EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

PA to the Director
Esther Liebig
Room: ATC B2303
Tel: +49 6221 387-8914
Fax: +49 6221 387-8144
E-mail: director@embl.org
Administrative Assistant
Christine Turcotte
Room: ATC B2303
Tel: +49 6221 387-8766
Fax: +49 6221 387-8144
E-mail: director@embl.org
Senior Project Officer
Nina Papritz-Knapp
Room: ATC B2303
Tel: +49 6221 387-8909
Fax: +49 6221 387-8144
E-mail: director@embl.org

Biography

  • MD 1984, University of Münster.
    Postdoctoral training at the NIH, Bethesda.
    Group Leader at EMBL since 1989. Senior Scientist since 1998. Associate Director 2005-2013. Director since 2013.
    Co-Director of the EMBL/University of Heidelberg Molecular Medicine Partnership Unit since 2002.
    ERC Advanced Investigator since 2011.

Publications

Total: 263 publication(s)

1997

Ostareck DH, Ostareck-Lederer A, Wilm M, Thiele BJ, Mann M, Hentze MW. (1997)

mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end

Cell 89(4):597-606. doi: 10.1016/s0092-8674(00)80241-x
Europe PMC | doi

Pantopoulos K, Mueller S, Atzberger A, Ansorge W, Stremmel W, Hentze MW. (1997)

Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress

J. Biol. Chem. 272(15):9802-9808. doi: 10.1074/jbc.272.15.9802
Europe PMC | doi

Hentze MW. (1997)

eIF4G: a multipurpose ribosome adapter?

Science 275(5299):500-501. doi: 10.1126/science.275.5299.500
Europe PMC | doi

Muckenthaler M, Hentze MW. (1997)

Mechanisms for posttranscriptional regulation by iron-responsive elements and iron regulatory proteins

Prog. Mol. Subcell. Biol. 18:93-115.
Europe PMC

Weiss G, Bogdan C, Hentze MW. (1997)

Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13

J. Immunol. 158(1):420-425.
Europe PMC


1996

Hentze MW. (1996)

Iron-sulfur clusters and oxidant stress responses

Trends Biochem. Sci. 21(8):282-283. doi: 10.1016/0968-0004(96)20019-2
Europe PMC | doi

Hentze MW, Kühn LC. (1996)

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

Proc. Natl. Acad. Sci. U.S.A. 93(16):8175-8182. doi: 10.1073/pnas.93.16.8175
Europe PMC | doi

Frishman D, Hentze MW. (1996)

Conservation of aconitase residues revealed by multiple sequence analysis. Implications for structure/function relationships

Eur. J. Biochem. 239(1):197-200. doi: 10.1111/j.1432-1033.1996.0197u.x
Europe PMC | doi

Pantopoulos K, Weiss G, Hentze MW. (1996)

Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways

Mol. Cell. Biol. 16(7):3781-3788.
Europe PMC

Paraskeva E, Hentze MW. (1996)

Iron-sulphur clusters as genetic regulatory switches: the bifunctional iron regulatory protein-1

FEBS Lett. 389(1):40-43. doi: 10.1016/0014-5793(96)00574-1
Europe PMC | doi

Gray NK, Pantopoulos K, Dandekar T, Ackrell BA, Hentze MW. (1996)

Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements

Proc. Natl. Acad. Sci. U.S.A. 93(10):4925-4930. doi: 10.1073/pnas.93.10.4925
Europe PMC | doi

Kollmus H, Hentze MW, Hauser H. (1996)

Regulated ribosomal frameshifting by an RNA-protein interaction

RNA 2(4):316-323.
Europe PMC

Picard V, Renaudie F, Porcher C, Hentze MW, Grandchamp B, Beaumont C. (1996)

Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution

Blood 87(5):2057-2064.
Europe PMC


1995

Hentze MW. (1995)

Translational regulation: versatile mechanisms for metabolic and developmental control.

Curr. Opin. Cell Biol. 7(3):393-398. doi: 10.1016/0955-0674(95)80095-6
Europe PMC | doi

Pantopoulos K, Hentze MW. (1995)

Rapid responses to oxidative stress mediated by iron regulatory protein

EMBO J. 14(12):2917-2924.
Europe PMC

Oria R, Sánchez L, Houston T, Hentze MW, Liew FY, Brock JH. (1995)

Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells.

Blood 85(10):2962-2966.
Europe PMC

Pantopoulos K, Gray NK, Hentze MW. (1995)

Differential regulation of two related RNA-binding proteins, iron regulatory protein (IRP) and IRPB.

RNA 1(2):155-163.
Europe PMC

Dandekar T, Hentze MW. (1995)

Finding the hairpin in the haystack: searching for RNA motifs.

Trends Genet. 11(2):45-50. doi: 10.1016/s0168-9525(00)88996-9
Europe PMC | doi

Kugler W, Enssle J, Hentze MW, Kulozik AE. (1995)

Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?

Nucleic Acids Res. 23(3):413-418. doi: 10.1093/nar/23.3.413
Europe PMC | doi

Pantopoulos K, Hentze MW. (1995)

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts

Proc. Natl. Acad. Sci. U.S.A. 92(5):1267-1271. doi: 10.1073/pnas.92.5.1267
Europe PMC | doi


1994

Johansson HE, Belsham GJ, Sproat BS, Hentze MW. (1994)

Target-specific arrest of mRNA translation by antisense 2'-O-alkyloligoribonucleotides

Nucleic Acids Res. 22(22):4591-4598. doi: 10.1093/nar/22.22.4591
Europe PMC | doi

Stripecke R, Oliveira CC, McCarthy JE, Hentze MW. (1994)

Proteins binding to 5' untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells.

Mol. Cell. Biol. 14(9):5898-5909. doi: 10.1128/mcb.14.9.5898
Europe PMC | doi

Weiss G, Werner-Felmayer G, Werner ER, Grünewald K, Wachter H, Hentze MW. (1994)

Iron regulates nitric oxide synthase activity by controlling nuclear transcription

J. Exp. Med. 180(3):969-976. doi: 10.1084/jem.180.3.969
Europe PMC | doi

Gray NK, Hentze MW. (1994)

Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.

EMBO J. 13(16):3882-3891.
Europe PMC

Gray NK, Hentze MW. (1994)

Regulation of protein synthesis by mRNA structure.

Mol. Biol. Rep. 19(3):195-200. doi: 10.1007/bf00986961
Europe PMC | doi

Hentze MW. (1994)

Enzymes as RNA-binding proteins: a role for (di)nucleotide-binding domains?

Trends Biochem. Sci. 19(3):101-103. doi: 10.1016/0968-0004(94)90198-8
Europe PMC | doi

Pantopoulos K, Weiss G, Hentze MW. (1994)

Nitric oxide and the post-transcriptional control of cellular iron traffic.

Trends Cell Biol. 4(3):82-86. doi: 10.1016/0962-8924(94)90179-1
Europe PMC | doi


1993

Gray NK, Quick S, Goossen B, Constable A, Hirling H, Kühn LC, Hentze MW. (1993)

Recombinant iron-regulatory factor functions as an iron-responsive-element-binding protein, a translational repressor and an aconitase. A functional assay for translational repression and direct demonstration of the iron switch

Eur. J. Biochem. 218(2):657-667. doi: 10.1111/j.1432-1033.1993.tb18420.x
Europe PMC | doi

Hentze MW. (1993)

Translational control by iron-responsive elements.

Adv. Exp. Med. Biol. 356:119-126.
Europe PMC

Melefors O, Hentze MW. (1993)

Iron regulatory factor--the conductor of cellular iron regulation.

Blood Rev. 7(4):251-258. doi: 10.1016/0268-960x(93)90012-s
Europe PMC | doi

Pantopoulos K, Johansson HE, Hentze MW. (1993)

The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies.

Prog. Nucleic Acid Res. Mol. Biol. 48:181-238.
Europe PMC

Weiss G, Goossen B, Doppler W, Fuchs D, Pantopoulos K, Werner-Felmayer G, Grünewald K, Wachter H, Hentze MW. (1993)

Stimulation of IRE-BP activity of IRF by tetrahydrobiopterin and cytokine dependent induction of nitric oxide synthase.

Adv. Exp. Med. Biol. 356:133-139.
Europe PMC

Enssle J, Kugler W, Hentze MW, Kulozik AE. (1993)

Determination of mRNA fate by different RNA polymerase II promoters

Proc. Natl. Acad. Sci. U.S.A. 90(21):10091-10095. doi: 10.1073/pnas.90.21.10091
Europe PMC | doi

Oliveira CC, Goossen B, Zanchin NI, McCarthy JE, Hentze MW, Stripecke R. (1993)

Translational repression by the human iron-regulatory factor (IRF) in Saccharomyces cerevisiae

Nucleic Acids Res. 21(23):5316-5322. doi: 10.1093/nar/21.23.5316
Europe PMC | doi

Weiss G, Goossen B, Doppler W, Fuchs D, Pantopoulos K, Werner-Felmayer G, Wachter H, Hentze MW. (1993)

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

EMBO J. 12(9):3651-3657.
Europe PMC

Melefors O, Goossen B, Johansson HE, Stripecke R, Gray NK, Hentze MW. (1993)

Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells.

J. Biol. Chem. 268(8):5974-5978.
Europe PMC

Melefors O, Hentze MW. (1993)

Translational regulation by mRNA/protein interactions in eukaryotic cells: ferritin and beyond.

Bioessays 15(2):85-90. doi: 10.1002/bies.950150203
Europe PMC | doi


1992

Stripecke R, Hentze MW. (1992)

Bacteriophage and spliceosomal proteins function as position-dependent cis/trans repressors of mRNA translation in vitro

Nucleic Acids Res. 20(21):5555-5564. doi: 10.1093/nar/20.21.5555
Europe PMC | doi

Coccia EM, Profita V, Fiorucci G, Romeo G, Affabris E, Testa U, Hentze MW, Battistini A. (1992)

Modulation of ferritin H-chain expression in Friend erythroleukemia cells: transcriptional and translational regulation by hemin.

Mol. Cell. Biol. 12(7):3015-3022. doi: 10.1128/MCB.12.7.3015
Europe PMC | doi

Constable A, Quick S, Gray NK, Hentze MW. (1992)

Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?

Proc. Natl. Acad. Sci. U.S.A. 89(10):4554-4558. doi: 10.1073/pnas.89.10.4554
Europe PMC | doi

Goossen B, Hentze MW. (1992)

Position is the critical determinant for function of iron-responsive elements as translational regulators.

Mol. Cell. Biol. 12(5):1959-1966.
Europe PMC


1991

Kühn LC, Hentze MW. (1991)

Coordination of cellular iron metabolism by post-transcriptional gene regulation.

J. Inorg. Biochem. 47(3-4):183-195. doi: 10.1016/0162-0134(92)84064-t
Europe PMC | doi

Hentze MW. (1991)

Determinants and regulation of cytoplasmic mRNA stability in eukaryotic cells.

Biochim. Biophys. Acta 1090(3):281-292. doi: 10.1016/0167-4781(91)90191-n
Europe PMC | doi

Dandekar T, Stripecke R, Gray NK, Goossen B, Constable A, Johansson HE, Hentze MW. (1991)

Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.

EMBO J. 10(7):1903-1909.
Europe PMC

Hentze MW, Argos P. (1991)

Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase

Nucleic Acids Res. 19(8):1739-1740. doi: 10.1093/nar/19.8.1739
Europe PMC | doi

Johansson HE, De Groot N, Hochberg AA, Hentze MW. (1991)

Effect of heparin contained in preparations of small cytoplasmic RNAs on cell-free translation.

J. Biol. Chem. 266(3):1921-1925.
Europe PMC


1990

Goossen B, Caughman SW, Harford JB, Klausner RD, Hentze MW. (1990)

Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo.

EMBO J. 9(12):4127-4133.
Europe PMC

Hentze MW. (1990)

Translational regulation of ferritin biosynthesis by iron: a review.

Curr Stud Hematol Blood Transfus (58):115-126.
Europe PMC

Hentze MW. (1990)

Overcoming inhibitions.

In: sponsored by the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA, September 13-17, 1989., Translational Control, vol 2. pp 33-36.New Biol. 2(1):33-36.
Europe PMC


1989

Hentze MW, Goossen B, Caughman SW. (1989)

Complex formation between a cytoplasmic protein and the ferritin mRNA regulates translation initiation.

Mol. Biol. Rep. 14(2-3) doi: 10.1007/bf00360416
Europe PMC | doi

Haile DJ, Hentze MW, Rouault TA, Harford JB, Klausner RD. (1989)

Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements.

Mol. Cell. Biol. 9(11):5055-5061.
Europe PMC

Hentze MW, Seuanez HN, O'Brien SJ, Harford JB, Klausner RD. (1989)

Chromosomal localization of nucleic acid-binding proteins by affinity mapping: assignment of the IRE-binding protein gene to human chromosome 9.

Nucleic Acids Res. 17(15):6103-6108. doi: 10.1093/nar/17.15.6103
Europe PMC | doi

Rouault TA, Hentze MW, Haile DJ, Harford JB, Klausner RD. (1989)

The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.

Proc. Natl. Acad. Sci. U.S.A. 86(15):5768-5772. doi: 10.1073/pnas.86.15.5768
Europe PMC | doi

Koeller DM, Casey JL, Hentze MW, Gerhardt EM, Chan LN, Klausner RD, Harford JB. (1989)

A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.

Proc. Natl. Acad. Sci. U.S.A. 86(10):3574-3578. doi: 10.1073/pnas.86.10.3574
Europe PMC | doi

Hentze MW, Rouault TA, Harford JB, Klausner RD. (1989)

Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.

Science 244(4902):357-359. doi: 10.1126/science.2711187
Europe PMC | doi


1988

Caughman SW, Hentze MW, Rouault TA, Harford JB, Klausner RD. (1988)

The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor.

J. Biol. Chem. 263(35):19048-19052.
Europe PMC

Hentze MW, Caughman SW, Casey JL, Koeller DM, Rouault TA, Harford JB, Klausner RD. (1988)

A model for the structure and functions of iron-responsive elements.

Gene 72(1-2):201-208. doi: 10.1016/0378-1119(88)90145-x
Europe PMC | doi

Rouault TA, Hentze MW, Caughman SW, Harford JB, Klausner RD. (1988)

Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA.

Science 241(4870):1207-1210. doi: 10.1126/science.3413484
Europe PMC | doi

Casey JL, Hentze MW, Koeller DM, Caughman SW, Rouault TA, Klausner RD, Harford JB. (1988)

Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.

Science 240(4854):924-928. doi: 10.1126/science.2452485
Europe PMC | doi


1987

Hentze MW, Caughman SW, Rouault TA, Barriocanal JG, Dancis A, Harford JB, Klausner RD. (1987)

Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.

Science 238(4833):1570-1573. doi: 10.1126/science.3685996
Europe PMC | doi

Hentze MW, Rouault TA, Caughman SW, Dancis A, Harford JB, Klausner RD. (1987)

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

Proc. Natl. Acad. Sci. U.S.A. 84(19):6730-6734. doi: 10.1073/pnas.84.19.6730
Europe PMC | doi

Rouault TA, Hentze MW, Dancis A, Caughman W, Harford JB, Klausner RD. (1987)

Influence of altered transcription on the translational control of human ferritin expression.

Proc. Natl. Acad. Sci. U.S.A. 84(18):6335-6339. doi: 10.1073/pnas.84.18.6335
Europe PMC | doi


1986

Hentze MW, Keim S, Papadopoulos P, O'Brien S, Modi W, Drysdale J, Leonard WJ, Harford JB, Klausner RD. (1986)

Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.

Proc. Natl. Acad. Sci. U.S.A. 83(19):7226-7230. doi: 10.1073/pnas.83.19.7226
Europe PMC | doi