EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Tel: +49 6221 387- 8201
Fax: +49 6221 387- 8211
|Assistant to the Director General / Head of Council Secretariat|
Tel: +49 6221 387-8288
Fax: +49 6221 387-8211
BA, 1986, University of Cambridge, UK.
PhD 1990, Imperial Cancer Research Fund Laboratory, London, UK.
Postdoctoral researcher and CNRS scientist, Institut Pasteur, Paris, France.
Group leader and Director of Genetics and Developmental Biology Unit, Institut Curie, Paris, France.
Professor, Collège de France, since 2012.
Director General, EMBL, since January 2019.
Group leader, EMBL, since January 2019.
2019 Hansen Family Award, 2019.
2020 elected to the Max Planck Society Senate.
2020 Cambridge University, Doctor of Science Honoris causa.
2020 L’Oréal-UNESCO prize for Women in Science International Award 2020.
Total: 140 publication(s)
Chaumeil J, Okamoto I, Heard E. (2004)
X-chromosome inactivation in mouse embryonic stem cells: analysis of histone modifications and transcriptional activity using immunofluorescence and FISH.
Heard E, Chaumeil J, Masui O, Okamoto I. (2004)
Mammalian X-chromosome inactivation: an epigenetics paradigm.
Rougeulle C, Chaumeil J, Sarma K, Allis CD, Reinberg D, Avner P, Heard E. (2004)
Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome.
Heard E. (2004)
Recent advances in X-chromosome inactivation.
Okamoto I, Otte AP, Allis CD, Reinberg D, Heard E. (2004)
Epigenetic dynamics of imprinted X inactivation during early mouse development.
Narita M, Nunez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW. (2003)
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
Xin Z, Tachibana M, Guggiari M, Heard E, Shinkai Y, Wagstaff J. (2003)
Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center.
Chaumeil J, Okamoto I, Guggiari M, Heard E. (2002)
Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells.
Rougeulle C, Heard E. (2002)
Antisense RNA in imprinting: spreading silence through Air.
Huang KC, Rao PH, Lau CC, Heard E, Ng SK, Brown C, Mok SC, Berkowitz RS, Ng SW. (2002)
Relationship of XIST expression and responses of ovarian cancer to chemotherapy.
Mol. Cancer Ther. 1(10):769-76.
Boggs BA, Cheung P, Heard E, Spector DL, Chinault AC, Allis CD. (2002)
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes.
Heard E. (2002)
The X-inactivation center; the XIST gene.
In: Campbell AM et al., Wiley Encyclopedia of Molecular Medicine. John Wiley & Sons, Inc..doi: 10.1002/0471203076
Monier K, Heliot L, Rougeulle C, Heard E, Robert-Nicoud M, Vourc'h C, Bensimon A, Usson Y. (2001)
Improvement of FISH mapping resolution on combed DNA molecules by iterative constrained deconvolution: a quantitative study.
Heard E, Rougeulle C, Arnaud D, Avner P, Allis CD, Spector DL. (2001)
Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation
Avner P, Heard E. (2001)
X-chromosome inactivation: Counting, choice and initiation
Heard E, Avner P. (2000)
Trans-Siberian X press report - International Symposium on X Chromosome Inactivation in Mammals, Institute of Cytology and Genetics, Novosibirsk, Russia, 6-12 September, 1999
Paper presented at the International Symposium on X Chromosome Inactivation in Mammals, Institute of Cytology and Genetics, Novosibirsk, Russia, 6–12 September 1999.Trends Genet. 16(2):64-65. doi: 10.1016/S0168-9525(99)01944-7
Europe PMC | doi
Debrand E, Chureau C, Arnaud D, Avner P, Heard E. (1999)
Functional analysis of the DXPas34 locus, a 3' regulator of Xist expression.
Mol. Cell. Biol. 19(12):8513-25.
Heard E, Mongelard F, Arnaud D, Chureau C, Vourc'h C, Avner P. (1999)
Human XIST yeast artificial chromosome transgenes show partial X inactivation center function in mouse embryonic stem cells.
O'Neill LP, Keohane AM, Lavender JS, McCabe V, Heard E, Avner P, Brockdorff N, Turner BM. (1999)
A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation.
Heard E, Lovell-Badge R, Avner P. (1999)
Heard E, Mongelard F, Arnaud D, Avner P. (1999)
Xist yeast artificial chromosome transgenes function as X-inactivation centers only in multicopy arrays and not as single copies.
Mol. Cell. Biol. 19(4):3156-66.
Avner P, Prissette M, Arnaud D, Courtier B, Cecchi C, Heard E. (1998)
Molecular correlates of the murine Xce locus.
Debrand E, Heard E, Avner P. (1998)
Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene.
Simmler MC, Heard E, Rougeulle C, Cruaud C, Weissenbach J, Avner P. (1997)
Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region.
Heard E, Clerc P, Avner P. (1997)
X-chromosome inactivation in mammals
Heard E, Kress C, Mongelard F, Courtier B, Rougeulle C, Ashworth A, Vourc'h C, Babinet C, Avner P. (1996)
Transgenic mice carrying an Xist-containing YAC.
Melanitou E, Simmler MC, Heard E, Rougeulle C, Avner P. (1996)
Selected methods related to the mouse as a model system.
In: Adolph KW, Methods in Molecular Genetics. Vol. 8, Human Molecular Genetics. Academic Press. pp 439-469.
Fairhead C, Heard E, Arnaud D, Avner P, Dujon B. (1995)
Insertion of unique sites into YAC arms for rapid physical analysis following YAC transfer into mammalian cells.
Courtier B, Heard E, Avner P. (1995)
Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist.
Heard E, Avner P. (1994)
Role play in X-inactivation.
Heard E, Avner P, Rothstein R. (1994)
Creation of a deletion series of mouse YACs covering a 500 kb region around Xist.
Fried M, Feo S, Heard E. (1993)
Involvement of inverted duplications in the generation of gene amplification in mammalian cells.
In: Kellems RE, Gene Amplification in Mammalian Cells. Marcel Dekker, Inc., New York. pp 447-460.
Heard E, Simmler MC, Larin Z, Rougeulle C, Courtier B, Lehrach H, Avner P. (1993)
Physical mapping and YAC contig analysis of the region surrounding Xist on the mouse X chromosome.
Hayashi Y, Heard E, Fried M. (1993)
A large inverted duplicated DNA region associated with an amplified oncogene is stably maintained in a YAC.
Fried M, Feo S, Heard E. (1991)
The role of inverted duplication in the generation of gene amplification in mammalian cells.
Heard E, Williams SV, Sheer D, Fried M. (1991)
Gene amplification accompanied by the loss of a chromosome containing the native allele and the appearance of the amplified DNA at a new chromosomal location.
Heard E, Fried M. (1990)
The use of 5-azacytidine to increase cleavage of methylation sensitive rare cutting restriction enzymes sites in amplified DNA.
Davies B, Feo S, Heard E, Fried M. (1989)
A strategy to detect and isolate an intron-containing gene in the presence of multiple processed pseudogenes.
Heard E, Davies B, Feo S, Fried M. (1989)
An improved method for the screening of YAC libraries.
Augui S, Heard E. (1900)
[Inactivation of X chromosome: cells know how to count two X chromosomes].