V, Antonin W, Jaedicke A, Sachse M, Santarella R, Haselmann U, Mattaj I. (2008)

A role for gp210 in mitotic nuclear-envelope breakdown

J. Cell. Sci. 121(Pt 3):317-328. doi: 10.1242/jcs.022525
Europe PMC | doi

Cohen M, Santarella R, Wiesel N, Mattaj I, Gruenbaum Y. (2008)

Electron microscopy of lamin and the nuclear lamina in Caenorhabditis elegans

Methods Cell Biol. 88:411-429. doi: 10.1016/s0091-679x(08)00421-4
Europe PMC | doi

Kitao S, Segref A, Kast J, Wilm M, Mattaj IW, Ohno M. (2008)

A compartmentalized phosphorylation/dephosphorylation system that regulates U snRNA export from the nucleus

Mol. Cell. Biol. 28(1):487-497. doi: 10.1128/mcb.01189-07
Europe PMC | doi

Mattaj I. (2008)

Comments from the European Molecular Biology Laboratory

Dis Model Mech 1(1):16. doi: 10.1242/dmm.000794
Europe PMC | doi


Arai K, Cech T, Chameau JL, Horn P, Mattaj I, Potocnik J, Wiley J. (2007)

The future of research universities. Is the model of research-intensive universities still valid at the beginning of the twenty-first century?

EMBO Rep. 8(9):804-810. doi: 10.1038/sj.embor.7401052
Europe PMC | doi

Mattaj IW. (2007)

The Ran GTPase as a spatial regulator in mitosis

FEBS J 274:33.

Fortes P, Longman D, McCracken S, Ip JY, Poot R, Mattaj IW, Cáceres JF, Blencowe BJ. (2007)

Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation

FEBS Lett. 581(16):3087-3097. doi: 10.1016/j.febslet.2007.05.066
Europe PMC | doi

Gorjánácz M, Jaedicke A, Mattaj IW. (2007)

What can Caenorhabditis elegans tell us about the nuclear envelope?

FEBS Lett. 581(15):2794-2801. doi: 10.1016/j.febslet.2007.03.052
Europe PMC | doi

Mattaj IW, Tocchini-Valentini GP. (2007)

Laying solid foundations for Europe

Nature 447(7143):377-378. doi: 10.1038/447377a
Europe PMC | doi

Franz C, Walczak R, Yavuz S, Santarella R, Gentzel M, Askjaer P, Galy V, Hetzer M, Mattaj IW, Antonin W. (2007)

MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly

EMBO Rep. 8(2):165-172. doi: 10.1038/sj.embor.7400889
Europe PMC | doi

Ribbeck K, Raemaekers T, Carmeliet G, Mattaj IW. (2007)

A role for NuSAP in linking microtubules to mitotic chromosomes

Curr. Biol. 17(3):230-236. doi: 10.1016/j.cub.2006.11.050
Europe PMC | doi

Gorjánácz M, Klerkx EP, Galy V, Santarella R, López-Iglesias C, Askjaer P, Mattaj IW. (2007)

Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly

EMBO J. 26(1):132-143. doi: 10.1038/sj.emboj.7601470
Europe PMC | doi

Gorjánácz M, Mattaj IW, Rietdorf J. (2007)

Some Like It Hot

Imaging & Microscopy 9(1):28-29.
Europe PMC


Ulbert S, Antonin W, Platani M, Mattaj IW. (2006)

The inner nuclear membrane protein Lem2 is critical for normal nuclear envelope morphology

FEBS Lett. 580(27):6435-6441. doi: 10.1016/j.febslet.2006.10.060
Europe PMC | doi

Galy V, Askjaer P, Franz C, López-Iglesias C, Mattaj IW. (2006)

MEL-28, a novel nuclear-envelope and kinetochore protein essential for zygotic nuclear-envelope assembly in C. elegans

Curr. Biol. 16(17):1748-1756. doi: 10.1016/j.cub.2006.06.067
Europe PMC | doi

Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW. (2006)

NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules

Mol. Biol. Cell 17(6):2646-2660. doi: 10.1091/mbc.e05-12-1178
Europe PMC | doi

Ulbert S, Platani M, Boue S, Mattaj IW. (2006)

Direct membrane protein-DNA interactions required early in nuclear envelope assembly

J. Cell Biol. 173(4):469-476. doi: 10.1083/jcb.200512078
Europe PMC | doi

Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW. (2006)

HURP is part of a Ran-dependent complex involved in spindle formation

Curr. Biol. 16(8):743-754. doi: 10.1016/j.cub.2006.03.056
Europe PMC | doi

Mansfeld J, Güttinger S, Hawryluk-Gara LA, Panté N, Mall M, Galy V, Haselmann U, Mühlhäusser P, Wozniak RW, Mattaj IW, Kutay U, Antonin W. (2006)

The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells

Mol. Cell 22(1):93-103. doi: 10.1016/j.molcel.2006.02.015
Europe PMC | doi

Czaplinski K, Mattaj IW. (2006)

40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-localization element

RNA 12(2):213-222. doi: 10.1261/rna.2820106
Europe PMC | doi

Schetter A, Askjaer P, Piano F, Mattaj I, Kemphues K. (2006)

Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans

Dev. Biol. 289(2):360-371. doi: 10.1016/j.ydbio.2005.10.038
Europe PMC | doi


Franz C, Askjaer P, Antonin W, Iglesias CL, Haselmann U, Schelder M, de Marco A, Wilm M, Antony C, Mattaj IW. (2005)

Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates

EMBO J. 24(20):3519-3531. doi: 10.1038/sj.emboj.7600825
Europe PMC | doi

Mattaj I. (2005)

EMBL's fourth decade

EMBO Rep. 6(10):904-907. doi: 10.1038/sj.embor.7400546
Europe PMC | doi

Czaplinski K, Köcher T, Schelder M, Segref A, Wilm M, Mattaj IW. (2005)

Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis

Dev. Cell 8(4):505-515. doi: 10.1016/j.devcel.2005.01.012
Europe PMC | doi

Becskei A, Mattaj IW. (2005)

Quantitative models of nuclear transport

Curr. Opin. Cell Biol. 17(1):27-34. doi: 10.1016/j.ceb.2004.12.010
Europe PMC | doi

Antonin W, Franz C, Haselmann U, Antony C, Mattaj IW. (2005)

The integral membrane nucleoporin pom121 functionally links nuclear pore complex assembly and nuclear envelope formation

Mol. Cell 17(1):83-92. doi: 10.1016/j.molcel.2004.12.010
Europe PMC | doi

Antonin W, Mattaj IW. (2005)

Nuclear pore complexes: round the bend?

Nat. Cell Biol. 7(1):10-12. doi: 10.1038/ncb0105-10
Europe PMC | doi

Hetzer MW, Walther TC, Mattaj IW. (2005)

Pushing the envelope: structure, function, and dynamics of the nuclear periphery

Annu. Rev. Cell Dev. Biol. 21:347-380. doi: 10.1146/annurev.cellbio.21.090704.151152
Europe PMC | doi


Petosa C, Schoehn G, Askjaer P, Bauer U, Moulin M, Steuerwald U, Soler-López M, Baudin F, Mattaj IW, Müller CW. (2004)

Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex

Mol. Cell 16(5):761-775. doi: 10.1016/j.molcel.2004.11.018
Europe PMC | doi

Koffa MD, Schatz CA, Kocher T, Wilm M, Mattaj IW. (2004)

Identification of a Ran - Regulated complex involved in spindle bipolarity


Santarella RA, Mattaj IW, Hoenger A, Ribbeck K. (2004)

NuSAP appears to promote microtubule growth by catalyzing the assembly of protofilaments


Yamada M, Mattaj IW, Yoneda Y. (2004)

An ATP-dependent activity that releases RanGDP from NTF2

J. Biol. Chem. 279(35):36228-36234. doi: 10.1074/jbc.m403101200
Europe PMC | doi

Hachet V, Köcher T, Wilm M, Mattaj IW. (2004)

Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro

EMBO J. 23(7):1526-1535. doi: 10.1038/sj.emboj.7600154
Europe PMC | doi

Mattaj IW. (2004)

Sorting out the nuclear envelope from the endoplasmic reticulum

Nat. Rev. Mol. Cell Biol. 5(1):65-69. doi: 10.1038/nrm1263
Europe PMC | doi


Galy V, Mattaj IW, Askjaer P. (2003)

Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo

Mol. Biol. Cell 14(12):5104-5115. doi: 10.1091/mbc.e03-04-0237
Europe PMC | doi

Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M. (2003)

RanGTP mediates nuclear pore complex assembly

Nature 424(6949):689-694. doi: 10.1038/nature01898
Europe PMC | doi

Schatz CA, Santarella R, Hoenger A, Karsenti E, Mattaj IW, Gruss OJ, Carazo-Salas RE. (2003)

Importin alpha-regulated nucleation of microtubules by TPX2

EMBO J. 22(9):2060-2070. doi: 10.1093/emboj/cdg195
Europe PMC | doi

Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V. (2003)

The conserved Nup107-160 complex is critical for nuclear pore complex assembly

Cell 113(2):195-206. doi: 10.1016/s0092-8674(03)00235-6
Europe PMC | doi

Becskei A, Mattaj IW. (2003)

The strategy for coupling the RanGTP gradient to nuclear protein export

Proc. Natl. Acad. Sci. U.S.A. 100(4):1717-1722. doi: 10.1073/pnas.252766999
Europe PMC | doi


Askjaer P, Galy V, Hannak E, Mattaj IW. (2002)

Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos

Mol. Biol. Cell 13(12):4355-4370. doi: 10.1091/mbc.e02-06-0346
Europe PMC | doi

Mazza C, Segref A, Mattaj IW, Cusack S. (2002)

Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering

Acta Crystallogr. D Biol. Crystallogr. 58(Pt 12):2194-2197. doi: 10.1107/s0907444902015445
Europe PMC | doi

Gruss OJ, Wittmann M, Yokoyama H, Pepperkok R, Kufer T, Silljé H, Karsenti E, Mattaj IW, Vernos I. (2002)

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells

Nat. Cell Biol. 4(11):871-879. doi: 10.1038/ncb870
Europe PMC | doi

Hetzer MW, Bilbao-Cortes D, Langst G, Becker PB, Mattaj IW. (2002)

The role of Ran GTPase in NE formation


Schatz CA, Mattaj IW. (2002)

Importin alpha is sufficient to regulate TPX2 microtubule nucleation activity

MOL BIOL CELL 13:188A-189A.

Walther TC, Pickersgill HS, Cordes VC, Goldberg MW, Allen TD, Mattaj IW, Fornerod M. (2002)

The cytoplasmic filaments of the nuclear pore complex are dispensible for selective nuclear import

MOL BIOL CELL 13:381A-382A.

Mazza C, Segref A, Mattaj IW, Cusack S. (2002)

Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex

EMBO J. 21(20):5548-5557. doi: 10.1093/emboj/cdf538
Europe PMC | doi

Massenet S, Pellizzoni L, Paushkin S, Mattaj IW, Dreyfuss G. (2002)

The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway

Mol. Cell. Biol. 22(18):6533-6541. doi: 10.1128/mcb.22.18.6533-6541.2002
Europe PMC | doi

Kuersten S, Arts GJ, Walther TC, Englmeier L, Mattaj IW. (2002)

Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains

Mol. Cell. Biol. 22(16):5708-5720. doi: 10.1128/mcb.22.16.5708-5720.2002
Europe PMC | doi

Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. (2002)

Ran binds to chromatin by two distinct mechanisms

Curr. Biol. 12(13):1151-1156. doi: 10.1016/s0960-9822(02)00927-2
Europe PMC | doi

Hetzer M, Gruss OJ, Mattaj IW. (2002)

The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly

Nat. Cell Biol. 4(7):E177-84. doi: 10.1038/ncb0702-e177
Europe PMC | doi

Walther TC, Pickersgill HS, Cordes VC, Goldberg MW, Allen TD, Mattaj IW, Fornerod M. (2002)

The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import

J. Cell Biol. 158(1):63-77. doi: 10.1083/jcb.200202088
Europe PMC | doi

Ohno M, Segref A, Kuersten S, Mattaj IW. (2002)

Identity elements used in export of mRNAs

Mol. Cell 9(3):659-671. doi: 10.1016/s1097-2765(02)00454-9
Europe PMC | doi


Hetzer M, Meyer HH, Walther TC, Bilbao-Cortes D, Warren G, Mattaj IW. (2001)

Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly

Nat. Cell Biol. 3(12):1086-1091. doi: 10.1038/ncb1201-1086
Europe PMC | doi

Kuersten S, Ohno M, Mattaj IW. (2001)

Nucleocytoplasmic transport: Ran, beta and beyond

Trends Cell Biol. 11(12):497-503. doi: 10.1016/s0962-8924(01)02144-4
Europe PMC | doi

Hetzer MW, Meyer HH, Walther TC, Warren G, Mattaj IW. (2001)

The AAA-ATPase p97 functions in two discrete steps of nuclear envelope formation


Englmeier L, Fornerod M, Bischoff FR, Petosa C, Mattaj IW, Kutay U. (2001)

RanBP3 influences interactions between CRM1 and its nuclear protein export substrates

EMBO Rep. 2(10):926-932. doi: 10.1093/embo-reports/kve200
Europe PMC | doi

Koffa MD, Clements JB, Izaurralde E, Wadd S, Wilson SA, Mattaj IW, Kuersten S. (2001)

Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway

EMBO J. 20(20):5769-5778. doi: 10.1093/emboj/20.20.5769
Europe PMC | doi

Walther TC, Fornerod M, Pickersgill H, Goldberg M, Allen TD, Mattaj IW. (2001)

The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins

EMBO J. 20(20):5703-5714. doi: 10.1093/emboj/20.20.5703
Europe PMC | doi

Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S. (2001)

Crystal structure of the human nuclear cap binding complex

Mol. Cell 8(2):383-396. doi: 10.1016/s1097-2765(01)00299-4
Europe PMC | doi

Carazo-Salas RE, Gruss OJ, Mattaj IW, Karsenti E. (2001)

Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly

Nat. Cell Biol. 3(3):228-234. doi: 10.1038/35060009
Europe PMC | doi

Segref A, Mattaj IW, Ohno M. (2001)

The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export

RNA 7(3):351-360. doi: 10.1017/s1355838201002278
Europe PMC | doi

Gruss OJ, Carazo-Salas RE, Schatz CA, Guarguaglini G, Kast J, Wilm M, Le Bot N, Vernos I, Karsenti E, Mattaj IW. (2001)

Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity

Cell 104(1):83-93. doi: 10.1016/s0092-8674(01)00193-3
Europe PMC | doi


Carazo-Salas RE, Mattaj IW, Karsenti E. (2000)

Many roles of the GTPase Ran during mitotic spindle assembly in Xenopus egg extracts


Walther TC, Fornerod M, Pickersgill H, Goldberg M, Allen T, Mattaj IW. (2000)

Effects of depletion of nucleoporins Nup153 and CAN/Nup214 on nuclear pore complex formation and nuclear transport


Fortes P, Inada T, Preiss T, Hentze MW, Mattaj IW, Sachs AB. (2000)

The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation

Mol. Cell 6(1):191-196. doi: 10.1016/s1097-2765(00)00020-4
Europe PMC | doi

Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. (2000)

GTP hydrolysis by Ran is required for nuclear envelope assembly

Mol. Cell 5(6):1013-1024. doi: 10.1016/s1097-2765(00)80266-x
Europe PMC | doi

Ohno M, Segref A, Bachi A, Wilm M, Mattaj IW. (2000)

PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation

Cell 101(2):187-198. doi: 10.1016/s0092-8674(00)80829-6
Europe PMC | doi

Varani L, Gunderson SI, Mattaj IW, Kay LE, Neuhaus D, Varani G. (2000)

The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein

Nat. Struct. Biol. 7(4):329-335. doi: 10.1038/74101
Europe PMC | doi

Vagner S, Rüegsegger U, Gunderson SI, Keller W, Mattaj IW. (2000)

Position-dependent inhibition of the cleavage step of pre-mRNA 3'-end processing by U1 snRNP

RNA 6(2):178-188. doi: 10.1017/s1355838200991854
Europe PMC | doi

Vagner S, Vagner C, Mattaj IW. (2000)

The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3'-end processing and splicing

Genes Dev. 14(4):403-413.
Europe PMC

Hetzer M, Mattaj IW. (2000)

An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins

J. Cell Biol. 148(2):293-303. doi: 10.1083/jcb.148.2.293
Europe PMC | doi


Mattaj IW. (1999)

The RanGTPase in nuclear export and spindle formation


Fortes P, Kufel J, Fornerod M, Polycarpou-Schwarz M, Lafontaine D, Tollervey D, Mattaj IW. (1999)

Genetic and physical interactions involving the yeast nuclear cap-binding complex

Mol. Cell. Biol. 19(10):6543-6553.
Europe PMC

Askjaer P, Bachi A, Wilm M, Bischoff FR, Weeks DL, Ogniewski V, Ohno M, Niehrs C, Kjems J, Mattaj IW, Fornerod M. (1999)

RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase

Mol. Cell. Biol. 19(9):6276-6285.
Europe PMC

Fortes P, Bilbao-Cortés D, Fornerod M, Rigaut G, Raymond W, Séraphin B, Mattaj IW. (1999)

Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition

Genes Dev. 13(18):2425-2438. doi: 10.1101/gad.13.18.2425
Europe PMC | doi

Carazo-Salas RE, Guarguaglini G, Gruss OJ, Segref A, Karsenti E, Mattaj IW. (1999)

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

Nature 400(6740):178-181. doi: 10.1038/22133
Europe PMC | doi