EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
PA to the Director Esther Liebig Room: >ATC B2303 Tel: +49 6221 387-8914 E-mail:director@embl.org | Administrative Assistant Christine Georgi-Turcotte Room: ATC B2303 Tel: +49 6221 387-8766 E-mail: director@embl.org | Project Officer / Executive Assistant Niki Pham Room: ATC B2303 Tel: +49 6221-387 8909 E-mail: director@embl.org |
Biography
MD 1984, University of Münster.
Postdoctoral training at the NIH, Bethesda.
Group Leader at EMBL since 1989. Senior Scientist since 1998. Associate Director 2005-2013. Director since 2013.
Co-Director of the EMBL/University of Heidelberg Molecular Medicine Partnership Unit since 2002.
ERC Advanced Investigator from 2011 to 2017.
Publications
Total: 283 publication(s)
2020
Gebauer F, Schwarzl T, Valcárcel J, Hentze MW. (2020)
RNA-binding proteins in human genetic disease.
Nat Rev Genet doi: 10.1038/s41576-020-00302-y
Europe PMC | doi
Perez-Perri JI, Noerenberg M, Kamel W, Lenz CE, Mohammed S, Hentze MW, Castello A. (2020)
Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.
Nat Protoc 16(1):27-60. doi: 10.1038/s41596-020-00404-1
Europe PMC | doi
Iserman C, Desroches Altamirano C, Jegers C, Friedrich U, Zarin T, Fritsch AW, Mittasch M, Domingues A, Hersemann L, Jahnel M, Richter D, Guenther UP, Hentze MW, Moses AM, Hyman AA, Kreysing M, Kramer G, Alberti S, Franzmann TM. (2020)
Condensation of Ded1p promotes a translational switch from housekeeping to stress protein production.
Cell 181(4):818-831.e19. doi: 10.1016/j.cell.2020.04.009
Europe PMC | doi
Backlund M, Stein F, Rettel M, Schwarzl T, Perez-Perri JI, Brosig A, Zhou Y, Neu-Yilik G, Hentze MW, Kulozik AE. (2020)
Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins.
Nucleic Acids Res. 48(9) doi: 10.1093/nar/gkaa256
Europe PMC | doi
Büscher M, Horos R, Hentze MW. (2020)
'High vault-age': non-coding RNA control of autophagy.
Open Biol 10(2) doi: 10.1098/rsob.190307
Europe PMC | doi
Dziuba D, Hoffmann JE, Hentze MW, Schultz C. (2020)
A genetically encoded diazirine analogue for RNA-protein photocrosslinking.
Chembiochem 21(1-2):88-93. doi: 10.1002/cbic.201900559
Europe PMC | doi
2019
Cooke A, Schwarzl T, Huppertz I, Kramer G, Mantas P, Alleaume AM, Huber W, Krijgsveld J, Hentze MW. (2019)
The RNA-binding protein YBX3 controls amino acid levels by regulating SLC mRNA abundance.
Cell Rep 27(11):3097-3106.e5. doi: 10.1016/j.celrep.2019.05.039
Europe PMC | doi
Horos R, Büscher M, Sachse C, Hentze MW. (2019)
Vault RNA emerges as a regulator of selective autophagy.
Autophagy 15(8) doi: 10.1080/15548627.2019.1609861
Europe PMC | doi
Vinchi F, Porto G, Simmelbauer A, Altamura S, Passos ST, Garbowski M, Silva AMN, Spaich S, Seide SE, Sparla R, Hentze MW, Muckenthaler MU. (2019)
Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.
Eur. Heart J. 41(28) doi: 10.1093/eurheartj/ehz112
Europe PMC | doi
Horos R, Büscher M, Kleinendorst R, Alleaume AM, Tarafder AK, Schwarzl T, Dziuba D, Tischer C, Zielonka EM, Adak A, Castello A, Huber W, Sachse C, Hentze MW. (2019)
The small non-coding vault RNA1-1 acts as a riboregulator of autophagy.
Cell 176(5):1054-1067.e12. doi: 10.1016/j.cell.2019.01.030
Europe PMC | doi
Trendel J, Schwarzl T, Horos R, Prakash A, Bateman A, Hentze MW, Krijgsveld J. (2019)
The human RNA-binding proteome and its dynamics during translational arrest.
Cell 176(1-2):391-403.e19. doi: 10.1016/j.cell.2018.11.004
Europe PMC | doi
2018
Perez-Perri JI, Rogell B, Schwarzl T, Stein F, Zhou Y, Rettel M, Brosig A, Hentze MW. (2018)
Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture.
Nat Commun 9(1) doi: 10.1038/s41467-018-06557-8
Europe PMC | doi
Asencio C, Chatterjee A, Hentze MW. (2018)
Silica-based solid-phase extraction of cross-linked nucleic acid-bound proteins.
Life Sci Alliance 1(3) doi: 10.26508/lsa.201800088
Europe PMC | doi
Hentze MW, Valcárcel J.. (2018)
Elisa Izaurralde 1959-2018.
Nat. Struct. Mol. Biol. 25(7) doi: 10.1038/s41594-018-0081-1
Europe PMC | doi
Hentze MW, Castello A, Schwarzl T, Preiss T. (2018)
A brave new world of RNA-binding proteins.
Nat Rev Mol Cell Biol 19(5):327-341. doi: 10.1038/nrm.2017.130
Europe PMC | doi
Kwon E, Todorova K, Wang J, Horos R, Lee KK, Neel VA, Negri GL, Sorensen PH, Lee SW, Hentze MW, Mandinova A. (2018)
The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.
Nat Commun 9(1) doi: 10.1038/s41467-018-04092-0
Europe PMC | doi
2017
Castello A, Frese CK, Fischer B, Järvelin AI, Horos R, Alleaume AM, Foehr S, Curk T, Krijgsveld J, Hentze MW. (2017)
Identification of RNA-binding domains of RNA-binding proteins in cultured cells on a system-wide scale with RBDmap.
Nat Protoc 12(12):2447-2464. doi: 10.1038/nprot.2017.106
Europe PMC | doi
Quintas A, Pérez-Núñez D, Sánchez EG, Nogal ML, Hentze MW, Castelló A, Revilla Y. (2017)
Characterization of the African swine fever virus decapping enzyme during infection.
J. Virol. 91(24) doi: 10.1128/JVI.00990-17
Europe PMC | doi
Costa da Silva M, Breckwoldt MO, Vinchi F, Correia MP, Stojanovic A, Thielmann CM, Meister M, Muley T, Warth A, Platten M, Hentze MW, Cerwenka A, Muckenthaler MU. (2017)
Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages.
Front Immunol 8 doi: 10.3389/fimmu.2017.01479
Europe PMC | doi
Neu-Yilik G, Raimondeau E, Eliseev B, Yeramala L, Amthor B, Deniaud A, Huard K, Kerschgens K, Hentze MW, Schaffitzel C, Kulozik AE. (2017)
Dual function of UPF3B in early and late translation termination.
EMBO J 36(20) doi: 10.15252/embj.201797079
Europe PMC | doi
Haberman N, Huppertz I, Attig J, König J, Wang Z, Hauer C, Hentze MW, Kulozik AE, Le Hir H, Curk T, Sibley CR, Zarnack K, Ule J. (2017)
Erratum to: Insights into the design and interpretation of iCLIP experiments.
Genome Biol 18(1) doi: 10.1186/s13059-017-1294-z
Europe PMC | doi
da Silva AR, Neves J, Mleczko-Sanecka K, Tandon A, Sauer SW, Hentze MW, Muckenthaler MU. (2017)
Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin.
J. Mol. Med. 95(8):851-860. doi: 10.1007/s00109-017-1551-3
Europe PMC | doi
Rogell BM, Fischer B, Rettel M, Krijgsveld J, Castello A, Hentze MW. (2017)
Specific RNP capture with antisense LNA/DNA mixmers.
RNA 23(8) doi: 10.1261/rna.060798.117
Europe PMC | doi
Haddad S, Wang Y, Galy B, Korf-Klingebiel M, Hirsch V, Baru AM, Rostami F, Reboll MR, Heineke J, Flögel U, Groos S, Renner A, Toischer K, Zimmermann F, Engeli S, Jordan J, Bauersachs J, Hentze MW, Wollert KC, Kempf T. (2017)
Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure.
Eur. Heart J. 38(5):362-372. doi: 10.1093/eurheartj/ehw333
Europe PMC | doi
Muckenthaler MU, Rivella S, Hentze MW, Galy B. (2017)
A Red Carpet for Iron Metabolism.
Cell 168(3):344-361. doi: 10.1016/j.cell.2016.12.034
Europe PMC | doi
Haberman N, Huppertz I, Attig J, König J, Wang Z, Hauer C, Hentze MW, Kulozik AE, Le Hir H, Curk T, Sibley CR, Zarnack K, Ule J. (2017)
Insights into the design and interpretation of iCLIP experiments.
Genome Biol. 18(1):7. doi: 10.1186/s13059-016-1130-x
Europe PMC | doi
2016
Reichel M, Liao Y, Rettel M, Ragan C, Evers M, Alleaume AM, Horos R, Hentze MW, Preiss T, Millar AA. (2016)
In planta determination of the mRNA-binding proteome of Arabidopsis etiolated seedlings.
Plant Cell 28(10) doi: 10.1105/tpc.16.00562
Europe PMC | doi
Castello A, Fischer B, Frese CK, Horos R, Alleaume AM, Foehr S, Curk T, Krijgsveld J, Hentze MW. (2016)
Comprehensive Identification of RNA-Binding Domains in Human Cells.
Mol. Cell 63(4):696-710. doi: 10.1016/j.molcel.2016.06.029
Europe PMC | doi
Hauer C, Sieber J, Schwarzl T, Hollerer I, Curk T, Alleaume AM, Hentze MW, Kulozik AE. (2016)
Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.
Cell Rep 16(6):1588-1603. doi: 10.1016/j.celrep.2016.06.096
Europe PMC | doi
Liepelt A, Naarmann-de Vries IS, Simons N, Eichelbaum K, Foehr S, Archer SK, Castello A, Usadel B, Krijgsveld J, Preiss T, Marx G, Hentze MW, Ostareck DH, Ostareck-Lederer A. (2016)
Identification of RNA-binding proteins in macrophages by interactome capture.
Mol. Cell Proteomics 15(8):2699-2714. doi: 10.1074/mcp.M115.056564
Europe PMC | doi
Liao Y, Castello A, Fischer B, Leicht S, Föehr S, Frese C, Ragan C, Kurscheid S, Pagler E, Yang H, Krijgsveld J, Hentze MW, Preiss T. (2016)
The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease
Cell Rep 16(5):1456-1469. doi: 10.1016/j.celrep.2016.06.084
Europe PMC | doi
Hollerer I, Curk T, Haase B, Benes V, Hauer C, Neu-Yilik G, Bhuvanagiri M, Hentze MW, Kulozik AE. (2016)
The differential expression of alternatively polyadenylated transcripts is a common stress-induced response mechanism that modulates mammalian mRNA expression in a quantitative and qualitative fashion.
RNA 22(9):1441-1453. doi: 10.1261/rna.055657.115
Europe PMC | doi
Sysoev VO, Fischer B, Frese CK, Gupta I, Krijgsveld J, Hentze MW, Castello A, Ephrussi A. (2016)
Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila.
Nat Commun 7:12128. doi: 10.1038/ncomms12128
Europe PMC | doi
Kovac S, Böser P, Cui Y, Ferring-Appel D, Casarrubea D, Huang L, Fung E, Popp A, Mueller BK, Hentze MW. (2016)
Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels.
Haematologica 101(5):e173-176. doi: 10.3324/haematol.2015.140772
Europe PMC | doi
Sieber J, Hauer C, Bhuvanagiri M, Leicht S, Krijgsveld J, Neu-Yilik G, Hentze MW, Kulozik AE. (2016)
Proteomic analysis reveals branch-specific regulation of the unfolded protein response by nonsense-mediated mRNA decay.
Mol. Cell Proteomics 15(5) doi: 10.1074/mcp.M115.054056
Europe PMC | doi
Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL. (2016)
Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
FASEB J. 30(2):813-823. doi: 10.1096/fj.15-276758
Europe PMC | doi
Gebauer F, Hentze MW. (2016)
IRES unplugged.
Science 351(6270) doi: 10.1126/science.aad8540
Europe PMC | doi
Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW. (2016)
Comprehensive Identification of RNA-Binding Proteins by RNA Interactome Capture.
Methods Mol. Biol. 1358:131-139. doi: 10.1007/978-1-4939-3067-8_8
Europe PMC | doi
2015
Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, Jantsch J. (2015)
Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen.
Cell Rep 13(10):2048-2055. doi: 10.1016/j.celrep.2015.11.005
Europe PMC | doi
Popow J, Alleaume AM, Curk T, Schwarzl T, Sauer S, Hentze MW. (2015)
FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.
RNA 21(11) doi: 10.1261/rna.052365.115
Europe PMC | doi
Beckmann BM, Horos R, Fischer B, Castello A, Eichelbaum K, Alleaume AM, Schwarzl T, Curk T, Foehr S, Huber W, Krijgsveld J, Hentze MW. (2015)
The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs.
Nat Commun 6 doi: 10.1038/ncomms10127
Europe PMC | doi
Castello A, Hentze MW, Preiss T. (2015)
Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins.
Trends Endocrinol. Metab. 26(12):746-757. doi: 10.1016/j.tem.2015.09.012
Europe PMC | doi
Nairz M, Ferring-Appel D, Casarrubea D, Sonnweber T, Viatte L, Schroll A, Haschka D, Fang FC, Hentze MW, Weiss G, Galy B. (2015)
Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection
Cell Host Microbe 18(2):254-261. doi: 10.1016/j.chom.2015.06.017
Europe PMC | doi
Hauer C, Curk T, Anders S, Schwarzl T, Alleaume AM, Sieber J, Hollerer I, Bhuvanagiri M, Huber W, Hentze MW, Kulozik AE. (2015)
Improved binding site assignment by high-resolution mapping of RNA-protein interactions using iCLIP.
Nat Commun 6:7921. doi: 10.1038/ncomms8921
Europe PMC | doi
Guida C, Altamura S, Klein FA, Galy B, Boutros M, Ulmer AJ, Hentze MW, Muckenthaler MU. (2015)
A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.
Blood 125(14):2265-2275. doi: 10.1182/blood-2014-08-595256
Europe PMC | doi
Martelli A, Schmucker S, Reutenauer L, Mathieu JR, Peyssonnaux C, Karim Z, Puy H, Galy B, Hentze MW, Puccio H. (2015)
Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.
Cell Metab. 21(2):311-322. doi: 10.1016/j.cmet.2015.01.010
Europe PMC | doi
2014
Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE. (2014)
5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
EMBO Mol Med 6(12):1509-1639. doi: 10.15252/emmm.201404461
Europe PMC | doi
Kramer K, Sachsenberg T, Beckmann BM, Qamar S, Boon KL, Hentze MW, Kohlbacher O, Urlaub H. (2014)
Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins.
Nat. Methods 11(10):1064-1070. doi: 10.1038/nmeth.3092
Europe PMC | doi
Altamura S, Kessler R, Gröne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU. (2014)
Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload
Cell Metab. 20(2):359-367. doi: 10.1016/j.cmet.2014.07.007
Europe PMC | doi
Strein C, Alleaume AM, Rothbauer U, Hentze MW, Castello A. (2014)
A versatile assay for RNA-binding proteins in living cells
RNA 20(5):721-731. doi: 10.1261/rna.043562.113
Europe PMC | doi
Chung J, Anderson SA, Gwynn B, Deck KM, Chen MJ, Langer NB, Shaw GC, Huston NC, Boyer LF, Datta S, Paradkar PN, Li L, Wei Z, Lambert AJ, Sahr K, Wittig JG, Chen W, Lu W, Galy B, Schlaeger TM, Hentze MW, Ward DM, Kaplan J, Eisenstein RS, Peters LL, Paw BH. (2014)
Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria
J. Biol. Chem. 289(11):7835-7843. doi: 10.1074/jbc.m114.547778
Europe PMC | doi
Mleczko-Sanecka K, Roche F, da Silva AR, Call D, D'Alessio F, Ragab A, Lapinski PE, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro LA, Klingmüller U, King PD, Boutros M, Hentze MW, Muckenthaler MU. (2014)
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.
Blood 123(10):1574-1585. doi: 10.1182/blood-2013-07-515957
Europe PMC | doi
Hollerer I, Grund K, Hentze MW, Kulozik AE. (2014)
mRNA 3'end processing: A tale of the tail reaches the clinic
EMBO Mol Med 6(1):16-26. doi: 10.1002/emmm.201303300
Europe PMC | doi
2013
Altamura S, Grone HJ, Kessler R, Galy B, Hentze MW, Muckenthaler MU. (2013)
In Vivo Disruption Of The Hepcidin-Ferroportin Regulatory Circuitry Causes Fatal Systemic and Exocrine Pancreatic Iron Overload
BLOOD 122(21) doi: 10.1182/blood.V122.21.175.175
doi
Danckwardt S, Hentze MW, Kulozik AE. (2013)
Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond
J. Mol. Med. 91(11):1257-1271. doi: 10.1007/s00109-013-1074-5
Europe PMC | doi
Kwon SC, Yi H, Eichelbaum K, Föhr S, Fischer B, You KT, Castello A, Krijgsveld J, Hentze MW, Kim VN. (2013)
The RNA-binding protein repertoire of embryonic stem cells
Nat. Struct. Mol. Biol. 20(9):1122-1130. doi: 10.1038/nsmb.2638
Europe PMC | doi
Casarrubea D, Viatte L, Hallas T, Vasanthakumar A, Eisenstein RS, Schümann K, Hentze MW, Galy B. (2013)
Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function
J. Mol. Med. 91(7):871-881. doi: 10.1007/s00109-013-1008-2
Europe PMC | doi
Hentze MW, Izaurralde E. (2013)
Making sense of nonsense
Nat. Struct. Mol. Biol. 20(6):651-653. doi: 10.1038/nsmb.2601
Europe PMC | doi
Castello A, Fischer B, Hentze MW, Preiss T. (2013)
RNA-binding proteins in Mendelian disease
Trends Genet. 29(5):318-327. doi: 10.1016/j.tig.2013.01.004
Europe PMC | doi
Galy B, Ferring-Appel D, Becker C, Gretz N, Grone HJ, Schumann K, Hentze MW. (2013)
IRON REGULATORY PROTEINS SECURE EFFICIENT DIETARY IRON INTAKE AND DEFINE A BASAL SET POINT FOR THE REGULATION OF IRON ABSORPTION
AM J HEMATOL 88(5):E28.
Guida C, Altamura S, Klein F, Boutros M, Hentze MW, Martina UM. (2013)
IDENTIFICATION OF NOVEL REGULATORS OF FERROPORTIN EXPRESSION
AM J HEMATOL 88(5):E128-E129.
Nairz M, Ferring-Appel D, Schroll A, Hentze MW, Weiss G, Galy B. (2013)
IRON REGULATORY PROTEINS MEDIATE MACROPHAGE INNATE IMMUNITY AGAINST SALMONELLA
AM J HEMATOL 88(5):E26.
Hentze MW, Preiss T. (2013)
Circular RNAs: splicing's enigma variations
EMBO J. 32(7):923-925. doi: 10.1038/emboj.2013.53
Europe PMC | doi
Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW. (2013)
System-wide identification of RNA-binding proteins by interactome capture
Nat Protoc 8(3):491-500. doi: 10.1038/nprot.2013.020
Europe PMC | doi
Galy B, Ferring-Appel D, Becker C, Gretz N, Gröne HJ, Schümann K, Hentze MW. (2013)
Iron regulatory proteins control a mucosal block to intestinal iron absorption
Cell Rep 3(3):844-857. doi: 10.1016/j.celrep.2013.02.026
Europe PMC | doi
Anderson SA, Nizzi CP, Chang YI, Deck KM, Schmidt PJ, Galy B, Damnernsawad A, Broman AT, Kendziorski C, Hentze MW, Fleming MD, Zhang J, Eisenstein RS. (2013)
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption
Cell Metab. 17(2):282-290. doi: 10.1016/j.cmet.2013.01.007
Europe PMC | doi
2012
D'Alessio F, Hentze MW, Muckenthaler MU. (2012)
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation
J. Hepatol. 57(5):1052-1060. doi: 10.1016/j.jhep.2012.06.015
Europe PMC | doi
Casanova CM, Sehr P, Putzker K, Hentze MW, Neumann B, Duncan KE, Thoma C. (2012)
Automated high-throughput RNAi screening in human cells combined with reporter mRNA transfection to identify novel regulators of translation
PLoS ONE 7(9):e45943. doi: 10.1371/journal.pone.0045943
Europe PMC | doi
Gebauer F, Preiss T, Hentze MW. (2012)
From cis-regulatory elements to complex RNPs and back
Cold Spring Harb Perspect Biol 4(7):a012245. doi: 10.1101/cshperspect.a012245
Europe PMC | doi
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW. (2012)
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell 149(6):1393-1406. doi: 10.1016/j.cell.2012.04.031
Europe PMC | doi
Moretti F, Kaiser C, Zdanowicz-Specht A, Hentze MW. (2012)
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding
Nat. Struct. Mol. Biol. 19(6):603-608. doi: 10.1038/nsmb.2309
Europe PMC | doi
2011
Sanchez M, Galy B, Schwanhaeusser B, Blake J, Bähr-Ivacevic T, Benes V, Selbach M, Muckenthaler MU, Hentze MW. (2011)
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins
Blood 118(22):e168-79. doi: 10.1182/blood-2011-04-343541
Europe PMC | doi
Medenbach J, Seiler M, Hentze MW. (2011)
Translational control via protein-regulated upstream open reading frames
Cell 145(6):902-913. doi: 10.1016/j.cell.2011.05.005
Europe PMC | doi
Neu-Yilik G, Amthor B, Gehring NH, Bahri S, Paidassi H, Hentze MW, Kulozik AE. (2011)
Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon
RNA 17(5):843-854. doi: 10.1261/rna.2401811
Europe PMC | doi
Rakotondrafara AM, Hentze MW. (2011)
An efficient factor-depleted mammalian in vitro translation system
Nat Protoc 6(5):563-571. doi: 10.1038/nprot.2011.314
Europe PMC | doi
Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU. (2011)
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
J. Clin. Invest. 121(4):1386-1396. doi: 10.1172/jci44883
Europe PMC | doi
Danckwardt S, Gantzert AS, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Gröne HJ, Schirmacher P, Hentze MW, Kulozik AE. (2011)
p38 MAPK controls prothrombin expression by regulated RNA 3' end processing
Mol. Cell 41(3):298-310. doi: 10.1016/j.molcel.2010.12.032
Europe PMC | doi
2010
Moretti F, Thermann R, Hentze MW. (2010)
Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame
RNA 16(12):2493-2502. doi: 10.1261/rna.2384610
Europe PMC | doi
Bhuvanagiri M, Schlitter AM, Hentze MW, Kulozik AE. (2010)
NMD: RNA biology meets human genetic medicine
Biochem. J. 430(3):365-377. doi: 10.1042/bj20100699
Europe PMC | doi
Cohen LA, Gutierrez L, Weiss A, Leichtmann-Bardoogo Y, Zhang DL, Crooks DR, Sougrat R, Morgenstern A, Galy B, Hentze MW, Lazaro FJ, Rouault TA, Meyron-Holtz EG. (2010)
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway
Blood 116(9):1574-1584. doi: 10.1182/blood-2009-11-253815
Europe PMC | doi
Galy B, Ferring-Appel D, Sauer SW, Kaden S, Lyoumi S, Puy H, Kölker S, Gröne HJ, Hentze MW. (2010)
Iron regulatory proteins secure mitochondrial iron sufficiency and function
Cell Metab. 12(2):194-201. doi: 10.1016/j.cmet.2010.06.007
Europe PMC | doi
Hentze MW, Preiss T. (2010)
The REM phase of gene regulation
Trends Biochem. Sci. 35(8):423-426. doi: 10.1016/j.tibs.2010.05.009
Europe PMC | doi
Campillos M, Cases I, Hentze MW, Sanchez M. (2010)
SIREs: searching for iron-responsive elements
Nucleic Acids Res. 38(Web Server issue):W360-7. doi: 10.1093/nar/gkq371
Europe PMC | doi
Hentze MW, Muckenthaler MU, Galy B, Camaschella C. (2010)
Two to tango: regulation of Mammalian iron metabolism
Cell 142(1):24-38. doi: 10.1016/j.cell.2010.06.028
Europe PMC | doi
Mleczko-Sanecka K, Casanovas G, Ragab A, Breitkopf K, Müller A, Boutros M, Dooley S, Hentze MW, Muckenthaler MU. (2010)
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
Blood 115(13):2657-2665. doi: 10.1182/blood-2009-09-238105
Europe PMC | doi
Lopes TJ, Luganskaja T, Vujić Spasić M, Hentze MW, Muckenthaler MU, Schümann K, Reich JG. (2010)
Systems analysis of iron metabolism: the network of iron pools and fluxes
BMC Syst Biol 4:112. doi: 10.1186/1752-0509-4-112
Europe PMC | doi
Pisarev AV, Skabkin MA, Pisareva VP, Skabkina OV, Rakotondrafara AM, Hentze MW, Hellen CU, Pestova TV. (2010)
The role of ABCE1 in eukaryotic posttermination ribosomal recycling
Mol. Cell 37(2):196-210. doi: 10.1016/j.molcel.2009.12.034
Europe PMC | doi
Vainshtein Y, Sanchez M, Brazma A, Hentze MW, Dandekar T, Muckenthaler MU. (2010)
The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays
BMC Bioinformatics 11:112. doi: 10.1186/1471-2105-11-112
Europe PMC | doi
2009
Duncan KE, Strein C, Hentze MW. (2009)
The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA
Mol. Cell 36(4):571-582. doi: 10.1016/j.molcel.2009.09.042
Europe PMC | doi
Viatte L, Gröne HJ, Hentze MW, Galy B. (2009)
In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation
J. Mol. Med. 87(9):913-921. doi: 10.1007/s00109-009-0494-8
Europe PMC | doi
Zdanowicz A, Thermann R, Kowalska J, Jemielity J, Duncan K, Preiss T, Darzynkiewicz E, Hentze MW. (2009)
Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression
Mol. Cell 35(6):881-888. doi: 10.1016/j.molcel.2009.09.009
Europe PMC | doi
Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S. (2009)
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2
EMBO J. 28(15):2293-2306. doi: 10.1038/emboj.2009.175
Europe PMC | doi
Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU. (2009)
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
J. Mol. Med. 87(5):471-480. doi: 10.1007/s00109-009-0447-2
Europe PMC | doi
Gehring NH, Lamprinaki S, Hentze MW, Kulozik AE. (2009)
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
PLoS Biol. 7(5):e1000120. doi: 10.1371/journal.pbio.1000120
Europe PMC | doi
Gehring NH, Lamprinaki S, Kulozik AE, Hentze MW. (2009)
Disassembly of exon junction complexes by PYM
Cell 137(3):536-548. doi: 10.1016/j.cell.2009.02.042
Europe PMC | doi
Hentze MW. (2009)
EMBO Molecular Medicine: Conquering new frontiers
EMBO Mol Med 1(1):5. doi: 10.1002/emmm.200900011
Europe PMC | doi
Beilharz TH, Humphreys DT, Clancy JL, Thermann R, Martin DI, Hentze MW, Preiss T. (2009)
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells
PLoS ONE 4(8) doi: 10.1371/journal.pone.0006783
Europe PMC | doi
Ferring-Appel D, Hentze MW, Galy B. (2009)
Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism
Blood 113(3):679-687. doi: 10.1182/blood-2008-05-155093
Europe PMC | doi
2008
Thoma C, Fraterman S, Gentzel M, Wilm M, Hentze MW. (2008)
Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail
RNA 14(8):1579-1589. doi: 10.1261/rna.1043908
Europe PMC | doi
Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU. (2008)
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells
J. Mol. Med. 86(5):531-540. doi: 10.1007/s00109-008-0313-7
Europe PMC | doi