EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Personal Assistant
Kirsi Heerde
Room: 209-212
Tel: +49 6221 387- 8201
Fax: +49 6221 387- 8211
E-mail: dg-office@embl.org


  • PhD 1979, University of Leeds, UK.
    Postdoctoral work at the Friedrich Miescher Institute and the Biocenter, Basel, Switzerland.
    Group Leader at EMBL since 1985.
    Programme Coordinator since 1990.
    Scientific Director of EMBL 1999-2005.
    Director General since 2005.


Total: 239 publication(s)


Hamm J, Scherly D, Mattaj IW. (1988)

Small nuclear RNA-protein complexes

Biochem. Soc. Trans. 16(6):943-944. doi: 10.1042/bst0160943
Europe PMC | doi

Tebb G, Mattaj IW. (1988)

Positionally exact initiation is required for the formation of a stable RNA polymerase II transcription complex in vivo

EMBO J 7(12):3785-3792. doi: 10.1002/j.1460-2075.1988.tb03263.x
Europe PMC | doi

Mattaj IW, Dathan NA, Parry HD, Carbon P, Krol A. (1988)

Changing the RNA polymerase specificity of U snRNA gene promoters

Cell 55(3):435-442. doi: 10.1016/0092-8674(88)90029-3
Europe PMC | doi

Hamm J, van Santen VL, Spritz RA, Mattaj IW. (1988)

Loop I of U1 small nuclear RNA is the only essential RNA sequence for binding of specific U1 small nuclear ribonucleoprotein particle proteins

Mol. Cell Biol. 8(11):4787-4791. doi: 10.1128/MCB.8.11.4787
Europe PMC | doi

Dreyfuss G, Philipson L, Mattaj IW. (1988)

Ribonucleoprotein particles in cellular processes

J. Cell Biol. 106(5):1419-1425. doi: 10.1083/jcb.106.5.1419
Europe PMC | doi


Hamm J, Kazmaier M, Mattaj IW. (1987)

In vitro assembly of U1 snRNPs

EMBO J 6(11):3479-3485.
Europe PMC

Carbon P, Murgo S, Ebel JP, Krol A, Tebb G, Mattaj LW. (1987)

A common octamer motif binding protein is involved in the transcription of U6 snRNA by RNA polymerase III and U2 snRNA by RNA polymerase II

Cell 51(1):71-79. doi: 10.1016/0092-8674(87)90011-0
Europe PMC | doi

Kazmaier M, Tebb G, Mattaj IW. (1987)

Functional characterization of X. laevis U5 snRNA genes

EMBO J 6(10):3071-3078.
Europe PMC

Konings DA, Mattaj IW. (1987)

Mutant U2 snRNAs of Xenopus which can form an altered higher order RNA structure are unable to enter the nucleus

Exp. Cell Res. 172(2):329-339. doi: 10.1016/0014-4827(87)90391-0
Europe PMC | doi

Mattaj IW, Coppard NJ, Brown RS, Clark BF, De Robertis EM. (1987)

42S p48--the most abundant protein in previtellogenic Xenopus oocytes--resembles elongation factor 1 alpha structurally and functionally

EMBO J. 6(8):2409-2413.
Europe PMC

Tebb G, Bohmann D, Mattaj IW. (1987)

Only two of the four sites of interaction with nuclear factors within the Xenopus U2 gene promoter are necessary for efficient transcription

Nucleic Acids Res. 15(16):6437-6453. doi: 10.1093/nar/15.16.6437
Europe PMC | doi

Burglin TR, Mattaj IW, Newmeyer DD, Zeller R, Derobertis EM. (1987)

Cloning of nucleoplasmin from Xenopus laevis oocytes and analysis of its developmental expression

Gene. Dev. 1(1):97-107. doi: 10.1101/gad.1.1.97
Europe PMC | doi

Ciliberto G, Palla F, Tebb G, Mattaj IW, Philipson L. (1987)

Properties of a U1 RNA enhancer-like sequence

Nucleic Acids Res. 15(6):2403-2416. doi: 10.1093/nar/15.6.2403
Europe PMC | doi

Tollervey D, Mattaj IW. (1987)

Fungal small nuclear ribonucleoproteins share properties with plant and vertebrate U-snRNPs

EMBO J 6(2):469-476.
Europe PMC

Bohmann D, Keller W, Dale T, Schöler HR, Tebb G, Mattaj IW. (1987)

A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes

Nature 325(6101):268-272. doi: 10.1038/325268a0
Europe PMC | doi

Hamm J, Dathan N, Kazmaier M, Mattaj IW. (1987)

Functional roles of U snRNP components

Mol Biol Rep 12(3):174-175. doi: 10.1007/BF00356885

Tebb G, Kazmaier M, Parry H, Dathan N, Mattaj IW. (1987)

Transcription of Xenopus U snRNA genes

Mol Biol Rep 12(3):147-149. doi: 10.1007/BF00356870

Tebb G, Mattaj IW, Keller W, Bohmann D. (1987)

Characterization of an Enhancer-Binding Protein

In: Reznikoff WS, RNA Polymerase and the Control of Transcription, vol 16. Steenbock Symposium. pp 421-426.


Ciliberto G, Dathan N, Frank R, Philipson L, Mattaj IW. (1986)

Formation of the 3' end on U snRNAs requires at least three sequence elements

EMBO J 5(11):2931-2937.
Europe PMC

Mattaj IW. (1986)

Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding

Cell 46(6):905-911. doi: 10.1016/0092-8674(86)90072-3
Europe PMC | doi

Mattaj IW, Habets WJ, van Venrooij WJ. (1986)

Monospecific antibodies reveal details of U2 snRNP structure and interaction between U1 and U2 snRNPs

EMBO J 5(5):997-1002.
Europe PMC

Mattaj IW. (1986)

The role of RNA-protein interactions in intracellular targeting

In: Peters R, Trendelenburg M, Nucleocytoplasmic Transport. Nucleocytoplasmic Transport edn. Springer Verlag, Berlin Heidelberg. pp 275-285.


De Robertis EM, Fritz A, Goetz J, Martin G, Mattaj IW, Salo E, Smith GD, Wright C, Zeller R. (1985)

The Xenopus homeo boxes

Cold Spring Harb Symp Quant Biol 50:271-275. doi: 10.1101/SQB.1985.050.01.034
Europe PMC | doi

Mattaj IW, De Robertis EM. (1985)

Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins

Cell 40(1):111-118. doi: 10.1016/0092-8674(85)90314-9
Europe PMC | doi

Mattaj IW, Lienhard S, Jiricny J, De Robertis EM. (1985)

An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes

Nature 316(6024):163-167. doi: 10.1038/316163a0
Europe PMC | doi

Mattaj IW, Zeller R, Carrasco AE, Jamrich M, Lienhard S, De Robertis EM. (1985)

U snRNA gene families in Xenopus laevis

In: Maclean N, Oxford Surveys on Eukaryotic Genes, vol 2. Oxford University Press. pp 121-140.
Europe PMC


Zeller R, Carri MT, Mattaj IW, De Robertis EM. (1984)

Xenopus laevis U1 snRNA genes: characterisation of transcriptionally active genes reveals major and minor repeated gene families

EMBO J. 3(5):1075-1081.
Europe PMC

Brack C, Mattaj IW, Gautschi J, Cammisuli S. (1984)

Cyclosporin A is a differential inhibitor of eukaryotic RNA polymerases

Exp. Cell Res. 151(2):314-321. doi: 10.1016/0014-4827(84)90382-3
Europe PMC | doi

Mattaj IW. (1984)

SnRNAs: from gene architecture to RNA processing

Trends Biochem Sci 9(10):435-437. doi: 10.1016/0968-0004(84)90151-8



EXPERIENTIA 40(6):642.


Mattaj IW, Lienhard S, Zeller R, DeRobertis EM. (1983)

Nuclear exclusion of transcription factor IIIA and the 42s particle transfer RNA-binding protein in Xenopus oocytes: a possible mechanism for gene control?

J. Cell Biol. 97(4):1261-1265. doi: 10.1083/jcb.97.4.1261
Europe PMC | doi

Mattaj IW, Zeller R. (1983)

Xenopus laevis U2 snRNA genes: tandemly repeated transcription units sharing 5' and 3' flanking homology with other RNA polymerase II transcribed genes

EMBO J. 2(11):1883-1891.
Europe PMC

De Robertis EM, Zeller R, Carrasco A, Mattaj IW. (1983)

Nucleocytoplasmic transport of macromolecules in frog oocytes and embryos

In: Wyllie CC, McLaren A, British Society for Developmental Biology Symposia. Cambridge University Press. pp 377-391.

Geiser M, Mattaj IW, Wilks AF, Seldran M, Jost JP. (1983)

Structure and sequence of the promoter area and of a 5' upstream demethylation site of the estrogen-regulated chicken vitellogenin-II gene

J Biol Chem 258(14):9024-9030.
Europe PMC



EXPERIENTIA 39(6):668-669.


Mattaj IW, McPherson MJ, Wootton JC. (1982)

Localisation of a strongly conserved section of coding sequence in glutamate dehydrogenase genes

FEBS Lett. 147(1):21-25. doi: 10.1016/0014-5793(82)81003-x
Europe PMC | doi

Mattaj IW, Mackenzie A, Jost JP. (1982)

Cloning in a cosmid vector of complete 37 kb and 25 kb ribosomal DNA repeat units from the chicken

Biochim. Biophys. Acta 698(2):204-210. doi: 10.1016/0167-4781(82)90136-1
Europe PMC | doi

Wilks AF, Cozens PJ, Mattaj IW, Jost JP. (1982)

Estrogen induces a demethylation at the 5' end region of the chicken vitellogenin gene

Proc Natl Acad Sci USA 79(14):4252-4255. doi: 10.1073/pnas.79.14.4252
Europe PMC | doi


Wilks A, Cato AC, Cozens PJ, Mattaj IW, Jost JP. (1981)

Isolation and fine structure organisation of an avian vitellogenin gene coding for the major estrogen-inducible mRNA

Gene 16(1-3):249-259. doi: 10.1016/0378-1119(81)90081-0
Europe PMC | doi