EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

PA to the Director
Esther Liebig
Room: ATC B2303
Tel: +49 6221 387-8914
Fax: +49 6221 387-8144
E-mail: director@embl.org
Administrative Assistant
Christine Turcotte
Room: ATC B2303
Tel: +49 6221 387-8766
Fax: +49 6221 387-8144
E-mail: director@embl.org
Senior Project Officer
Nina Papritz-Knapp
Room: ATC B2303
Tel: +49 6221 387-8909
Fax: +49 6221 387-8144
E-mail: director@embl.org

Biography

  • MD 1984, University of Münster.
    Postdoctoral training at the NIH, Bethesda.
    Group Leader at EMBL since 1989. Senior Scientist since 1998. Associate Director 2005-2013. Director since 2013.
    Co-Director of the EMBL/University of Heidelberg Molecular Medicine Partnership Unit since 2002.
    ERC Advanced Investigator since 2011.

Publications

Total: 263 publication(s)

2007

Sanchez M, Galy B, Hentze MW, Muckenthaler MU. (2007)

Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays

Nat Protoc 2(8):2033-2042. doi: 10.1038/nprot.2007.293
Europe PMC | doi

Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. (2007)

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

Blood 109(1):353-358. doi: 10.1182/blood-2006-07-033969
Europe PMC | doi

Viegas MH, Gehring NH, Breit S, Hentze MW, Kulozik AE. (2007)

The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway

Nucleic Acids Res. 35(13):4542-4551. doi: 10.1093/nar/gkm461
Europe PMC | doi


2006

Boelz S, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. (2006)

A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay

Biochem. Biophys. Res. Commun. 349(1):186-191. doi: 10.1016/j.bbrc.2006.08.017
Europe PMC | doi

Galy B, Hölter SM, Klopstock T, Ferring D, Becker L, Kaden S, Wurst W, Gröne HJ, Hentze MW. (2006)

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

Nat. Genet. 38(9):967-9; discussion 969-70. doi: 10.1038/ng0906-967
Europe PMC | doi

Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stolte J, Muckenthaler MU, Hentze MW. (2006)

Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy

J. Biol. Chem. 281(32):22865-22874. doi: 10.1074/jbc.m603876200
Europe PMC | doi

Corna G, Galy B, Hentze MW, Cairo G. (2006)

IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice

J. Mol. Med. 84(7):551-560. doi: 10.1007/s00109-006-0068-y
Europe PMC | doi

Holbrook JA, Neu-Yilik G, Gehring NH, Kulozik AE, Hentze MW. (2006)

Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay

EMBO Rep. 7(7):722-726. doi: 10.1038/sj.embor.7400721
Europe PMC | doi

Kunz JB, Neu-Yilik G, Hentze MW, Kulozik AE, Gehring NH. (2006)

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

RNA 12(6):1015-1022. doi: 10.1261/rna.12506
Europe PMC | doi

Castoldi M, Schmidt S, Benes V, Noerholm M, Kulozik AE, Hentze MW, Muckenthaler MU. (2006)

A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA)

RNA 12(5):913-920. doi: 10.1261/rna.2332406
Europe PMC | doi

Danckwardt S, Hartmann K, Katz B, Hentze MW, Levy Y, Eichele R, Deutsch V, Kulozik AE, Ben-Tal O. (2006)

The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing

J. Thromb. Haemost. 4(5):1078-1085. doi: 10.1111/j.1538-7836.2006.01885.x
Europe PMC | doi

Mok H, Mlodnicka AE, Hentze MW, Muckenthaler M, Schumacher A. (2006)

The molecular circuitry regulating the switch between iron deficiency and overload in mice

J. Biol. Chem. 281(12):7946-7951. doi: 10.1074/jbc.m509857200
Europe PMC | doi

Chekulaeva M, Hentze MW, Ephrussi A. (2006)

Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles

Cell 124(3):521-533. doi: 10.1016/j.cell.2006.01.031
Europe PMC | doi

Duncan K, Grskovic M, Strein C, Beckmann K, Niggeweg R, Abaza I, Gebauer F, Wilm M, Hentze MW. (2006)

Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation

Genes Dev. 20(3):368-379. doi: 10.1101/gad.371406
Europe PMC | doi

Danckwardt S, Hartmann K, Gehring NH, Hentze MW, Kulozik AE. (2006)

3' end processing of the prothrombin mRNA in thrombophilia

Acta Haematol. 115(3-4):192-197. doi: 10.1159/000090934
Europe PMC | doi

Stockklausner C, Breit S, Neu-Yilik G, Echner N, Hentze MW, Kulozik AE, Gehring NH. (2006)

The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD)

Nucleic Acids Res. 34(8):2355-2363. doi: 10.1093/nar/gkl277
Europe PMC | doi


2005

Galy B, Ferring D, Hentze MW. (2005)

Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes

Genesis 43(4):181-188. doi: 10.1002/gene.20169
Europe PMC | doi

Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K, Hentze MW. (2005)

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

Blood 106(7):2580-2589. doi: 10.1182/blood-2005-04-1365
Europe PMC | doi

Gehring NH, Kunz JB, Neu-Yilik G, Breit S, Viegas MH, Hentze MW, Kulozik AE. (2005)

Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements

Mol. Cell 20(1):65-75. doi: 10.1016/j.molcel.2005.08.012
Europe PMC | doi

Hundsdoerfer P, Thoma C, Hentze MW. (2005)

Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation

Proc. Natl. Acad. Sci. U.S.A. 102(38):13421-13426. doi: 10.1073/pnas.0506536102
Europe PMC | doi

Beckmann K, Grskovic M, Gebauer F, Hentze MW. (2005)

A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila

Cell 122(4):529-540. doi: 10.1016/j.cell.2005.06.011
Europe PMC | doi

Fillebeen C, Rivas-Estilla AM, Bisaillon M, Ponka P, Muckenthaler M, Hentze MW, Koromilas AE, Pantopoulos K. (2005)

Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus

J. Biol. Chem. 280(10):9049-9057. doi: 10.1074/jbc.m412687200
Europe PMC | doi


2004

Gebauer F, Hentze MW. (2004)

Molecular mechanisms of translational control

Nat. Rev. Mol. Cell Biol. 5(10):827-835. doi: 10.1038/nrm1488
Europe PMC | doi

Thoma C, Bergamini G, Galy B, Hundsdoerfer P, Hentze MW. (2004)

Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP

Mol. Cell 15(6):925-935. doi: 10.1016/j.molcel.2004.08.021
Europe PMC | doi

Holbrook JA, Neu-Yilik G, Hentze MW, Kulozik AE. (2004)

Nonsense-mediated decay approaches the clinic

Nat. Genet. 36(8):801-808. doi: 10.1038/ng1403
Europe PMC | doi

Danckwardt S, Gehring NH, Neu-Yilik G, Hundsdoerfer P, Pforsich M, Frede U, Hentze MW, Kulozik AE. (2004)

The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations

Blood 104(2):428-435. doi: 10.1182/blood-2003-08-2894
Europe PMC | doi

Galy B, Ferring D, Benesova M, Benes V, Hentze MW. (2004)

Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo

RNA 10(7):1019-1025. doi: 10.1261/rna.7220704
Europe PMC | doi

Bonnah RA, Muckenthaler MU, Carlson H, Minana B, Enns CA, Hentze MW, So M. (2004)

Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis

Cell. Microbiol. 6(5):473-484. doi: 10.1111/j.1462-5822.2004.00376.x
Europe PMC | doi

Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK, Sanchez M, Gaudino A, Hentze MW, Andrews NC, Muckenthaler MU. (2004)

An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice

Nat. Genet. 36(5):481-485. doi: 10.1038/ng1350
Europe PMC | doi

Hentze MW, Muckenthaler MU, Andrews NC. (2004)

Balancing acts: molecular control of mammalian iron metabolism

Cell 117(3):285-297. doi: 10.1016/s0092-8674(04)00343-5
Europe PMC | doi

Schümann K, Brennan K, Weiss M, Pantopoulos K, Hentze MW. (2004)

Rat duodenal IRP1 activity and iron absorption in iron deficiency and after H2O2 perfusion

Eur. J. Clin. Invest. 34(4):275-282. doi: 10.1111/j.1365-2362.2004.01335.x
Europe PMC | doi

Wang J, Chen G, Muckenthaler M, Galy B, Hentze MW, Pantopoulos K. (2004)

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

Mol. Cell. Biol. 24(3):954-965. doi: 10.1128/mcb.24.3.954-965.2004
Europe PMC | doi

Baron-Benhamou J, Gehring NH, Kulozik AE, Hentze MW. (2004)

Using the lambdaN peptide to tether proteins to RNAs

Methods Mol. Biol. 257:135-154. doi: 10.1385/1-59259-750-5:135
Europe PMC | doi

Herrmann T, Muckenthaler M, van der Hoeven F, Brennan K, Gehrke SG, Hubert N, Sergi C, Gröne HJ, Kaiser I, Gosch I, Volkmann M, Riedel HD, Hentze MW, Stewart AF, Stremmel W. (2004)

Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin

J. Mol. Med. 82(1):39-48. doi: 10.1007/s00109-003-0508-x
Europe PMC | doi

Muckenthaler MU, Rodrigues P, Macedo MG, Minana B, Brennan K, Cardoso EM, Hentze MW, de Sousa M. (2004)

Molecular analysis of iron overload in beta2-microglobulin-deficient mice

Blood Cells Mol. Dis. 33(2):125-131. doi: 10.1016/j.bcmd.2004.05.003
Europe PMC | doi

Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. (2004)

Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife

Genome Biol. 5(4):218. doi: 10.1186/gb-2004-5-4-218
Europe PMC | doi

Thoma C, Ostareck-Lederer A, Hentze MW. (2004)

A poly(A) tail-responsive in vitro system for cap- or IRES-driven translation from HeLa cells

Methods Mol. Biol. 257:171-180. doi: 10.1385/1-59259-750-5:171
Europe PMC | doi


2003

Preiss T, Baron-Benhamou J, Ansorge W, Hentze MW. (2003)

Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock

Nat. Struct. Biol. 10(12):1039-1047. doi: 10.1038/nsb1015
Europe PMC | doi

Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, Hachiya T, Hentze MW, Anderson P, Ohno S. (2003)

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

Mol. Cell 12(5):1187-1200. doi: 10.1016/s1097-2765(03)00443-x
Europe PMC | doi

Grskovic M, Hentze MW, Gebauer F. (2003)

A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA

EMBO J. 22(20):5571-5581. doi: 10.1093/emboj/cdg539
Europe PMC | doi

Schell T, Köcher T, Wilm M, Seraphin B, Kulozik AE, Hentze MW. (2003)

Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells

Biochem. J. 373(Pt 3):775-783. doi: 10.1042/bj20021920
Europe PMC | doi

Baron-Benhamou J, Fortes P, Inada T, Preiss T, Hentze MW. (2003)

The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast

RNA 9(6):654-662. doi: 10.1261/rna.5100903
Europe PMC | doi

Gebauer F, Grskovic M, Hentze MW. (2003)

Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA

Mol. Cell 11(5):1397-1404. doi: 10.1016/s1097-2765(03)00176-x
Europe PMC | doi

Muckenthaler M, Richter A, Gunkel N, Riedel D, Polycarpou-Schwarz M, Hentze S, Falkenhahn M, Stremmel W, Ansorge W, Hentze MW. (2003)

Relationships and distinctions in iron-regulatory networks responding to interrelated signals

Blood 101(9):3690-3698. doi: 10.1182/blood-2002-07-2140
Europe PMC | doi

Muckenthaler M, Roy CN, Custodio AO, Miñana B, deGraaf J, Montross LK, Andrews NC, Hentze MW. (2003)

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

Nat. Genet. 34(1):102-107. doi: 10.1038/ng1152
Europe PMC | doi

Gehring NH, Neu-Yilik G, Schell T, Hentze MW, Kulozik AE. (2003)

Y14 and hUpf3b form an NMD-activating complex

Mol. Cell 11(4):939-949. doi: 10.1016/s1097-2765(03)00142-4
Europe PMC | doi

Thompson K, Menzies S, Muckenthaler M, Torti FM, Wood T, Torti SV, Hentze MW, Beard J, Connor J. (2003)

Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress

J. Neurosci. Res. 71(1):46-63. doi: 10.1002/jnr.10463
Europe PMC | doi


2002

Hubert N, Hentze MW. (2002)

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function

Proc. Natl. Acad. Sci. U.S.A. 99(19):12345-12350. doi: 10.1073/pnas.192423399
Europe PMC | doi

Richter A, Schwager C, Hentze S, Ansorge W, Hentze MW, Muckenthaler M. (2002)

Comparison of fluorescent tag DNA labeling methods used for expression analysis by DNA microarrays

BioTechniques 33(3):620-8, 630.
Europe PMC

Schümann K, Borch-Iohnsen B, Hentze MW, Marx JJ. (2002)

Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board

Am. J. Clin. Nutr. 76(3):499-500.
Europe PMC

Ostareck-Lederer A, Ostareck DH, Cans C, Neubauer G, Bomsztyk K, Superti-Furga G, Hentze MW. (2002)

c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs

Mol. Cell. Biol. 22(13):4535-4543. doi: 10.1128/mcb.22.13.4535-4543.2002
Europe PMC | doi

Danckwardt S, Neu-Yilik G, Thermann R, Frede U, Hentze MW, Kulozik AE. (2002)

Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay

Blood 99(5):1811-1816. doi: 10.1182/blood.v99.5.1811
Europe PMC | doi

Brocke KS, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. (2002)

The human intronless melanocortin 4-receptor gene is NMD insensitive

Hum. Mol. Genet. 11(3):331-335. doi: 10.1093/hmg/11.3.331
Europe PMC | doi

Schell T, Kulozik AE, Hentze MW. (2002)

Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway

Genome Biol. 3(3):REVIEWS1006. doi: 10.1186/gb-2002-3-3-reviews1006
Europe PMC | doi


2001

Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC, Hediger MA. (2001)

Iron-dependent regulation of the divalent metal ion transporter

FEBS Lett. 509(2):309-316. doi: 10.1016/s0014-5793(01)03189-1
Europe PMC | doi

Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M Jr, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. (2001)

New ways of initiating translation in eukaryotes.

Mol. Cell. Biol. 21(23):8238-8246. doi: 10.1128/mcb.21.23.8238-8246.2001
Europe PMC | doi

Thoma C, Hasselblatt P, Köck J, Chang SF, Hockenjos B, Will H, Hentze MW, Blum HE, von Weizsäcker F, Offensperger WB. (2001)

Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides

Mol. Cell 8(4):865-872. doi: 10.1016/s1097-2765(01)00364-1
Europe PMC | doi

Gebauer F, Hentze MW. (2001)

Fertility facts: male and female germ cell development requires translational control by CPEB

Mol. Cell 8(2):247-249. doi: 10.1016/s1097-2765(01)00326-4
Europe PMC | doi

Gehring NH, Frede U, Neu-Yilik G, Hundsdoerfer P, Vetter B, Hentze MW, Kulozik AE. (2001)

Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia

Nat. Genet. 28(4):389-392. doi: 10.1038/ng578
Europe PMC | doi

Hentze MW. (2001)

Protein synthesis. Believe it or not-translation in the nucleus

Science 293(5532):1058-1059. doi: 10.1126/science.1063290
Europe PMC | doi

Mueller S, Pantopoulos K, Hübner CA, Stremmel W, Hentze MW. (2001)

IRP1 activation by extracellular oxidative stress in the perfused rat liver

J. Biol. Chem. 276(25):23192-23196. doi: 10.1074/jbc.m100654200
Europe PMC | doi

Pöyry TA, Hentze MW, Jackson RJ. (2001)

Construction of regulatable picornavirus IRESes as a test of current models of the mechanism of internal translation initiation

RNA 7(5):647-660. doi: 10.1017/s1355838201001911
Europe PMC | doi

Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z. (2001)

ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation

Nat. Cell Biol. 3(3):325-330. doi: 10.1038/35060131
Europe PMC | doi

Neu-Yilik G, Gehring NH, Thermann R, Frede U, Hentze MW, Kulozik AE. (2001)

Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs

EMBO J. 20(3):532-540. doi: 10.1093/emboj/20.3.532
Europe PMC | doi

De Gregorio E, Baron J, Preiss T, Hentze MW. (2001)

Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure

RNA 7(1):106-113. doi: 10.1017/s1355838201000577
Europe PMC | doi

Gebauer F, Ostareck DH, Ostareck-Lederer A, Grskovic M, Hentze MW. (2001)

Translational control of 15-lipoxygenase and msl-2 mRNAs: single regulators or corepressor assemblies?

Cold Spring Harb. Symp. Quant. Biol. 66:329-336. doi: 10.1101/sqb.2001.66.329
Europe PMC | doi

Ostareck DH, Ostareck-Lederer A, Shatsky IN, Hentze MW. (2001)

Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining

Cell 104(2):281-290. doi: 10.1016/s0092-8674(01)00212-4
Europe PMC | doi


2000

Bergamini G, Preiss T, Hentze MW. (2000)

Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system

RNA 6(12):1781-1790. doi: 10.1017/s1355838200001679
Europe PMC | doi

Hentze MW, Izaurralde E, Séraphin B. (2000)

A new era for the RNA world. Conference: RNA 2000

EMBO Rep. 1(5):394-398. doi: 10.1093/embo-reports/kvd100
Europe PMC | doi

Fortes P, Inada T, Preiss T, Hentze MW, Mattaj IW, Sachs AB. (2000)

The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation

Mol. Cell 6(1):191-196. doi: 10.1016/s1097-2765(00)00020-4
Europe PMC | doi

Volkmann M, Schiff JH, Hör M, Hentze MW, Fiehn W, Merkt J. (2000)

[Pair of siblings of Italian ethnicity with hyperferritinemia and cataract]

Internist (Berl) 41(4):381-384. doi: 10.1007/s001080050521
Europe PMC | doi

Castagnetti S, Hentze MW, Ephrussi A, Gebauer F. (2000)

Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries

Development 127(5):1063-1068.
Europe PMC

McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, Simpson RJ. (2000)

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

Mol. Cell 5(2):299-309. doi: 10.1016/s1097-2765(00)80425-6
Europe PMC | doi

Pantopoulos K, Hentze MW. (2000)

Nitric oxide, oxygen radicals, and iron metabolism

In: L.J. Ignarro, (ed.). Academic Press, Nitric Oxide: Biology and Pathobiology. pp 293-313.
Europe PMC

Paraskeva E, Hentze MW. (2000)

Translational repression assay procedure: a method to study RNA-protein interactions in yeast

Meth. Enzymol. 318:374-384. doi: 10.1016/s0076-6879(00)18064-4
Europe PMC | doi

Wickens M, Goodwin EB, Kimble J, Strickland S, Hentze MW. (2000)

Translational Control of Developmental Decisions

In: N. Sonenberg, J. W.B. Hershey, M.B. Mathews, (eds.), Cold Spring Harbor Press, Translational Control. pp 295-370.
Europe PMC


1999

Riedel HD, Muckenthaler MU, Gehrke SG, Mohr I, Brennan K, Herrmann T, Fitscher BA, Hentze MW, Stremmel W. (1999)

HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells

Blood 94(11):3915-3921.
Europe PMC

Gebauer F, Corona DF, Preiss T, Becker PB, Hentze MW. (1999)

Translational control of dosage compensation in Drosophila by Sex-lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail

EMBO J. 18(21):6146-6154. doi: 10.1093/emboj/18.21.6146
Europe PMC | doi

Preiss T, Hentze MW. (1999)

From factors to mechanisms: translation and translational control in eukaryotes

Curr. Opin. Genet. Dev. 9(5):515-521. doi: 10.1016/s0959-437x(99)00005-2
Europe PMC | doi

De Gregorio E, Preiss T, Hentze MW. (1999)

Translation driven by an eIF4G core domain in vivo

EMBO J. 18(17):4865-4874. doi: 10.1093/emboj/18.17.4865
Europe PMC | doi

Brazzolotto X, Gaillard J, Pantopoulos K, Hentze MW, Moulis JM. (1999)

Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro but is not activated for iron-responsive element binding

J. Biol. Chem. 274(31):21625-21630. doi: 10.1074/jbc.274.31.21625
Europe PMC | doi

Gegout V, Schlegl J, Schläger B, Hentze MW, Reinbolt J, Ehresmann B, Ehresmann C, Romby P. (1999)

Ligand-induced structural alterations in human iron regulatory protein-1 revealed by protein footprinting

J. Biol. Chem. 274(21):15052-15058. doi: 10.1074/jbc.274.21.15052
Europe PMC | doi

Gehring NH, Hentze MW, Pantopoulos K. (1999)

Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress

J. Biol. Chem. 274(10):6219-6225. doi: 10.1074/jbc.274.10.6219
Europe PMC | doi

Hentze MW, Kulozik AE. (1999)

A perfect message: RNA surveillance and nonsense-mediated decay

Cell 96(3):307-310. doi: 10.1016/s0092-8674(00)80542-5
Europe PMC | doi

Paraskeva E, Gray NK, Schläger B, Wehr K, Hentze MW. (1999)

Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements

Mol. Cell. Biol. 19(1):807-816.
Europe PMC


1998

Ostareck-Lederer A, Ostareck DH, Hentze MW. (1998)

Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2

Trends Biochem. Sci. 23(11):409-411. doi: 10.1016/s0968-0004(98)01301-2
Europe PMC | doi

Preiss T, Muckenthaler M, Hentze MW. (1998)

Poly(A)-tail-promoted translation in yeast: implications for translational control

RNA 4(11):1321-1331. doi: 10.1017/s1355838298980669
Europe PMC | doi

Muckenthaler M, Gray NK, Hentze MW. (1998)

IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F

Mol. Cell 2(3):383-388. doi: 10.1016/s1097-2765(00)80282-8
Europe PMC | doi

Pantopoulos K, Hentze MW. (1998)

Activation of iron regulatory protein-1 by oxidative stress in vitro

Proc. Natl. Acad. Sci. U.S.A. 95(18):10559-10563. doi: 10.1073/pnas.95.18.10559
Europe PMC | doi

De Gregorio E, Preiss T, Hentze MW. (1998)

Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent

RNA 4(7):828-836. doi: 10.1017/s1355838298980372
Europe PMC | doi

Muckenthaler M, Gunkel N, Frishman D, Cyrklaff A, Tomancak P, Hentze MW. (1998)

Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans

Eur. J. Biochem. 254(2):230-237. doi: 10.1046/j.1432-1327.1998.2540230.x
Europe PMC | doi

Thermann R, Neu-Yilik G, Deters A, Frede U, Wehr K, Hagemeier C, Hentze MW, Kulozik AE. (1998)

Binary specification of nonsense codons by splicing and cytoplasmic translation

EMBO J. 17(12):3484-3494. doi: 10.1093/emboj/17.12.3484
Europe PMC | doi

Preiss T, Hentze MW. (1998)

Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast

Nature 392(6675):516-520. doi: 10.1038/33192
Europe PMC | doi

Gebauer F, Merendino L, Hentze MW, Valcárcel J. (1998)

The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA

RNA 4(2):142-150.
Europe PMC

Paraskeva E, Atzberger A, Hentze MW. (1998)

A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo

Proc. Natl. Acad. Sci. U.S.A. 95(3):951-956. doi: 10.1073/pnas.95.3.951
Europe PMC | doi

Dandekar T, Beyer K, Bork P, Kenealy MR, Pantopoulos K, Hentze M, Sonntag-Buck V, Flouriot G, Gannon F, Schreiber S. (1998)

Systematic genomic screening and analysis of mRNA in untranslated regions and mRNA precursors: combining experimental and computational approaches

Paper presented at the German Conference on Bioinformatics (GCB 97), KLOSTER IRSEE, GERMANY, SEP, 1997.Bioinformatics 14(3):271-278. doi: 10.1093/bioinformatics/14.3.271
Europe PMC | doi


1997

Gebauer F, Merendino L, Hentze MW, Valcárcel J. (1997)

Novel functions for 'nuclear factors' in the cytoplasm: the Sex-lethal paradigm

Semin. Cell Dev. Biol. 8(6):561-566. doi: 10.1006/scdb.1997.0181
Europe PMC | doi

Schlegl J, Gegout V, Schläger B, Hentze MW, Westhof E, Ehresmann C, Ehresmann B, Romby P. (1997)

Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1

RNA 3(10):1159-1172.
Europe PMC

Muckenthaler M, Gunkel N, Stripecke R, Hentze MW. (1997)

Regulated poly(A) tail shortening in somatic cells mediated by cap-proximal translational repressor proteins and ribosome association

RNA 3(9):983-995.
Europe PMC

Sachs AB, Sarnow P, Hentze MW. (1997)

Starting at the beginning, middle, and end: translation initiation in eukaryotes

Cell 89(6):831-838. doi: 10.1016/s0092-8674(00)80268-8
Europe PMC | doi